Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease.

Journal Article (Journal Article)

Adiposity status and change are potential risk factors for Alzheimer's disease (AD). The authors used data on 2,322 participants in the Baltimore Longitudinal Study of Aging to analyze the relation between AD incidence and adiposity in Cox proportional hazards models, with adjustment for sociodemographic factors and smoking status. Body mass index (BMI; weight (kg)/height (m)(2)) and waist circumference at specific ages were predicted by empirical Bayes estimators from mixed-effects regression models. After a median of 23.4 years of follow-up between 1958 and 2006, 187 participants developed AD. Among men, being underweight (BMI or=30) at age 30, 40, or 45 years and jointly centrally obese (waist circumference >or=80th percentile) at age 30, 35, or 50 years increased AD risk (HR = 6.57, 95% CI: 1.96, 22.02). Women who lost weight (BMI change <10th percentile) between ages 30 and 45 years were also at increased risk (HR = 2.02, 95% CI: 1.06, 3.85). Weight gain among men (BMI change >90th percentile) between ages 30 and 50 years increased AD risk (HR = 3.70, 95% CI: 1.43, 9.56). Future studies should identify age- and gender-specific optimal weights and weight-loss strategies for preventing AD and investigate potential mechanisms.

Full Text

Duke Authors

Cited Authors

  • Beydoun, MA; Lhotsky, A; Wang, Y; Dal Forno, G; An, Y; Metter, EJ; Ferrucci, L; O'Brien, R; Zonderman, AB

Published Date

  • November 15, 2008

Published In

Volume / Issue

  • 168 / 10

Start / End Page

  • 1179 - 1189

PubMed ID

  • 18835864

Pubmed Central ID

  • PMC2582058

Electronic International Standard Serial Number (EISSN)

  • 1476-6256

Digital Object Identifier (DOI)

  • 10.1093/aje/kwn229


  • eng

Conference Location

  • United States