Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions.

Journal Article (Journal Article;Review)

An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune responses, with a broad spectrum of chemicals displaying the potential to adversely influence immunosurveillance. The evaluation of the cumulative effects of low-dose exposures from the occupational and natural environment, especially if multiple chemicals target the same gene(s) or pathway(s), is a challenge. We reviewed common environmental chemicals and discussed their potential effects on immunosurveillance. Our overarching objective was to review related signaling pathways influencing immune surveillance such as the pathways involving PI3K/Akt, chemokines, TGF-β, FAK, IGF-1, HIF-1α, IL-6, IL-1α, CTLA-4 and PD-1/PDL-1 could individually or collectively impact immunosurveillance. A number of chemicals that are common in the anthropogenic environment such as fungicides (maneb, fluoxastrobin and pyroclostrobin), herbicides (atrazine), insecticides (pyridaben and azamethiphos), the components of personal care products (triclosan and bisphenol A) and diethylhexylphthalate with pathways critical to tumor immunosurveillance. At this time, these chemicals are not recognized as human carcinogens; however, it is known that they these chemicalscan simultaneously persist in the environment and appear to have some potential interfere with the host immune response, therefore potentially contributing to promotion interacting with of immune evasion mechanisms, and promoting subsequent tumor growth and progression.

Full Text

Duke Authors

Cited Authors

  • Kravchenko, J; Corsini, E; Williams, MA; Decker, W; Manjili, MH; Otsuki, T; Singh, N; Al-Mulla, F; Al-Temaimi, R; Amedei, A; Colacci, AM; Vaccari, M; Mondello, C; Scovassi, AI; Raju, J; Hamid, RA; Memeo, L; Forte, S; Roy, R; Woodrick, J; Salem, HK; Ryan, EP; Brown, DG; Bisson, WH; Lowe, L; Lyerly, HK

Published Date

  • June 2015

Published In

Volume / Issue

  • 36 Suppl 1 /

Start / End Page

  • S111 - S127

PubMed ID

  • 26002081

Pubmed Central ID

  • PMC4565606

Electronic International Standard Serial Number (EISSN)

  • 1460-2180

Digital Object Identifier (DOI)

  • 10.1093/carcin/bgv033


  • eng

Conference Location

  • England