Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.

Journal Article (Journal Article)

We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.

Full Text

Duke Authors

Cited Authors

  • Zhu, K; Qin, H; Cha, S-C; Neelapu, SS; Overwijk, W; Lizee, GA; Abbruzzese, JL; Hwu, P; Radvanyi, L; Kwak, LW; Chang, DZ

Published Date

  • November 14, 2007

Published In

Volume / Issue

  • 25 / 46

Start / End Page

  • 7955 - 7961

PubMed ID

  • 17933439

International Standard Serial Number (ISSN)

  • 0264-410X

Digital Object Identifier (DOI)

  • 10.1016/j.vaccine.2007.08.050


  • eng

Conference Location

  • Netherlands