Daily mortality of infants born at less than 30weeks' gestation.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND: Few studies have reported odds of mortality for hospitalized premature infants stratified by postnatal age and adjusted for severity of illness. Our objective was to examine day-by-day mortality of premature infants in a large multicenter cohort of infants, adjusted for demographics, severity of illness, and receipt of therapeutic interventions. METHODS: This was a multicenter cohort study of infants cared for in 362 neonatal intensive care units with a shared clinical data warehouse from 1997 to 2013. We included all inborn infants born at 22-29weeks' gestational age with available mortality discharge data. We report the point prevalence of survival to hospital discharge stratified by gestational and postnatal age. RESULTS: We identified 64,896 infants, of whom 55,348 (85%) survived to hospital discharge. Survival increased with gestational and postnatal age, until infants reached a postmenstrual age of approximately 37weeks, after which survival began to decrease. Overall survival increased over time (80% in 1997 to 88% in 2013, P<.001). CONCLUSIONS: Given the known association between gestational age and postnatal age, survival predictions should be adjusted for both covariates.

Full Text

Duke Authors

Cited Authors

  • Hornik, CP; Sherwood, AL; Cotten, CM; Laughon, MM; Clark, RH; Smith, PB

Published Date

  • May 2016

Published In

Volume / Issue

  • 96 /

Start / End Page

  • 27 - 30

PubMed ID

  • 27018746

Pubmed Central ID

  • PMC4862884

Electronic International Standard Serial Number (EISSN)

  • 1872-6232

Digital Object Identifier (DOI)

  • 10.1016/j.earlhumdev.2016.03.003


  • eng

Conference Location

  • Ireland