Reproducibility of the pharmacokinetic-hemodynamic response to nitroglycerin in the dog: a model for studying the effects of chronic treatment.

Published

Journal Article

We studied six dogs to determine the hemodynamic response to and pharmacokinetics of intravenous nitroglycerin (i.v. GTN) before and after a five-day treatment with placebo ointment. On the first study day, the major hemodynamic response to 21 micrograms/min i.v. GTN was an 11.4% +/- 5.6 (S.D.) fall in systolic blood pressure (SBP) from a control of 180 mmHg +/- 16 to 158 mmHg at 21 micrograms/min i.v. GTN. This finding was reproduced (a 12.6% +/- 5.6 fall in SBP) on the second study day. On the first day, the relationship between the arterial GTN concentration and the infusion rate was linear, the arterial t1/2 for GTN was short (1.9 min +/- 0.6) and there was an 80% arterial-venous extraction for GTN; these values were unchanged by five days of treatment with placebo. We conclude that this model is a sensitive and reproducible system for studying the in vivo effects of sustained drug treatment.

Full Text

Duke Authors

Cited Authors

  • Moffat, JA; Abdollah, H; Watts, DG; Armstrong, PW

Published Date

  • March 1, 1984

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 41 - 51

PubMed ID

  • 6425569

Pubmed Central ID

  • 6425569

International Standard Serial Number (ISSN)

  • 0160-5402

Language

  • eng

Conference Location

  • United States