John S Yi | Scholars@Duke

John S Yi
Adjunct Assistant Professor in the Department of Surgery

I am an immunologist, with a focus to characterize the immune system in response to infectious and non-infectious diseases including cancer, HIV, autoimmune disease, and transplantation. My goals are to identify novel biomarkers/immune signatures that clinicians can utilize to diagnosis, predict disease outcomes, and determine patients' response to treatment.

Current Appointments & Affiliations

Adjunct Assistant Professor in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2016

Contact Information

915 S. Lasalle Street, 204 Sorf (Bldg. 41) Box 2926, Durham, NC 27710
john.yi@duke.edu (919) 684-4846

Background
Education, Training, & Certifications
- Ph.D., University of Alabama Birmingham 2010
Previous Appointments & Affiliations
- Assistant Professor in Surgery, Surgery, Surgical Sciences, Surgery 2021
- Assistant Professor of Surgery, Surgery, Surgical Sciences, Surgery 2015 - 2020
Expertise
Subject Headings
Research
Selected Grants
- Defining the clinical phenotype and immunopathology of seronegative MG awarded by Myasthenia Gravis Foundation 2021 - 2022
- VTEU Task D Option 2 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2022
- Biomarkers predicting response to eculizumab in MG (NonFed) awarded by The George Washington University 2021 - 2022
- Biomarkers predicting response to eculizumab in myasthenia gravis awarded by The George Washington University 2021 - 2022
- RARE DISEASE NETWORK FOR MYASTHENIA GRAVIS awarded by The George Washington University 2019 - 2022
- Mechanisms of immune checkpoint resistance mediated by LKB1 tumor suppressor in lung cancer awarded by Department of Defense 2019 - 2021
- Metabolic Pathways Of Pathogenic Th17 Cells In Myasthenia Gravis awarded by Myasthenia Gravis Foundation 2020 - 2021
- Overcoming checkpoint blockade resistance in ovarian cancer awarded by Society for Immunotherapy of Cancer 2019 - 2021
- Pathogenic Th17 cell pathology in CIDP awarded by GBS/CIDP Foundation International 2019 - 2021
- Characterization of porcine synovial cells in co-culture awarded by Piedmont Orthopedic Foundation 2020
- Feasibility of using Bortezomib-based immunosuppressive approach to deplete anti-AAV antibodies in mice awarded by Asklepios BioPharmaceutical, Inc. 2018 - 2020
- Immune modulation of CaMKK2 in the ovarian tumor microenvironment awarded by American Association of Obstetricians and Gynecologists Foundation 2019 - 2020
- GAA-iTEM: Personalizing the Prediction of Anti-therapeutic Antibody Response in Pome Disease Patients awarded by EpiVax, Inc. 2018 - 2020
- Immunologic Changes in the Treatment of Myasthenia Gravis awarded by Ra Pharmaceuticals, Inc 2017 - 2019
- Role of CD4 T cell subsets as drivers of MG disease awarded by Myasthenia Gravis Foundation 2016 - 2019
- The interface of B and T cells in Transplant awarded by Cystic Fibrosis Foundation Therapeutics, Inc. 2016 - 2019
- Acetylcholine receptor binding B cells as biomarker for myasthenia gravis awarded by AFM-Telethon 2017 - 2018
- High Impact Pilot Project on Myasthenia Gravis and Related Neuromuscular Junction Disorders awarded by Myasthenia Gravis Foundation 2014 - 2017
- Profiling of ACHR-Specific B Cells in Myasthenia Gravis awarded by Myasthenia Gravis Foundation of Illinois 2015 - 2016
- VTEU Task A Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Goel, Shom, Antoinette R. Tan, Hope S. Rugo, Philippe Aftimos, Zoran Andrić, Andrew Beelen, Jingshan Zhang, John S. Yi, Rajesh Malik, and Joyce O’Shaughnessy. “Trilaciclib prior to gemcitabine plus carboplatin for metastatic triple-negative breast cancer: phase III PRESERVE 2.” Future Oncol 18, no. 33 (October 2022): 3701–11. https://doi.org/10.2217/fon-2022-0773.
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  - Kim-Wang, Sophia Y., Abigail G. Holt, Alyssa M. McGowan, Stephanie T. Danyluk, Adam P. Goode, Brian C. Lau, Alison P. Toth, et al. “Immune cell profiles in synovial fluid after anterior cruciate ligament and meniscus injuries.” Arthritis Res Ther 23, no. 1 (November 4, 2021): 280. https://doi.org/10.1186/s13075-021-02661-1.
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  - Li, Yingkai, John S. Yi, James F. Howard, Manisha Chopra, Melissa A. Russo, and Jeffrey T. Guptill. “Cellular changes in eculizumab early responders with generalized myasthenia gravis.” Clin Immunol 231 (October 2021): 108830. https://doi.org/10.1016/j.clim.2021.108830.
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  - Schmitz, Robin, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, et al. “C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.” Nat Commun 12, no. 1 (September 15, 2021): 5456. https://doi.org/10.1038/s41467-021-25745-7.
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  - Buchanan, Michael W., Bridgette D. Furman, Jacob H. Zeitlin, Janet L. Huebner, Virginia B. Kraus, John S. Yi, and Steven A. Olson. “Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency.” J Orthop Res 39, no. 8 (August 2021): 1710–21. https://doi.org/10.1002/jor.24899.
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  - Furman, B. D., J. H. Zeitlin, M. W. Buchanan, J. L. Huebner, V. B. Kraus, J. S. Yi, S. B. Adams, and S. A. Olson. “Immune cell profiling in the joint following human and murine articular fracture.” Osteoarthritis Cartilage 29, no. 6 (June 2021): 915–23. https://doi.org/10.1016/j.joca.2021.02.565.
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  - Li, Yingkai, John S. Yi, Melissa A. Russo, Marilyn Rosa-Bray, Kent J. Weinhold, and Jeffrey T. Guptill. “Normative dataset for plasma cytokines in healthy human adults.” Data Brief 35 (April 2021): 106857. https://doi.org/10.1016/j.dib.2021.106857.
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  - Guptill, Jeffrey T., Richard Barfield, Cliburn Chan, Melissa A. Russo, Doug Emmett, Shruti Raja, Janice M. Massey, et al. “Reduced plasmablast frequency is associated with seronegative myasthenia gravis.” Muscle Nerve 63, no. 4 (April 2021): 577–85. https://doi.org/10.1002/mus.27140.
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  - Salama, April K. S., Manisha Palta, Christel N. Rushing, M Angelica Selim, Kristen N. Linney, Brian G. Czito, David S. Yoo, et al. “Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.” Clin Cancer Res 27, no. 5 (March 1, 2021): 1287–95. https://doi.org/10.1158/1078-0432.CCR-20-2452.
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  - Hendrix, James A., Angelika Amon, Leonard Abbeduto, Stamatis Agiovlasitis, Tarek Alsaied, Heather A. Anderson, Lisa J. Bain, et al. “Opportunities, barriers, and recommendations in down syndrome research.” Transl Sci Rare Dis 5, no. 3–4 (2021): 99–129. https://doi.org/10.3233/trd-200090.
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  - De Groot, Anne S., Ankit K. Desai, Sandra Lelias, SM Shahjahan Miah, Frances E. Terry, Sundos Khan, Cindy Li, et al. “Immune Tolerance-Adjusted Personalized Immunogenicity Prediction for Pompe Disease.” Front Immunol 12 (2021): 636731. https://doi.org/10.3389/fimmu.2021.636731.
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  - Li, Yingkai, Jeffrey T. Guptill, Melissa A. Russo, James F. Howard, Janice M. Massey, Vern C. Juel, Lisa D. Hobson-Webb, et al. “Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.” J Neuroimmunol 345 (August 15, 2020): 577279. https://doi.org/10.1016/j.jneuroim.2020.577279.
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  - Yi, John S., Melissa A. Russo, Shruti Raja, Janice M. Massey, Vern C. Juel, Jay Shin, Lisa D. Hobson-Webb, Karissa Gable, and Jeffrey T. Guptill. “Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.” Exp Neurol 325 (March 2020): 113146. https://doi.org/10.1016/j.expneurol.2019.113146.
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  - Ezekian, Brian, Paul M. Schroder, Michael S. Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, et al. “Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients.” J Am Soc Nephrol 30, no. 12 (December 2019): 2399–2411. https://doi.org/10.1681/ASN.2019030304.
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  - Kwun, Jean, Marie Matignon, Miriam Manook, Soulef Guendouz, Vincent Audard, David Kheav, Elsa Poullot, et al. “Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use.” J Am Soc Nephrol 30, no. 7 (July 2019): 1206–19. https://doi.org/10.1681/ASN.2018121254.
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  - Li, Yingkai, Jeffrey T. Guptill, Melissa A. Russo, Janice M. Massey, Vern C. Juel, Lisa D. Hobson-Webb, James F. Howard, Manisha Chopra, Weibin Liu, and John S. Yi. “Tacrolimus inhibits Th1 and Th17 responses in MuSK-antibody positive myasthenia gravis patients.” Exp Neurol 312 (February 2019): 43–50. https://doi.org/10.1016/j.expneurol.2018.11.006.
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  - Yi, John S., Marilyn Rosa-Bray, Janet Staats, Pearl Zakroysky, Cliburn Chan, Melissa A. Russo, Chelsae Dumbauld, et al. “Establishment of normative ranges of the healthy human immune system with comprehensive polychromatic flow cytometry profiling.” Plos One 14, no. 12 (2019): e0225512. https://doi.org/10.1371/journal.pone.0225512.
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  - Yi, John S., Jeffrey T. Guptill, Panos Stathopoulos, Richard J. Nowak, and Kevin C. O’Connor. “B cells in the pathophysiology of myasthenia gravis.” Muscle Nerve 57, no. 2 (February 2018): 172–84. https://doi.org/10.1002/mus.25973.
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  - “Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119.” Blood Adv 2, no. 2 (January 23, 2018): 89. https://doi.org/10.1182/bloodadvances.2017015446.
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  - Kwun, Jean, Jaeberm Park, John S. Yi, Alton B. Farris, Allan D. Kirk, and Stuart J. Knechtle. “IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.” Front Immunol 9 (2018): 2323. https://doi.org/10.3389/fimmu.2018.02323.
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  - Reap, Elizabeth A., Carter M. Suryadevara, Kristen A. Batich, Luis Sanchez-Perez, Gary E. Archer, Robert J. Schmittling, Pamela K. Norberg, et al. “Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.” Cancer Res 78, no. 1 (January 1, 2018): 256–64. https://doi.org/10.1158/0008-5472.CAN-17-0469.
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  - Yi, John S., Neal Ready, Patrick Healy, Chelsae Dumbauld, Robyn Osborne, Mark Berry, Debra Shoemaker, et al. “Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab.” Clin Cancer Res 23, no. 24 (December 15, 2017): 7474–82. https://doi.org/10.1158/1078-0432.CCR-17-2005.
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  - Kwun, Jean, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, et al. “Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates.” Blood Adv 1, no. 24 (November 14, 2017): 2115–19. https://doi.org/10.1182/bloodadvances.2017010991.
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  - Yi, John S., Melissa A. Russo, Janice M. Massey, Vern Juel, Lisa D. Hobson-Webb, Karissa Gable, Shruti M. Raja, Kristina Balderson, Kent J. Weinhold, and Jeffrey T. Guptill. “B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.” Front Neurol 8 (2017): 34. https://doi.org/10.3389/fneur.2017.00034.
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  - Guptill, Jeffrey T., Vern C. Juel, Janice M. Massey, Amanda C. Anderson, Manisha Chopra, John S. Yi, Ehsanollah Esfandiari, et al. “Effect of therapeutic plasma exchange on immunoglobulins in myasthenia gravis.” Autoimmunity 49, no. 7 (November 2016): 472–79. https://doi.org/10.1080/08916934.2016.1214823.
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  - Gaillard, Stephanie, John Yi, Chelsae Dumbauld, Jessie Ehrisman, Andrew Berchuck, and Kent Weinhold. “Evaluating the Repertoire of Immune Checkpoint Markers Expressed Within Ovarian Cancers.” Journal of Womens Health 25, no. 9 (September 1, 2016): 962–962.
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  - Yi, John S., Melissa A. Russo, Kent J. Weinhold, and Jeffrey T. Guptill. “Adaptive immune response to therapy in hmgcr autoantibody myopathy.” Muscle Nerve 53, no. 2 (February 2016): 313–17. https://doi.org/10.1002/mus.24947.
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  - Snyder, Laurie D., Cliburn Chan, Darongsae Kwon, John S. Yi, Jessica A. Martissa, C Ashley Finlen Copeland, Robyn J. Osborne, Sara D. Sparks, Scott M. Palmer, and Kent J. Weinhold. “Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation.” Am J Respir Crit Care Med 193, no. 1 (January 1, 2016): 78–85. https://doi.org/10.1164/rccm.201504-0733OC.
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  - Abedini-Nassab, Roozbeh, Daniel Y. Joh, Melissa A. Van Heest, John S. Yi, Cody Baker, Zohreh Taherifard, David M. Margolis, et al. “Characterizing the Switching Thresholds of Magnetophoretic Transistors.” Adv Mater 27, no. 40 (October 28, 2015): 6176–80. https://doi.org/10.1002/adma.201502352.
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  - Guptill, Jeffrey T., John S. Yi, Donald B. Sanders, Amanda C. Guidon, Vern C. Juel, Janice M. Massey, James F. Howard, et al. “Characterization of B cells in muscle-specific kinase antibody myasthenia gravis.” Neurol Neuroimmunol Neuroinflamm 2, no. 2 (April 2015): e77. https://doi.org/10.1212/NXI.0000000000000077.
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  - Yi, J. S., A. Guidon, S. Sparks, R. Osborne, V. C. Juel, J. M. Massey, D. B. Sanders, K. J. Weinhold, and J. T. Guptill. “Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis.” J Autoimmun 52 (August 2014): 130–38. https://doi.org/10.1016/j.jaut.2013.12.005.
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  - Ingram, Jennifer T., John S. Yi, and Allan J. Zajac. “Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.” Plos Pathog 7, no. 9 (September 2011): e1002273. https://doi.org/10.1371/journal.ppat.1002273.
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  - Yi, John S., Maureen A. Cox, and Allan J. Zajac. “Interleukin-21: a multifunctional regulator of immunity to infections.” Microbes Infect 12, no. 14–15 (December 2010): 1111–19. https://doi.org/10.1016/j.micinf.2010.08.008.
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  - Yi, John S., Jennifer T. Ingram, and Allan J. Zajac. “IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.” J Immunol 185, no. 8 (October 15, 2010): 4835–45. https://doi.org/10.4049/jimmunol.1001032.
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  - Yi, John S., Maureen A. Cox, and Allan J. Zajac. “T-cell exhaustion: characteristics, causes and conversion.” Immunology 129, no. 4 (April 2010): 474–81. https://doi.org/10.1111/j.1365-2567.2010.03255.x.
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  - Yi, John S., Ming Du, and Allan J. Zajac. “A vital role for interleukin-21 in the control of a chronic viral infection.” Science 324, no. 5934 (June 19, 2009): 1572–76. https://doi.org/10.1126/science.1175194.
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  - Hsu, Hui-Chen, PingAr Yang, John Wang, Qi Wu, Riley Myers, Jian Chen, John Yi, et al. “Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.” Nat Immunol 9, no. 2 (February 2008): 166–75. https://doi.org/10.1038/ni1552.
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  - Michalek, Ryan D., Kimberly J. Nelson, Beth C. Holbrook, John S. Yi, Daya Stridiron, Larry W. Daniel, Jacquelyn S. Fetrow, S Bruce King, Leslie B. Poole, and Jason M. Grayson. “The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.” J Immunol 179, no. 10 (November 15, 2007): 6456–67. https://doi.org/10.4049/jimmunol.179.10.6456.
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  - Yi, John S., Beth C. Holbrook, Ryan D. Michalek, Nathan G. Laniewski, and Jason M. Grayson. “Electron transport complex I is required for CD8+ T cell function.” J Immunol 177, no. 2 (July 15, 2006): 852–62. https://doi.org/10.4049/jimmunol.177.2.852.
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- Other Articles
  - Yi, J. S. “The Rise of Checkpoint Blockade Therapy to Front Line Cancer Therapy.” Edited by A. H. Lichtman. Translational Immunology Update, n.d.
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- Conference Papers
  - Gaillard, S., G. Broadwater, W. S. Andrews, M. D. Starr, R. A. Previs, L. J. Havrilesky, B. A. Davidson, et al. “Pembrolizumab window study: Illuminating the immunologic landscape in gynecologic cancers.” In Gynecologic Oncology, 159:41–41. Elsevier BV, 2020. https://doi.org/10.1016/j.ygyno.2020.06.087.
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  - Schroder, P., J. S. Yi, K. J. Weinhold, C. Chan, M. Joshi, C. Walters, J. Kwun, and S. J. Knechtle. “Pre-Transplant Multidimensional Flow Cytometric Analysis of Kidney Transplant Recipients Reveals Novel Immune Signature of Allograft Rejection.” In American Journal of Transplantation, 19:765–66. WILEY, 2019.
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  - Gaillard, Stephanie, Chelsae Dumbauld, Alyssa Bilewski, Jessie A. Ehrisman, Angeles Alvarez Secord, Laura Jean Havrilesky, Andrew Berchuck, Kent Weinhold, Cliburn Chan, and John Yi. “Evaluating the repertoire of immune checkpoint markers expressed on peripheral and ascites CD8⁺ T cells in ovarian cancer.” In Journal of Clinical Oncology, 35:5571–5571. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.5571.
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  - Yi, John, Jeffrey Melson Clarke, Patrick Healy, Xiaofei F. Wang, Debra Shoemaker, Mark W. Onaitis, Chelsae Dumbauld, et al. “Immune profiling of circulating T cells and TILs following neoadjuvant ipilimumab and chemotherapy in non-small cell lung cancer (NSCLC).” In Journal of Clinical Oncology, 35:26–26. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.7_suppl.26.
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  - Guptill, J. T., V. C. Juel, J. M. Massey, A. C. Anderson, J. S. Yi, M. Chopra, and J. F. Howard. “EFFECT OF THERAPEUTIC PLASMA EXCHANGE ON IMMUNOGLOBULINS.” In Muscle & Nerve, 52:S140–S140. WILEY-BLACKWELL, 2015.
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  - Dunphy, Frank, John Yi, Mark Onaitis, Robyn Osborne, David Harpole, Jeffrey Crawford, Thomas D’Amico, Kent Weinhold, and Neal Ready. “Immunophenotyping of Circulating T Cells and TILs with Chemotherapy and Phased Ipilimumab in Non-Small Cell Lung Cancer.” In Journal of Thoracic Oncology, 10:S356–57. ELSEVIER SCIENCE INC, 2015.
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  - Hobson-Webb, L. D., J. T. Guptill, M. A. Russo, A. C. Anderson, J. M. Massey, K. Gable, V. C. Juel, E. W. Massey, D. B. Sanders, and J. S. Yi. “T CELL REACTIVITY IN INCLUSION BODY MYOSITIS (IBM).” In Muscle & Nerve, 52:S11–S11. WILEY-BLACKWELL, 2015.
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  - Snyder, L. D., C. Chan, D. Kwon, J. Yi, J. A. Martissa, CA Finlen Copeland, R. Osborne, S. D. Sparks, S. M. Palmer, and K. J. Weinhold. “Polyfunctional T Cell Immunity Predicts Cytomegalovirus Infection After Lung Transplant.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Yi, J. S., D. B. Sanders, J. M. Massey, V. C. Juel, K. J. Weinhold, and J. T. Guptill. “COMPARISON OF B10 CELLS IN IMMUNOSLTPPRESSED AND IMMUNOSUPPRESSION NAIVE ACHR plus MG.” In Muscle & Nerve, 50:716–716. WILEY-BLACKWELL, 2014.
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  - Yi, J. S., E. Choi, D. B. Sanders, K. J. Weinhold, and J. T. Guptill. “PROLONGED B CELL DEPLETION IN MUSK MYASTHENIA GRAVIS FOLLOWING RITUXIMAB TREATMENT.” In Muscle & Nerve, 48:691–691. WILEY-BLACKWELL, 2013.
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  - Yi, John, and Kent Weinhold. “The role of IL-21 in rescuing CD8 T Cell responses in chronically infected HIV patients.” In Journal of Immunology, Vol. 188. AMER ASSOC IMMUNOLOGISTS, 2012.
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  - Yi, John, Ming Du, and Allan Zajac. “IL-21 Dictates the Quality and Maintenance of CD8 T Cell Responses during Acute and Chronic Infections.” In Clinical Immunology, 135:S33–S33. Elsevier BV, 2010. https://doi.org/10.1016/j.clim.2010.03.102.
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  - Michalek, Ryan D., Kimberly J. Nelson, John S. Yi, Daya Stridiron, S Bruce King, Leslie B. Poole, and Jason M. Grayson. “The Requirement of Reversible Cysteine Sulfenic Acid Formation in T Cell Activation and Function.” In Journal of Immunology, Vol. 178. AMER ASSOC IMMUNOLOGISTS, 2007.
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Scholarly, Clinical, & Service Activities
Presentations & Appearances
- Immuno-Oncology Checkpoint Panel: Latest Tool in Cancer Immune Monitoring. Exploring the Tumor Microenvironment. Affymetrix. June 2016 2016
Service to the Profession
Service to Duke
- Associate Director. Duke Immune Profiling Core. 2015 2015

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Education, Training, & Certifications

Previous Appointments & Affiliations

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Other Articles

Conference Papers

Presentations & Appearances

Service to the Profession

Service to Duke