Jean Kwun | Scholars@Duke

Jean Kwun
Assistant Professor of Surgery

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Current Appointments & Affiliations

Assistant Professor of Surgery, Surgery, Abdominal Transplant Surgery, Surgery 2015

Contact Information

362 Jones Building, 207 Research Dr, Durham, NC 27710
jean.kwun@duke.edu (919) 668-6792

Background
Education, Training, & Certifications
- Ph.D., University of Wisconsin at Madison 2007
Duke Appointment History
- Instructor, Temporary in the Department of Surgery, Surgery, Abdominal Transplant Surgery, Surgery 2015
Research
Selected Grants
- Acoustic Device to Prevent Antibody Mediated Organ Transplant Failure 2019 - 2022
- Enzyvant Monkey Study 2019 - 2020
- Acoustic based plasmapheresis to prevent antibody-mediated organ transplant 2019 - 2020
- Prevention of Homograft Induced Cardiac Allograft Vasculopathy in Pediatric Heart Transplantation awarded by American Heart Association 2015 - 2018
- Thymus transplantation to induce tolerance to heart transplants 2017 - 2018
- Transplant Tolerance in Non-Human Primates awarded by Emory University 2015 - 2017
- Preventing allograft rejection but not tolerance by blockade of the lymphocyte store-operated calcium channel awarded by Department of Defense 2016 - 2017
- Prevention of Homograft Induced Cardiac Allograft Vasculopathy in Pediatric Heart Transplantation 2015 - 2016
- Preventing allograft rejection but not tolerance by blockade of the lymphocyte store-operated calcium channel 2015 - 2016
- Inducible Regulatory B Cells in Transplantation Tolerance awarded by University of Wisconsin 2015 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ezekian, Brian, Paul M. Schroder, Michael S. Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, et al. “Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients..” J Am Soc Nephrol 30, no. 12 (December 2019): 2399–2411. https://doi.org/10.1681/ASN.2019030304.
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  - Schmitz, Robin, Zachary Fitch, Paul Schroder, Ashley Choi, Annette Jackson, Stuart Knechtle, and Jean Kwun. “B cells in transplant tolerance and rejection: friends or foes?.” Transpl Int, November 9, 2019. https://doi.org/10.1111/tri.13549.
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  - Eppensteiner, John, Jean Kwun, Uwe Scheuermann, Andrew Barbas, Alexander T. Limkakeng, Maggie Kuchibhatla, Eric A. Elster, Allan D. Kirk, and Jaewoo Lee. “Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness..” Jci Insight 4, no. 16 (August 22, 2019). https://doi.org/10.1172/jci.insight.127925.
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  - Schroder, Paul M., Zachary W. Fitch, Robin Schmitz, Ashley Y. Choi, Jean Kwun, and Stuart J. Knechtle. “The past, present, and future of costimulation blockade in organ transplantation..” Curr Opin Organ Transplant 24, no. 4 (August 2019): 391–401. https://doi.org/10.1097/MOT.0000000000000656.
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  - Fitch, Zachary, Robin Schmitz, Jean Kwun, Bernhard Hering, Joren Madsen, and Stuart J. Knechtle. “Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation..” Transplant Rev (Orlando) 33, no. 3 (July 2019): 115–29. https://doi.org/10.1016/j.trre.2019.03.002.
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  - Knechtle, Stuart J., and Jean Kwun. “Parallels between antibody-mediated rejection and ischemic kidney injury with respect to B cell activation..” Ann Transl Med 7, no. Suppl 3 (July 2019). https://doi.org/10.21037/atm.2019.06.36.
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  - Kwun, Jean, Marie Matignon, Miriam Manook, Soulef Guendouz, Vincent Audard, David Kheav, Elsa Poullot, et al. “Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use..” J Am Soc Nephrol 30, no. 7 (July 2019): 1206–19. https://doi.org/10.1681/ASN.2018121254.
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  - Scheuermann, Uwe, Minghua Zhu, Mingqing Song, John Yerxa, Qimeng Gao, Robert P. Davis, Min Zhang, et al. “Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology..” Liver Transpl 25, no. 4 (April 2019): 610–26. https://doi.org/10.1002/lt.25429.
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  - Burghuber, Christopher K., Miriam Manook, Brian Ezekian, Adriana C. Gibby, Frank V. Leopardi, Minqing Song, Jennifer Jenks, et al. “Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients..” Am J Transplant 19, no. 3 (March 2019): 724–36. https://doi.org/10.1111/ajt.15067.
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  - Gu, Yuyang, Chuyi Chen, Zeyu Wang, Po-Hsun Huang, Hai Fu, Lin Wang, Mengxi Wu, et al. “Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation..” Lab Chip 19, no. 3 (January 29, 2019): 394–402. https://doi.org/10.1039/c8lc00527c.
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  - Ezekian, Brian, Paul M. Schroder, Kyle Freischlag, Janghoon Yoon, Jean Kwun, and Stuart J. Knechtle. “Contemporary Strategies and Barriers to Transplantation Tolerance..” Transplantation 102, no. 8 (August 2018): 1213–22. https://doi.org/10.1097/TP.0000000000002242.
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  - Manook, Miriam, Jean Kwun, Steven Sacks, Anthony Dorling, Nizam Mamode, and Stuart Knechtle. “Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient..” Transplant Rev (Orlando) 32, no. 3 (July 2018): 119–26. https://doi.org/10.1016/j.trre.2018.01.001.
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  - “Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119..” Blood Adv 2, no. 2 (January 23, 2018). https://doi.org/10.1182/bloodadvances.2017015446.
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  - Eppensteiner, John, Robert Patrick Davis, Andrew S. Barbas, Jean Kwun, and Jaewoo Lee. “Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults..” Front Immunol 9 (2018). https://doi.org/10.3389/fimmu.2018.00190.
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  - Kwun, Jean, Jaeberm Park, John S. Yi, Alton B. Farris, Allan D. Kirk, and Stuart J. Knechtle. “IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade..” Front Immunol 9 (2018). https://doi.org/10.3389/fimmu.2018.02323.
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  - Kwun, Jean, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, et al. “Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates..” Blood Adv 1, no. 24 (November 14, 2017): 2115–19. https://doi.org/10.1182/bloodadvances.2017010991.
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  - “Erratum..” Am J Transplant 17, no. 11 (November 2017). https://doi.org/10.1111/ajt.14501.
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  - Manook, M., J. Kwun, C. Burghuber, K. Samy, M. Mulvihill, J. Yoon, H. Xu, et al. “Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation..” Am J Transplant 17, no. 8 (August 2017): 2055–64. https://doi.org/10.1111/ajt.14234.
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  - Kwun, Jean, Christopher Burghuber, Miriam Manook, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, and Stuart Knechtle. “Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients..” J Am Soc Nephrol 28, no. 7 (July 2017): 1991–96. https://doi.org/10.1681/ASN.2016070727.
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  - Kwun, Jean, Miriam Manook, Eugenia Page, Christopher Burghuber, Jungjoo Hong, and Stuart J. Knechtle. “Crosstalk Between T and B Cells in the Germinal Center After Transplantation..” Transplantation 101, no. 4 (April 2017): 704–12. https://doi.org/10.1097/TP.0000000000001588.
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  - Lee, Jaewoo, Jennifer G. Jackman, Jean Kwun, Miriam Manook, Angelo Moreno, Eric A. Elster, Allan D. Kirk, Kam W. Leong, and Bruce A. Sullenger. “Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis..” Biomaterials 120 (March 2017): 94–102. https://doi.org/10.1016/j.biomaterials.2016.12.024.
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  - George, Roshan P., Aneesh K. Mehta, Sebastian D. Perez, Pamela Winterberg, Jennifer Cheeseman, Brandi Johnson, Jean Kwun, et al. “Premature T Cell Senescence in Pediatric CKD..” J Am Soc Nephrol 28, no. 1 (January 2017): 359–67. https://doi.org/10.1681/ASN.2016010053.
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  - Schroder, Paul M., Brian Ezekian, Mandy Ford, Stuart J. Knechtle, and Jean Kwun. “Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation..” Front Immunol 8 (2017). https://doi.org/10.3389/fimmu.2017.01615.
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  - Oh, B., J. Yoon, A. Farris, A. Kirk, S. Knechtle, and J. Kwun. “Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig..” Am J Transplant 16, no. 9 (September 2016): 2612–23. https://doi.org/10.1111/ajt.13789.
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  - Burghuber, C. K., J. Kwun, E. J. Page, M. Manook, A. C. Gibby, F. V. Leopardi, M. Song, et al. “Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology..” Am J Transplant 16, no. 6 (June 2016): 1726–38. https://doi.org/10.1111/ajt.13688.
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  - Kwun, Jean, Alton B. Farris, Hyunjin Song, William T. Mahle, William J. Burlingham, and Stuart J. Knechtle. “Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft..” Transplantation 99, no. 12 (December 2015): 2485–93. https://doi.org/10.1097/TP.0000000000000805.
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  - Kwun, J., E. Page, J. J. Hong, A. Gibby, J. Yoon, A. B. Farris, F. Villinger, and S. Knechtle. “Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model..” Am J Transplant 15, no. 3 (March 2015): 815–22. https://doi.org/10.1111/ajt.13045.
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  - Kim, E. J., J. Kwun, A. C. Gibby, J. J. Hong, A. B. Farris, N. N. Iwakoshi, F. Villinger, A. D. Kirk, and S. J. Knechtle. “Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection..” Am J Transplant 14, no. 1 (January 2014): 59–69. https://doi.org/10.1111/ajt.12526.
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  - Page, Eugenia, Jean Kwun, Byoungchol Oh, and Stuart Knechtle. “Lymphodepletional strategies in transplantation..” Cold Spring Harb Perspect Med 3, no. 7 (July 1, 2013). https://doi.org/10.1101/cshperspect.a015511.
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  - Kwun, J., B. C. Oh, A. C. Gibby, R. Ruhil, V. T. Lu, D. W. Kim, E. K. Page, et al. “Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment..” Am J Transplant 12, no. 10 (October 2012): 2641–51. https://doi.org/10.1111/j.1600-6143.2012.04181.x.
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  - Page, E. K., A. J. Page, J. Kwun, A. C. Gibby, F. Leopardi, J. B. Jenkins, E. A. Strobert, et al. “Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques..” Am J Transplant 12, no. 9 (September 2012): 2395–2405. https://doi.org/10.1111/j.1600-6143.2012.04074.x.
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  - Kwun, Jean, Pinar Bulut, Eugenia Kim, Wasim Dar, Byoungchol Oh, Ravi Ruhil, Neal Iwakoshi, and Stuart J. Knechtle. “The role of B cells in solid organ transplantation..” Semin Immunol 24, no. 2 (April 2012): 96–108. https://doi.org/10.1016/j.smim.2011.08.022.
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  - Kwun, Jean, Subramaniam Malarkannan, William J. Burlingham, and Stuart J. Knechtle. “Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation..” J Immunol 187, no. 8 (October 15, 2011): 3997–4006. https://doi.org/10.4049/jimmunol.1003918.
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  - Haustein, Silke, Jean Kwun, John Fechner, Ayhan Kayaoglu, Jean-Pierre Faure, Drew Roenneburg, Jose Torrealba, and Stuart J. Knechtle. “Interleukin-15 receptor blockade in non-human primate kidney transplantation..” Transplantation 89, no. 8 (April 27, 2010): 937–44. https://doi.org/10.1097/TP.0b013e3181d05a58.
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  - Kwun, Jean, and Stuart J. Knechtle. “Overcoming Chronic Rejection-Can it B?.” Transplantation 88, no. 8 (October 27, 2009): 955–61. https://doi.org/10.1097/TP.0b013e3181b96646.
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  - Bloom, D., Z. Chang, K. Pauly, J. Kwun, J. Fechner, C. Hayes, M. Samaniego, and S. Knechtle. “BAFF is increased in renal transplant patients following treatment with alemtuzumab..” Am J Transplant 9, no. 8 (August 2009): 1835–45. https://doi.org/10.1111/j.1600-6143.2009.02710.x.
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  - Hu, Huaizhong, Jean Kwun, Brian D. Aizenstein, and Stuart J. Knechtle. “Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine..” Transplantation 87, no. 12 (June 27, 2009): 1814–20. https://doi.org/10.1097/TP.0b013e3181a66b3e.
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  - Knechtle, S. J., J. Pascual, D. D. Bloom, J. R. Torrealba, E. Jankowska-Gan, W. J. Burlingham, J. Kwun, et al. “Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring..” Am J Transplant 9, no. 5 (May 2009): 1087–98. https://doi.org/10.1111/j.1600-6143.2009.02581.x.
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  - Knechtle, Stuart J., and Jean Kwun. “Unique aspects of rejection and tolerance in liver transplantation..” Semin Liver Dis 29, no. 1 (February 2009): 91–101. https://doi.org/10.1055/s-0029-1192058.
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  - Bloom, Debra D., Kyle Pauly, Zhen Chang, John H. Fechner, Jean Kwun, Millie Samaniego, and Stuart J. Knechtle. “BAFF Dysregulation in Renal Transplant Patients Treated with Campath-1H.” American Journal of Transplantation 9 (January 1, 2009): 226–226.
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  - Kwun, J., S. M. Hazinedaroglu, E. Schadde, H. A. Kayaoglu, J. Fechner, H. Z. Hu, D. Roenneburg, et al. “Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients..” Am J Transplant 8, no. 8 (August 2008): 1593–1603. https://doi.org/10.1111/j.1600-6143.2008.02250.x.
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  - Kwun, Jean, Huaizhong Hu, Erik Schadde, Drew Roenneburg, Kathleen A. Sullivan, Julie DeMartino, William J. Burlingham, and Stuart J. Knechtle. “Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients..” J Immunol 179, no. 12 (December 15, 2007): 8016–25. https://doi.org/10.4049/jimmunol.179.12.8016.
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  - Molitor-Dart, Melanie L., Joachim Andrassy, Jean Kwun, H Ayhan Kayaoglu, Drew A. Roenneburg, Lynn D. Haynes, Jose R. Torrealba, et al. “Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance..” J Immunol 179, no. 10 (November 15, 2007): 6749–61. https://doi.org/10.4049/jimmunol.179.10.6749.
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  - Kwun, Jean, Stuart J. Knechtle, and Huaizhong Hu. “Determination of the functional status of alloreactive T cells by interferon-gamma kinetics..” Transplantation 81, no. 4 (February 27, 2006): 590–98. https://doi.org/10.1097/01.tp.0000196353.04494.14.
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  - Jeon, Y., J. Kim, H. Yu, J. Kwun, S. Lee, J. Seo, and D. Hong. “Known postfix based cell search technique for OFDM cellular systems.” Ieice Transactions on Communications E89-B, no. 4 (January 1, 2006): 1405–11. https://doi.org/10.1093/ietcom/e89-b.4.1405.
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  - Kanmaz, Turan, Ping Feng, Jose Torrealba, Jean Kwun, John H. Fechner, Jacqueline M. Schultz, Yinchen Dong, et al. “Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine..” Transplantation 78, no. 7 (October 15, 2004): 1002–7. https://doi.org/10.1097/01.tp.0000134397.55564.71.
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- Other Articles
  - Knechtle, Stuart J., Jean Kwun, and Neal Iwakoshi. “Prevention trumps treatment of antibody-mediated transplant rejection..” J Clin Invest, April 2010. https://doi.org/10.1172/JCI42532.
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- Conference Papers
  - Kwun, Jean, Janghoon Yoon, Adella Clark, Dong-Feng Chen, Stuart J. Knechtle, and Annette M. Jackson. “P153 Utilizing single HLA antigen beads to sensitized nonhuman primate model.” In Human Immunology, 80:174–174. Elsevier BV, 2019. https://doi.org/10.1016/j.humimm.2019.07.206.
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  - Kwun, J., B. Ezekian, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Yi, and S. Knechtle. “Costimulation Blockade Modulates Humoral Responses in Highly Sensitized Transplant Recipients.” In American Journal of Transplantation, 19:326–326. WILEY, 2019.
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  - Scheuermann, U., E. R. Seyferth, M. Zhu, M. Song, J. Yerxa, R. P. Davis, W. Parker, et al. “Damage-Associated Molecular Pattern Release and Toll-Like Receptor Activation during Cold Storage and Ex Vivo Reperfusion of Old Rat livers..” In American Journal of Transplantation, 19:742–43. WILEY, 2019.
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  - Schmitz, R., M. S. Mulvihill, P. M. Schroder, Z. Fitch, F. Leopardi, D. Magnani, J. Kwun, S. J. Knechtle, and A. D. Kirk. “Depletional Induction Therapy in Non-Human Primates - Preclinical Modeling of Polyclonal Depletion with Rhesus-Specific ATG..” In American Journal of Transplantation, 19:597–597. WILEY, 2019.
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  - Schroder, P. M., R. Schmitz, Z. Fitch, B. Ezekian, J. Yoon, A. Choi, A. Barbas, et al. “Dual Targeting Desensitization with Carfilzomib Plus Lulizumab Significantly Prolongs Kidney Transplant Survival in Allosensitized Nonhuman Primates..” In American Journal of Transplantation, 19:429–429. WILEY, 2019.
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  - Schroder, P., J. S. Yi, K. J. Weinhold, C. Chan, M. Joshi, C. Walters, J. Kwun, and S. J. Knechtle. “Pre-Transplant Multidimensional Flow Cytometric Analysis of Kidney Transplant Recipients Reveals Novel Immune Signature of Allograft Rejection..” In American Journal of Transplantation, 19:765–66. WILEY, 2019.
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  - Schroder, P., J. Yoon, R. Schmitz, Z. Fitch, J. Kwun, and S. J. Knechtle. “Novel In Vitro Germinal Center Culture System Demonstrates More Aggressive B Cell to Plasma Blast Differentiation in Allosensitized Nonhuman Primates..” In American Journal of Transplantation, 19:1090–1090. WILEY, 2019.
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  - Yoon, J., B. Ezekian, M. Manook, J. Kwun, and S. Knechtle. “alpha-1,3-galactosyltransferase Knockout Porcine Tissue And Organ May Reduce The Risks Of Antibody Mediated Rejection Via Less Rhesus Igm Cross-reactivity.” In American Journal of Transplantation, 19:1057–1057. WILEY, 2019.
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  - Scheuermann, Uwe, Minghua Zhu, Mingqing Song, John Yerxa, Qimeng Gao, Robert Davis, Min Zhang, et al. “DAMP Release and Inflammasome Activation during Machine Preservation of the Liver.” In American Journal of Transplantation, 19:34–35. WILEY, 2019.
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  - Ezekian, B., J. Kwun, M. Manook, P. Schroder, J. Yoon, M. Mulvihill, K. Freischlag, et al. “Combination Proteasome Inhibition and Anti-BAFF Therapy Permits Highly Sensitized Rhesus Kidney Transplantation..” In American Journal of Transplantation, 18:309–10. WILEY, 2018.
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  - Ezekian, B., J. Kwun, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, et al. “Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation..” In American Journal of Transplantation, 18:246–246. WILEY, 2018.
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  - Freischlag, K., B. Ezekian, P. Schroder, J. Everitt, J. Yoon, M. Swiderska-Syn, W. Parker, A. Diehl, J. Kwun, and S. Knechtle. “Long-Term HIF-1 alpha Stabilization is Associated with Fibrosis in Rat Lung Allografts..” In American Journal of Transplantation, 18:490–91. WILEY, 2018.
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  - Kwun, J., B. Ezekian, M. Manook, J. Park, J. Yoon, J. Sloan-Lancaster, C. Fortier, P. Rao, and S. Knechtle. “Targeting Calcium Release-Activated Calcium (CRAC) Channel in Non-Human Primate Kidney Transplantation..” In American Journal of Transplantation, 18:901–901. WILEY, 2018.
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  - Kwun, J., E. Brian, M. Manook, J. Park, K. Freischlag, J. Yoon, J. Yi, M. Stegall, and S. Knechtle. “Targeting Plasma Cells with Anti-CD38mAb (Daratumumab) and CXCR4 Antagonist (Plerixafor) for Desensitization..” In American Journal of Transplantation, 18:890–890. WILEY, 2018.
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  - Kwun, J., J. Li, C. Rouse, J. Park, A. Kirk, and L. Markert. “Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation..” In American Journal of Transplantation, 18:620–620. WILEY, 2018.
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  - Schroder, P., B. Ezekian, F. Saccoccio, J. Yoon, M. Dennis, K. Freischlag, J. Kwun, S. Permar, and S. Knechtle. “Humoral Immunity to CMV Remains Intact after Dual Targeting Desensitization in Allosensitized Nonhuman Primates..” In American Journal of Transplantation, 18:899–900. WILEY, 2018.
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  - Yoon, J., B. Ezekian, M. Manook, J. Kwun, and S. Knechtle. “Rhesus Monkey Have natural Antibody toward Swine That is Not Influenced by Allosensitization nor by Carfilzomib/tocilizumab..” In American Journal of Transplantation, 18:764–764. WILEY, 2018.
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  - Driscoll, J., S. Knechtle, J. Kwun, S. Tremblay, N. Salomonis, S. Potter, B. Aronow, et al. “Induction of Proliferative Responses in B Cell and Plasma Cell Populations Following Proteasome Inhibitor Desensitization Treatment in Rhesus Macacques and Humans.” In American Journal of Transplantation, 17:244–244. WILEY, 2017.
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  - Ezekian, B., J. Kwun, M. Manook, K. Freischlag, V. Curfman, E. Branum, J. Park, J. Yi, S. Jordan, and S. Knechtle. “Dual Targeting with Carfilzomib and Tocilizumab Abrogates Antibody-Mediated Rejection and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation.” In American Journal of Transplantation, 17:211–211. WILEY, 2017.
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  - Kwun, J., B. Ezekian, M. Manook, E. Branum, V. Curfman, J. Park, K. Freishlag, J. Yoon, and S. Knechtle. “Effective Targeting Plasma Cells with Daratumumab (Anti-CD38) and Mozobil (Anti-CXCR4) in a Sensitized Non-Human Primate Model..” In American Journal of Transplantation, 17:211–12. WILEY, 2017.
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  - Kwun, J., C. Burghuber, M. Manook, B. Ezekian, J. Park, K. Freishlag, J. Yoon, N. Iwakoshi, A. Farris, and S. Knechtle. “Dual Targeting of Costimulation and Proteasome to Desensitize and Prolong Graft Survival of Sensitized Nonhuman Primates.” In American Journal of Transplantation, 17:212–212. WILEY, 2017.
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  - Kwun, J., J. Lee, J. Jackman, M. Manook, E. Elster, A. Kirk, and B. Sullenger. “Nucleic Acid Scavenging Microfiber Mesh Inhibits Trauma Induced Inflammation and Thrombosis After Organ Transplantation.” In American Journal of Transplantation, 17:245–46. WILEY, 2017.
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  - Manook, M., J. Kwun, J. Yoon, K. Samy, A. MacDonald, H. Xu, R. Smith, et al. “Thrombalexin and Mirococept Synergistically Reduce IBMIR in a Porcine to Rhesus Xenoislet Model.” In American Journal of Transplantation, 17:616–616. WILEY, 2017.
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  - Manook, M., J. Kwun, J. Yoon, K. Samy, A. MacDonlad, H. Xu, R. Smith, et al. “Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.” In American Journal of Transplantation, 17:212–212. WILEY, 2017.
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  - Kwun, J., C. Burghuber, M. Manook, A. Clark, D. Chen, and S. Knechtle. “Utilizing HLA Single Antigen Flow Beads Assays to Evaluate Anti-MAMU Antibody in Sensitized Nonhuman Primate Model.” In American Journal of Transplantation, 16:410–410. WILEY-BLACKWELL, 2016.
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  - Kwun, J., C. Burghuber, N. Iwakoshi, A. Gibby, and S. Knechtle. “Limited Efficacy of Bortezomib on Desensitization via Rapid Humoral Compensation in a Sensitized Rhesus Model.” In American Journal of Transplantation, 16:406–406. WILEY-BLACKWELL, 2016.
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  - Manook, M., J. Kwun, J. Yoon, S. Sacks, A. Dorling, N. Mamode, R. Smith, and S. Knechtle. “Thrombalexin: Detection & Efficacy of a Membrane-Bound Anti-Thrombin Agent..” In American Journal of Transplantation, 16:719–20. WILEY-BLACKWELL, 2016.
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  - Burghuber, C. K., J. Kwun, E. J. Kim, F. V. Leopardi, A. C. Gibby, N. N. Iwakoshi, and S. J. Knechtle. “NEW DESENSITIZATION STRATEGY IN A KIDNEY TRANSPLANTATION MODEL WITH RHESUS MONKEYS.” In Transplant International, 28:12–12. WILEY-BLACKWELL, 2015.
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  - Burghuber, C., J. Kwun, A. Gibby, N. Iwakoshi, and S. Knechtle. “MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
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  - Burghuber, C., J. Kwun, E. Page, A. Gibby, F. Leopardi, A. Farris, N. Iwakoshi, and S. Knechtle. “Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
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  - Burghuber, C., J. Kwun, E. Page, F. Leopardi, A. Gibby, A. Farris, N. Iwakoshi, and S. Knechtle. “T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
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  - Burghuber, C., J. Kwun, F. Leopardi, A. Gibby, A. Farris, N. Iwakoshi, and S. Knechtle. “Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
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  - Kwun, J., B. Oh, H. Song, A. Farris, A. Kirk, W. Mahle, and S. Knechtle. “LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
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  - Kwun, J., C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, and S. Knechtle. “Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
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  - Mou, D., J. Espinosa, L. Stempora, J. Kwun, N. Iwakoshi, and A. Kirk. “Virus Induced CD28 Down-Regulation as a Potential Driver of Costimulation Blockade Resistant Rejection.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
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  - Burghuber, C., E. Kim, J. Kwun, F. Leopardi, A. Gibby, E. Strobert, N. Iwakoshi, and S. Knechtle. “Developing a Nonhuman Primate Model of Sensitization..” In Transplantation, 98:387–88. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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  - Burghuber, C., J. Kwun, E. Kim, F. Leopardi, A. Gibby, E. Strobert, N. Iwakoshi, W. Wakwe, A. Adams, and S. Knechtle. “First Experiences With Kidney Transplantation in a Model of Sensitized Rhesus Macaques.” In Transplantation, 98:388–388. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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  - Kwun, J., B. Oh, M. MaConmara, H. Song, and S. Knechtle. “The Role of Splenic CD4(+)CD25(+) T reg Cells On Alloreactive B Cell Formation and DSA Production in a Murine CAMR Model..” In Transplantation, 98:385–385. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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  - Kwun, J., C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, and S. Knechtle. “Successful Desensitization With Combination of Costimulation Blockade and Bortezomib Via Regulating Plasma Cells and Follicular Helper T Cells in Sensitized Rhesus Model..” In Transplantation, 98:378–378, 2014.
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  - Kwun, J., E. Page, A. Gibby, and S. Knechtle. “The Effect of CCR5 Blockade On De Novo DSA and Long-Term Graft Survival in Non-Human Primate AMR Model.” In Transplantation, 98:26–26. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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  - Kwun, J., E. Page, A. Gibby, J. Hong, A. Farris, F. Villinger, and S. Knechtle. “The Effect of Neutralizing BAFF With Atacicept in a T Cell Depletion-Induced Nonhuman Primate AMR Model..” In Transplantation, 98:380–81. Ovid Technologies (Wolters Kluwer Health), 2014. https://doi.org/10.1097/00007890-201407151-01244.
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  - Burghuber, C., E. Kim, J. Kwun, F. Leopardi, A. Gibby, E. Strobert, N. Iwakoshi, and S. Knechtle. “Developing a Nonhuman Primate Model of Sensitization.” In American Journal of Transplantation, 14:387–88, 2014.
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  - Burghuber, C., J. Kwun, E. Kim, F. Leopardi, A. Gibby, E. Strobert, N. Iwakoshi, W. Wakwe, A. Adams, and S. Knechtle. “First Experiences With Kidney Transplantation in a Model of Sensitized Rhesus Macaques.” In American Journal of Transplantation, 14:388–388. WILEY-BLACKWELL, 2014.
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  - Kwun, J., B. Oh, M. MaConmara, H. Song, and S. Knechtle. “The Role of Splenic CD4(+)CD25(+) T reg Cells On Alloreactive B Cell Formation and DSA Production in a Murine CAMR Model.” In American Journal of Transplantation, 14:385–385. WILEY-BLACKWELL, 2014.
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  - Kwun, J., C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, and S. Knechtle. “Successful Desensitization With Combination of Costimulation Blockade and Bortezomib Via Regulating Plasma Cells and Follicular Helper T Cells in Sensitized Rhesus Model.” In American Journal of Transplantation, 14:378–378. WILEY-BLACKWELL, 2014.
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  - Kwun, J., E. Page, A. Gibby, J. Hong, A. Farris, F. Villinger, and S. Knechtle. “The Effect of Neutralizing BAFF With Atacicept in a T Cell Depletion-Induced Nonhuman Primate AMR Model.” In American Journal of Transplantation, 14:380–81. WILEY-BLACKWELL, 2014.
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  - Kwun, J., E. Page, A. Gibby, and S. Knechtle. “The Effect of CCR5 Blockade On De Novo DSA and Long-Term Graft Survival in Non-Human Primate AMR Model.” In American Journal of Transplantation, 14:26–26. WILEY-BLACKWELL, 2014.
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  - Kwun, J., B. Oh, A. Gibby, E. Page, N. Iwakoshi, and S. Knechtle. “The Role of CD4(+)CD25(+) T reg Cells on Allo-B Cell Formation and DSA Production in a Chronic Rejection Model after T Cell Depletion..” In American Journal of Transplantation, 13:459–459. WILEY-BLACKWELL, 2013.
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  - Kwun, J., E. Page, A. Gibby, J. Hong, A. Farris, A. Adams, N. Iwakoshi, C. Larsen, A. Kirk, and S. Knechtle. “Follicular Helper T Cell Modulation by Costimulation Blockade Prevents Antibody-Mediated Rejection in Nonhuman Primate Renal Transplantation.” In American Journal of Transplantation, 13:177–177. WILEY-BLACKWELL, 2013.
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  - Kwun, J., E. Page, A. Gibby, N. Iwakoshi, and S. Knechtle. “The Effect of Belatacept on Follicular Helper T Cell and Humoral Response in Sensitized Rhesus Macaques..” In American Journal of Transplantation, 13:465–465. WILEY-BLACKWELL, 2013.
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  - Oh, B., J. Kwun, R. Ruhil, A. Gibby, A. Kirk, S. Knechtle, and N. Iwakoshi. “CTLA-4 Ig Prevents Chronic Antibody-Mediated Rejection..” In American Journal of Transplantation, 13:463–463. WILEY-BLACKWELL, 2013.
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  - Oh, B., J. Kwun, R. Ruhil, A. Gibby, E. Page, A. Farris, A. Kirk, N. Iwakoshi, and S. Knechtle. “Rapamycin Enhances Early Alloantibody Production by Hampering the Homeostatic Proliferation of Regulatory T Cells..” In American Journal of Transplantation, 13:383–84. WILEY-BLACKWELL, 2013.
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  - Oh, B., R. Ruhil, O. Bulut, J. Kwun, A. Kirk, S. Knechtle, and N. Iwakoshi. “The Effects of Viral Infection on Chronic Anti-Mediated Rejection..” In American Journal of Transplantation, 13:132–132. WILEY-BLACKWELL, 2013.
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  - Page, E., J. Kwun, A. Gibby, B. Oh, N. Iwakoshi, and S. Knechtle. “The Development of a Nonhuman Primate Model of Sensitization after Transplantation..” In American Journal of Transplantation, 13:462–462. WILEY-BLACKWELL, 2013.
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  - Page, E., J. Kwun, A. Gibby, S. Knechtle, and N. Iwakoshi. “Immunophenotyping and Targeting of Plasma Cells in Sensitized Nonhuman Primates..” In American Journal of Transplantation, 13:461–461. WILEY-BLACKWELL, 2013.
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  - Kwun, J., B. Oh, A. Gibby, N. Iwakoshi, and S. J. Knechtle. “The Role of CD4(+)CD25(+) T reg Cells on Alloantibody Production in a Model of Chronic Rejection after T Cell Depletion..” In American Journal of Transplantation, 12:447–447. WILEY-BLACKWELL, 2012.
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  - Kwun, J., B. Oh, A. Gibby, R. Ruhil, V. Lu, O. P. Bulut, M. Song, et al. “Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection after Alemtuzumab Treatment..” In American Journal of Transplantation, 12:278–278. WILEY-BLACKWELL, 2012.
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  - Oh, B., J. Kwun, R. Ruhil, A. Gibby, E. Page, V. Lu, D. Kim, et al. “Rapamycin Enhances Donor-Specific Antibody and Chronic Rejection of Full MHC Mismatched Cardiac Allografts after Alemtuzumab Treatment.” In American Journal of Transplantation, 12:463–463. WILEY-BLACKWELL, 2012.
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  - Page, E. K., A. C. Gibby, J. Kwun, F. Leopardi, A. B. Adams, C. L. Courtney, J. B. Jenkins, E. Strobert, N. Iwakoshi, and S. J. Knechtle. “Belatacept Prevents De Novo Alloantibody Production in Rhesus Macaques..” In American Journal of Transplantation, 12:276–276. WILEY-BLACKWELL, 2012.
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  - Page, E. K., A. J. Page, J. Kwun, A. C. Gibby, F. Leopardi, E. Strobert, J. B. Jenkins, et al. “Enhanced De Novo Alloantibody and Antibody-Mediated Injury in Rhesus Macaques..” In American Journal of Transplantation, 12:51–51. WILEY-BLACKWELL, 2012.
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  - Ruhil, R., B. Oh, V. T. Lu, O. P. Bulut, J. Kwun, S. Talebagha, S. Knechtle, and N. Iwakoshi. “Tacrolimus Inhibits Alloantibody and Plasma Cell Development but Permits Germinal Center Reaction and Accumulation of Memory B Cells: Implications for Humoral Rejection..” In American Journal of Transplantation, 12:53–53. WILEY-BLACKWELL, 2012.
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  - Ruhil, R., D. Sairsingh, O. P. Bulut, S. Talebagha, B. Oh, J. Kwun, V. T. Lu, S. Knechtle, and N. N. Iwakoshi. “Chronic Viral Infection Leads to Distinct Alloreactive B Cell Development and Sustained Allosensitization.” In American Journal of Transplantation, 12:40–40. WILEY-BLACKWELL, 2012.
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  - Ruhil, R., S. Talebagha, O. P. Bulut, B. Oh, D. Sairsingh, J. Kwun, V. T. Lu, S. Knechtle, and N. Iwakoshi. “Acute Viral Infection Mediates Allosensitization and Abrogates Humoral Tolerance.” In American Journal of Transplantation, 12:39–39. WILEY-BLACKWELL, 2012.
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  - Bulut, O. P., V. T. Lu, R. Ruhil, J. Kwun, E. Dai, S. J. Knechtle, and N. N. Iwakoshi. “mTOR Inhibition Abrogates Costimulation-Blockade Induced Suppression of Alloantibody.” In American Journal of Transplantation, 11:139–139. WILEY-BLACKWELL, 2011.
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  - Gupta, N. A., V. Kolachala, J. Kwun, B. Chandrasekharan, R. Romero, F. Anania, A. Kirk, and S. Knechtle. “GLP-1R Agonists Improve Hepatic Cell Survival in ob/ob Mice Undergoing Ischemia Reperfusion Injury.” In American Journal of Transplantation, 11:505–505. WILEY-BLACKWELL, 2011.
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  - Kim, D., J. Beus, A. Gibby, L. Kean, A. D. Kirk, S. J. Knechtle, and J. Kwun. “Differential Effect of Costimulation Blockade on the Primary vs. Latent Infection in Minor Mismatched Skin Transplantation.” In American Journal of Transplantation, 11:523–523. WILEY-BLACKWELL, 2011.
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  - Kim, E. J., J. Kwun, A. J. Page, F. Leopardi, A. C. Gibby, A. D. Kirk, and S. J. Knechtle. “A Non-Human Primate Model for Alloantibody Production after T Cell Depletion.” In American Journal of Transplantation, 11:369–369. WILEY-BLACKWELL, 2011.
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  - Kim, E. J., J. Kwun, A. J. Page, F. Leopardi, A. C. Gibby, A. D. Kirk, and S. J. Knechtle. “Alefacept Overcomes Memory T Cell Barrier after T Cell Depletion with a Novel Recombinant CD3-Immunotoxin (A-DmDT390-ScfbDb) in a Non-Human Primate Renal Transplantation Model..” In American Journal of Transplantation, 11:453–453. WILEY-BLACKWELL, 2011.
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  - Lu, V. T., O. P. Bulut, R. Ruhil, J. Kwun, E. Dai, and N. N. Iwakoshi. “Identification of Novel IgM and IgG Donor-Specific Memory B-Cells in Murine Models.” In American Journal of Transplantation, 11:369–369. WILEY-BLACKWELL, 2011.
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  - Gupta, Nitika A., Jean Kwun, Allan D. Kirk, Frank A. Anania, Rene Romero, and Stuart J. Knechtle. “ROLE OF GLP-1R AGONISTS IN DECREASING HEPATIC STEATOSIS AND APOPTOSIS IN OB/OB MICE UNDERGOING ISCHEMIA REPERFUSION INJURY.” In Hepatology, 52:1041A-1042A. WILEY-BLACKWELL, 2010.
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  - Gupta, Nitin, Ashish Kumar, Barjesh Sharma, and Shiv K. Sarin. “ADDITION OF PROBIOTICS TO PROPRANOLOL IMPROVES RESPONSE FOR PRIMARY PROPHYLAXIS OF VARICEAL BLEEDING IN PATIENTS WITH CIRRHOSIS AND LARGE ESOPHAGEAL VARICES.” In Hepatology, 52:1064A-1064A. WILEY-BLACKWELL, 2010.
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  - Jackson, J. A., A. Mohammed, J. Kwun, B. Zhao, C. Walsh, B. Button, J. Rossio, L. Kean, and Allan Kirk. “Stable Grafts: What Lurks beneath the Guise of a Stable Creatinine?.” In American Journal of Transplantation, 10:192–93. WILEY-BLACKWELL PUBLISHING, INC, 2010.
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  - Kwun, Jean, Andrew Page, Frank Leopardi, Adriana Cardona, Allan D. Kirk, and Stuart J. Knechtle. “Limited Effect of a Novel Recombinant CD3-Immunotoxin (A-DmDT390-ScfbDb) in a Non-Human Primate Model.” In American Journal of Transplantation, 10:214–214. WILEY-BLACKWELL PUBLISHING, INC, 2010.
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  - Kwun, Jean, Neal Iwakoshi, Adriana Cardona, Dongwoon Kim, Justin Mendel, Allan D. Kirk, and Stuart J. Knechtle. “Abrogation of Alloreactive B Cells and Alloantibody after TACI-Ig Treatment in Alemtuzumab Treated CD52Tg Cardiac Allograft Recipient Mice.” In American Journal of Transplantation, 10:116–17. WILEY-BLACKWELL PUBLISHING, INC, 2010.
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  - Mendel, Brett, Jean Kwun, Adriana Cardona, Kate M. Smith, Allan D. Kirk, Stuart Knechtle, and Neal N. Iwakoshi. “Unique Alloreactive B-Cell Development in an Alemtuzumab Treated CD52 Transgenic Cardiac Allograft Recipient Mice..” In American Journal of Transplantation, 10:400–400. WILEY-BLACKWELL PUBLISHING, INC, 2010.
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  - Rao, Vinaya, Jean Kwun, Kurinji Singaravelu, Alicia Deiner, Stuart J. Knechtle, and Babu Padanilam. “PARP-1 Mediates Inflammation in Mouse Renal Transplants.” In American Journal of Transplantation, 10:498–498. WILEY-BLACKWELL PUBLISHING, INC, 2010.
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  - Dart, Melanie L., Melissa Keller, Jean Kwun, Drew A. Roenneburg, Jose Torrealba, Daniel Greenspan, and William J. Burlingham. “Th17 Mediated Autoimmunity to Collagen V Causes Acute Rejection Pathology and Adventitial Fibrosis in B6 Heart Isografts..” In American Journal of Transplantation, 9:625–625. WILEY-BLACKWELL PUBLISHING, INC, 2009.
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  - Haustein, Silke V., Jeffrey J. Sundblad, Jean Kwun, Drew A. Roenneburg, Glen E. Leverson, Huaizhong Hu, Jose R. Torrealba, and Stuart J. Knechtle. “Cytokine and chemokine production differ in acute rejection and recurrent hepatitis C after liver transplantation.” In American Journal of Transplantation, 8:634–634. BLACKWELL PUBLISHING, 2008.
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  - Kwun, Jean, Huaizhong Hu, Jose Torrealba, William J. Burlingham, and Stuart J. Knechtle. “Immunodominant H60-specific CD8 T cells play a key role in acute rejection but not in chronic allograft vasculopathy.” In American Journal of Transplantation, 8:251–251. BLACKWELL PUBLISHING, 2008.
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  - Kwun, Jean, Subramaniam Malarkannan, William J. Burlingham, and Stuart J. Knechtle. “Mechanisms of differential T cell immunodominance in organ transplantation..” In American Journal of Transplantation, 8:417–417. BLACKWELL PUBLISHING, 2008.
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  - Molitor, M. L., J. Andrassy, J. Kwun, H. A. Kayaoglu, Lynn D. Haynes, and W. J. Burlingham. “Tolerance to a heart allograft expressing non-inherited maternal antigens is associated with a CD4+CD25+, latent TGF-beta expressing T regulatory cell and IL-10..” In American Journal of Transplantation, 7:171–171. BLACKWELL PUBLISHING, 2007.
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  - Hazinedaroglu, S. M., T. Kanmaz, J. H. Fechner, J. Torrealba, W. Dar, J. Kwun, D. Hines, et al. “Monoclonal antibody targeting of CD4(+) and CD8(+) cells for prolongation of baboon renal allograft survival..” In American Journal of Transplantation, 5:422–422. BLACKWELL PUBLISHING, 2005.
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  - Huaizhong, H., B. D. Aizenstein, J. Kwun, M. M. Hamawy, and S. J. Knechtle. “Detection of acute and chronic injury in human renal transplants by a urinary cytokine/chemokine multiplex assay..” In American Journal of Transplantation, 5:436–436. BLACKWELL PUBLISHING, 2005.
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  - Hancock, W. W., T. Kanmaz, Y. C. Dong, W. Dar, J. Kwun, J. R. Rottman, S. X. Qin, et al. “Beneficial effects of targeting the CXCR3 chemokine receptor in non-human primate renal allograft recipients..” In American Journal of Transplantation, 4:287–287. BLACKWELL MUNKSGAARD, 2004.
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  - Kanmaz, T., P. Feng, J. Torrealba, J. Kwun, J. H. Fechner, J. M. Schultz, Y. C. Dong, et al. “Association of urinary excretion of the IP-10, MIG, and I-TAC with acute allograft rejection in baboon kidney transplantation..” In American Journal of Transplantation, 4:248–248. BLACKWELL MUNKSGAARD, 2004.
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