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The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.

Publication ,  Journal Article
Saxena, R; Brown, LG; Hawkins, T; Alagappan, RK; Skaletsky, H; Reeve, MP; Reijo, R; Rozen, S; Dinulos, MB; Disteche, CM; Page, DC
Published in: Nat Genet
November 1996

It is widely believed that most or all Y-chromosomal genes were once shared with the X chromosome. The DAZ gene is a candidate for the human Y-chromosomal Azoospermia Factor (AZF). We report multiple copies of DAZ (> 99% identical in DNA sequence) clustered in the AZF region and a functional DAZ homologue (DAZH) on human chromosome 3. The entire gene family appears to be expressed in germ cells. Sequence analysis indicates that the Y-chromosomal DAZ cluster arose during primate evolution by (i) transposing the autosomal gene to the Y, (ii) amplifying and pruning exons within the transposed gene and (iii) amplifying the modified gene. These results challenge prevailing views of sex chromosome evolution, suggesting that acquisition of autosomal fertility genes is an important process in Y chromosome evolution.

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Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

November 1996

Volume

14

Issue

3

Start / End Page

292 / 299

Location

United States

Related Subject Headings

  • Y Chromosome
  • Transcription, Genetic
  • Tissue Distribution
  • Sequence Homology, Nucleic Acid
  • RNA-Binding Proteins
  • Ovary
  • Multigene Family
  • Molecular Sequence Data
  • Male
  • Humans
 

Citation

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Saxena, R., Brown, L. G., Hawkins, T., Alagappan, R. K., Skaletsky, H., Reeve, M. P., … Page, D. C. (1996). The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. Nat Genet, 14(3), 292–299. https://doi.org/10.1038/ng1196-292
Saxena, R., L. G. Brown, T. Hawkins, R. K. Alagappan, H. Skaletsky, M. P. Reeve, R. Reijo, et al. “The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.Nat Genet 14, no. 3 (November 1996): 292–99. https://doi.org/10.1038/ng1196-292.
Saxena R, Brown LG, Hawkins T, Alagappan RK, Skaletsky H, Reeve MP, et al. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. Nat Genet. 1996 Nov;14(3):292–9.
Saxena, R., et al. “The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.Nat Genet, vol. 14, no. 3, Nov. 1996, pp. 292–99. Pubmed, doi:10.1038/ng1196-292.
Saxena R, Brown LG, Hawkins T, Alagappan RK, Skaletsky H, Reeve MP, Reijo R, Rozen S, Dinulos MB, Disteche CM, Page DC. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. Nat Genet. 1996 Nov;14(3):292–299.

Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

November 1996

Volume

14

Issue

3

Start / End Page

292 / 299

Location

United States

Related Subject Headings

  • Y Chromosome
  • Transcription, Genetic
  • Tissue Distribution
  • Sequence Homology, Nucleic Acid
  • RNA-Binding Proteins
  • Ovary
  • Multigene Family
  • Molecular Sequence Data
  • Male
  • Humans