Overview
Current Appointments & Affiliations
Professor of Medicine
·
2017 - Present
Medicine, Infectious Diseases,
Medicine
Recent Publications
Phase 2C clinical trial of novel short-course regimens for the treatment of pulmonary tuberculosis: TBTC study 38/CRUSH-TB design.
Journal Article Contemp Clin Trials · November 2025 INTRODUCTION: Preclinical and clinical study data show that combining bedaquiline (B or BDQ), moxifloxacin (M), and pyrazinamide (Z), known as BMZ, has potent antimicrobial activity that might shorten treatment duration for drug-susceptible pulmonary tuber ... Full text Link to item CitePaired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation.
Journal Article mBio · September 10, 2025 Granulomas are classic manifestations of tuberculosis pathogenesis. They result from an ensemble of immune responses to Mycobacterium tuberculosis infection, but the identities, arrangement, cellular interactions, and regulation of the cells that comprise ... Full text Link to item CiteCathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.
Journal Article PLoS Biol · September 2025 Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB dise ... Full text Link to item CiteRecent Grants
Interdisciplinary Research Training Program in AIDS
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2010 - 2030The Genetic Base of Bone Disease in Mycobacterial Infection
ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2023 - 2028Innate Immune Determinants of Granuloma Formation in the Zebrafish
ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2017 - 2027View All Grants
Education, Training & Certifications
State University of New York Upstate Medical University ·
1996
M.D.