Bloodstream Infections and Frequency of Pretreatment Associated With Age and Hospitalization Status in Sub-Saharan Africa.

Journal Article (Journal Article)

BACKGROUND: The clinical diagnosis of bacterial bloodstream infections (BSIs) in sub-Saharan Africa is routinely confused with malaria due to overlapping symptoms. The Typhoid Surveillance in Africa Program (TSAP) recruited febrile inpatients and outpatients of all ages using identical study procedures and enrollment criteria, thus providing an opportunity to assess disease etiology and pretreatment patterns among children and adults. METHODS: Inpatients and outpatients of all ages with tympanic or axillary temperatures of ≥38.0 or ≥37.5°C, respectively, and inpatients only reporting fever within the previous 72 hours were eligible for recruitment. All recruited patients had one blood sample drawn and cultured for microorganisms. Data from 11 TSAP surveillance sites in nine different countries were used in the analysis. Bivariate analysis was used to compare frequencies of pretreatment and BSIs in febrile children (<15 years old) and adults (≥15 years old) in each country. Pooled Cochran Mantel-Haenszel odds ratios (ORs) were calculated for overall trends. RESULTS: There was no significant difference in the odds of a culture-proven BSI between children and adults among inpatients or outpatients. Among both inpatients and outpatients, children had significantly higher odds of having a contaminated blood culture compared with adults. Using country-pooled data, child outpatients had 66% higher odds of having Salmonella Typhi in their bloodstream than adults (OR, 1.66; 95% confidence interval [CI], 1.01-2.73). Overall, inpatient children had 59% higher odds of pretreatment with analgesics in comparison to inpatient adults (OR, 1.59; 95% CI, 1.28-1.97). CONCLUSIONS: The proportion of patients with culture-proven BSIs in children compared with adults was similar across the TSAP study population; however, outpatient children were more likely to have Salmonella Typhi infections than outpatient adults. This finding points to the importance of including outpatient facilities in surveillance efforts, particularly for the surveillance of typhoid fever. Strategies to reduce contamination among pediatric blood cultures are needed across the continent to prevent the misdiagnosis of BSI cases in children.

Full Text

Duke Authors

Cited Authors

  • Nichols, C; Cruz Espinoza, LM; von Kalckreuth, V; Aaby, P; Ahmed El Tayeb, M; Ali, M; Aseffa, A; Bjerregaard-Andersen, M; Breiman, RF; Cosmas, L; Crump, JA; Dekker, DM; Gassama Sow, A; Gasmelseed, N; Hertz, JT; Im, J; Kabore, LP; Keddy, KH; Konings, F; Valborg Løfberg, S; Meyer, CG; Montgomery, JM; Niang, A; Njariharinjakamampionona, A; Olack, B; Pak, GD; Panzner, U; Park, JK; Park, SE; Rabezanahary, H; Rakotondrainiarivelo, JP; Rakotozandrindrainy, R; Raminosoa, TM; Rubach, MP; Teferi, M; Seo, HJ; Sooka, A; Soura, A; Tall, A; Toy, T; Yeshitela, B; Clemens, JD; Wierzba, TF; Baker, S; Marks, F

Published Date

  • November 1, 2015

Published In

Volume / Issue

  • 61 Suppl 4 /

Start / End Page

  • S372 - S379

PubMed ID

  • 26449954

Pubmed Central ID

  • PMC4596935

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1093/cid/civ730


  • eng

Conference Location

  • United States