Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.
Publication
, Journal Article
Zhu, K; Qin, H; Cha, S-C; Neelapu, SS; Overwijk, W; Lizee, GA; Abbruzzese, JL; Hwu, P; Radvanyi, L; Kwak, LW; Chang, DZ
Published in: Vaccine
November 14, 2007
We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.
Duke Scholars
Published In
Vaccine
DOI
ISSN
0264-410X
Publication Date
November 14, 2007
Volume
25
Issue
46
Start / End Page
7955 / 7961
Location
Netherlands
Related Subject Headings
- Virology
- Vaccines, DNA
- Survivin
- Repressor Proteins
- Pancreatic Neoplasms
- Neoplasms, Experimental
- Neoplasm Proteins
- Microtubule-Associated Proteins
- Mice, Inbred BALB C
- Mice
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhu, K., Qin, H., Cha, S.-C., Neelapu, S. S., Overwijk, W., Lizee, G. A., … Chang, D. Z. (2007). Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models. Vaccine, 25(46), 7955–7961. https://doi.org/10.1016/j.vaccine.2007.08.050
Zhu, Kuichun, Hong Qin, Soung-Chul Cha, Sattva S. Neelapu, Willem Overwijk, Gregory A. Lizee, James L. Abbruzzese, et al. “Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.” Vaccine 25, no. 46 (November 14, 2007): 7955–61. https://doi.org/10.1016/j.vaccine.2007.08.050.
Zhu K, Qin H, Cha S-C, Neelapu SS, Overwijk W, Lizee GA, et al. Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models. Vaccine. 2007 Nov 14;25(46):7955–61.
Zhu, Kuichun, et al. “Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.” Vaccine, vol. 25, no. 46, Nov. 2007, pp. 7955–61. Pubmed, doi:10.1016/j.vaccine.2007.08.050.
Zhu K, Qin H, Cha S-C, Neelapu SS, Overwijk W, Lizee GA, Abbruzzese JL, Hwu P, Radvanyi L, Kwak LW, Chang DZ. Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models. Vaccine. 2007 Nov 14;25(46):7955–7961.
Published In
Vaccine
DOI
ISSN
0264-410X
Publication Date
November 14, 2007
Volume
25
Issue
46
Start / End Page
7955 / 7961
Location
Netherlands
Related Subject Headings
- Virology
- Vaccines, DNA
- Survivin
- Repressor Proteins
- Pancreatic Neoplasms
- Neoplasms, Experimental
- Neoplasm Proteins
- Microtubule-Associated Proteins
- Mice, Inbred BALB C
- Mice