Crosstalk Between T and B Cells in the Germinal Center After Transplantation.

Journal Article (Journal Article;Review)

Crosstalk between B and T cells in transplantation is increasingly recognized as being important in the alloimmune response. T cell activation of B cells occurs by a 3-stage pathway, culminating with costimulation signals. We review the distinct T cell subtypes required for B-cell activation and discuss the formation of the germinal center (GC) after transplantation, with particular reference to the repopulation of the GC after depletional induction, and the subsequent effect of immunosuppressive manipulation of T cell-B cell interactions. In addition, ectopic GCs are seen in transplantation, but their role is not fully understood. Therapeutic options to target T cell-B cell interactions are of considerable interest, both as immunosuppressive tools, and to aid in the further understanding of these important alloimmune mechanisms.

Full Text

Duke Authors

Cited Authors

  • Kwun, J; Manook, M; Page, E; Burghuber, C; Hong, J; Knechtle, SJ

Published Date

  • April 2017

Published In

Volume / Issue

  • 101 / 4

Start / End Page

  • 704 - 712

PubMed ID

  • 27906827

Pubmed Central ID

  • PMC5360505

Electronic International Standard Serial Number (EISSN)

  • 1534-6080

Digital Object Identifier (DOI)

  • 10.1097/TP.0000000000001588


  • eng

Conference Location

  • United States