Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.

Journal Article (Journal Article)

Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show that DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary tumor formation at a significantly higher frequency in the Smad3 heterozygous mice than in the Smad3 wild type mice. This is the first genetic evidence showing that Smad3 inhibits mammary tumor formation in a mouse model. Our findings support the notion that Smad3 has important tumor suppressor function for breast cancer.

Full Text

Duke Authors

Cited Authors

  • Liu, Z; Kundu-Roy, T; Matsuura, I; Wang, G; Lin, Y; Lou, Y-R; Barnard, NJ; Wang, X-F; Huang, M-T; Suh, N; Liu, F

Published Date

  • October 4, 2016

Published In

Volume / Issue

  • 7 / 40

Start / End Page

  • 64878 - 64885

PubMed ID

  • 27588495

Pubmed Central ID

  • PMC5323122

Electronic International Standard Serial Number (EISSN)

  • 1949-2553

Digital Object Identifier (DOI)

  • 10.18632/oncotarget.11713


  • eng

Conference Location

  • United States