Jean Kwun | Scholars@Duke

Jean Kwun
Assistant Professor of Surgery

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Current Appointments & Affiliations

Assistant Professor of Surgery, Surgery, Abdominal Transplant Surgery, Surgery 2015

Contact Information

362 Jones Building, 207 Research Dr, Durham, NC 27710
jean.kwun@duke.edu (919) 668-6792

Background
Education, Training, & Certifications
- Ph.D., University of Wisconsin at Madison 2007
Duke Appointment History
- Instructor, Temporary in the Department of Surgery, Surgery, Abdominal Transplant Surgery, Surgery 2015
Research
Selected Grants
- Acoustic Device to Prevent Antibody Mediated Organ Transplant Failure awarded by Hartwell Foundation 2019 - 2022
- Prevention of Homograft Induced Cardiac Allograft Vasculopathy in Pediatric Heart Transplantation awarded by American Heart Association 2015 - 2018
- Thymus transplantation to induce tolerance to heart transplants awarded by Enzyvant Sciences Ltd. 2017 - 2018
- Transplant Tolerance in Non-Human Primates awarded by Emory University 2015 - 2017
- Preventing allograft rejection but not tolerance by blockade of the lymphocyte store-operated calcium channel awarded by Department of Defense 2016 - 2017
- Prevention of Homograft Induced Cardiac Allograft Vasculopathy in Pediatric Heart Transplantation awarded by Enduring Hearts 2015 - 2016
- Preventing allograft rejection but not tolerance by blockade of the lymphocyte store-operated calcium channel awarded by Synta Pharmaceuticals Corp. 2015 - 2016
- Inducible Regulatory B Cells in Transplantation Tolerance awarded by University of Wisconsin 2015 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Fitch, Z, Schmitz, R, Kwun, J, Hering, B, Madsen, J, and Knechtle, SJ. "Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation." Transplantation Reviews (Orlando, Fla.) (April 5, 2019). (Review) Full Text
  - Scheuermann, U, Zhu, M, Song, M, Yerxa, J, Gao, Q, Davis, RP, Zhang, M, Parker, W, Hartwig, MG, Kwun, J, Brennan, TV, Lee, J, and Barbas, AS. "Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology." Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 25, no. 4 (April 2019): 610-626. Full Text
  - Burghuber, CK, Manook, M, Ezekian, B, Gibby, AC, Leopardi, FV, Song, M, Jenks, J, Saccoccio, F, Permar, S, Farris, AB, Iwakoshi, NN, Kwun, J, and Knechtle, SJ. "Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 19, no. 3 (March 2019): 724-736. Full Text
  - Gu, Y, Chen, C, Wang, Z, Huang, P-H, Fu, H, Wang, L, Wu, M, Chen, Y, Gao, T, Gong, J, Kwun, J, Arepally, GM, and Huang, TJ. "Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation." Lab on a Chip 19, no. 3 (January 2019): 394-402. Full Text
  - Ezekian, B, Schroder, PM, Freischlag, K, Yoon, J, Kwun, J, and Knechtle, SJ. "Contemporary Strategies and Barriers to Transplantation Tolerance." Transplantation 102, no. 8 (August 2018): 1213-1222. (Review) Full Text
  - Manook, M, Kwun, J, Sacks, S, Dorling, A, Mamode, N, and Knechtle, S. "Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient." Transplantation Reviews (Orlando, Fla.) 32, no. 3 (July 2018): 119-126. (Review) Full Text
  - "Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119." Blood advances 2, no. 2 (January 2018): 89-. Full Text
  - Eppensteiner, J, Davis, RP, Barbas, AS, Kwun, J, and Lee, J. "Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults." Frontiers in Immunology 9 (January 2018): 190-null. (Review) Full Text
  - Kwun, J, Park, J, Yi, JS, Farris, AB, Kirk, AD, and Knechtle, SJ. "IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade." Frontiers in Immunology 9 (January 2018): 2323-null. Full Text
  - "Erratum." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 11 (November 2017): 2993-. Full Text
  - Kwun, J, Burghuber, C, Manook, M, Ezekian, B, Park, J, Yoon, J, Yi, JS, Iwakoshi, N, Gibby, A, Hong, JJ, Farris, AB, Kirk, AD, and Knechtle, SJ. "Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates." Blood advances 1, no. 24 (November 2017): 2115-2119. Full Text
  - Manook, M, Kwun, J, Burghuber, C, Samy, K, Mulvihill, M, Yoon, J, Xu, H, MacDonald, AL, Freischlag, K, Curfman, V, Branum, E, Howell, D, Farris, AB, Smith, RA, Sacks, S, Dorling, A, Mamode, N, and Knechtle, SJ. "Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 8 (August 2017): 2055-2064. Full Text
  - Kwun, J, Burghuber, C, Manook, M, Iwakoshi, N, Gibby, A, Hong, JJ, and Knechtle, S. "Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients." Journal of the American Society of Nephrology : Jasn 28, no. 7 (July 2017): 1991-1996. Full Text
  - Kwun, J, Manook, M, Page, E, Burghuber, C, Hong, J, and Knechtle, SJ. "Crosstalk Between T and B Cells in the Germinal Center After Transplantation." Transplantation 101, no. 4 (April 2017): 704-712. (Review) Full Text
  - Lee, J, Jackman, JG, Kwun, J, Manook, M, Moreno, A, Elster, EA, Kirk, AD, Leong, KW, and Sullenger, BA. "Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis." Biomaterials 120 (March 2017): 94-102. Full Text
  - George, RP, Mehta, AK, Perez, SD, Winterberg, P, Cheeseman, J, Johnson, B, Kwun, J, Monday, S, Stempora, L, Warshaw, B, and Kirk, AD. "Premature T Cell Senescence in Pediatric CKD." Journal of the American Society of Nephrology : JASN 28, no. 1 (January 2017): 359-367. Full Text
  - Schroder, PM, Ezekian, B, Ford, M, Knechtle, SJ, and Kwun, J. "Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation." Frontiers in immunology 8 (January 2017): 1615-. Full Text Open Access Copy
  - Oh, B, Yoon, J, Farris, A, Kirk, A, Knechtle, S, and Kwun, J. "Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 9 (September 2016): 2612-2623. Full Text Open Access Copy
  - Burghuber, CK, Kwun, J, Page, EJ, Manook, M, Gibby, AC, Leopardi, FV, Song, M, Farris, AB, Hong, JJ, Villinger, F, Adams, AB, Iwakoshi, NN, and Knechtle, SJ. "Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 6 (June 2016): 1726-1738. Full Text
  - Kwun, J, Farris, AB, Song, H, Mahle, WT, Burlingham, WJ, and Knechtle, SJ. "Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft." Transplantation 99, no. 12 (December 2015): 2485-2493. Full Text Open Access Copy
  - Kwun, J, Page, E, Hong, JJ, Gibby, A, Yoon, J, Farris, AB, Villinger, F, and Knechtle, S. "Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 3 (March 2015): 815-822. Full Text Open Access Copy
  - Kim, EJ, Kwun, J, Gibby, AC, Hong, JJ, Farris, AB, Iwakoshi, NN, Villinger, F, Kirk, AD, and Knechtle, SJ. "Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 1 (January 2014): 59-69. Full Text Open Access Copy
  - Page, E, Kwun, J, Oh, B, and Knechtle, S. "Lymphodepletional strategies in transplantation." Cold Spring Harbor Perspectives in Medicine 3, no. 7 (July 2013). (Review) Full Text
  - Kwun, J, Oh, BC, Gibby, AC, Ruhil, R, Lu, VT, Kim, DW, Page, EK, Bulut, OP, Song, MQ, Farris, AB, Kirk, AD, Knechtle, SJ, and Iwakoshi, NN. "Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 12, no. 10 (October 2012): 2641-2651. Full Text Open Access Copy
  - Page, EK, Page, AJ, Kwun, J, Gibby, AC, Leopardi, F, Jenkins, JB, Strobert, EA, Song, M, Hennigar, RA, Iwakoshi, N, and Knechtle, SJ. "Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 12, no. 9 (September 2012): 2395-2405. Full Text Open Access Copy
  - Kwun, J, Bulut, P, Kim, E, Dar, W, Oh, B, Ruhil, R, Iwakoshi, N, and Knechtle, SJ. "The role of B cells in solid organ transplantation." Seminars in immunology 24, no. 2 (April 2012): 96-108. (Review) Full Text Open Access Copy
  - Kwun, J, Malarkannan, S, Burlingham, WJ, and Knechtle, SJ. "Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation." Journal of Immunology (Baltimore, Md. : 1950) 187, no. 8 (October 2011): 3997-4006. Full Text Open Access Copy
  - Haustein, S, Kwun, J, Fechner, J, Kayaoglu, A, Faure, J-P, Roenneburg, D, Torrealba, J, and Knechtle, SJ. "Interleukin-15 receptor blockade in non-human primate kidney transplantation." Transplantation 89, no. 8 (April 2010): 937-944. Full Text Open Access Copy
  - Kwun, J, and Knechtle, SJ. "Overcoming Chronic Rejection-Can it B?." Transplantation 88, no. 8 (October 2009): 955-961. (Review) Full Text
  - Bloom, D, Chang, Z, Pauly, K, Kwun, J, Fechner, J, Hayes, C, Samaniego, M, and Knechtle, S. "BAFF is increased in renal transplant patients following treatment with alemtuzumab." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 9, no. 8 (August 2009): 1835-1845. Full Text
  - Hu, H, Kwun, J, Aizenstein, BD, and Knechtle, SJ. "Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine." Transplantation 87, no. 12 (June 2009): 1814-1820. Full Text
  - Knechtle, SJ, Pascual, J, Bloom, DD, Torrealba, JR, Jankowska-Gan, E, Burlingham, WJ, Kwun, J, Colvin, RB, Seyfert-Margolis, V, Bourcier, K, and Sollinger, HW. "Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 9, no. 5 (May 2009): 1087-1098. Full Text
  - Knechtle, SJ, and Kwun, J. "Unique aspects of rejection and tolerance in liver transplantation." Seminars in Liver Disease 29, no. 1 (February 23, 2009): 91-101. (Review) Full Text
  - Bloom, DD, Pauly, K, Chang, Z, Fechner, JH, Kwun, J, Samaniego, M, and Knechtle, SJ. "BAFF Dysregulation in Renal Transplant Patients Treated with Campath-1H." AMERICAN JOURNAL OF TRANSPLANTATION 9 (2009): 226-226. Link to Item
  - Kwun, J, Hazinedaroglu, SM, Schadde, E, Kayaoglu, HA, Fechner, J, Hu, HZ, Roenneburg, D, Torrealba, J, Shiao, L, Hong, X, Peng, R, Szewczyk, JW, Sullivan, KA, DeMartino, J, and Knechtle, SJ. "Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 8, no. 8 (August 2008): 1593-1603. Full Text
  - Kwun, J, Hu, H, Schadde, E, Roenneburg, D, Sullivan, KA, DeMartino, J, Burlingham, WJ, and Knechtle, SJ. "Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients." Journal of immunology (Baltimore, Md. : 1950) 179, no. 12 (December 2007): 8016-8025. Full Text
  - Molitor-Dart, ML, Andrassy, J, Kwun, J, Kayaoglu, HA, Roenneburg, DA, Haynes, LD, Torrealba, JR, Bobadilla, JL, Sollinger, HW, Knechtle, SJ, and Burlingham, WJ. "Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance." Journal of Immunology (Baltimore, Md. : 1950) 179, no. 10 (November 2007): 6749-6761. Full Text
  - Kwun, J, Knechtle, SJ, and Hu, H. "Determination of the functional status of alloreactive T cells by interferon-gamma kinetics." Transplantation 81, no. 4 (February 2006): 590-598. Full Text
  - Kanmaz, T, Feng, P, Torrealba, J, Kwun, J, Fechner, JH, Schultz, JM, Dong, Y, Kim, HT, Dar, W, Hamawy, MM, Knechtle, SJ, and Hu, H. "Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine." Transplantation 78, no. 7 (October 2004): 1002-1007. Full Text
- Other Articles
  - Knechtle, SJ, Kwun, J, and Iwakoshi, N. "Prevention trumps treatment of antibody-mediated transplant rejection." The Journal of Clinical Investigation 120, no. 4 (April 2010): 1036-1039. Full Text Open Access Copy
- Conference Papers
  - Scheuermann, U, Zhu, M, Song, M, Yerxa, J, Gao, Q, Davis, R, Zhang, M, Parker, W, Hartwig, M, Brennan, T, Kwun, J, Lee, J, and Barbas, A. "DAMP Release and Inflammasome Activation during Machine Preservation of the Liver." 19th Annual State of the Art Winter Symposium of the American-Society-of-Transplant-Surgeons (ASTS). Miami, FL. January 10, 2019 - January 13, 2019.: WILEY, January 1, 2019. Link to Item
  - Ezekian, B, Kwun, J, Manook, M, Schroder, P, Yoon, J, Mulvihill, M, Freischlag, K, Park, J, Cochran, J, Kroning, K, Yi, J, and Knechtle, S. "Combination Proteasome Inhibition and Anti-BAFF Therapy Permits Highly Sensitized Rhesus Kidney Transplantation." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Ezekian, B, Kwun, J, Schroder, P, Manook, M, Yoon, J, Mulvihill, M, Freischlag, K, Cochran, J, Kroning, K, Yi, J, and Knechtle, S. "Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Freischlag, K, Ezekian, B, Schroder, P, Everitt, J, Yoon, J, Swiderska-Syn, M, Parker, W, Diehl, A, Kwun, J, and Knechtle, S. "Long-Term HIF-1 alpha Stabilization is Associated with Fibrosis in Rat Lung Allografts." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Kwun, J, Brian, E, Manook, M, Park, J, Freischlag, K, Yoon, J, Yi, J, Stegall, M, and Knechtle, S. "Targeting Plasma Cells with Anti-CD38mAb (Daratumumab) and CXCR4 Antagonist (Plerixafor) for Desensitization." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Kwun, J, Ezekian, B, Manook, M, Park, J, Yoon, J, Sloan-Lancaster, J, Fortier, C, Rao, P, and Knechtle, S. "Targeting Calcium Release-Activated Calcium (CRAC) Channel in Non-Human Primate Kidney Transplantation." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Kwun, J, Li, J, Rouse, C, Park, J, Kirk, A, and Markert, L. "Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Schroder, P, Ezekian, B, Saccoccio, F, Yoon, J, Dennis, M, Freischlag, K, Kwun, J, Permar, S, and Knechtle, S. "Humoral Immunity to CMV Remains Intact after Dual Targeting Desensitization in Allosensitized Nonhuman Primates." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Yoon, J, Ezekian, B, Manook, M, Kwun, J, and Knechtle, S. "Rhesus Monkey Have natural Antibody toward Swine That is Not Influenced by Allosensitization nor by Carfilzomib/tocilizumab." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Driscoll, J, Knechtle, S, Kwun, J, Tremblay, S, Salomonis, N, Potter, S, Aronow, B, Manook, M, Alloway, R, Singh, H, and Woodle, E. "Induction of Proliferative Responses in B Cell and Plasma Cell Populations Following Proteasome Inhibitor Desensitization Treatment in Rhesus Macacques and Humans." April 2017. Link to Item
  - Ezekian, B, Kwun, J, Manook, M, Freischlag, K, Curfman, V, Branum, E, Park, J, Yi, J, Jordan, S, and Knechtle, S. "Dual Targeting with Carfilzomib and Tocilizumab Abrogates Antibody-Mediated Rejection and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation." April 2017. Link to Item
  - Kwun, J, Burghuber, C, Manook, M, Ezekian, B, Park, J, Freishlag, K, Yoon, J, Iwakoshi, N, Farris, A, and Knechtle, S. "Dual Targeting of Costimulation and Proteasome to Desensitize and Prolong Graft Survival of Sensitized Nonhuman Primates." April 2017. Link to Item
  - Kwun, J, Ezekian, B, Manook, M, Branum, E, Curfman, V, Park, J, Freishlag, K, Yoon, J, and Knechtle, S. "Effective Targeting Plasma Cells with Daratumumab (Anti-CD38) and Mozobil (Anti-CXCR4) in a Sensitized Non-Human Primate Model." April 2017. Link to Item
  - Kwun, J, Lee, J, Jackman, J, Manook, M, Elster, E, Kirk, A, and Sullenger, B. "Nucleic Acid Scavenging Microfiber Mesh Inhibits Trauma Induced Inflammation and Thrombosis After Organ Transplantation." April 2017. Link to Item
  - Manook, M, Kwun, J, Yoon, J, Samy, K, MacDonald, A, Xu, H, Smith, R, Dorling, A, Kirk, A, Mamode, N, and Knechtle, S. "Thrombalexin and Mirococept Synergistically Reduce IBMIR in a Porcine to Rhesus Xenoislet Model." April 2017. Link to Item
  - Manook, M, Kwun, J, Yoon, J, Samy, K, MacDonlad, A, Xu, H, Smith, R, Sacks, S, Dorling, A, Mamode, N, and Knechtle, S. "Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation." April 2017. Link to Item
  - Kwun, J, Burghuber, C, Iwakoshi, N, Gibby, A, and Knechtle, S. "Limited Efficacy of Bortezomib on Desensitization via Rapid Humoral Compensation in a Sensitized Rhesus Model." June 2016. Link to Item
  - Kwun, J, Burghuber, C, Manook, M, Clark, A, Chen, D, and Knechtle, S. "Utilizing HLA Single Antigen Flow Beads Assays to Evaluate Anti-MAMU Antibody in Sensitized Nonhuman Primate Model." June 2016. Link to Item
  - Manook, M, Kwun, J, Yoon, J, Sacks, S, Dorling, A, Mamode, N, Smith, R, and Knechtle, S. "Thrombalexin: Detection & Efficacy of a Membrane-Bound Anti-Thrombin Agent." June 2016. Link to Item
  - Burghuber, CK, Kwun, J, Kim, EJ, Leopardi, FV, Gibby, AC, Iwakoshi, NN, and Knechtle, SJ. "NEW DESENSITIZATION STRATEGY IN A KIDNEY TRANSPLANTATION MODEL WITH RHESUS MONKEYS." October 2015. Link to Item
  - Burghuber, C, Kwun, J, Gibby, A, Iwakoshi, N, and Knechtle, S. "MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation." May 2015. Link to Item
  - Burghuber, C, Kwun, J, Leopardi, F, Gibby, A, Farris, A, Iwakoshi, N, and Knechtle, S. "Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization." May 2015. Link to Item
  - Burghuber, C, Kwun, J, Page, E, Gibby, A, Leopardi, F, Farris, A, Iwakoshi, N, and Knechtle, S. "Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation." May 2015. Link to Item
  - Burghuber, C, Kwun, J, Page, E, Leopardi, F, Gibby, A, Farris, A, Iwakoshi, N, and Knechtle, S. "T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques." May 2015. Link to Item
  - Kwun, J, Burghuber, C, Page, E, Gibby, A, Iwakoshi, N, and Knechtle, S. "Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival." May 2015. Link to Item
  - Kwun, J, Oh, B, Song, H, Farris, A, Kirk, A, Mahle, W, and Knechtle, S. "LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection." May 2015. Link to Item
  - Mou, D, Espinosa, J, Stempora, L, Kwun, J, Iwakoshi, N, and Kirk, A. "Virus Induced CD28 Down-Regulation as a Potential Driver of Costimulation Blockade Resistant Rejection." May 2015. Link to Item
  - Burghuber, C, Kim, E, Kwun, J, Leopardi, F, Gibby, A, Strobert, E, Iwakoshi, N, and Knechtle, S. "Developing a Nonhuman Primate Model of Sensitization." July 15, 2014. Link to Item
  - Burghuber, C, Kwun, J, Kim, E, Leopardi, F, Gibby, A, Strobert, E, Iwakoshi, N, Wakwe, W, Adams, A, and Knechtle, S. "First Experiences With Kidney Transplantation in a Model of Sensitized Rhesus Macaques." July 15, 2014. Link to Item
  - Kwun, J, Burghuber, C, Page, E, Gibby, A, Iwakoshi, N, and Knechtle, S. "Successful Desensitization With Combination of Costimulation Blockade and Bortezomib Via Regulating Plasma Cells and Follicular Helper T Cells in Sensitized Rhesus Model." July 15, 2014. Link to Item
  - Kwun, J, Oh, B, MaConmara, M, Song, H, and Knechtle, S. "The Role of Splenic CD4(+)CD25(+) T reg Cells On Alloreactive B Cell Formation and DSA Production in a Murine CAMR Model." July 15, 2014. Link to Item
  - Kwun, J, Page, E, Gibby, A, and Knechtle, S. "The Effect of CCR5 Blockade On De Novo DSA and Long-Term Graft Survival in Non-Human Primate AMR Model." July 15, 2014. Link to Item
  - Kwun, J, Page, E, Gibby, A, Hong, J, Farris, A, Villinger, F, and Knechtle, S. "The Effect of Neutralizing BAFF With Atacicept in a T Cell Depletion-Induced Nonhuman Primate AMR Model." July 2014. Full Text
  - Burghuber, C, Kim, E, Kwun, J, Leopardi, F, Gibby, A, Strobert, E, Iwakoshi, N, and Knechtle, S. "Developing a Nonhuman Primate Model of Sensitization." June 2014. Link to Item
  - Burghuber, C, Kwun, J, Kim, E, Leopardi, F, Gibby, A, Strobert, E, Iwakoshi, N, Wakwe, W, Adams, A, and Knechtle, S. "First Experiences With Kidney Transplantation in a Model of Sensitized Rhesus Macaques." June 2014. Link to Item
  - Kwun, J, Burghuber, C, Page, E, Gibby, A, Iwakoshi, N, and Knechtle, S. "Successful Desensitization With Combination of Costimulation Blockade and Bortezomib Via Regulating Plasma Cells and Follicular Helper T Cells in Sensitized Rhesus Model." June 2014. Link to Item
  - Kwun, J, Oh, B, MaConmara, M, Song, H, and Knechtle, S. "The Role of Splenic CD4(+)CD25(+) T reg Cells On Alloreactive B Cell Formation and DSA Production in a Murine CAMR Model." June 2014. Link to Item
  - Kwun, J, Page, E, Gibby, A, Hong, J, Farris, A, Villinger, F, and Knechtle, S. "The Effect of Neutralizing BAFF With Atacicept in a T Cell Depletion-Induced Nonhuman Primate AMR Model." June 2014. Link to Item
  - Kwun, J, Page, E, Gibby, A, and Knechtle, S. "The Effect of CCR5 Blockade On De Novo DSA and Long-Term Graft Survival in Non-Human Primate AMR Model." June 2014. Link to Item
  - Kwun, J, Oh, B, Gibby, A, Page, E, Iwakoshi, N, and Knechtle, S. "The Role of CD4(+)CD25(+) T reg Cells on Allo-B Cell Formation and DSA Production in a Chronic Rejection Model after T Cell Depletion." April 2013. Link to Item
  - Kwun, J, Page, E, Gibby, A, Hong, J, Farris, A, Adams, A, Iwakoshi, N, Larsen, C, Kirk, A, and Knechtle, S. "Follicular Helper T Cell Modulation by Costimulation Blockade Prevents Antibody-Mediated Rejection in Nonhuman Primate Renal Transplantation." April 2013. Link to Item
  - Kwun, J, Page, E, Gibby, A, Iwakoshi, N, and Knechtle, S. "The Effect of Belatacept on Follicular Helper T Cell and Humoral Response in Sensitized Rhesus Macaques." April 2013. Link to Item
  - Oh, B, Kwun, J, Ruhil, R, Gibby, A, Kirk, A, Knechtle, S, and Iwakoshi, N. "CTLA-4 Ig Prevents Chronic Antibody-Mediated Rejection." April 2013. Link to Item
  - Oh, B, Kwun, J, Ruhil, R, Gibby, A, Page, E, III, FA, Kirk, A, Iwakoshi, N, and Knechtle, S. "Rapamycin Enhances Early Alloantibody Production by Hampering the Homeostatic Proliferation of Regulatory T Cells." April 2013. Link to Item
  - Oh, B, Ruhil, R, Bulut, O, Kwun, J, Kirk, A, Knechtle, S, and Iwakoshi, N. "The Effects of Viral Infection on Chronic Anti-Mediated Rejection." April 2013. Link to Item
  - Page, E, Kwun, J, Gibby, A, Knechtle, S, and Iwakoshi, N. "Immunophenotyping and Targeting of Plasma Cells in Sensitized Nonhuman Primates." April 2013. Link to Item
  - Page, E, Kwun, J, Gibby, A, Oh, B, Iwakoshi, N, and Knechtle, S. "The Development of a Nonhuman Primate Model of Sensitization after Transplantation." April 2013. Link to Item
  - Kwun, J, Oh, B, Gibby, A, Iwakoshi, N, and Knechtle, SJ. "The Role of CD4(+)CD25(+) T reg Cells on Alloantibody Production in a Model of Chronic Rejection after T Cell Depletion." May 2012. Link to Item
  - Kwun, J, Oh, B, Gibby, A, Ruhil, R, Lu, V, Bulut, OP, Song, M, Page, E, Kim, D, Farris, AB, Kirk, AD, Knechtle, SJ, and Iwakoshi, NN. "Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection after Alemtuzumab Treatment." May 2012. Link to Item
  - Oh, B, Kwun, J, Ruhil, R, Gibby, A, Page, E, Lu, V, Kim, D, Bulut, OP, III, FA, Kirk, AD, Knechtle, SJ, and Iwakoshi, NN. "Rapamycin Enhances Donor-Specific Antibody and Chronic Rejection of Full MHC Mismatched Cardiac Allografts after Alemtuzumab Treatment." May 2012. Link to Item
  - Page, EK, Gibby, AC, Kwun, J, Leopardi, F, Adams, AB, Courtney, CL, Jenkins, JB, Strobert, E, Iwakoshi, N, and Knechtle, SJ. "Belatacept Prevents De Novo Alloantibody Production in Rhesus Macaques." May 2012. Link to Item
  - Page, EK, Page, AJ, Kwun, J, Gibby, AC, Leopardi, F, Strobert, E, Jenkins, JB, Song, M, Hennigar, RA, Iwakoshi, N, and Knechtle, SJ. "Enhanced De Novo Alloantibody and Antibody-Mediated Injury in Rhesus Macaques." May 2012. Link to Item
  - Ruhil, R, Oh, B, Lu, VT, Bulut, OP, Kwun, J, Talebagha, S, Knechtle, S, and Iwakoshi, N. "Tacrolimus Inhibits Alloantibody and Plasma Cell Development but Permits Germinal Center Reaction and Accumulation of Memory B Cells: Implications for Humoral Rejection." May 2012. Link to Item
  - Ruhil, R, Sairsingh, D, Bulut, OP, Talebagha, S, Oh, B, Kwun, J, Lu, VT, Knechtle, S, and Iwakoshi, NN. "Chronic Viral Infection Leads to Distinct Alloreactive B Cell Development and Sustained Allosensitization." May 2012. Link to Item
  - Ruhil, R, Talebagha, S, Bulut, OP, Oh, B, Sairsingh, D, Kwun, J, Lu, VT, Knechtle, S, and Iwakoshi, N. "Acute Viral Infection Mediates Allosensitization and Abrogates Humoral Tolerance." May 2012. Link to Item
  - Bulut, OP, Lu, VT, Ruhil, R, Kwun, J, Dai, E, Knechtle, SJ, and Iwakoshi, NN. "mTOR Inhibition Abrogates Costimulation-Blockade Induced Suppression of Alloantibody." April 2011. Link to Item
  - Gupta, NA, Kolachala, V, Kwun, J, Chandrasekharan, B, Romero, R, Anania, F, Kirk, A, and Knechtle, S. "GLP-1R Agonists Improve Hepatic Cell Survival in ob/ob Mice Undergoing Ischemia Reperfusion Injury." April 2011. Link to Item
  - Kim, D, Beus, J, Gibby, A, Kean, L, Kirk, AD, Knechtle, SJ, and Kwun, J. "Differential Effect of Costimulation Blockade on the Primary vs. Latent Infection in Minor Mismatched Skin Transplantation." April 2011. Link to Item
  - Kim, EJ, Kwun, J, Page, AJ, Leopardi, F, Gibby, AC, Kirk, AD, and Knechtle, SJ. "A Non-Human Primate Model for Alloantibody Production after T Cell Depletion." April 2011. Link to Item
  - Kim, EJ, Kwun, J, Page, AJ, Leopardi, F, Gibby, AC, Kirk, AD, and Knechtle, SJ. "Alefacept Overcomes Memory T Cell Barrier after T Cell Depletion with a Novel Recombinant CD3-Immunotoxin (A-DmDT390-ScfbDb) in a Non-Human Primate Renal Transplantation Model." April 2011. Link to Item
  - Lu, VT, Bulut, OP, Ruhil, R, Kwun, J, Dai, E, and Iwakoshi, NN. "Identification of Novel IgM and IgG Donor-Specific Memory B-Cells in Murine Models." April 2011. Link to Item
  - Gupta, N, Kumar, A, Sharma, B, and Sarin, SK. "ADDITION OF PROBIOTICS TO PROPRANOLOL IMPROVES RESPONSE FOR PRIMARY PROPHYLAXIS OF VARICEAL BLEEDING IN PATIENTS WITH CIRRHOSIS AND LARGE ESOPHAGEAL VARICES." October 2010. Link to Item
  - Gupta, NA, Kwun, J, Kirk, AD, Anania, FA, Romero, R, and Knechtle, SJ. "ROLE OF GLP-1R AGONISTS IN DECREASING HEPATIC STEATOSIS AND APOPTOSIS IN OB/OB MICE UNDERGOING ISCHEMIA REPERFUSION INJURY." October 2010. Link to Item
  - Jackson, JA, Mohammed, A, Kwun, J, Zhao, B, Walsh, C, Button, B, Rossio, J, Kean, L, and Kirk, A. "Stable Grafts: What Lurks beneath the Guise of a Stable Creatinine?." April 2010. Link to Item
  - Kwun, J, Iwakoshi, N, Cardona, A, Kim, D, Mendel, J, Kirk, AD, and Knechtle, SJ. "Abrogation of Alloreactive B Cells and Alloantibody after TACI-Ig Treatment in Alemtuzumab Treated CD52Tg Cardiac Allograft Recipient Mice." April 2010. Link to Item
  - Kwun, J, Page, A, Leopardi, F, Cardona, A, Kirk, AD, and Knechtle, SJ. "Limited Effect of a Novel Recombinant CD3-Immunotoxin (A-DmDT390-ScfbDb) in a Non-Human Primate Model." April 2010. Link to Item
  - Mendel, B, Kwun, J, Cardona, A, Smith, KM, Kirk, AD, Knechtle, S, and Iwakoshi, NN. "Unique Alloreactive B-Cell Development in an Alemtuzumab Treated CD52 Transgenic Cardiac Allograft Recipient Mice." April 2010. Link to Item
  - Rao, V, Kwun, J, Singaravelu, K, Deiner, A, Knechtle, SJ, and Padanilam, B. "PARP-1 Mediates Inflammation in Mouse Renal Transplants." April 2010. Link to Item
  - Dart, ML, Keller, M, Kwun, J, Roenneburg, DA, Torrealba, J, Greenspan, D, and Burlingham, WJ. "Th17 Mediated Autoimmunity to Collagen V Causes Acute Rejection Pathology and Adventitial Fibrosis in B6 Heart Isografts." 2009. Link to Item
  - Haustein, SV, Sundblad, JJ, Kwun, J, Roenneburg, DA, Leverson, GE, Hu, H, Torrealba, JR, and Knechtle, SJ. "Cytokine and chemokine production differ in acute rejection and recurrent hepatitis C after liver transplantation." May 2008. Link to Item
  - Kwun, J, Hu, H, Torrealba, J, Burlingham, WJ, and Knechtle, SJ. "Immunodominant H60-specific CD8 T cells play a key role in acute rejection but not in chronic allograft vasculopathy." May 2008. Link to Item
  - Kwun, J, Malarkannan, S, Burlingham, WJ, and Knechtle, SJ. "Mechanisms of differential T cell immunodominance in organ transplantation." May 2008. Link to Item
  - Molitor, ML, Andrassy, J, Kwun, J, Kayaoglu, HA, Haynes, LD, and Burlingham, WJ. "Tolerance to a heart allograft expressing non-inherited maternal antigens is associated with a CD4+CD25+, latent TGF-beta expressing T regulatory cell and IL-10." May 2007. Link to Item
  - Hazinedaroglu, SM, Kanmaz, T, Fechner, JH, Torrealba, J, Dar, W, Kwun, J, Hines, D, Ching, SM, Ponath, P, Rao, PE, Ringler, DJ, Waldmann, H, Kim, HT, Dong, Y, Baba, F, Oberly, TD, Schultz, JM, Hu, HH, Hamawy, MM, and Knechtle, SJ. "Monoclonal antibody targeting of CD4(+) and CD8(+) cells for prolongation of baboon renal allograft survival." May 2005. Link to Item
  - Huaizhong, H, Aizenstein, BD, Kwun, J, Hamawy, MM, and Knechtle, SJ. "Detection of acute and chronic injury in human renal transplants by a urinary cytokine/chemokine multiplex assay." May 2005. Link to Item
  - Hancock, WW, Kanmaz, T, Dong, YC, Dar, W, Kwun, J, Rottman, JR, Qin, SX, Newman, W, Ye, QR, Torrealba, JR, Fechner, JH, and Knechtle, SJ. "Beneficial effects of targeting the CXCR3 chemokine receptor in non-human primate renal allograft recipients." 2004. Link to Item
  - Kanmaz, T, Feng, P, Torrealba, J, Kwun, J, Fechner, JH, Schultz, JM, Dong, YC, Kim, HT, Dar, W, Hamawy, MM, Knechtle, SJ, and Hu, HZ. "Association of urinary excretion of the IP-10, MIG, and I-TAC with acute allograft rejection in baboon kidney transplantation." 2004. Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Other Articles

Conference Papers