A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

Published

Journal Article

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.

Full Text

Duke Authors

Cited Authors

  • Monda, KL; Chen, GK; Taylor, KC; Palmer, C; Edwards, TL; Lange, LA; Ng, MCY; Adeyemo, AA; Allison, MA; Bielak, LF; Chen, G; Graff, M; Irvin, MR; Rhie, SK; Li, G; Liu, Y; Liu, Y; Lu, Y; Nalls, MA; Sun, YV; Wojczynski, MK; Yanek, LR; Aldrich, MC; Ademola, A; Amos, CI; Bandera, EV; Bock, CH; Britton, A; Broeckel, U; Cai, Q; Caporaso, NE; Carlson, CS; Carpten, J; Casey, G; Chen, W-M; Chen, F; Chen, Y-DI; Chiang, CWK; Coetzee, GA; Demerath, E; Deming-Halverson, SL; Driver, RW; Dubbert, P; Feitosa, MF; Feng, Y; Freedman, BI; Gillanders, EM; Gottesman, O; Guo, X; Haritunians, T; Harris, T; Harris, CC; Hennis, AJM; Hernandez, DG; McNeill, LH; Howard, TD; Howard, BV; Howard, VJ; Johnson, KC; Kang, SJ; Keating, BJ; Kolb, S; Kuller, LH; Kutlar, A; Langefeld, CD; Lettre, G; Lohman, K; Lotay, V; Lyon, H; Manson, JE; Maixner, W; Meng, YA; Monroe, KR; Morhason-Bello, I; Murphy, AB; Mychaleckyj, JC; Nadukuru, R; Nathanson, KL; Nayak, U; N'diaye, A; Nemesure, B; Wu, S-Y; Leske, MC; Neslund-Dudas, C; Neuhouser, M; Nyante, S; Ochs-Balcom, H; Ogunniyi, A; Ogundiran, TO; Ojengbede, O; Olopade, OI; Palmer, JR; Ruiz-Narvaez, EA; Palmer, ND; Press, MF; Rampersaud, E; Rasmussen-Torvik, LJ; Rodriguez-Gil, JL; Salako, B; Schadt, EE; Schwartz, AG; Shriner, DA; Siscovick, D; Smith, SB; Wassertheil-Smoller, S; Speliotes, EK; Spitz, MR; Sucheston, L; Taylor, H; Tayo, BO; Tucker, MA; Van Den Berg, DJ; Edwards, DRV; Wang, Z; Wiencke, JK; Winkler, TW; Witte, JS; Wrensch, M; Wu, X; Yang, JJ; Levin, AM; Young, TR; Zakai, NA; Cushman, M; Zanetti, KA; Zhao, JH; Zhao, W; Zheng, Y; Zhou, J; Ziegler, RG; Zmuda, JM; Fernandes, JK; Gilkeson, GS; Kamen, DL; Hunt, KJ; Spruill, IJ; Ambrosone, CB; Ambs, S; Arnett, DK; Atwood, L; Becker, DM; Berndt, SI; Bernstein, L; Blot, WJ; Borecki, IB; Bottinger, EP; Bowden, DW; Burke, G; Chanock, SJ; Cooper, RS; Ding, J; Duggan, D; Evans, MK; Fox, C; Garvey, WT; Bradfield, JP; Hakonarson, H; Grant, SFA; Hsing, A; Chu, L; Hu, JJ; Huo, D; Ingles, SA; John, EM; Jordan, JM; Kabagambe, EK; Kardia, SLR; Kittles, RA; Goodman, PJ; Klein, EA; Kolonel, LN; Le Marchand, L; Liu, S; McKnight, B; Millikan, RC; Mosley, TH; Padhukasahasram, B; Williams, LK; Patel, SR; Peters, U; Pettaway, CA; Peyser, PA; Psaty, BM; Redline, S; Rotimi, CN; Rybicki, BA; Sale, MM; Schreiner, PJ; Signorello, LB; Singleton, AB; Stanford, JL; Strom, SS; Thun, MJ; Vitolins, M; Zheng, W; Moore, JH; Williams, SM; Ketkar, S; Zhu, X; Zonderman, AB; NABEC Consortium, ; UKBEC Consortium, ; BioBank Japan Project, ; AGEN Consortium, ; Kooperberg, C; Papanicolaou, GJ; Henderson, BE; Reiner, AP; Hirschhorn, JN; Loos, RJF; North, KE; Haiman, CA

Published Date

  • June 2013

Published In

Volume / Issue

  • 45 / 6

Start / End Page

  • 690 - 696

PubMed ID

  • 23583978

Pubmed Central ID

  • 23583978

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

Digital Object Identifier (DOI)

  • 10.1038/ng.2608

Language

  • eng

Conference Location

  • United States