Thomas Arthur Sporn
Associate Professor of Pathology
Mesothelioma, lung cancer, occupational and asbestos-related diseases
Current Appointments & Affiliations
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2009
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1995
Contact Information
- 203M Davison Bldg, Durham, NC 27710
- Duke Box 3712, Durham, NC 27710
-
sporn001@mc.duke.edu
(919) 684-3056
- Background
-
Education, Training, & Certifications
- Pulmonary Fellow, Pathology, Duke University 1997 - 1998
- Resident, Pathology, Duke University 1995 - 1998
- Forensic Pathologist/Assistant Chief Medical Examiner, Pathology, University of North Carolina at Chapel Hill 1994 - 1995
- Resident, Pathology, Duke University 1993 - 1994
- Resident, Pulmonary Diseases And Critical Care Medicine, Georgetown University 1989 - 1992
- M.D., Georgetown University 1986
- B.A., University of Vermont 1982
-
Duke Appointment History
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 1998 - 2008
- Instructor, Temporary of Pathology, Pathology, Clinical Science Departments 1998
- Research
-
Selected Grants
- Phase I/II Trial of ZD1839 and Celecoxib in Ex-Smokers awarded by National Institutes of Health 2002 - 2007
- Publications & Artistic Works
-
Selected Publications
-
Books
- Oury, TD, Sporn, TA, and Roggli, VL. Pathology of asbestos-associated diseases, third edition. January 1, 2014. Full Text
-
Book Sections
- Pavlisko, EN, and Sporn, TA. "Mesothelioma." In Pathology of Asbestos-Associated Diseases, Third Edition, 81-140. January 1, 2014. Full Text
- Schneider, F, and Sporn, TA. "Cytopathology of asbestos-associated diseases." In Pathology of Asbestos-Associated Diseases, Third Edition, 193-213. January 1, 2014. Full Text
- Sporn, TA, and Roggli, VL. "Asbestosis." In Pathology of Asbestos-Associated Diseases, Third Edition, 53-80. January 1, 2014. Full Text
- Sporn, TA. "The mineralogy of asbestos." In Pathology of Asbestos-Associated Diseases, Third Edition, 1-10. January 1, 2014. Full Text
- Sporn, TA. "SV40 and the lung." In Viruses and the Lung: Infections and Non-Infectious Viral-Linked Lung Disorders, 197-202. July 1, 2013. Full Text
- Sporn, T, and Roggli, VL. "Occupational lung disease." In Spencer's Pathology of the Lung, Sixth Edition, 512-562. January 1, 2012. Full Text
-
Conference Papers
-
Journal Articles
- Butnor, KJ, Pavlisko, EN, Sporn, TA, and Roggli, VL. "Malignant peritoneal mesothelioma and Crohn disease." Journal of clinical pathology 70, no. 3 (March 2017): 228-232. Full Text
- Butnor, KJ, Brownlee, NA, Mahar, A, Pavlisko, EN, Sporn, TA, and Roggli, VL. "Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases." Lung cancer (Amsterdam, Netherlands) 95 (May 2016): 1-7. Full Text
- Galeotti, J, Sporn, TA, Ingram, P, Wahidi, MM, and Roggli, VL. "Endogenous pneumoconiosis: Analytical scanning electron microscopic analysis of a case." Ultrastructural pathology 40, no. 3 (May 2016): 159-162. Full Text
- Kraynie, A, de Ridder, GG, Sporn, TA, Pavlisko, EN, and Roggli, VL. "Malignant mesothelioma not related to asbestos exposure: Analytical scanning electron microscopic analysis of 83 cases and comparison with 442 asbestos-related cases." Ultrastructural pathology 40, no. 3 (May 2016): 142-146. Full Text
- Roggli, VL, and Sporn, TA. "Carcinoma of the lung in the absence of asbestosis: The value of lung fiber burden analysis." Ultrastructural pathology 40, no. 3 (May 2016): 151-154. Full Text
- Sporn, TA, and Roggli, VL. "A hard (metal) case: Value of analytical scanning electron microscopy." Ultrastructural pathology 40, no. 3 (May 2016): 147-150. Full Text
- Dahhan, T, Kaushik, SS, He, M, Mammarappallil, JG, Tapson, VF, McAdams, HP, Sporn, TA, Driehuys, B, and Rajagopal, S. "Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease." Pulmonary circulation 6, no. 1 (March 2016): 126-131. Full Text
- Li, X, Brownlee, NA, Sporn, TA, Mahar, A, and Roggli, VL. "Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases." Archives of pathology & laboratory medicine 139, no. 9 (September 2015): 1129-1136. Full Text
- Xu, X, Huang, L, Futtner, C, Schwab, B, Rampersad, RR, Lu, Y, Sporn, TA, Hogan, BLM, and Onaitis, MW. "The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2." Genes & development 28, no. 17 (September 2014): 1929-1939. Full Text
- Pavlisko, EN, Roggli, VL, Sporn, TA, and Oury, TD. "Relationship between pulmonary emphysema and renal function in smokers." Chest 143, no. 5 (May 2013): 1516-1517. (Letter) Full Text Link to Item
- Leslie, KO, Cool, CD, Sporn, TA, Curran-Everett, D, Steele, MP, Brown, KK, Wahidi, MM, and Schwartz, DA. "Familial idiopathic interstitial pneumonia: histopathology and survival in 30 patients." Arch Pathol Lab Med 136, no. 11 (November 2012): 1366-1376. Full Text Link to Item
- Higgins, KA, Chino, JP, Ready, N, D'Amico, TA, Berry, MF, Sporn, T, Boyd, J, and Kelsey, CR. "Lymphovascular invasion in non-small-cell lung cancer: implications for staging and adjuvant therapy." J Thorac Oncol 7, no. 7 (July 2012): 1141-1147. Full Text Link to Item
- West, KL, Sporn, T, and Puri, PK. "Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis." Arch Dermatol 148, no. 2 (February 2012): 228-232. Full Text Link to Item
- Butnor, KJ, Sporn, TA, and Roggli, VL. "Erratum: Exposure to brake dust and malignant mesothelioma: A study of 10 cases with mineral fiber analyses (Annals of Occupational Hygiene (2003) 47:4 (325-330))." Annals of Occupational Hygiene 56, no. 8 (2012): 975--. Full Text
- Meltzer, EB, Barry, WT, D'Amico, TA, Davis, RD, Lin, SS, Onaitis, MW, Morrison, LD, Sporn, TA, Steele, MP, and Noble, PW. "Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle. (Published online)" BMC Med Genomics 4 (October 5, 2011): 70-. Full Text Link to Item
- Sporn, TA. "Mineralogy of asbestos." Recent Results Cancer Res 189 (2011): 1-11. (Review) Full Text Link to Item
- Chen, JG, Eldridge, DL, Lodeserto, FJ, Ming, DY, Turner, KM, Vanderford, JL, Sporn, TA, and Schulman, SR. "Paraquat ingestion: a challenging diagnosis." Pediatrics 125, no. 6 (June 2010): e1505-e1509. Full Text Link to Item
- Klebe, S, Brownlee, NA, Mahar, A, Burchette, JL, Sporn, TA, Vollmer, RT, and Roggli, VL. "Sarcomatoid mesothelioma: a clinical-pathologic correlation of 326 cases." Mod Pathol 23, no. 3 (March 2010): 470-479. Full Text Link to Item
- Schneider, F, Sporn, TA, and Roggli, VL. "Asbestos fiber content of lungs with diffuse interstitial fibrosis: An analytical scanning electron microscopic analysis of 249 cases." Arch Pathol Lab Med 134, no. 3 (March 2010): 457-461. Full Text Link to Item
- Zagar, TM, Blackwell, S, Crawford, J, D'Amico, T, Christensen, JD, Sporn, TA, and Kelsey, CR. "Preoperative radiation therapy and chemotherapy for pulmonary blastoma: a case report." J Thorac Oncol 5, no. 2 (February 2010): 282-283. Full Text Link to Item
- Wahidi, MM, Shofer, SL, Sporn, TA, and Ernst, A. "Comparison of transbronchial lung biopsy yield between standard forceps and electrocautery hot forceps in swine." Respiration 79, no. 2 (2010): 137-140. Full Text Link to Item
- Berry, MF, Sporn, TA, Moore, JO, and D'Amico, TA. "Giant thoracic liposarcoma treated with induction chemotherapy followed by surgical resection." J Thorac Oncol 4, no. 6 (June 2009): 768-769. Full Text Link to Item
- Roggli, VL, Sporn, TA, Case, BW, and Butnor, KJ. "Comments on Asbestos fibre concentrations in the lungs of brake workers: another look." Ann Occup Hyg 53, no. 2 (March 2009): 191-. (Letter) Full Text Link to Item
- Sporn, TA, and Roggli, VL. "Pneumoconioses, mineral and vegetable." 1 (December 1, 2008): 911-949. (Chapter) Full Text
- Downing, TE, Sporn, TA, Bollinger, RR, Davis, RD, Parker, W, and Lin, SS. "Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity." Exp Biol Med (Maywood) 233, no. 10 (October 2008): 1202-1212. Full Text Link to Item
- Roggli, VL, Sporn, TA, and Butnor, KJ. "Comments on Dodson et al., A technical comparison of evaluating asbestos concentration by phase contrast microscopy (PCM), scanning electron microscopy (SEM), and analytical transmission electron microscopy (ATEM) as illustrated from data generated from a case report." Inhal Toxicol 20, no. 12 (September 2008): 1113-1114. (Letter) Full Text Link to Item
- Schneider, F, Sporn, TA, and Roggli, VL. "Crocidolite and mesothelioma." Ultrastruct Pathol 32, no. 5 (September 2008): 171-177. Full Text Link to Item
- Liby, K, Black, CC, Royce, DB, Williams, CR, Risingsong, R, Yore, MM, Liu, X, Honda, T, Gribble, GW, Lamph, WW, Sporn, TA, Dmitrovsky, E, and Sporn, MB. "The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis." Mol Cancer Ther 7, no. 5 (May 2008): 1251-1257. Full Text Link to Item
- Wong, TZ, Lacy, JL, Petry, NA, Hawk, TC, Sporn, TA, Dewhirst, MW, and Vlahovic, G. "PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator." AJR Am J Roentgenol 190, no. 2 (February 2008): 427-432. Full Text Link to Item
- Brown, WJ, Pyhtila, JW, Terry, NG, Chalut, KJ, D'Amico, TA, Sporn, TA, Obando, JV, and Wax, A. "Review and recent development of angle-resolved low-coherence interferometry for detection of precancerous cells in human esophageal epithelium." IEEE Journal on Selected Topics in Quantum Electronics 14, no. 1 (2008): 88-96. Full Text
- Butnor, KJ, Sporn, TA, Ordonez, NG, and Association of Directors of Anatomic and Surgical Pathology, . "Recommendations for the reporting of pleural mesothelioma." Hum Pathol 38, no. 11 (November 2007): 1587-1589. Full Text Link to Item
- Reddy, AJ, Govert, JA, Sporn, TA, and Wahidi, MM. "Broncholith removal using cryotherapy during flexible bronchoscopy: a case report." Chest 132, no. 5 (November 2007): 1661-1663. Full Text Link to Item
- Leipsic, JA, McAdams, HP, and Sporn, TA. "Follicular dendritic cell sarcoma of the mediastinum." AJR Am J Roentgenol 188, no. 6 (June 2007): W554-W556. Full Text Link to Item
- Liby, K, Royce, DB, Williams, CR, Risingsong, R, Yore, MM, Honda, T, Gribble, GW, Dmitrovsky, E, Sporn, TA, and Sporn, MB. "The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice." Cancer Res 67, no. 6 (March 15, 2007): 2414-2419. Full Text Link to Item
- Butnor, KJ, Sporn, TA, Ordonez, NG, and Association of Direstors of Anatomic and Surgical Pathology (ADASP), . "Recommendations for the reporting of pleural mesothelioma." Virchows Arch 450, no. 1 (January 2007): 15-23. Full Text Link to Item
- Butnor, KJ, Sporn, TA, and Ordonez, NG. "Recommendations for the reporting of pleural mesothelioma." American Journal of Clinical Pathology 127, no. 1 (2007): 15-19. Full Text
- Yang, IV, Burch, LH, Steele, MP, Savov, JD, Hollingsworth, JW, McElvania-Tekippe, E, Berman, KG, Speer, MC, Sporn, TA, Brown, KK, Schwarz, MI, and Schwartz, DA. "Gene expression profiling of familial and sporadic interstitial pneumonia." Am J Respir Crit Care Med 175, no. 1 (January 1, 2007): 45-54. Full Text Link to Item
- Hargett, CW, Sporn, TA, Roggli, VL, and Hollingsworth, JW. "Giant cell interstitial pneumonia associated with nitrofurantoin." Lung 184, no. 3 (May 2006): 147-149. Full Text Link to Item
- Roggli, VL, Piantadosi, CA, MacIntyre, NR, Young, SL, Kussin, PS, Steele, MP, Carraway, MS, Welty-Wolf, KE, Govert, JA, McMahon, TJ, Palmer, SM, Sporn, TA, and Ghio, AJ. "Physician subsidies for tobacco advertising." Am J Respir Crit Care Med 173, no. 2 (January 15, 2006): 246-. (Letter) Full Text Link to Item
- Steele, MP, Speer, MC, Loyd, JE, Brown, KK, Herron, A, Slifer, SH, Burch, LH, Wahidi, MM, Phillips, JA, Sporn, TA, McAdams, HP, Schwarz, MI, and Schwartz, DA. "Clinical and pathologic features of familial interstitial pneumonia." Am J Respir Crit Care Med 172, no. 9 (November 1, 2005): 1146-1152. Full Text Link to Item
- Hurwitz, LM, McAdams, HP, and Sporn, TA. "A 73-year-old woman with a cough." Chest 128, no. 2 (August 2005): 1018-1021. Full Text Link to Item
- Brownlee, NA, Mahar, A, and Sporn, TA. "Bilateral pulmonary nodules in a 37-year-old woman with malignant melanoma. Pulmonary Langerhans cell histiocytosis (eosinophilic granuloma)." Arch Pathol Lab Med 129, no. 5 (May 2005): e136-e137. Full Text Link to Item
- Butnor, KJ, Burchette, JL, Sporn, TA, Hammar, SP, and Roggli, VL. "The spectrum of Kit (CD117) immunoreactivity in lung and pleural tumors: a study of 96 cases using a single-source antibody with a review of the literature." Arch Pathol Lab Med 128, no. 5 (May 2004): 538-543. (Review) Full Text Link to Item
- Volmar, KE, Sporn, TA, Toloza, EM, Martinez, S, Dodd, LG, and Xie, HB. "Giant cell tumor of rib masquerading as thymoma: a diagnostic pitfall in needle core biopsy of the mediastinum." Archives of pathology & laboratory medicine 128, no. 4 (April 2004): 452-455. Full Text
- Schneider, F, Volmar, KE, and Sporn, TA. "Pathologic quiz case: a 53-year-old man with chest pain and cough. Malignant (diffuse) pleural mesothelioma, biphasic variant, with heterologous differentiation." Arch Pathol Lab Med 128, no. 1 (January 2004): 107-108. Full Text Link to Item
- Schneider, F, Volmar, KE, and Sporn, TA. "Pathologic Quiz Case: A 53-Year-Old Man with Chest Pain and Cough." Archives of Pathology and Laboratory Medicine 128, no. 1 (2004): 107-108.
- Sellon, RK, Johnson, JL, Leathers, CW, Sporn, T, and Beckley, JC. "Tracheobronchopathia osteochondroplastica in a dog." Journal of Veterinary Internal Medicine 18, no. 3 (2004): 359-362. Full Text
- Butnor, KJ, Sporn, TA, Ingram, P, Gunasegaram, S, Pinto, JF, and Roggli, VL. "Beryllium detection in human lung tissue using electron probe X-ray microanalysis." Mod Pathol 16, no. 11 (November 2003): 1171-1177. Full Text Link to Item
- Taylor, JL, Quiñones Maymí, DM, Sporn, TA, McAdam, HP, and Wahidi, MM. "Multiple lung nodules in a woman with a history of melanoma." Respiration 70, no. 5 (September 2003): 544-548. Full Text Link to Item
- Volmar, KE, Sporn, TA, and Cummings, TJ. "Pathologic quiz case: a 54-year-old man with multiple pulmonary nodules." Arch Pathol Lab Med 127, no. 7 (July 2003): e319-e320. Full Text Link to Item
- Butnor, KJ, Sporn, TA, and Roggli, VL. "Exposure to brake dust and malignant mesothelioma: a study of 10 cases with mineral fiber analyses." Ann Occup Hyg 47, no. 4 (June 2003): 325-330. Link to Item
- Butnor, KJ, and Sporn, TA. "Human parainfluenza virus giant cell pneumonia following cord blood transplant associated with pulmonary alveolar proteinosis." Arch Pathol Lab Med 127, no. 2 (February 2003): 235-238. Full Text Link to Item
- Abushamaa, AM, Sporn, TA, and Folz, RJ. "Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen." Am J Physiol Lung Cell Mol Physiol 283, no. 2 (August 2002): L336-L345. Full Text Link to Item
- Roggli, VL, Vollmer, RT, Butnor, KJ, and Sporn, TA. "Tremolite and mesothelioma." Ann Occup Hyg 46, no. 5 (July 2002): 447-453. Link to Item
- Voynow, JA, Schanberg, L, Sporn, T, and Kredich, D. "Pulmonary complications associated with Kawasaki disease." J Pediatr 140, no. 6 (June 2002): 786-787. (Letter) Link to Item
- Roggli, VL, Sharma, A, Butnor, KJ, Sporn, T, and Vollmer, RT. "Malignant mesothelioma and occupational exposure to asbestos: a clinicopathological correlation of 1445 cases." Ultrastruct Pathol 26, no. 2 (March 2002): 55-65. Full Text Link to Item
- Abushamaa, AM, Sporn, TA, and Folz, RJ. "Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen." American Journal of Physiology - Lung Cellular and Molecular Physiology 283, no. 2 27-2 (2002): L336-L345.
- Hadjiliadis, D, Sporn, TA, Perfect, JR, Tapson, VF, Davis, RD, and Palmer, SM. "Outcome of lung transplantation in patients with mycetomas." Chest 121, no. 1 (January 2002): 128-134. Link to Item
- Ingram, P, Butnor, KJ, Sporn, TA, and Roggli, VL. "Detection of beryllium in human lung tissue using energy dispersive X-ray analysis." Microscopy and Microanalysis 8, no. SUPPL. 2 (2002): 918-919.
- Butnor, KJ, Sporn, TA, Hammar, SP, and Roggli, VL. "Well-differentiated papillary mesothelioma." Am J Surg Pathol 25, no. 10 (October 2001): 1304-1309. Link to Item
- Butnor, KJ, Sporn, TA, and Roggli, VL. "Pulmonary apical cap." Am J Surg Pathol 25, no. 10 (October 2001): 1344-. (Letter) Link to Item
- Butnor, KJ, Sporn, TA, and Dodd, LG. "Fine needle aspiration cytology of mucinous cystadenocarcinoma of the lung: report of a case with radiographic and histologic correlation." Acta Cytol 45, no. 5 (September 2001): 779-783. Full Text Link to Item
- Ravenel, JG, McAdams, HP, Plankeel, JF, Butnor, KJ, and Sporn, TA. "Sarcoidosis induced by interferon therapy." AJR Am J Roentgenol 177, no. 1 (July 2001): 199-201. Full Text Link to Item
- Bhagat, R, Sporn, TA, Long, GD, and Folz, RJ. "Amiodarone and cyclophosphamide: potential for enhanced lung toxicity." Bone Marrow Transplant 27, no. 10 (May 2001): 1109-1111. Full Text Link to Item
- Harpole, DH, Moore, MB, Herndon, JE, Aloia, T, D'Amico, TA, Sporn, T, Parr, A, Linoila, I, and Allegra, C. "The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer." Clin Cancer Res 7, no. 3 (March 2001): 562-569. Link to Item
- Kong, FM, Anscher, MS, Sporn, TA, Washington, MK, Clough, R, Barcellos-Hoff, MH, and Jirtle, RL. "Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury." Int J Radiat Oncol Biol Phys 49, no. 1 (January 1, 2001): 35-41. Link to Item
- Crotty, EJ, McAdams, HP, Erasmus, JJ, Sporn, TA, and Roggli, VL. "Epithelioid hemangioendothelioma of the pleura: clinical and radiologic features." AJR Am J Roentgenol 175, no. 6 (December 2000): 1545-1549. Full Text Link to Item
- Rossi, SE, Erasmus, JJ, McAdams, HP, Sporn, TA, and Goodman, PC. "Pulmonary drug toxicity: radiologic and pathologic manifestations." Radiographics 20, no. 5 (September 2000): 1245-1259. (Review) Full Text Link to Item
- Rossi, SE, McAdams, HP, Erasmus, JJ, and Sporn, TA. "A 63-year-old woman with a 2-month history of dyspnea." Chest 117, no. 5 (May 2000): 1505-1507. Link to Item
- Matar, LD, McAdams, HP, and Sporn, TA. "Hypersensitivity pneumonitis." AJR Am J Roentgenol 174, no. 4 (April 2000): 1061-1066. Full Text Link to Item
- Matar, LD, McAdams, HP, and Sporn, TA. "Pictorial essay. Hypersensitivity pneumonitis." American Journal of Roentgenology 174, no. 4 (2000): 1061-1066.
- Marom, EM, McAdams, HP, Palmer, SM, Erasmus, JJ, Sporn, TA, Tapson, VF, Davis, RD, and Goodman, PC. "Cystic fibrosis: usefulness of thoracic CT in the examination of patients before lung transplantation." Radiology 213, no. 1 (October 1999): 283-288. Full Text Link to Item
- Stamat, JC, Chekan, EG, Ali, A, Ko, A, Sporn, TA, and Eubanks, WS. "Laparoscopy and mesothelioma." J Laparoendosc Adv Surg Tech A 9, no. 5 (October 1999): 433-437. Full Text Link to Item
- Nolan, RL, McAdams, HP, Sporn, TA, Roggli, VL, Tapson, VF, and Goodman, PC. "Pulmonary cholesterol granulomas in patients with pulmonary artery hypertension: chest radiographic and CT findings." AJR Am J Roentgenol 172, no. 5 (May 1999): 1317-1319. Full Text Link to Item
- Marom, EM, McAdams, HP, Sporn, TA, and Goodman, PC. "Lentil aspiration pneumonia: radiographic and CT findings." J Comput Assist Tomogr 22, no. 4 (July 1998): 598-600. (Review) Link to Item
- Read, CA, Sporn, TA, and Yeager, H. "Parapneumonic empyema. A pitfall in diagnosis." Chest 101, no. 6 (June 1992): 1712-1713. Link to Item
-
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.
