Adaptive immune response to therapy in hmgcr autoantibody myopathy.

Journal Article (Journal Article)

INTRODUCTION: We evaluated the response to immunosuppression in a case of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)-autoantibody myopathy. METHODS: T- and B-cell subsets were determined by flow cytometry pre- and posttherapy. RESULTS: Baseline immune profiling demonstrated strikingly elevated T-follicular helper (Tfh) cells and plasmablasts. Immunosuppression resulted in clinical improvement and decreased Tfh cells, plasmablasts, and autoantibodies. CONCLUSIONS: Immune profiling in HMGCR-autoantibody myopathy suggests a B-cell-mediated disease. Tfh cells and plasmablasts may be therapeutic biomarkers.

Full Text

Duke Authors

Cited Authors

  • Yi, JS; Russo, MA; Weinhold, KJ; Guptill, JT

Published Date

  • February 2016

Published In

Volume / Issue

  • 53 / 2

Start / End Page

  • 313 - 317

PubMed ID

  • 26492512

Pubmed Central ID

  • PMC4718836

Electronic International Standard Serial Number (EISSN)

  • 1097-4598

Digital Object Identifier (DOI)

  • 10.1002/mus.24947

Language

  • eng

Conference Location

  • United States