Reproducibility of the pharmacokinetic-hemodynamic response to nitroglycerin in the dog: a model for studying the effects of chronic treatment.

Journal Article

We studied six dogs to determine the hemodynamic response to and pharmacokinetics of intravenous nitroglycerin (i.v. GTN) before and after a five-day treatment with placebo ointment. On the first study day, the major hemodynamic response to 21 micrograms/min i.v. GTN was an 11.4% +/- 5.6 (S.D.) fall in systolic blood pressure (SBP) from a control of 180 mmHg +/- 16 to 158 mmHg at 21 micrograms/min i.v. GTN. This finding was reproduced (a 12.6% +/- 5.6 fall in SBP) on the second study day. On the first day, the relationship between the arterial GTN concentration and the infusion rate was linear, the arterial t1/2 for GTN was short (1.9 min +/- 0.6) and there was an 80% arterial-venous extraction for GTN; these values were unchanged by five days of treatment with placebo. We conclude that this model is a sensitive and reproducible system for studying the in vivo effects of sustained drug treatment.

Full Text

Duke Authors

Cited Authors

  • Moffat, JA; Abdollah, H; Watts, DG; Armstrong, PW

Published Date

  • March 1, 1984

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 41 - 51

PubMed ID

  • 6425569

International Standard Serial Number (ISSN)

  • 0160-5402

Digital Object Identifier (DOI)

  • 10.1016/0160-5402(84)90051-2

Language

  • eng