Skip to main content
Journal cover image

In-hospital worsening heart failure.

Publication ,  Journal Article
Butler, J; Gheorghiade, M; Kelkar, A; Fonarow, GC; Anker, S; Greene, SJ; Papadimitriou, L; Collins, S; Ruschitzka, F; Yancy, CW; Teerlink, JR ...
Published in: Eur J Heart Fail
November 2015

Acute worsening heart failure (WHF) is seen in a sizable portion of patients hospitalized for heart failure, and is increasingly being recognized as an entity that is associated with an adverse in-hospital course. WHF is generally defined as worsening heart failure symptoms and signs requiring an intensification of therapy, and is reported to be seen in anywhere from 5% to 42% of heart failure admissions. It is difficult to ascertain the exact epidemiology of WHF due to varying definitions used in the literature. Studies indicate that WHF cannot be precisely predicted on the basis of baseline variables assessed at the time of admission. Recent data suggest that some experimental therapies may reduce the risk of development of WHF among hospitalized heart failure patients, and this is associated with a reduction in risk of subsequent post-discharge cardiovascular mortality. In this respect, WHF holds promise as a endpoint for acute heart failure clinical trials to better elucidate the benefit of targeted novel therapies. Better understanding of the pathophysiology and a consensus on the definition of WHF will further improve our epidemiological and clinical understanding of this entity.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

November 2015

Volume

17

Issue

11

Start / End Page

1104 / 1113

Location

England

Related Subject Headings

  • Therapies, Investigational
  • Symptom Flare Up
  • Secondary Prevention
  • Prognosis
  • Humans
  • Hospitalization
  • Heart Failure
  • Disease Progression
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Butler, J., Gheorghiade, M., Kelkar, A., Fonarow, G. C., Anker, S., Greene, S. J., … Filippatos, G. (2015). In-hospital worsening heart failure. Eur J Heart Fail, 17(11), 1104–1113. https://doi.org/10.1002/ejhf.333
Butler, Javed, Mihai Gheorghiade, Anita Kelkar, Gregg C. Fonarow, Stefan Anker, Stephen J. Greene, Lampros Papadimitriou, et al. “In-hospital worsening heart failure.Eur J Heart Fail 17, no. 11 (November 2015): 1104–13. https://doi.org/10.1002/ejhf.333.
Butler J, Gheorghiade M, Kelkar A, Fonarow GC, Anker S, Greene SJ, et al. In-hospital worsening heart failure. Eur J Heart Fail. 2015 Nov;17(11):1104–13.
Butler, Javed, et al. “In-hospital worsening heart failure.Eur J Heart Fail, vol. 17, no. 11, Nov. 2015, pp. 1104–13. Pubmed, doi:10.1002/ejhf.333.
Butler J, Gheorghiade M, Kelkar A, Fonarow GC, Anker S, Greene SJ, Papadimitriou L, Collins S, Ruschitzka F, Yancy CW, Teerlink JR, Adams K, Cotter G, Ponikowski P, Felker GM, Metra M, Filippatos G. In-hospital worsening heart failure. Eur J Heart Fail. 2015 Nov;17(11):1104–1113.
Journal cover image

Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

November 2015

Volume

17

Issue

11

Start / End Page

1104 / 1113

Location

England

Related Subject Headings

  • Therapies, Investigational
  • Symptom Flare Up
  • Secondary Prevention
  • Prognosis
  • Humans
  • Hospitalization
  • Heart Failure
  • Disease Progression
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology