Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.

Published

Journal Article (Review)

Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.

Full Text

Duke Authors

Cited Authors

  • Tong, SYC; Davis, JS; Eichenberger, E; Holland, TL; Fowler, VG

Published Date

  • July 2015

Published In

Volume / Issue

  • 28 / 3

Start / End Page

  • 603 - 661

PubMed ID

  • 26016486

Pubmed Central ID

  • 26016486

Electronic International Standard Serial Number (EISSN)

  • 1098-6618

Digital Object Identifier (DOI)

  • 10.1128/CMR.00134-14

Language

  • eng

Conference Location

  • United States