Scholars@Duke
Thomas Arthur Sporn

Thomas Arthur Sporn

Adjunct Associate Professor in the Department of Pathology
Pathology
sporn001@mc.duke.edu
Duke Box 3712, Durham, NC 27710
203M Davison Bldg, Durham, NC 27710

Selected Publications

Recent trends in the causation of peritoneal mesothelioma: fiber burden analysis of ten cases.

Journal Article Ultrastruct Pathol · 2025 Mesothelioma in the past has been strongly associated with a history of asbestos exposure. Studies have shown that, on average, a higher dose of asbestos exposure is required for the development of peritoneal mesothelioma, and a smaller percentage of cases ... Full text Link to item Cite

Mesothelioma

Other The 5-Minute Clinical Consult 2025 · 2025 Cite

Pathology of Asbestos-Associated Diseases

Book · January 1, 2025 The fourth edition of Pathology of Asbestos-Associated Diseases builds on the success of the previous editions by fully updating knowledge on diagnostic and epidemiologic aspects and presenting important new insights derived from new epidemiologic studies ... Full text Cite

Asbestosis

Chapter · January 1, 2025 Environmental and/or occupational mineral fiber inhalation can result in significant pulmonary disease (pneumoconiosis). Asbestosis, or parenchymal lung disease due to asbestos fiber inhalation, results from significant fiber burden related to both the int ... Full text Cite

Cytopathology of Asbestos-Associated Diseases

Chapter · January 1, 2025 Cytology specimens have shown utility for the diagnosis of asbestos-associated diseases in the clinical setting and for detection of asbestos bodies in the occupational setting. Effusion cytology specimens are of particular clinical importance as effusions ... Full text Cite

Pulmonary Actinomycosis in a 65-Year-Old Female with Poor Oral Dentition.

Journal Article Diagnostics (Basel) · July 3, 2024 Pulmonary actinomycosis is an uncommon clinical entity that can be challenging to diagnose due to its non-specific symptomatology. Misdiagnosis and delayed treatment may result in invasive procedures and extended antimicrobial treatment courses. We report ... Full text Link to item Cite

The diagnosis of asbestosis in the 21st century: a clinicopathological correlation of 102 cases.

Journal Article Ultrastruct Pathol · March 3, 2024 Asbestosis, defined as diffuse pulmonary fibrosis caused by inhalation of asbestos fibers, occurs after heavy exposures to asbestos dust over several decades. Because workplace exposures have been significantly curtailed since the banning of asbestos in in ... Full text Link to item Cite

Diagnostic Approach to Pulmonary B-Cell Lymphomas in Small Biopsies, with Practical Recommendations to Avoid Misinterpretation.

Journal Article Diagnostics (Basel) · October 26, 2023 Pulmonary lymphomas are rare. With the current less invasive approaches used to obtain material for diagnosis, the diagnosis of pulmonary lymphoma is now frequently established in a small biopsy rather than in a resection. Therefore, the diagnosis has beco ... Full text Link to item Cite

Diagnostic approach to prevascular (anterior) mediastinal lymphomas: when thoracic pathology meets hematopathology.

Journal Article Mediastinum · 2023 Lymphomas are among the most common malignant tumors occurring in the anterior/prevascular mediastinum. Their diagnoses can be challenging in small biopsies, the current most common method of sampling of an anterior mediastinal mass. Because the initial cl ... Full text Link to item Cite

Perioperative outcomes of pulmonary resection after neoadjuvant pembrolizumab in patients with non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · February 2022 OBJECTIVES: Pembrolizumab is a programmed death receptor-1 masking antibody approved for metastatic non-small cell lung cancer. This Phase 2 study (NCT02818920) of neoadjuvant pembrolizumab in non-small cell lung cancer had a primary end point of safety an ... Full text Link to item Cite

Multi-Institutional Prospective Validation of Prognostic mRNA Signatures in Early Stage Squamous Lung Cancer (Alliance).

Journal Article J Thorac Oncol · November 2020 INTRODUCTION: Surgical resection is curative for some patients with early lung squamous cell carcinoma. Staging and clinical factors do not adequately predict recurrence risk. We sought to validate the discriminative performance of proposed prognostic gene ... Full text Link to item Cite

Talc and mesothelioma: mineral fiber analysis of 65 cases with clinicopathological correlation.

Journal Article Ultrastruct Pathol · March 3, 2020 Malignant mesothelioma is strongly associated with prior asbestos exposure. Recently there has been interest in the role of talc exposure in the pathogenesis of mesothelioma. We have analyzed lung tissue samples from a large series of malignant mesotheliom ... Full text Link to item Cite

Malignant Diffuse Mesothelioma in Women: A Study of 354 Cases.

Journal Article Am J Surg Pathol · March 2020 We reviewed 354 cases of malignant diffuse mesothelioma (MM) in women from a database of 2858 histologically confirmed MM cases. There was a pleural predominance with 78% pleural MM and 22% peritoneal MM. The pleural tumors consisted of 72% epithelioid, 19 ... Full text Link to item Cite

Mesothelioma of the tunica vaginalis testis.

Journal Article Hum Pathol · October 2019 Malignant mesothelioma (MM) arising from the serosal membranes of the tunica vaginalis testis (TVT) is rare. Most examples in the published medical literature are individual case reports. This study presents the clinicopathological findings of mesothelioma ... Full text Link to item Cite

Dusting off the numbers of in situ particle analysis: a 35-year experience.

Journal Article Ultrastruct Pathol · 2019 A variety of fibrotic lung diseases are caused by the inhalation of organic dusts. Many of these disorders have distinctive histopathology and can be readily diagnosed by routine histopathologic examination. However, in some instances, there is overlap in ... Full text Link to item Cite

Malignant peritoneal mesothelioma in patients with endometriosis.

Journal Article J Clin Pathol · November 2018 AIMS: Florid mesothelial hyperplasia is known to result from endometriosis. Well-differentiated papillary mesothelioma and multiloculated peritoneal inclusion cysts have also been described in women with endometriosis. To our knowledge, peritoneal diffuse ... Full text Link to item Cite

Dendriform pulmonary ossification leading to bilateral lung transplant: a case report.

Journal Article Virchows Arch · September 2018 Metaplastic ossification within the lung is seen in a variety of diseases, usually as sequela of either a separate primary pulmonary parenchymal disease or an underlying cardiac disorder such as valvular disease. Primary intraalveolar ossification or ossif ... Full text Link to item Cite

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms.

Journal Article Arch Pathol Lab Med · June 2018 CONTEXT: - Malignant mesothelioma (MM) is a component of the BAP1 tumor predisposition syndrome. Other than in BAP1 familial studies, nonmesothelial neoplasms in individuals with MM has not been comprehensively assessed. OBJECTIVE: - To assess the spectrum ... Full text Link to item Cite

Primary Pleural Neoplasms

Chapter · January 1, 2018 Full text Cite

Malignant peritoneal mesothelioma and Crohn disease.

Journal Article J Clin Pathol · March 2017 AIMS: Mesothelial reaction simulating peritoneal diffuse malignant mesothelioma (MM) has been reported in the setting of Crohn ileitis. To our knowledge, peritoneal MM arising in patients with inflammatory bowel disease (IBD) has not been reported. The pur ... Full text Link to item Cite

Mesothelioma Pathology

Chapter · 2017 Cite

Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases.

Journal Article Lung Cancer · May 2016 OBJECTIVES: To examine the clinicopathologic characteristics of individuals with diffuse malignant mesothelioma (DMM) occurring concurrently with lung cancer (LC). MATERIALS AND METHODS: A database of approximately 3800 patients with DMM was reviewed, from ... Full text Link to item Cite

Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease.

Journal Article Pulm Circ · March 2016 The diagnosis of pulmonary vascular disease (PVD) is usually based on hemodynamic and/or clinical criteria. Noninvasive imaging of the heart and proximal vasculature can also provide useful information. An alternate approach to such criteria in the diagnos ... Full text Link to item Cite

A hard (metal) case: Value of analytical scanning electron microscopy.

Journal Article Ultrastruct Pathol · 2016 Exposure to hard metal (tungsten carbide) dust is a rare cause of interstitial lung disease. Although most cases have a distinctive morphology known as giant cell interstitial pneumonitis, other patterns have been described as well. In such cases, the true ... Full text Link to item Cite

Carcinoma of the lung in the absence of asbestosis: The value of lung fiber burden analysis.

Journal Article Ultrastruct Pathol · 2016 Asbestos is universally recognized as a carcinogen for the lower respiratory tract. However, asbestos is a contributory factor in a small fraction of lung cancers, the vast majority of which are related to cigarette smoking. The challenge for the pathologi ... Full text Link to item Cite

Malignant mesothelioma not related to asbestos exposure: Analytical scanning electron microscopic analysis of 83 cases and comparison with 442 asbestos-related cases.

Journal Article Ultrastruct Pathol · 2016 Epidemiological studies indicate that 80-90% of mesotheliomas are asbestos related. This suggests that 10-20% are not. Lung fiber burden analysis provides objective information about past exposures to asbestos. We have performed lung fiber burden analysis ... Full text Link to item Cite

Endogenous pneumoconiosis: Analytical scanning electron microscopic analysis of a case.

Journal Article Ultrastruct Pathol · 2016 Pneumoconiosis is often considered a disease of the lung initiated by exposure to dust or other airborne particles, resulting in injury to the lungs. The term "endogenous pneumoconiosis" has been used in the literature to describe the deposition of compoun ... Full text Link to item Cite

Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases.

Journal Article Arch Pathol Lab Med · September 2015 CONTEXT: Ionizing radiation has a role in the development of malignant mesothelioma, in several epidemiologic studies, including patients with hematologic malignancies. OBJECTIVE: To study the clinicopathologic characteristics of patients with malignant me ... Full text Link to item Cite

The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.

Journal Article Genes Dev · September 1, 2014 Cell type-specific conditional activation of oncogenic K-Ras is a powerful tool for investigating the cell of origin of adenocarcinomas in the mouse lung. Our previous studies showed that K-Ras activation with a CC10(Scgb1a1)-CreER driver leads to adenocar ... Full text Link to item Cite

Mesothelioma

Chapter · January 1, 2014 Mesothelioma, literally “tumor of the mesothelium,” is a term often used synonymously with malignant (diffuse) mesothelioma, the malignant neoplasm arising from the serosal linings of the pleural, pericardial, or peritoneal cavities. These major body cavit ... Full text Cite

Asbestosis

Chapter · January 1, 2014 The term pneumoconiosis dates to Zenker’s 1866 description of pulmonary disease processes related to the inhalation of dusts [1]. As some dust, including asbestos fibers, may be found in the lungs of virtually all adults from the general population, pneumo ... Full text Cite

Pathology of asbestos-associated diseases, third edition

Book · January 1, 2014 The third edition of Pathology of Asbestos-Associated Diseases builds on the success of the previous editions by fully updating knowledge on diagnostic and epidemiologic aspects and presenting important new insights derived from new epidemiologic studies a ... Full text Cite

Cytopathology of asbestos-associated diseases

Chapter · January 1, 2014 Asbestos is the generic term typically used for six naturally occurring fibrous silicates that are or have been exploited commercially: the serpentine chrysotile and the amphiboles amosite, crocidolite, anthophyllite, tremolite, and actinolite [1]. ... Full text Cite

The mineralogy of asbestos

Chapter · January 1, 2014 Minerals are naturally occurring inorganic compounds of specific chemical composition and crystal structure. Their nomenclature typically stems as an honorific, to indicate a pertinent geographic area or to highlight a distinctive characteristic of the com ... Full text Cite

Consideration of Occupational Lung Disease and Pneumoconiosis in Forensic Pathology

Journal Article Academic Forensic Pathology · December 1, 2013 Reports of workers stricken with lung disease sustained during the course of their employment date to antiquity. Despite stringent regulations to mitigate all manners of work place hazards, and the emergence of agencies and physicians engaged in the advanc ... Full text Cite

SV40 and the lung

Chapter · July 1, 2013 Subsequent to its identification as an inadvertent contaminant of early poliovirus vaccines and in view of its potential to induce a number of tumors in animal models, simian virus 40 (SV40) has become among the most studied animal viruses. Studies of SV40 ... Full text Cite

Familial idiopathic interstitial pneumonia: histopathology and survival in 30 patients.

Journal Article Arch Pathol Lab Med · November 2012 CONTEXT: Familial idiopathic interstitial pneumonia (F-IIP) describes the unexplained occurrence of diffuse parenchymal lung disease in related individuals. Prevailing wisdom suggests that the histopathology of F-IIP is indistinguishable from that of idiop ... Full text Link to item Cite

Lymphovascular invasion in non-small-cell lung cancer: implications for staging and adjuvant therapy.

Journal Article J Thorac Oncol · July 2012 BACKGROUND: Lymphovascular space invasion (LVI) is an established negative prognostic factor and an indication for postoperative radiation therapy in many malignancies. The purpose of this study was to evaluate LVI in patients with early-stage non-small-ce ... Full text Link to item Cite

Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis.

Journal Article Arch Dermatol · February 2012 BACKGROUND: Multicentric reticulohistiocytosis (MRH) is a rare disease of uncertain etiology that most commonly presents as a papulonodular cutaneous eruption accompanied by erosive polyarthritis. Although MRH is considered a systemic disorder in that it t ... Full text Link to item Cite

Occupational lung disease

Chapter · January 1, 2012 Introduction Occupational lung disease is the most significant form of work-related illness in the United States in terms of its severity, frequency and cost to society. The US Department of Labor reported the occurrence of some 4.1 million workplace injur ... Full text Cite

Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle.

Journal Article BMC Med Genomics · October 5, 2011 BACKGROUND: The accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is a major clinical challenge. We developed a model to diagnose IPF by applying Bayesian probit regression (BPR) modelling to gene expression profiles of whole lung tissue. METHODS: ... Full text Link to item Cite

Mineralogy of asbestos.

Journal Article Recent Results Cancer Res · 2011 The term asbestos collectively refers to a group of naturally occurring fibrous minerals which have been exploited in numerous commercial and industrial settings and applications dating to antiquity. Its myriad uses as a "miracle mineral" owe to its remark ... Full text Link to item Cite

Paraquat ingestion: a challenging diagnosis.

Journal Article Pediatrics · June 2010 Paraquat is an herbicide that is highly toxic to humans. Pediatric ingestion has become uncommon in the United States because of preventative efforts. We report here an unintentional, fatal paraquat ingestion by an 8-year-old child. Storage in an inappropr ... Full text Link to item Cite

Sarcomatoid mesothelioma: a clinical-pathologic correlation of 326 cases.

Journal Article Mod Pathol · March 2010 Sarcomatoid mesothelioma is the least common, but most aggressive of the three major histological types of mesotheliomas. This study comprises 326 cases of sarcomatoid mesotheliomas among 2000 consecutive malignant mesothelioma cases received in consultati ... Full text Link to item Cite

Asbestos fiber content of lungs with diffuse interstitial fibrosis: An analytical scanning electron microscopic analysis of 249 cases.

Journal Article Arch Pathol Lab Med · March 2010 CONTEXT: Asbestosis is one of many forms of diffuse interstitial pulmonary fibrosis. Its histologic diagnosis rests on the pattern of fibrosis and the presence of asbestos bodies by light microscopy in lung biopsies. OBJECTIVE: To determine the asbestos fi ... Full text Link to item Cite

Comparison of transbronchial lung biopsy yield between standard forceps and electrocautery hot forceps in swine.

Journal Article Respiration · 2010 BACKGROUND: Transbronchial lung biopsy (TBLB) is a commonly performed bronchoscopic procedure. Previous studies have suggested that larger biopsy forceps may improve diagnostic yield; however, the risk of bleeding associated with larger samples may be incr ... Full text Link to item Cite

Pneumoconioses, mineral and vegetable

Journal Article · December 1, 2008 The term pneumoconiosis, originally coined by Zenker,1 literally means dust in the lung. Because various types of dust can be found in the lungs of virtually all adults, this term has come to mean the accumulation of abnormal amounts of dust in the lungs a ... Full text Cite

Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity.

Journal Article Exp Biol Med (Maywood) · October 2008 Gastroesophageal reflux has become a major health concern in industrialized countries, with drugs aimed at blocking acid production being more frequently prescribed than any other drug. Damage to lung tissue as a result of chronic aspiration of gastric flu ... Full text Link to item Cite

The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis.

Journal Article Mol Cancer Ther · May 2008 Female A/J mice injected with the carcinogen vinyl carbamate develop atypical adenomatous hyperplasias in lungs 4 weeks after injection with the carcinogen. The number and severity of tumors then increase over time, making these mice a useful model for eva ... Full text Link to item Cite

PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator.

Journal Article AJR Am J Roentgenol · February 2008 OBJECTIVE: Copper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) and copper-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) are being studied as potential markers of hypoxia and perfusion, respectively. The use of short-lived radionuclides (e.g ... Full text Link to item Cite

Primary Pleural Neoplasms

Chapter · January 1, 2008 Full text Cite

Review and recent development of angle-resolved low-coherence interferometry for detection of precancerous cells in human esophageal epithelium

Journal Article IEEE Journal on Selected Topics in Quantum Electronics · January 1, 2008 The combination of low-coherence interferometry with angle-resolved light scattering measurements has been shown to be a powerful method for determining the structure of cell nuclei within intact tissue samples. The nuclear morphology data have been used a ... Full text Cite

Crocidolite and mesothelioma.

Journal Article Ultrastruct Pathol · 2008 This study reports changes in the frequency of detection of various asbestos fiber types between 1982 and 2005. Crocidolite is increasingly detected in U.S. mesothelioma patients. The percentage of crocidolite fibers detected in lung tissue has risen from ... Full text Link to item Cite

Recommendations for the reporting of pleural mesothelioma.

Journal Article Hum Pathol · November 2007 It has been evident for decades that pathology reports are very variable even within a single institution. Standardization of reporting is the optimal way to ensure that information necessary for patient management, prognostic and predictive factor assessm ... Full text Link to item Cite

Broncholith removal using cryotherapy during flexible bronchoscopy: a case report.

Journal Article Chest · November 2007 Pulmonary broncholithiasis can cause a management dilemma depending on its location and the possible involvement of vascular structures. Many patients undergo rigid bronchoscopy or surgical interventions for the removal of broncholiths. In this case report ... Full text Link to item Cite

Follicular dendritic cell sarcoma of the mediastinum.

Journal Article AJR Am J Roentgenol · June 2007 Full text Link to item Cite

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.

Journal Article Cancer Res · March 15, 2007 We report the first use of new synthetic triterpenoids to prevent lung cancer in experimental animals. Female A/J mice were treated with the mutagenic carcinogen vinyl carbamate, which induces adenocarcinoma of the lung in all animals within 16 weeks. If m ... Full text Link to item Cite

Gene expression profiling of familial and sporadic interstitial pneumonia.

Journal Article Am J Respir Crit Care Med · January 1, 2007 RATIONALE: Idiopathic interstitial pneumonia (IIP) and its familial variants are progressive and largely untreatable disorders with poorly understood molecular mechanisms. Both the genetics and the histologic type of IIP play a role in the etiology and pat ... Full text Link to item Cite

Physician subsidies for tobacco advertising.

Journal Article Am J Respir Crit Care Med · January 15, 2006 Full text Link to item Cite

Giant cell interstitial pneumonia associated with nitrofurantoin.

Journal Article Lung · 2006 A case of giant cell interstitial pneumonia (GIF) that occurred in association with exposure to nitrofurantoin is presented. While the diagnosis of GIP is confirmed by histopathology, this diagnosis can be supported by the findings of bizarre multinucleate ... Full text Link to item Cite

Clinical and pathologic features of familial interstitial pneumonia.

Journal Article Am J Respir Crit Care Med · November 1, 2005 RATIONALE: Several lines of evidence suggest that genetic factors and environmental exposures play a role in the development of pulmonary fibrosis. OBJECTIVES: We evaluated families with 2 or more cases of idiopathic interstitial pneumonia among first-degr ... Full text Link to item Cite

A 73-year-old woman with a cough.

Journal Article Chest · August 2005 Full text Link to item Cite

The spectrum of Kit (CD117) immunoreactivity in lung and pleural tumors: a study of 96 cases using a single-source antibody with a review of the literature.

Journal Article Arch Pathol Lab Med · May 2004 CONTEXT: The development of successful chemotherapeutic agents directed against the Kit receptor tyrosine kinase protein has generated intense interest in the Kit (CD117) immunoreactivity of various neoplasms. Immunoreactivity for Kit in small cell lung ca ... Full text Link to item Cite

Giant cell tumor of rib masquerading as thymoma: a diagnostic pitfall in needle core biopsy of the mediastinum.

Journal Article Arch Pathol Lab Med · April 2004 Giant cell tumor of bone is rarely seen in the rib, where it may present as a mediastinal mass. The diagnosis of giant cell tumor of bone is generally straightforward by fine-needle aspiration or needle core biopsy, but sampling problems may lead to confus ... Full text Link to item Cite

Pathologic Quiz Case: A 53-Year-Old Man with Chest Pain and Cough

Journal Article Archives of Pathology and Laboratory Medicine · January 1, 2004 Full text Cite

Beryllium detection in human lung tissue using electron probe X-ray microanalysis.

Journal Article Mod Pathol · November 2003 Chronic berylliosis is an uncommon disease that is caused by the inhalation of beryllium particles, dust, or fumes. The distinction between chronic berylliosis and sarcoidosis can be difficult both clinically and histologically, as both entities can have s ... Full text Link to item Cite

Exposure to brake dust and malignant mesothelioma: a study of 10 cases with mineral fiber analyses.

Journal Article Ann Occup Hyg · June 2003 OBJECTIVES: A large number of workers in the USA are exposed to chrysotile asbestos through brake repair, yet only a few cases of malignant mesothelioma (MM) have been described in this population. Epidemiologic and industrial hygiene studies have failed t ... Full text Link to item Cite

Human parainfluenza virus giant cell pneumonia following cord blood transplant associated with pulmonary alveolar proteinosis.

Journal Article Arch Pathol Lab Med · February 2003 Giant cell pneumonia secondary to human parainfluenza virus 3 has been reported only rarely in immunocompromised hosts. The few cases documented after bone marrow transplant have resulted in significant morbidity and mortality. To our knowledge, this entit ... Full text Link to item Cite

Multiple lung nodules in a woman with a history of melanoma.

Journal Article Respiration · 2003 A 61-year-old Caucasian female presented with a 6-week history of dry persistent cough. She had no shortness of breath, chest pain, fever, chills, or weight loss. She had been diagnosed with melanoma on the left thigh 6 months earlier. It was a spindle cel ... Full text Link to item Cite

Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen.

Journal Article Am J Physiol Lung Cell Mol Physiol · August 2002 Delayed pulmonary toxicity syndrome after high-dose chemotherapy (HDC) and autologous hematopoietic support occurs in up to 64% of women with advanced-stage breast cancer. Using a similar, but nonmyeloablative, HDC treatment regimen in mice, we found both ... Full text Link to item Cite

Tremolite and mesothelioma.

Journal Article Ann Occup Hyg · July 2002 BACKGROUND: Exposure to chrysotile dust has been associated with the development of mesothelioma and recent studies have implicated contaminating tremolite fibers as the likely etiological factor. Tremolite also contaminates talc, the most common non-asbes ... Link to item Cite

Malignant mesothelioma and occupational exposure to asbestos: An analysis of 1445 cases

Conference Annals of Occupational Hygiene · January 1, 2002 Asbestos exposure is indisputably associated with the development of malignant mesothelioma (MM). However, relatively few studies have correlated the manner of exposure with asbestos fiber content and type. We report findings from 1445 MMs with known expos ... Full text Cite

Outcome of lung transplantation in patients with mycetomas.

Journal Article Chest · January 2002 BACKGROUND: Lung transplantation has become an acceptable treatment option for many end-stage lung diseases. Pulmonary mycetomas are found in patients with end-stage lung diseases, especially sarcoidosis. The clinical course and long-term outcome of these ... Full text Link to item Cite

Malignant mesothelioma and occupational exposure to asbestos: a clinicopathological correlation of 1445 cases.

Journal Article Ultrastruct Pathol · 2002 Asbestos exposure is indisputably associated with development of mesothelioma. However, relatively few studies have evaluated the type of occupational exposure in correlation with asbestos fiber content and type. This study reports findings in 1445 cases o ... Full text Link to item Cite

Detection of beryllium in human lung tissue using energy dispersive X-ray analysis

Journal Article Microscopy and Microanalysis · January 1, 2002 Full text Cite

Pulmonary apical cap.

Journal Article Am J Surg Pathol · October 2001 Full text Link to item Cite

Well-differentiated papillary mesothelioma.

Journal Article Am J Surg Pathol · October 2001 Well-differentiated papillary mesothelioma is an unusual variant of epithelial mesothelioma considered to be of low malignant potential. The majority of previously reported cases developed in the peritoneum of young women without a history of asbestos expo ... Full text Link to item Cite

Sarcoidosis induced by interferon therapy.

Journal Article AJR Am J Roentgenol · July 2001 Full text Link to item Cite

Amiodarone and cyclophosphamide: potential for enhanced lung toxicity.

Journal Article Bone Marrow Transplant · May 2001 Antineoplastic therapy can be associated with drug-induced lung toxicity. With the increasing use of amiodarone for cardiac dysrhythmias there is an increasing possibility of its combined use with chemotherapies for various malignancies. We report a patien ... Full text Link to item Cite

The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer.

Journal Article Clin Cancer Res · March 2001 The purpose of this study was to define the prognostic value of a group of molecular tumor markers in a well-staged population of patients treated with trimodality therapy for esophageal cancer. The original pretreatment paraffin-embedded endoscopic esopha ... Link to item Cite

Fine needle aspiration cytology of mucinous cystadenocarcinoma of the lung: report of a case with radiographic and histologic correlation.

Journal Article Acta Cytol · 2001 BACKGROUND: Mucinous cystadenocarcinoma of the lung is an uncommon tumor. Because it contains relatively few neoplastic cells relative to the amount of mucin produced, diagnosis of this entity, particularly on small specimens, is exceedingly difficult. CAS ... Full text Link to item Cite

Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2001 PURPOSE: To investigate the relationship between loss of heterozygosity (LOH) at the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) gene locus and the development of radiation-induced lung injury. MATERIAL AND METHODS: Thirty-five lu ... Full text Link to item Cite

Epithelioid hemangioendothelioma of the pleura: clinical and radiologic features.

Journal Article AJR Am J Roentgenol · December 2000 OBJECTIVE: The purpose of our study was to describe the clinical and radiologic features of epithelioid hemangioendothelioma of the pleura. CONCLUSION: Pleural epithelioid hemangioendothelioma is an uncommon malignancy that typically affects older men, who ... Full text Link to item Cite

Hypersensitivity pneumonitis.

Journal Article AJR Am J Roentgenol · April 2000 Full text Link to item Cite

Pulmonary drug toxicity: radiologic and pathologic manifestations.

Journal Article Radiographics · 2000 Pulmonary drug toxicity is increasingly being diagnosed as a cause of acute and chronic lung disease. Numerous agents including cytotoxic and noncytotoxic drugs have the potential to cause pulmonary toxicity. The clinical and radiologic manifestations of t ... Full text Link to item Cite

Laparoscopy and mesothelioma.

Journal Article J Laparoendosc Adv Surg Tech A · October 1999 Malignant mesothelioma is a well-recognized long-term sequela of chronic asbestos exposure. Asbestos use in the United States began in the 1950s and was widespread until the mid-1970s. Although currently only 2.2 cases per million population per year are d ... Full text Link to item Cite

Cystic fibrosis: usefulness of thoracic CT in the examination of patients before lung transplantation.

Journal Article Radiology · October 1999 PURPOSE: To evaluate the usefulness of thoracic computed tomography (CT) in the pre-lung transplantation examination of patients with cystic fibrosis (CF). MATERIALS AND METHODS: Fifty-six patients (age range, 12-42 years) with CF were evaluated for possib ... Full text Link to item Cite

Pulmonary cholesterol granulomas in patients with pulmonary artery hypertension: chest radiographic and CT findings.

Journal Article AJR Am J Roentgenol · May 1999 OBJECTIVE: We describe the chest radiographic and CT findings of pulmonary cholesterol granulomas in patients with pulmonary artery hypertension. CONCLUSION: Histopathologic evidence of cholesterol granulomas was found in five (25%) of 20 patients with sev ... Full text Link to item Cite

Lentil aspiration pneumonia: radiographic and CT findings.

Journal Article J Comput Assist Tomogr · 1998 Aspiration of leguminous vegetables can cause a granulomatous pneumonitis know as lentil aspiration pneumonia that manifest on radiologic studies with small, poorly defined nodular opacities. We report two cases of lentil aspiration pneumonia that manifest ... Full text Link to item Cite

Parapneumonic empyema. A pitfall in diagnosis.

Journal Article Chest · June 1992 Two patients eventually shown to have empyema were encountered in which the initial thoracentesis revealed fluid compatible with either a simple or a complicated parapneumonic effusion. In both cases, the diagnosis of empyema was made by a second thoracent ... Full text Link to item Cite