The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.

Published

Journal Article

It is widely believed that most or all Y-chromosomal genes were once shared with the X chromosome. The DAZ gene is a candidate for the human Y-chromosomal Azoospermia Factor (AZF). We report multiple copies of DAZ (> 99% identical in DNA sequence) clustered in the AZF region and a functional DAZ homologue (DAZH) on human chromosome 3. The entire gene family appears to be expressed in germ cells. Sequence analysis indicates that the Y-chromosomal DAZ cluster arose during primate evolution by (i) transposing the autosomal gene to the Y, (ii) amplifying and pruning exons within the transposed gene and (iii) amplifying the modified gene. These results challenge prevailing views of sex chromosome evolution, suggesting that acquisition of autosomal fertility genes is an important process in Y chromosome evolution.

Full Text

Duke Authors

Cited Authors

  • Saxena, R; Brown, LG; Hawkins, T; Alagappan, RK; Skaletsky, H; Reeve, MP; Reijo, R; Rozen, S; Dinulos, MB; Disteche, CM; Page, DC

Published Date

  • November 1996

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 292 - 299

PubMed ID

  • 8896558

Pubmed Central ID

  • 8896558

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng1196-292

Language

  • eng

Conference Location

  • United States