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Reproducibility of the pharmacokinetic-hemodynamic response to nitroglycerin in the dog: a model for studying the effects of chronic treatment.

Publication ,  Journal Article
Moffat, JA; Abdollah, H; Watts, DG; Armstrong, PW
Published in: J Pharmacol Methods
March 1984

We studied six dogs to determine the hemodynamic response to and pharmacokinetics of intravenous nitroglycerin (i.v. GTN) before and after a five-day treatment with placebo ointment. On the first study day, the major hemodynamic response to 21 micrograms/min i.v. GTN was an 11.4% +/- 5.6 (S.D.) fall in systolic blood pressure (SBP) from a control of 180 mmHg +/- 16 to 158 mmHg at 21 micrograms/min i.v. GTN. This finding was reproduced (a 12.6% +/- 5.6 fall in SBP) on the second study day. On the first day, the relationship between the arterial GTN concentration and the infusion rate was linear, the arterial t1/2 for GTN was short (1.9 min +/- 0.6) and there was an 80% arterial-venous extraction for GTN; these values were unchanged by five days of treatment with placebo. We conclude that this model is a sensitive and reproducible system for studying the in vivo effects of sustained drug treatment.

Duke Scholars

Published In

J Pharmacol Methods

DOI

ISSN

0160-5402

Publication Date

March 1984

Volume

11

Issue

1

Start / End Page

41 / 51

Location

United States

Related Subject Headings

  • Nitroglycerin
  • Male
  • Kinetics
  • Infusions, Parenteral
  • Hemodynamics
  • Dogs
  • Blood Pressure
  • Animals
 

Citation

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Moffat, J. A., Abdollah, H., Watts, D. G., & Armstrong, P. W. (1984). Reproducibility of the pharmacokinetic-hemodynamic response to nitroglycerin in the dog: a model for studying the effects of chronic treatment. J Pharmacol Methods, 11(1), 41–51. https://doi.org/10.1016/0160-5402(84)90051-2
Moffat, J. A., H. Abdollah, D. G. Watts, and P. W. Armstrong. “Reproducibility of the pharmacokinetic-hemodynamic response to nitroglycerin in the dog: a model for studying the effects of chronic treatment.J Pharmacol Methods 11, no. 1 (March 1984): 41–51. https://doi.org/10.1016/0160-5402(84)90051-2.
Moffat, J. A., et al. “Reproducibility of the pharmacokinetic-hemodynamic response to nitroglycerin in the dog: a model for studying the effects of chronic treatment.J Pharmacol Methods, vol. 11, no. 1, Mar. 1984, pp. 41–51. Pubmed, doi:10.1016/0160-5402(84)90051-2.

Published In

J Pharmacol Methods

DOI

ISSN

0160-5402

Publication Date

March 1984

Volume

11

Issue

1

Start / End Page

41 / 51

Location

United States

Related Subject Headings

  • Nitroglycerin
  • Male
  • Kinetics
  • Infusions, Parenteral
  • Hemodynamics
  • Dogs
  • Blood Pressure
  • Animals