Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.
Publication
, Journal Article
Liu, Z; Kundu-Roy, T; Matsuura, I; Wang, G; Lin, Y; Lou, Y-R; Barnard, NJ; Wang, X-F; Huang, M-T; Suh, N; Liu, F
Published in: Oncotarget
October 4, 2016
Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show that DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary tumor formation at a significantly higher frequency in the Smad3 heterozygous mice than in the Smad3 wild type mice. This is the first genetic evidence showing that Smad3 inhibits mammary tumor formation in a mouse model. Our findings support the notion that Smad3 has important tumor suppressor function for breast cancer.
Duke Scholars
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Published In
Oncotarget
DOI
EISSN
1949-2553
Publication Date
October 4, 2016
Volume
7
Issue
40
Start / End Page
64878 / 64885
Location
United States
Related Subject Headings
- Tumor Suppressor Proteins
- Smad3 Protein
- Mice, Knockout
- Mice, Inbred C57BL
- Mice, 129 Strain
- Mice
- Mammary Neoplasms, Experimental
- Male
- Heterozygote
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Liu, Z., Kundu-Roy, T., Matsuura, I., Wang, G., Lin, Y., Lou, Y.-R., … Liu, F. (2016). Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice. Oncotarget, 7(40), 64878–64885. https://doi.org/10.18632/oncotarget.11713
Liu, Zhengxue, Tanima Kundu-Roy, Isao Matsuura, Guannan Wang, Yong Lin, You-Rong Lou, Nicola J. Barnard, et al. “Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.” Oncotarget 7, no. 40 (October 4, 2016): 64878–85. https://doi.org/10.18632/oncotarget.11713.
Liu Z, Kundu-Roy T, Matsuura I, Wang G, Lin Y, Lou Y-R, et al. Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice. Oncotarget. 2016 Oct 4;7(40):64878–85.
Liu, Zhengxue, et al. “Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.” Oncotarget, vol. 7, no. 40, Oct. 2016, pp. 64878–85. Pubmed, doi:10.18632/oncotarget.11713.
Liu Z, Kundu-Roy T, Matsuura I, Wang G, Lin Y, Lou Y-R, Barnard NJ, Wang X-F, Huang M-T, Suh N, Liu F. Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice. Oncotarget. 2016 Oct 4;7(40):64878–64885.
Published In
Oncotarget
DOI
EISSN
1949-2553
Publication Date
October 4, 2016
Volume
7
Issue
40
Start / End Page
64878 / 64885
Location
United States
Related Subject Headings
- Tumor Suppressor Proteins
- Smad3 Protein
- Mice, Knockout
- Mice, Inbred C57BL
- Mice, 129 Strain
- Mice
- Mammary Neoplasms, Experimental
- Male
- Heterozygote
- Female