Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine.

Journal Article (Journal Article;Multicenter Study)

Influenza A(H5N1) vaccination strategies that improve the speed of the immunological response and cross-clade protection are desired. We compared the immunogenicity of a single 15-μg or 90-μg dose of A/H5N1/Indonesia/05/05 (clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (clade 1) vaccine. High-dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low-dose priming with a mismatched pandemic influenza A(H5N1) vaccine would improve the rapidity, magnitude, and cross-reactivity of the immunological response following a single high-dose, unadjuvanted, pandemic vaccine.

Full Text

Duke Authors

Cited Authors

  • Winokur, PL; Patel, SM; Brady, R; Chen, WH; El-Kamary, SS; Edwards, K; Creech, CB; Frey, S; Keitel, WA; Belshe, R; Walter, E; Bellamy, A; Hill, H

Published Date

  • August 15, 2015

Published In

Volume / Issue

  • 212 / 4

Start / End Page

  • 525 - 530

PubMed ID

  • 25712967

Pubmed Central ID

  • PMC4598805

Electronic International Standard Serial Number (EISSN)

  • 1537-6613

Digital Object Identifier (DOI)

  • 10.1093/infdis/jiv087

Language

  • eng

Conference Location

  • United States