Adaptive immune response to therapy in hmgcr autoantibody myopathy.
Journal Article (Journal Article)
INTRODUCTION: We evaluated the response to immunosuppression in a case of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)-autoantibody myopathy. METHODS: T- and B-cell subsets were determined by flow cytometry pre- and posttherapy. RESULTS: Baseline immune profiling demonstrated strikingly elevated T-follicular helper (Tfh) cells and plasmablasts. Immunosuppression resulted in clinical improvement and decreased Tfh cells, plasmablasts, and autoantibodies. CONCLUSIONS: Immune profiling in HMGCR-autoantibody myopathy suggests a B-cell-mediated disease. Tfh cells and plasmablasts may be therapeutic biomarkers.
Full Text
Duke Authors
Cited Authors
- Yi, JS; Russo, MA; Weinhold, KJ; Guptill, JT
Published Date
- February 2016
Published In
Volume / Issue
- 53 / 2
Start / End Page
- 313 - 317
PubMed ID
- 26492512
Pubmed Central ID
- PMC4718836
Electronic International Standard Serial Number (EISSN)
- 1097-4598
Digital Object Identifier (DOI)
- 10.1002/mus.24947
Language
- eng
Conference Location
- United States