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A vital role for interleukin-21 in the control of a chronic viral infection.
Publication
, Journal Article
Yi, JS; Du, M; Zajac, AJ
Published in: Science
June 19, 2009
Understanding the factors that regulate the induction, quality, and longevity of antiviral T cell responses is essential for devising rational strategies to prevent or combat infections. In this study, we show that interleukin-21 (IL-21), likely produced by CD4+ T cells, directly influences the generation of polyfunctional CD8+ T cells and that the number of CD4+ T cells that produce IL-21 differs markedly between acute and chronic infections. IL-21 regulates the development of CD8+ T cell exhaustion and the ability to contain chronic lymphocytic choriomeningitis virus infection. Thus, IL-21 serves as a critical helper factor that shapes the functional quality of antiviral CD8+ T cells and is required for viral control.
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Published In
Science
DOI
EISSN
1095-9203
Publication Date
June 19, 2009
Volume
324
Issue
5934
Start / End Page
1572 / 1576
Location
United States
Related Subject Headings
- Viral Load
- Mice, Inbred C57BL
- Mice
- Lymphocytic choriomeningitis virus
- Lymphocytic Choriomeningitis
- Interleukins
- General Science & Technology
- Chronic Disease
- CD8-Positive T-Lymphocytes
- CD4-Positive T-Lymphocytes
Citation
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Yi, J. S., Du, M., & Zajac, A. J. (2009). A vital role for interleukin-21 in the control of a chronic viral infection. Science, 324(5934), 1572–1576. https://doi.org/10.1126/science.1175194
Yi, John S., Ming Du, and Allan J. Zajac. “A vital role for interleukin-21 in the control of a chronic viral infection.” Science 324, no. 5934 (June 19, 2009): 1572–76. https://doi.org/10.1126/science.1175194.
Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009 Jun 19;324(5934):1572–6.
Yi, John S., et al. “A vital role for interleukin-21 in the control of a chronic viral infection.” Science, vol. 324, no. 5934, June 2009, pp. 1572–76. Pubmed, doi:10.1126/science.1175194.
Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009 Jun 19;324(5934):1572–1576.
![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=1095-9203&client=dukeuniv)
Published In
Science
DOI
EISSN
1095-9203
Publication Date
June 19, 2009
Volume
324
Issue
5934
Start / End Page
1572 / 1576
Location
United States
Related Subject Headings
- Viral Load
- Mice, Inbred C57BL
- Mice
- Lymphocytic choriomeningitis virus
- Lymphocytic Choriomeningitis
- Interleukins
- General Science & Technology
- Chronic Disease
- CD8-Positive T-Lymphocytes
- CD4-Positive T-Lymphocytes