Adaptive immune response to therapy in hmgcr autoantibody myopathy.
Publication
, Journal Article
Yi, JS; Russo, MA; Weinhold, KJ; Guptill, JT
Published in: Muscle Nerve
February 2016
INTRODUCTION: We evaluated the response to immunosuppression in a case of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)-autoantibody myopathy. METHODS: T- and B-cell subsets were determined by flow cytometry pre- and posttherapy. RESULTS: Baseline immune profiling demonstrated strikingly elevated T-follicular helper (Tfh) cells and plasmablasts. Immunosuppression resulted in clinical improvement and decreased Tfh cells, plasmablasts, and autoantibodies. CONCLUSIONS: Immune profiling in HMGCR-autoantibody myopathy suggests a B-cell-mediated disease. Tfh cells and plasmablasts may be therapeutic biomarkers.
Duke Scholars
Published In
Muscle Nerve
DOI
EISSN
1097-4598
Publication Date
February 2016
Volume
53
Issue
2
Start / End Page
313 / 317
Location
United States
Related Subject Headings
- Neurology & Neurosurgery
- Neural Conduction
- Muscular Diseases
- Middle Aged
- Male
- Hydroxymethylglutaryl CoA Reductases
- Humans
- Autoantibodies
- Adaptive Immunity
- 32 Biomedical and clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Yi, J. S., Russo, M. A., Weinhold, K. J., & Guptill, J. T. (2016). Adaptive immune response to therapy in hmgcr autoantibody myopathy. Muscle Nerve, 53(2), 313–317. https://doi.org/10.1002/mus.24947
Yi, John S., Melissa A. Russo, Kent J. Weinhold, and Jeffrey T. Guptill. “Adaptive immune response to therapy in hmgcr autoantibody myopathy.” Muscle Nerve 53, no. 2 (February 2016): 313–17. https://doi.org/10.1002/mus.24947.
Yi JS, Russo MA, Weinhold KJ, Guptill JT. Adaptive immune response to therapy in hmgcr autoantibody myopathy. Muscle Nerve. 2016 Feb;53(2):313–7.
Yi, John S., et al. “Adaptive immune response to therapy in hmgcr autoantibody myopathy.” Muscle Nerve, vol. 53, no. 2, Feb. 2016, pp. 313–17. Pubmed, doi:10.1002/mus.24947.
Yi JS, Russo MA, Weinhold KJ, Guptill JT. Adaptive immune response to therapy in hmgcr autoantibody myopathy. Muscle Nerve. 2016 Feb;53(2):313–317.
Published In
Muscle Nerve
DOI
EISSN
1097-4598
Publication Date
February 2016
Volume
53
Issue
2
Start / End Page
313 / 317
Location
United States
Related Subject Headings
- Neurology & Neurosurgery
- Neural Conduction
- Muscular Diseases
- Middle Aged
- Male
- Hydroxymethylglutaryl CoA Reductases
- Humans
- Autoantibodies
- Adaptive Immunity
- 32 Biomedical and clinical sciences