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Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions.

Publication ,  Journal Article
Kravchenko, J; Corsini, E; Williams, MA; Decker, W; Manjili, MH; Otsuki, T; Singh, N; Al-Mulla, F; Al-Temaimi, R; Amedei, A; Colacci, AM ...
Published in: Carcinogenesis
June 2015

An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune responses, with a broad spectrum of chemicals displaying the potential to adversely influence immunosurveillance. The evaluation of the cumulative effects of low-dose exposures from the occupational and natural environment, especially if multiple chemicals target the same gene(s) or pathway(s), is a challenge. We reviewed common environmental chemicals and discussed their potential effects on immunosurveillance. Our overarching objective was to review related signaling pathways influencing immune surveillance such as the pathways involving PI3K/Akt, chemokines, TGF-β, FAK, IGF-1, HIF-1α, IL-6, IL-1α, CTLA-4 and PD-1/PDL-1 could individually or collectively impact immunosurveillance. A number of chemicals that are common in the anthropogenic environment such as fungicides (maneb, fluoxastrobin and pyroclostrobin), herbicides (atrazine), insecticides (pyridaben and azamethiphos), the components of personal care products (triclosan and bisphenol A) and diethylhexylphthalate with pathways critical to tumor immunosurveillance. At this time, these chemicals are not recognized as human carcinogens; however, it is known that they these chemicalscan simultaneously persist in the environment and appear to have some potential interfere with the host immune response, therefore potentially contributing to promotion interacting with of immune evasion mechanisms, and promoting subsequent tumor growth and progression.

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Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

June 2015

Volume

36 Suppl 1

Issue

Suppl 1

Start / End Page

S111 / S127

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Immunologic Surveillance
  • Immune Evasion
  • Humans
  • Hazardous Substances
  • Environment
  • Animals
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
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Kravchenko, J., Corsini, E., Williams, M. A., Decker, W., Manjili, M. H., Otsuki, T., … Lyerly, H. K. (2015). Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions. Carcinogenesis, 36 Suppl 1(Suppl 1), S111–S127. https://doi.org/10.1093/carcin/bgv033
Kravchenko, Julia, Emanuela Corsini, Marc A. Williams, William Decker, Masoud H. Manjili, Takemi Otsuki, Neetu Singh, et al. “Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions.Carcinogenesis 36 Suppl 1, no. Suppl 1 (June 2015): S111–27. https://doi.org/10.1093/carcin/bgv033.
Kravchenko J, Corsini E, Williams MA, Decker W, Manjili MH, Otsuki T, et al. Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions. Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S111–27.
Kravchenko, Julia, et al. “Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions.Carcinogenesis, vol. 36 Suppl 1, no. Suppl 1, June 2015, pp. S111–27. Pubmed, doi:10.1093/carcin/bgv033.
Kravchenko J, Corsini E, Williams MA, Decker W, Manjili MH, Otsuki T, Singh N, Al-Mulla F, Al-Temaimi R, Amedei A, Colacci AM, Vaccari M, Mondello C, Scovassi AI, Raju J, Hamid RA, Memeo L, Forte S, Roy R, Woodrick J, Salem HK, Ryan EP, Brown DG, Bisson WH, Lowe L, Lyerly HK. Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions. Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S111–S127.
Journal cover image

Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

June 2015

Volume

36 Suppl 1

Issue

Suppl 1

Start / End Page

S111 / S127

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Immunologic Surveillance
  • Immune Evasion
  • Humans
  • Hazardous Substances
  • Environment
  • Animals
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis