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A vital role for interleukin-21 in the control of a chronic viral infection.

Publication ,  Journal Article
Yi, JS; Du, M; Zajac, AJ
Published in: Science
June 19, 2009

Understanding the factors that regulate the induction, quality, and longevity of antiviral T cell responses is essential for devising rational strategies to prevent or combat infections. In this study, we show that interleukin-21 (IL-21), likely produced by CD4+ T cells, directly influences the generation of polyfunctional CD8+ T cells and that the number of CD4+ T cells that produce IL-21 differs markedly between acute and chronic infections. IL-21 regulates the development of CD8+ T cell exhaustion and the ability to contain chronic lymphocytic choriomeningitis virus infection. Thus, IL-21 serves as a critical helper factor that shapes the functional quality of antiviral CD8+ T cells and is required for viral control.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

June 19, 2009

Volume

324

Issue

5934

Start / End Page

1572 / 1576

Location

United States

Related Subject Headings

  • Viral Load
  • Mice, Inbred C57BL
  • Mice
  • Lymphocytic choriomeningitis virus
  • Lymphocytic Choriomeningitis
  • Interleukins
  • General Science & Technology
  • Chronic Disease
  • CD8-Positive T-Lymphocytes
  • CD4-Positive T-Lymphocytes
 

Citation

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Yi, J. S., Du, M., & Zajac, A. J. (2009). A vital role for interleukin-21 in the control of a chronic viral infection. Science, 324(5934), 1572–1576. https://doi.org/10.1126/science.1175194
Yi, John S., Ming Du, and Allan J. Zajac. “A vital role for interleukin-21 in the control of a chronic viral infection.Science 324, no. 5934 (June 19, 2009): 1572–76. https://doi.org/10.1126/science.1175194.
Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009 Jun 19;324(5934):1572–6.
Yi, John S., et al. “A vital role for interleukin-21 in the control of a chronic viral infection.Science, vol. 324, no. 5934, June 2009, pp. 1572–76. Pubmed, doi:10.1126/science.1175194.
Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009 Jun 19;324(5934):1572–1576.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

June 19, 2009

Volume

324

Issue

5934

Start / End Page

1572 / 1576

Location

United States

Related Subject Headings

  • Viral Load
  • Mice, Inbred C57BL
  • Mice
  • Lymphocytic choriomeningitis virus
  • Lymphocytic Choriomeningitis
  • Interleukins
  • General Science & Technology
  • Chronic Disease
  • CD8-Positive T-Lymphocytes
  • CD4-Positive T-Lymphocytes