Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.
Journal Article (Journal Article)
Limited data are available regarding the molecular epidemiology of Mycobacterium tuberculosis (Mtb) strains circulating in Guatemala. Beijing-lineage Mtb strains have gained prevalence worldwide and are associated with increased virulence and drug resistance, but there have been only a few cases reported in Central America. Here we report the first whole genome sequencing of Central American Beijing-lineage strains of Mtb. We find that multiple Beijing-lineage strains, derived from independent founding events, are currently circulating in Guatemala, but overall still represent a relatively small proportion of disease burden. Finally, we identify a specific Beijing-lineage outbreak centered on a poor neighborhood in Guatemala City.
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- Pubmed Central version
- Open Access Copy from Duke
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- Saelens, JW; Lau-Bonilla, D; Moller, A; Medina, N; Guzmán, B; Calderón, M; Herrera, R; Sisk, DM; Xet-Mull, AM; Stout, JE; Arathoon, E; Samayoa, B; Tobin, DM
- December 2015
Volume / Issue
- 95 / 6
Start / End Page
- 810 - 816
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)