Genetic architecture of human pain perception.

Journal Article (Journal Article;Review)

Pain is emotionally detrimental and consciously avoided; however, it is absolutely crucial for our survival. Pain perception is one of the most complicated measurable traits because it is an aggregate of several phenotypes associated with peripheral and central nervous system dynamics, stress responsiveness and inflammatory state. As a complex trait, it is expected to have a polygenic nature shaped by environmental pressures. Here we discuss what is known about these contributing genetic variants, including recent discoveries that show a crucial role of voltage-gated sodium channel Nav1.7 in pain perception and how we can advance our understanding of the pain genetic network. We propose how both rare deleterious genetic variants and common genetic polymorphisms are mediators of human pain perception and clinical pain phenotypes.

Full Text

Duke Authors

Cited Authors

  • Diatchenko, L; Nackley, AG; Tchivileva, IE; Shabalina, SA; Maixner, W

Published Date

  • December 2007

Published In

Volume / Issue

  • 23 / 12

Start / End Page

  • 605 - 613

PubMed ID

  • 18023497

International Standard Serial Number (ISSN)

  • 0168-9525

Digital Object Identifier (DOI)

  • 10.1016/j.tig.2007.09.004


  • eng

Conference Location

  • England