Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine.
Publication
, Journal Article
Winokur, PL; Patel, SM; Brady, R; Chen, WH; El-Kamary, SS; Edwards, K; Creech, CB; Frey, S; Keitel, WA; Belshe, R; Walter, E; Bellamy, A; Hill, H
Published in: J Infect Dis
August 15, 2015
Influenza A(H5N1) vaccination strategies that improve the speed of the immunological response and cross-clade protection are desired. We compared the immunogenicity of a single 15-μg or 90-μg dose of A/H5N1/Indonesia/05/05 (clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (clade 1) vaccine. High-dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low-dose priming with a mismatched pandemic influenza A(H5N1) vaccine would improve the rapidity, magnitude, and cross-reactivity of the immunological response following a single high-dose, unadjuvanted, pandemic vaccine.
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Published In
J Infect Dis
DOI
EISSN
1537-6613
Publication Date
August 15, 2015
Volume
212
Issue
4
Start / End Page
525 / 530
Location
United States
Related Subject Headings
- Young Adult
- Vaccines, Inactivated
- Neutralization Tests
- Middle Aged
- Microbiology
- Male
- Influenza, Human
- Influenza Vaccines
- Influenza A Virus, H5N1 Subtype
- Immunization, Secondary
Citation
APA
Chicago
ICMJE
MLA
NLM
Winokur, P. L., Patel, S. M., Brady, R., Chen, W. H., El-Kamary, S. S., Edwards, K., … Hill, H. (2015). Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine. J Infect Dis, 212(4), 525–530. https://doi.org/10.1093/infdis/jiv087
Winokur, Patricia L., Shital M. Patel, Rebecca Brady, Wilbur H. Chen, Samer S. El-Kamary, Kathryn Edwards, C Buddy Creech, et al. “Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine.” J Infect Dis 212, no. 4 (August 15, 2015): 525–30. https://doi.org/10.1093/infdis/jiv087.
Winokur PL, Patel SM, Brady R, Chen WH, El-Kamary SS, Edwards K, et al. Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine. J Infect Dis. 2015 Aug 15;212(4):525–30.
Winokur, Patricia L., et al. “Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine.” J Infect Dis, vol. 212, no. 4, Aug. 2015, pp. 525–30. Pubmed, doi:10.1093/infdis/jiv087.
Winokur PL, Patel SM, Brady R, Chen WH, El-Kamary SS, Edwards K, Creech CB, Frey S, Keitel WA, Belshe R, Walter E, Bellamy A, Hill H. Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine. J Infect Dis. 2015 Aug 15;212(4):525–530.
Published In
J Infect Dis
DOI
EISSN
1537-6613
Publication Date
August 15, 2015
Volume
212
Issue
4
Start / End Page
525 / 530
Location
United States
Related Subject Headings
- Young Adult
- Vaccines, Inactivated
- Neutralization Tests
- Middle Aged
- Microbiology
- Male
- Influenza, Human
- Influenza Vaccines
- Influenza A Virus, H5N1 Subtype
- Immunization, Secondary