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Malignant peritoneal mesothelioma and Crohn disease.

Publication ,  Journal Article
Butnor, KJ; Pavlisko, EN; Sporn, TA; Roggli, VL
Published in: J Clin Pathol
March 2017

AIMS: Mesothelial reaction simulating peritoneal diffuse malignant mesothelioma (MM) has been reported in the setting of Crohn ileitis. To our knowledge, peritoneal MM arising in patients with inflammatory bowel disease (IBD) has not been reported. The purpose of this study is to report the clinicopathological characteristics of patients with peritoneal MM and IBD. METHODS: A database of approximately 3800 MM was reviewed for cases of MM in patients with IBD. RESULTS: Three patients (0.08%) with peritoneal MM and Crohn disease (CD) were identified, including two women and one man ranging in age from 56 to 65 years. All had a long-standing history of diarrhoea and an established diagnosis of CD of 3 years or greater duration. Two had epithelial MM and one had biphasic MM. Only one had documented asbestos exposure. CONCLUSIONS: Peritoneal MM occurs rarely in patients with IBD, but interestingly, has only been observed in the setting of CD and not in patients with ulcerative colitis. Chronic inflammation has been associated with the development of MM in rare instances and these three cases suggest that CD with transmural inflammation may also be a precursor. The precise role of CD-related transmural inflammation in the carcinogenesis of peritoneal MM remains to be determined.

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Published In

J Clin Pathol

DOI

EISSN

1472-4146

Publication Date

March 2017

Volume

70

Issue

3

Start / End Page

228 / 232

Location

England

Related Subject Headings

  • Peritoneal Neoplasms
  • Pathology
  • Middle Aged
  • Mesothelioma, Malignant
  • Mesothelioma
  • Male
  • Lung Neoplasms
  • Humans
  • Female
  • Crohn Disease
 

Citation

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Butnor, K. J., Pavlisko, E. N., Sporn, T. A., & Roggli, V. L. (2017). Malignant peritoneal mesothelioma and Crohn disease. J Clin Pathol, 70(3), 228–232. https://doi.org/10.1136/jclinpath-2016-203945
Butnor, Kelly J., Elizabeth N. Pavlisko, Thomas A. Sporn, and Victor L. Roggli. “Malignant peritoneal mesothelioma and Crohn disease.J Clin Pathol 70, no. 3 (March 2017): 228–32. https://doi.org/10.1136/jclinpath-2016-203945.
Butnor KJ, Pavlisko EN, Sporn TA, Roggli VL. Malignant peritoneal mesothelioma and Crohn disease. J Clin Pathol. 2017 Mar;70(3):228–32.
Butnor, Kelly J., et al. “Malignant peritoneal mesothelioma and Crohn disease.J Clin Pathol, vol. 70, no. 3, Mar. 2017, pp. 228–32. Pubmed, doi:10.1136/jclinpath-2016-203945.
Butnor KJ, Pavlisko EN, Sporn TA, Roggli VL. Malignant peritoneal mesothelioma and Crohn disease. J Clin Pathol. 2017 Mar;70(3):228–232.

Published In

J Clin Pathol

DOI

EISSN

1472-4146

Publication Date

March 2017

Volume

70

Issue

3

Start / End Page

228 / 232

Location

England

Related Subject Headings

  • Peritoneal Neoplasms
  • Pathology
  • Middle Aged
  • Mesothelioma, Malignant
  • Mesothelioma
  • Male
  • Lung Neoplasms
  • Humans
  • Female
  • Crohn Disease