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Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.

Publication ,  Journal Article
Zhu, K; Qin, H; Cha, S-C; Neelapu, SS; Overwijk, W; Lizee, GA; Abbruzzese, JL; Hwu, P; Radvanyi, L; Kwak, LW; Chang, DZ
Published in: Vaccine
November 14, 2007

We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.

Duke Scholars

Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

November 14, 2007

Volume

25

Issue

46

Start / End Page

7955 / 7961

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccines, DNA
  • Survivin
  • Repressor Proteins
  • Pancreatic Neoplasms
  • Neoplasms, Experimental
  • Neoplasm Proteins
  • Microtubule-Associated Proteins
  • Mice, Inbred BALB C
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
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Zhu, K., Qin, H., Cha, S.-C., Neelapu, S. S., Overwijk, W., Lizee, G. A., … Chang, D. Z. (2007). Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models. Vaccine, 25(46), 7955–7961. https://doi.org/10.1016/j.vaccine.2007.08.050
Zhu, Kuichun, Hong Qin, Soung-Chul Cha, Sattva S. Neelapu, Willem Overwijk, Gregory A. Lizee, James L. Abbruzzese, et al. “Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.Vaccine 25, no. 46 (November 14, 2007): 7955–61. https://doi.org/10.1016/j.vaccine.2007.08.050.
Zhu K, Qin H, Cha S-C, Neelapu SS, Overwijk W, Lizee GA, et al. Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models. Vaccine. 2007 Nov 14;25(46):7955–61.
Zhu, Kuichun, et al. “Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.Vaccine, vol. 25, no. 46, Nov. 2007, pp. 7955–61. Pubmed, doi:10.1016/j.vaccine.2007.08.050.
Zhu K, Qin H, Cha S-C, Neelapu SS, Overwijk W, Lizee GA, Abbruzzese JL, Hwu P, Radvanyi L, Kwak LW, Chang DZ. Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models. Vaccine. 2007 Nov 14;25(46):7955–7961.
Journal cover image

Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

November 14, 2007

Volume

25

Issue

46

Start / End Page

7955 / 7961

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccines, DNA
  • Survivin
  • Repressor Proteins
  • Pancreatic Neoplasms
  • Neoplasms, Experimental
  • Neoplasm Proteins
  • Microtubule-Associated Proteins
  • Mice, Inbred BALB C
  • Mice