John S Yi

Journal Article Lung Cancer · July 2024 BACKGROUND: Direct comparison of tumor microenvironment of matched lung cancer biopsies and pleural effusions (PE) from the same patients is critical in understanding tumor biology but has not been performed. This is the first study to compare the lung can ... Full text Link to item Cite

Immune dysregulation in chronic inflammatory demyelinating polyneuropathy.

Journal Article J Neuroimmunol · June 15, 2024 OBJECTIVE: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disorder of the peripheral nerves with an incompletely understood underlying pathophysiology. This investigation focused on defining B and T cell frequencies, T cell funct ... Full text Link to item Cite

Investigating potential immune mechanisms of trilaciclib administered prior to chemotherapy in patients with metastatic triple-negative breast cancer.

Journal Article Breast Cancer Res Treat · September 2023 PURPOSE: In a phase II trial in patients with metastatic triple-negative breast cancer (mTNBC; NCT02978716), administering trilaciclib prior to gemcitabine plus carboplatin (GCb) enhanced T-cell activation and improved overall survival versus GCb alone. Th ... Full text Link to item Cite

Successful AAV8 readministration: Suppression of capsid-specific neutralizing antibodies by a combination treatment of bortezomib and CD20 mAb in a mouse model of Pompe disease.

Journal Article The journal of gene medicine · August 2023 BackgroundA major challenge to adeno-associated virus (AAV)-mediated gene therapy is the presence of anti-AAV capsid neutralizing antibodies (NAbs), which can block viral vector transduction even at very low titers. In the present study, we examin ... Full text Open Access Cite

Immunophenotype associated with high sustained antibody titers against enzyme replacement therapy in infantile-onset Pompe disease.

Journal Article Front Immunol · 2023 INTRODUCTION: The efficacy of enzyme replacement therapy (ERT) with alglucosidase alfa for infantile-onset Pompe disease (IOPD) is limited in some patients due to the development of high and sustained antibody titers (HSAT; ≥12,800). METHODS: We carried ou ... Full text Link to item Cite

Stress hormones are associated with inflammatory cytokines and attenuation of T-cell function in the ascites from patients with high grade serous ovarian cancer.

Journal Article Brain Behav Immun Health · December 2022 Mounting evidence suggests that chronic stress and subsequent distress can promote ovarian cancer progression. These altered psychological states have been linked to sustained release of stress hormones, activation of the β-adrenergic receptors in ovarian ... Full text Link to item Cite

Trilaciclib prior to gemcitabine plus carboplatin for metastatic triple-negative breast cancer: phase III PRESERVE 2.

Journal Article Future Oncol · October 2022 Triple-negative breast cancer (TNBC) is an aggressive malignancy for which cytotoxic chemotherapy remains the backbone of treatment. Trilaciclib is an intravenous cyclin-dependent kinase 4/6 inhibitor that induces transient cell cycle arrest of hematopoiet ... Full text Link to item Cite

Immune cell profiles in synovial fluid after anterior cruciate ligament and meniscus injuries.

Journal Article Arthritis Res Ther · November 4, 2021 BACKGROUND: Anterior cruciate ligament (ACL) and meniscus tears are common knee injuries. Despite the high rate of post-traumatic osteoarthritis (PTOA) following these injuries, the contributing factors remain unclear. In this study, we characterized the i ... Full text Open Access Link to item Cite

Cellular changes in eculizumab early responders with generalized myasthenia gravis.

Journal Article Clin Immunol · October 2021 Eculizumab (ECU), a C5 complement inhibitor, is approved to treat acetylcholine receptor autoantibody positive generalized myasthenia gravis (AChR MG). The clinical effect of ECU relies on inhibition of the terminal complement complex; however, the effect ... Full text Link to item Cite

C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.

Journal Article Nat Commun · September 15, 2021 Sensitized kidney transplant recipients experience high rates of antibody-mediated rejection due to the presence of donor-specific antibodies and immunologic memory. Here we show that transient peri-transplant treatment with the central complement componen ... Full text Link to item Cite

Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency.

Journal Article J Orthop Res · August 2021 The inflammatory response to joint injury, specifically intra-articular fracture, has been implicated in posttraumatic arthritis development. However, the role of T cells in regulating the development of posttraumatic arthritis is unclear. We hypothesized ... Full text Link to item Cite

Immune cell profiling in the joint following human and murine articular fracture.

Journal Article Osteoarthritis Cartilage · June 2021 OBJECTIVE: Human and in vivo animal research implicates inflammation following articular fracture as contributing to post-traumatic arthritis. However, relevant immune cell subsets present following injury are currently undefined. Immunophenotyping human a ... Full text Link to item Cite

Reduced plasmablast frequency is associated with seronegative myasthenia gravis.

Journal Article Muscle Nerve · April 2021 BACKGROUND: The immunopathology of autoimmune seronegative myasthenia gravis (SN MG) is poorly understood. Our objective was to determine immune profiles associated with a diagnosis of SN MG. METHODS: We performed high-dimensional flow cytometry on blood s ... Full text Link to item Cite

Normative dataset for plasma cytokines in healthy human adults.

Journal Article Data Brief · April 2021 We determined normative data for plasma cytokines established from a cohort of 126 carefully screened healthy adults aged 18 to 64 years. Participants were enrolled to ensure an even age and sex distribution and to include at least 30% non-Caucasians. Plas ... Full text Open Access Link to item Cite

Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.

Journal Article Clin Cancer Res · March 1, 2021 PURPOSE: In this prospective trial, we sought to assess the feasibility of concurrent administration of ipilimumab and radiation as adjuvant, neoadjuvant, or definitive therapy in patients with regionally advanced melanoma. PATIENTS AND METHODS: Twenty-fou ... Full text Link to item Cite

Immune Tolerance-Adjusted Personalized Immunogenicity Prediction for Pompe Disease.

Journal Article Front Immunol · 2021 Infantile-onset Pompe disease (IOPD) is a glycogen storage disease caused by a deficiency of acid alpha-glucosidase (GAA). Treatment with recombinant human GAA (rhGAA, alglucosidase alfa) enzyme replacement therapy (ERT) significantly improves clinical out ... Full text Link to item Cite

Opportunities, barriers, and recommendations in down syndrome research.

Journal Article Transl Sci Rare Dis · 2021 BACKGROUND: Recent advances in medical care have increased life expectancy and improved the quality of life for people with Down syndrome (DS). These advances are the result of both pre-clinical and clinical research but much about DS is still poorly under ... Full text Link to item Cite

Pembrolizumab window study: Illuminating the immunologic landscape in gynecologic cancers

Conference Gynecologic Oncology · October 2020 Full text Cite

Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.

Journal Article J Neuroimmunol · August 15, 2020 A detailed understanding of the role of Tfh cells in MuSK-antibody positive myasthenia gravis (MuSK-MG) is lacking. We characterized phenotype and function of Tfh cells in MuSK-MG patients and controls. We found similar overall Tfh and follicular regulator ... Full text Link to item Cite

Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.

Journal Article Exp Neurol · March 2020 IL-17 producing CD4 T cells (Th17) cells increase significantly with disease severity in myasthenia gravis (MG) patients. To suppress the generation of Th17 cells, we examined the effect of inhibiting retinoic acid receptor-related-orphan-receptor-C (RORγ) ... Full text Link to item Cite

Differences in microenvironment of lung cancer and pleural effusions by single-cell RNA sequencing.

Immune dysregulation in chronic inflammatory demyelinating polyneuropathy.

Investigating potential immune mechanisms of trilaciclib administered prior to chemotherapy in patients with metastatic triple-negative breast cancer.

Successful AAV8 readministration: Suppression of capsid-specific neutralizing antibodies by a combination treatment of bortezomib and CD20 mAb in a mouse model of Pompe disease.

Immunophenotype associated with high sustained antibody titers against enzyme replacement therapy in infantile-onset Pompe disease.

Stress hormones are associated with inflammatory cytokines and attenuation of T-cell function in the ascites from patients with high grade serous ovarian cancer.

Trilaciclib prior to gemcitabine plus carboplatin for metastatic triple-negative breast cancer: phase III PRESERVE 2.

Immune cell profiles in synovial fluid after anterior cruciate ligament and meniscus injuries.

Cellular changes in eculizumab early responders with generalized myasthenia gravis.

C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.

Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency.

Immune cell profiling in the joint following human and murine articular fracture.

Reduced plasmablast frequency is associated with seronegative myasthenia gravis.

Normative dataset for plasma cytokines in healthy human adults.

Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.

Immune Tolerance-Adjusted Personalized Immunogenicity Prediction for Pompe Disease.

Opportunities, barriers, and recommendations in down syndrome research.

Pembrolizumab window study: Illuminating the immunologic landscape in gynecologic cancers

Conference Gynecologic Oncology · October 2020 Full text Cite

Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.

Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.

Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients.

Journal Article J Am Soc Nephrol · December 2019 BACKGROUND: Patients with broad HLA sensitization have poor access to donor organs, high mortality while waiting for kidney transplant, and inferior graft survival. Although desensitization strategies permit transplantation via lowering of donor-specific a ... Full text Link to item Cite

Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use.

Journal Article J Am Soc Nephrol · July 2019 BACKGROUND: Donor-specific antibodies are associated with increased risk of antibody-mediated rejection and decreased allograft survival. Therefore, reducing the risk of these antibodies remains a clinical need in transplantation. Plasma cells are a logica ... Full text Link to item Cite

Pre-Transplant Multidimensional Flow Cytometric Analysis of Kidney Transplant Recipients Reveals Novel Immune Signature of Allograft Rejection.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2019 Link to item Cite

Tacrolimus inhibits Th1 and Th17 responses in MuSK-antibody positive myasthenia gravis patients.

Journal Article Exp Neurol · February 2019 Muscle specific tyrosine kinase antibody positive myasthenia gravis (MuSK- MG) is characterized by autoantibodies against the MuSK protein of the neuromuscular junction resulting in weakness of bulbar and proximal muscles. We previously demonstrated that p ... Full text Link to item Cite

Establishment of normative ranges of the healthy human immune system with comprehensive polychromatic flow cytometry profiling.

Journal Article PLoS One · 2019 Existing normative flow cytometry data have several limitations including small sample sizes, incompletely described study populations, variable flow cytometry methodology, and limited depth for defining lymphocyte subpopulations. To overcome these issues, ... Full text Open Access Link to item Cite

B cells in the pathophysiology of myasthenia gravis.

Journal Article Muscle Nerve · February 2018 Myasthenia gravis (MG) is an archetypal autoimmune disease. The pathology is characterized by autoantibodies to the acetylcholine receptor (AChR) in most patients or to muscle-specific tyrosine kinase (MuSK) in others and to a growing number of other posts ... Full text Link to item Cite

Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119.

Journal Article Blood Adv · January 23, 2018 Full text Link to item Cite

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.

Journal Article Cancer Res · January 1, 2018 Median survival for glioblastoma (GBM) remains <15 months. Human cytomegalovirus (CMV) antigens have been identified in GBM but not normal brain, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific immunotherapy targets. A recen ... Full text Link to item Cite

IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.

Journal Article Front Immunol · 2018 Despite its excellent efficacy in controlling T cell mediated acute rejection, lymphocyte depletion may promote a humoral response. While T cell repopulation after depletion has been evaluated in many aspects, the B cell response has not been fully elucida ... Full text Link to item Cite

Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab.

Journal Article Clin Cancer Res · December 15, 2017 Purpose: To determine the immunologic effects of neoadjuvant chemotherapy plus ipilimumab in early-stage non-small cell lung cancer (NSCLC) patients.Experimental Design: This is a single-arm chemotherapy plus phased ipilimumab phase II study of 24 treatmen ... Full text Link to item Cite

Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates.

Journal Article Blood Adv · November 14, 2017 The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound. Proteasome inhibitors (PIs) deplete antibody-p ... Full text Link to item Cite

Evaluating the repertoire of immune checkpoint markers expressed on peripheral and ascites CD8⁺ T cells in ovarian cancer.

Conference Journal of Clinical Oncology · May 20, 2017 5571 Background: Understanding the immune checkpoint marker repertoire can facilitate development of therapeutic strategies to improve efficacy of immune-based therapies. We used a novel high-dimensional flow cytometry panel to d ... Full text Cite

Immune profiling of circulating T cells and TILs following neoadjuvant ipilimumab and chemotherapy in non-small cell lung cancer (NSCLC).

Conference Journal of Clinical Oncology · March 1, 2017 26 Background: Ipilimumab (Ipi) is a humanized CTLA-4 antibody that blocks binding of CTLA-4 to B7, permitting T cell activation through CD28. Phased in Ipi added to chemotherapy (C) may enhance efficacy in NSCLC. Methods: Patien ... Full text Cite

B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.

Journal Article Front Neurol · 2017 Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated disease. The mechanisms for loss of self-tolerance in this disease are not well understood, and recently described regulatory B cell (Breg) subsets have not been thoroughly investigated. B10 cel ... Full text Open Access Link to item Cite

Effect of therapeutic plasma exchange on immunoglobulins in myasthenia gravis.

Journal Article Autoimmunity · November 2016 An integrated understanding of therapeutic plasma exchange (TPE) effects on immunoglobulins, autoantibodies, and natural or acquired (vaccine) protective antibodies in patients with autoimmune myasthenia gravis (MG) is lacking. Prior studies measured TPE e ... Full text Link to item Cite

Evaluating the Repertoire of Immune Checkpoint Markers Expressed Within Ovarian Cancers

Journal Article JOURNAL OF WOMENS HEALTH · September 1, 2016 Link to item Cite

Adaptive immune response to therapy in hmgcr autoantibody myopathy.

Journal Article Muscle Nerve · February 2016 INTRODUCTION: We evaluated the response to immunosuppression in a case of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)-autoantibody myopathy. METHODS: T- and B-cell subsets were determined by flow cytometry pre- and posttherapy. RESULTS: Baselin ... Full text Link to item Cite

Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation.

Journal Article Am J Respir Crit Care Med · January 1, 2016 RATIONALE: Cytomegalovirus (CMV), which is one of the most common infections after lung transplantation, is associated with chronic lung allograft dysfunction and worse post-transplantation survival. Current approaches for at-risk patients include a fixed ... Full text Link to item Cite

Characterizing the Switching Thresholds of Magnetophoretic Transistors.

Journal Article Adv Mater · October 28, 2015 The switching thresholds of magnetophoretic transistors for sorting cells in microfluidic environments are characterized. The transistor operating conditions require short 20-30 mA pulses of electrical current. By demonstrating both attractive and repulsiv ... Full text Open Access Link to item Cite

EFFECT OF THERAPEUTIC PLASMA EXCHANGE ON IMMUNOGLOBULINS

Conference MUSCLE & NERVE · October 1, 2015 Link to item Cite

T CELL REACTIVITY IN INCLUSION BODY MYOSITIS (IBM)

Conference MUSCLE & NERVE · September 1, 2015 Open Access Link to item Cite

Immunophenotyping of Circulating T Cells and TILs with Chemotherapy and Phased Ipilimumab in Non-Small Cell Lung Cancer

Conference JOURNAL OF THORACIC ONCOLOGY · September 1, 2015 Link to item Cite

Characterization of B cells in muscle-specific kinase antibody myasthenia gravis.

Journal Article Neurol Neuroimmunol Neuroinflamm · April 2015 OBJECTIVE: To characterize B-cell subsets in patients with muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG). METHODS: In accordance with Human Immunology Project Consortium guidelines, we performed polychromatic flow cytometry and ELISA assays ... Full text Open Access Link to item Cite

Polyfunctional T Cell Immunity Predicts Cytomegalovirus Infection After Lung Transplant

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

COMPARISON OF B10 CELLS IN IMMUNOSLTPPRESSED AND IMMUNOSUPPRESSION NAIVE ACHR plus MG

Conference MUSCLE & NERVE · October 1, 2014 Link to item Cite

Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis.

Journal Article J Autoimmun · August 2014 Muscle specific tyrosine kinase myasthenia gravis (MuSK MG) is a form of autoimmune MG that predominantly affects women and has unique clinical features, including prominent bulbar weakness, muscle atrophy, and excellent response to therapeutic plasma exch ... Full text Open Access Link to item Cite

PROLONGED B CELL DEPLETION IN MUSK MYASTHENIA GRAVIS FOLLOWING RITUXIMAB TREATMENT

Conference MUSCLE & NERVE · October 1, 2013 Link to item Cite

The role of IL-21 in rescuing CD8 T Cell responses in chronically infected HIV patients

Conference JOURNAL OF IMMUNOLOGY · May 1, 2012 Link to item Cite

Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.

Journal Article PLoS Pathog · September 2011 During many chronic infections virus-specific CD8 T cells succumb to exhaustion as they lose their ability to respond to antigenic activation. Combinations of IL-12, IL-18, and IL-21 have been shown to induce the antigen-independent production of interfero ... Full text Open Access Link to item Cite

Interleukin-21: a multifunctional regulator of immunity to infections.

Journal Article Microbes Infect · December 2010 Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical for s ... Full text Open Access Link to item Cite

IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.

Journal Article J Immunol · October 15, 2010 CD4 T cells are principal producers of IL-21 and are often required for optimal CD8 T cell responses. Therefore, we investigated the importance of IL-21 in determining the phenotypic attributes, functional quality, and maintenance of antiviral CD8 T cells ... Full text Open Access Link to item Cite

T-cell exhaustion: characteristics, causes and conversion.

Journal Article Immunology · April 2010 T-cell exhaustion is characterized by the stepwise and progressive loss of T-cell functions and can culminate in the physical deletion of the responding cells. Exhaustion is well-defined during chronic lymphocytic choriomeningitis virus infection and commo ... Full text Open Access Link to item Cite

IL-21 Dictates the Quality and Maintenance of CD8 T Cell Responses during Acute and Chronic Infections

Conference Clinical Immunology · January 2010 Full text Cite

A vital role for interleukin-21 in the control of a chronic viral infection.

Journal Article Science · June 19, 2009 Understanding the factors that regulate the induction, quality, and longevity of antiviral T cell responses is essential for devising rational strategies to prevent or combat infections. In this study, we show that interleukin-21 (IL-21), likely produced b ... Full text Open Access Link to item Cite

Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.

Journal Article Nat Immunol · February 2008 Interleukin 17 (IL-17) is a cytokine associated with inflammation, autoimmunity and defense against some bacteria. Here we show that IL-17 can promote autoimmune disease through a mechanism distinct from its proinflammatory effects. As compared with wild-t ... Full text Open Access Link to item Cite

The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.

Journal Article J Immunol · November 15, 2007 Reactive oxygen intermediates (ROI) generated in response to receptor stimulation play an important role in mediating cellular responses. We have examined the importance of reversible cysteine sulfenic acid formation in naive CD8(+) T cell activation and p ... Full text Link to item Cite

The Requirement of Reversible Cysteine Sulfenic Acid Formation in T Cell Activation and Function

Conference JOURNAL OF IMMUNOLOGY · April 1, 2007 Link to item Cite

Electron transport complex I is required for CD8+ T cell function.

Journal Article J Immunol · July 15, 2006 After Ag encounter, CD8+ T cells become activated and begin to proliferate. Early during infection, when Ag-specific effector CD8+ T cells are proliferating, producing cytokines, and lysing infected cells in vivo, their mitochondrial potential is increased ... Full text Link to item Cite

The Rise of Checkpoint Blockade Therapy to Front Line Cancer Therapy

Other Translational Immunology Update Link to item Cite