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Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease.

Publication ,  Journal Article
Beydoun, MA; Lhotsky, A; Wang, Y; Dal Forno, G; An, Y; Metter, EJ; Ferrucci, L; O'Brien, R; Zonderman, AB
Published in: Am J Epidemiol
November 15, 2008

Adiposity status and change are potential risk factors for Alzheimer's disease (AD). The authors used data on 2,322 participants in the Baltimore Longitudinal Study of Aging to analyze the relation between AD incidence and adiposity in Cox proportional hazards models, with adjustment for sociodemographic factors and smoking status. Body mass index (BMI; weight (kg)/height (m)(2)) and waist circumference at specific ages were predicted by empirical Bayes estimators from mixed-effects regression models. After a median of 23.4 years of follow-up between 1958 and 2006, 187 participants developed AD. Among men, being underweight (BMI

Duke Scholars

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

November 15, 2008

Volume

168

Issue

10

Start / End Page

1179 / 1189

Location

United States

Related Subject Headings

  • Risk Factors
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Incidence
  • Humans
  • Female
  • Epidemiology
  • Body Mass Index
  • Bayes Theorem
 

Citation

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Beydoun, M. A., Lhotsky, A., Wang, Y., Dal Forno, G., An, Y., Metter, E. J., … Zonderman, A. B. (2008). Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease. Am J Epidemiol, 168(10), 1179–1189. https://doi.org/10.1093/aje/kwn229
Beydoun, May A., April Lhotsky, Youfa Wang, Gloria Dal Forno, Yang An, E Jeffrey Metter, Luigi Ferrucci, Richard O’Brien, and Alan B. Zonderman. “Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease.Am J Epidemiol 168, no. 10 (November 15, 2008): 1179–89. https://doi.org/10.1093/aje/kwn229.
Beydoun MA, Lhotsky A, Wang Y, Dal Forno G, An Y, Metter EJ, et al. Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease. Am J Epidemiol. 2008 Nov 15;168(10):1179–89.
Beydoun, May A., et al. “Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease.Am J Epidemiol, vol. 168, no. 10, Nov. 2008, pp. 1179–89. Pubmed, doi:10.1093/aje/kwn229.
Beydoun MA, Lhotsky A, Wang Y, Dal Forno G, An Y, Metter EJ, Ferrucci L, O’Brien R, Zonderman AB. Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease. Am J Epidemiol. 2008 Nov 15;168(10):1179–1189.
Journal cover image

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

November 15, 2008

Volume

168

Issue

10

Start / End Page

1179 / 1189

Location

United States

Related Subject Headings

  • Risk Factors
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Incidence
  • Humans
  • Female
  • Epidemiology
  • Body Mass Index
  • Bayes Theorem