Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.


Journal Article

Limited data are available regarding the molecular epidemiology of Mycobacterium tuberculosis (Mtb) strains circulating in Guatemala. Beijing-lineage Mtb strains have gained prevalence worldwide and are associated with increased virulence and drug resistance, but there have been only a few cases reported in Central America. Here we report the first whole genome sequencing of Central American Beijing-lineage strains of Mtb. We find that multiple Beijing-lineage strains, derived from independent founding events, are currently circulating in Guatemala, but overall still represent a relatively small proportion of disease burden. Finally, we identify a specific Beijing-lineage outbreak centered on a poor neighborhood in Guatemala City.

Full Text

Duke Authors

Cited Authors

  • Saelens, JW; Lau-Bonilla, D; Moller, A; Medina, N; Guzmán, B; Calderón, M; Herrera, R; Sisk, DM; Xet-Mull, AM; Stout, JE; Arathoon, E; Samayoa, B; Tobin, DM

Published Date

  • December 2015

Published In

Volume / Issue

  • 95 / 6

Start / End Page

  • 810 - 816

PubMed ID

  • 26542222

Pubmed Central ID

  • 26542222

Electronic International Standard Serial Number (EISSN)

  • 1873-281X

Digital Object Identifier (DOI)

  • 10.1016/j.tube.2015.09.001


  • eng

Conference Location

  • Scotland