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Infective endocarditis.

Publication ,  Journal Article
Holland, TL; Baddour, LM; Bayer, AS; Hoen, B; Miro, JM; Fowler, VG
Published in: Nat Rev Dis Primers
September 1, 2016

Infective endocarditis (IE) is a rare, life-threatening disease that has long-lasting effects even among patients who survive and are cured. IE disproportionately affects those with underlying structural heart disease and is increasingly associated with health care contact, particularly in patients who have intravascular prosthetic material. In the setting of bacteraemia with a pathogenic organism, an infected vegetation may form as the end result of complex interactions between invading microorganisms and the host immune system. Once established, IE can involve almost any organ system in the body. The diagnosis of IE may be difficult to establish and a strategy that combines clinical, microbiological and echocardiography results has been codified in the modified Duke criteria. In cases of blood culture-negative IE, the diagnosis may be especially challenging, and novel microbiological and imaging techniques have been developed to establish its presence. Once diagnosed, IE is best managed by a multidisciplinary team with expertise in infectious diseases, cardiology and cardiac surgery. Antibiotic prophylaxis for the prevention of IE remains controversial. Efforts to develop a vaccine that targets common bacterial causes of IE are ongoing, but have not yet yielded a commercially available product.

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Published In

Nat Rev Dis Primers

DOI

EISSN

2056-676X

Publication Date

September 1, 2016

Volume

2

Start / End Page

16059

Location

England

Related Subject Headings

  • Infarction
  • Humans
  • Heart Valves
  • Endocarditis
  • Echocardiography
  • Bacteremia
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Holland, T. L., Baddour, L. M., Bayer, A. S., Hoen, B., Miro, J. M., & Fowler, V. G. (2016). Infective endocarditis. Nat Rev Dis Primers, 2, 16059. https://doi.org/10.1038/nrdp.2016.59
Holland, Thomas L., Larry M. Baddour, Arnold S. Bayer, Bruno Hoen, Jose M. Miro, and Vance G. Fowler. “Infective endocarditis.Nat Rev Dis Primers 2 (September 1, 2016): 16059. https://doi.org/10.1038/nrdp.2016.59.
Holland TL, Baddour LM, Bayer AS, Hoen B, Miro JM, Fowler VG. Infective endocarditis. Nat Rev Dis Primers. 2016 Sep 1;2:16059.
Holland, Thomas L., et al. “Infective endocarditis.Nat Rev Dis Primers, vol. 2, Sept. 2016, p. 16059. Pubmed, doi:10.1038/nrdp.2016.59.
Holland TL, Baddour LM, Bayer AS, Hoen B, Miro JM, Fowler VG. Infective endocarditis. Nat Rev Dis Primers. 2016 Sep 1;2:16059.

Published In

Nat Rev Dis Primers

DOI

EISSN

2056-676X

Publication Date

September 1, 2016

Volume

2

Start / End Page

16059

Location

England

Related Subject Headings

  • Infarction
  • Humans
  • Heart Valves
  • Endocarditis
  • Echocardiography
  • Bacteremia
  • 3202 Clinical sciences
  • 1103 Clinical Sciences