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Genetic architecture of human pain perception.

Publication ,  Journal Article
Diatchenko, L; Nackley, AG; Tchivileva, IE; Shabalina, SA; Maixner, W
Published in: Trends Genet
December 2007
Published version (DOI) Link to item

Pain is emotionally detrimental and consciously avoided; however, it is absolutely crucial for our survival. Pain perception is one of the most complicated measurable traits because it is an aggregate of several phenotypes associated with peripheral and central nervous system dynamics, stress responsiveness and inflammatory state. As a complex trait, it is expected to have a polygenic nature shaped by environmental pressures. Here we discuss what is known about these contributing genetic variants, including recent discoveries that show a crucial role of voltage-gated sodium channel Nav1.7 in pain perception and how we can advance our understanding of the pain genetic network. We propose how both rare deleterious genetic variants and common genetic polymorphisms are mediators of human pain perception and clinical pain phenotypes.

Duke Scholars

Luda Diatchenko
Author Luda Diatchenko Anesthesiology
Andrea Gail Nackley
Author Andrea Gail Nackley Anesthesiology
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Published In

Trends Genet

DOI

10.1016/j.tig.2007.09.004

ISSN

0168-9525

Publication Date

December 2007

Volume

23

Issue

12

Start / End Page

605 / 613

Location

England

Related Subject Headings

  • Signal Transduction
  • Psychophysiologic Disorders
  • Phenotype
  • Perception
  • Pain
  • Models, Biological
  • Humans
  • Headache
  • Genotype
  • Genetic Variation
 

Citation

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Diatchenko, L., Nackley, A. G., Tchivileva, I. E., Shabalina, S. A., & Maixner, W. (2007). Genetic architecture of human pain perception. Trends Genet, 23(12), 605–613. https://doi.org/10.1016/j.tig.2007.09.004
Diatchenko, Luda, Andrea G. Nackley, Inna E. Tchivileva, Svetlana A. Shabalina, and William Maixner. “Genetic architecture of human pain perception.” Trends Genet 23, no. 12 (December 2007): 605–13. https://doi.org/10.1016/j.tig.2007.09.004.
Diatchenko L, Nackley AG, Tchivileva IE, Shabalina SA, Maixner W. Genetic architecture of human pain perception. Trends Genet. 2007 Dec;23(12):605–13.
Diatchenko, Luda, et al. “Genetic architecture of human pain perception.” Trends Genet, vol. 23, no. 12, Dec. 2007, pp. 605–13. Pubmed, doi:10.1016/j.tig.2007.09.004.
Diatchenko L, Nackley AG, Tchivileva IE, Shabalina SA, Maixner W. Genetic architecture of human pain perception. Trends Genet. 2007 Dec;23(12):605–613.
Journal cover image

Published In

Trends Genet

DOI

10.1016/j.tig.2007.09.004

ISSN

0168-9525

Publication Date

December 2007

Volume

23

Issue

12

Start / End Page

605 / 613

Location

England

Related Subject Headings

  • Signal Transduction
  • Psychophysiologic Disorders
  • Phenotype
  • Perception
  • Pain
  • Models, Biological
  • Humans
  • Headache
  • Genotype
  • Genetic Variation