Jean Kwun | Scholars@Duke

Jean Kwun
Assistant Professor in Surgery

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Current Appointments & Affiliations

Assistant Professor in Surgery, Surgery, Abdominal Transplant Surgery, Surgery 2021

Contact Information

362 Jones Building, 207 Research Dr, Durham, NC 27710
jean.kwun@duke.edu (919) 668-6792

Background
Education, Training, & Certifications
- Ph.D., University of Wisconsin - Madison 2007
Previous Appointments & Affiliations
- Assistant Professor of Surgery, Surgery, Abdominal Transplant Surgery, Surgery 2015 - 2020
- Instructor, Temporary in the Department of Surgery, Surgery, Abdominal Transplant Surgery, Surgery 2015
Research
Selected Grants
- An Acoustofluidic Device for Biocompatible Platelet Separation awarded by Ascent Bio-Nano Technologies, Inc. 2022 - 2023
- Targeting complement C3 to prevent acute antibody-mediated rejection for a deceased-donor kidney transplant in sensitized recipients awarded by Alexion Pharmaceuticals, Inc. 2021 - 2023
- Developing clinically relevant immunosuppressive regimen for pig to rhesus kidney transplantation using transgenic pigs awarded by eGenesis, Inc. 2021 - 2023
- Novel development ofan acoustofluidic device for targeted antibody removal in pediatric organ transplan rejection awarded by National Institutes of Health 2021 - 2023
- Acoustic Device to Prevent Antibody Mediated Organ Transplant Failure awarded by Hartwell Foundation 2019 - 2023
- Alexion Sponsored Research Agreement awarded by Alexion Pharmaceuticals, Inc. 2020 - 2022
- Targeting complement C2 in a sensitized rat cardiac allograft model awarded by Alexion Pharmaceuticals, Inc. 2021 - 2022
- Targeting complement activation steps in antibody-mediated rejection awarded by Alexion Pharmaceuticals, Inc. 2021 - 2022
- Measuring the Impact of Allosensitization on Xenotransplantation awarded by National Institutes of Health 2020 - 2022
- Enzyvant Monkey Study awarded by Enzyvant 2019 - 2021
- Acoustic based plasmapheresis to prevent antibody-mediated organ transplant awarded by The Board of Regents of the University of Wisconsin System 2019 - 2021
- Prevention of Homograft Induced Cardiac Allograft Vasculopathy in Pediatric Heart Transplantation awarded by American Heart Association 2015 - 2018
- Thymus transplantation to induce tolerance to heart transplants awarded by Enzyvant Sciences Ltd. 2017 - 2018
- Transplant Tolerance in Non-Human Primates awarded by Emory University 2015 - 2017
- Preventing allograft rejection but not tolerance by blockade of the lymphocyte store-operated calcium channel awarded by Department of Defense 2016 - 2017
- Prevention of Homograft Induced Cardiac Allograft Vasculopathy in Pediatric Heart Transplantation awarded by Enduring Hearts 2015 - 2016
- Preventing allograft rejection but not tolerance by blockade of the lymphocyte store-operated calcium channel awarded by Synta Pharmaceuticals Corp. 2015 - 2016
- Inducible Regulatory B Cells in Transplantation Tolerance awarded by University of Wisconsin 2015 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Fitch, Zachary W., Lillian Kang, Jie Li, Stuart J. Knechtle, Joseph W. Turek, Allan D. Kirk, M Louise Markert, and Jean Kwun. “Introducing thymus for promoting transplantation tolerance.” J Allergy Clin Immunol, June 9, 2022. https://doi.org/10.1016/j.jaci.2022.05.006.
    Full Text Link to Item
  - Anwar, Imran J., Isabel DeLaura, Qimeng Gao, Stuart Knechtle, and Jean Kwun. “Letter to the editor in response to: Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life sustaining NHP renal allo- and xeno-transplants by Firl and Markmann.” Am J Transplant, February 18, 2022. https://doi.org/10.1111/ajt.17007.
    Full Text Link to Item
  - Song, Shengli, Miriam Manook, Jean Kwun, Annette M. Jackson, Stuart J. Knechtle, and Garnett Kelsoe. “A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines.” Commun Biol 4, no. 1 (November 25, 2021): 1338. https://doi.org/10.1038/s42003-021-02881-w.
    Full Text Link to Item
  - Schmitz, Robin, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, et al. “C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.” Nat Commun 12, no. 1 (September 15, 2021): 5456. https://doi.org/10.1038/s41467-021-25745-7.
    Full Text Link to Item
  - Jelly, Evan T., Jean Kwun, Robin Schmitz, Alton B. Farris, Zachary A. Steelman, Debra L. Sudan, Stuart J. Knechtle, and Adam Wax. “Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe.” J Biomed Opt 26, no. 9 (September 2021). https://doi.org/10.1117/1.JBO.26.9.096008.
    Full Text Link to Item
  - Olaso, Danae, Miriam Manook, Dimitrios Moris, Stuart Knechtle, and Jean Kwun. “Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient.” J Clin Med 10, no. 16 (August 18, 2021). https://doi.org/10.3390/jcm10163656.
    Full Text Link to Item
  - Schroder, Paul M., Robin Schmitz, Zachary W. Fitch, Brian Ezekian, Janghoon Yoon, Ashley Y. Choi, Miriam Manook, et al. “Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model.” Kidney Int 99, no. 1 (January 2021): 161–72. https://doi.org/10.1016/j.kint.2020.08.020.
    Full Text Link to Item
  - Anwar, Imran J., Annette M. Jackson, Jayme E. Locke, and Jean Kwun. “Editorial: Sensitization and Desensitization in Organ Transplantation.” Front Immunol 12 (2021): 784472. https://doi.org/10.3389/fimmu.2021.784472.
    Full Text Link to Item
  - Choi, Ashley Y., Miriam Manook, Danae Olaso, Brian Ezekian, Jaeberm Park, Kyle Freischlag, Annette Jackson, Stuart Knechtle, and Jean Kwun. “Emerging New Approaches in Desensitization: Targeted Therapies for HLA Sensitization.” Front Immunol 12 (2021): 694763. https://doi.org/10.3389/fimmu.2021.694763.
    Full Text Link to Item
  - Manook, Miriam, Walter J. Flores, Robin Schmitz, Zachary Fitch, Janghoon Yoon, Yeeun Bae, Brian Shaw, et al. “Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model.” Front Immunol 12 (2021): 660900. https://doi.org/10.3389/fimmu.2021.660900.
    Full Text Link to Item
  - Song, Shengli, Miriam Manook, Jean Kwun, Annette M. Jackson, Stuart J. Knechtle, and Garnett Kelsoe. “Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells.” Front Immunol 12 (2021): 705140. https://doi.org/10.3389/fimmu.2021.705140.
    Full Text Link to Item
  - Dangi, Anil, Naveen R. Natesh, Irma Husain, Zhicheng Ji, Laura Barisoni, Jean Kwun, Xiling Shen, Edward B. Thorp, and Xunrong Luo. “Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection.” Jci Insight 5, no. 20 (October 15, 2020). https://doi.org/10.1172/jci.insight.141321.
    Full Text Link to Item
  - Dangi, Anil, Shuangjin Yu, Frances T. Lee, Melanie Burnette, Stuart Knechtle, Jean Kwun, and Xunrong Luo. “Donor apoptotic cell-based therapy for effective inhibition of donor-specific memory T and B cells to promote long-term allograft survival in allosensitized recipients.” Am J Transplant 20, no. 10 (October 2020): 2728–39. https://doi.org/10.1111/ajt.15878.
    Full Text Link to Item
  - Kwun, Jean, and Stuart Knechtle. “Pharmacological approaches to antibody-mediated rejection-Are we getting closer?” Am J Transplant 20, no. 10 (October 2020): 2637–38. https://doi.org/10.1111/ajt.16061.
    Full Text Link to Item
  - Atia, Andrew, Dimitrios Moris, MacKenzie McRae, Mingqing Song, Linda Stempora, Francis Leopardi, Kyha Williams, et al. “Th17 cell inhibition in a costimulation blockade-based regimen for vascularized composite allotransplantation using a nonhuman primate model.” Transpl Int 33, no. 10 (October 2020): 1294–1301. https://doi.org/10.1111/tri.13612.
    Full Text Link to Item
  - Scheuermann, Uwe, Elisabeth R. Seyferth, Nader Abraham, Samuel J. Kesseli, Samantha E. Halpern, Minghua Zhu, Mingqing Song, et al. “Sirtuin-1 expression and activity is diminished in aged liver grafts.” Sci Rep 10, no. 1 (July 17, 2020): 11860. https://doi.org/10.1038/s41598-020-68314-6.
    Full Text Link to Item
  - Kwun, Jean, Jie Li, Clay Rouse, Jae Berm Park, Alton B. Farris, Maragatha Kuchibhatla, Joseph W. Turek, Stuart J. Knechtle, Allan D. Kirk, and M Louise Markert. “Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.” Jci Insight 5, no. 11 (June 4, 2020). https://doi.org/10.1172/jci.insight.129983.
    Full Text Open Access Copy Link to Item
  - Kwun, Jean, and Stuart Knechtle. “Experimental modeling of desensitization: What have we learned about preventing AMR?” Am J Transplant 20 Suppl 4 (June 2020): 2–11. https://doi.org/10.1111/ajt.15873.
    Full Text Link to Item
  - Kwun, Jean, Brian Ezekian, Miriam Manook, Jaeberm Park, Janghoon Yoon, Kyle Freischlag, Mingqing Song, et al. “Targeting Calcium Release-activated Calcium Channel Is Not Sufficient to Prevent Rejection in Nonhuman Primate Kidney Transplantation.” Transplantation 104, no. 5 (May 2020): 970–80. https://doi.org/10.1097/TP.0000000000003078.
    Full Text Link to Item
  - Schmitz, Robin, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Annette M. Jackson, Stuart J. Knechtle, and Jean Kwun. “B cells in transplant tolerance and rejection: friends or foes?” Transpl Int 33, no. 1 (January 2020): 30–40. https://doi.org/10.1111/tri.13549.
    Full Text Link to Item
  - Ezekian, Brian, Paul M. Schroder, Michael S. Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, et al. “Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients.” J Am Soc Nephrol 30, no. 12 (December 2019): 2399–2411. https://doi.org/10.1681/ASN.2019030304.
    Full Text Link to Item
  - Eppensteiner, John, Jean Kwun, Uwe Scheuermann, Andrew Barbas, Alexander T. Limkakeng, Maggie Kuchibhatla, Eric A. Elster, Allan D. Kirk, and Jaewoo Lee. “Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness.” Jci Insight 4, no. 16 (August 22, 2019). https://doi.org/10.1172/jci.insight.127925.
    Full Text Link to Item
  - Schroder, Paul M., Zachary W. Fitch, Robin Schmitz, Ashley Y. Choi, Jean Kwun, and Stuart J. Knechtle. “The past, present, and future of costimulation blockade in organ transplantation.” Curr Opin Organ Transplant 24, no. 4 (August 2019): 391–401. https://doi.org/10.1097/MOT.0000000000000656.
    Full Text Link to Item
  - Fitch, Zachary, Robin Schmitz, Jean Kwun, Bernhard Hering, Joren Madsen, and Stuart J. Knechtle. “Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation.” Transplant Rev (Orlando) 33, no. 3 (July 2019): 115–29. https://doi.org/10.1016/j.trre.2019.03.002.
    Full Text Link to Item
  - Knechtle, Stuart J., and Jean Kwun. “Parallels between antibody-mediated rejection and ischemic kidney injury with respect to B cell activation.” Ann Transl Med 7, no. Suppl 3 (July 2019): S151. https://doi.org/10.21037/atm.2019.06.36.
    Full Text Link to Item
  - Kwun, Jean, Marie Matignon, Miriam Manook, Soulef Guendouz, Vincent Audard, David Kheav, Elsa Poullot, et al. “Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use.” J Am Soc Nephrol 30, no. 7 (July 2019): 1206–19. https://doi.org/10.1681/ASN.2018121254.
    Full Text Link to Item
  - Scheuermann, Uwe, Minghua Zhu, Mingqing Song, John Yerxa, Qimeng Gao, Robert P. Davis, Min Zhang, et al. “Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology.” Liver Transpl 25, no. 4 (April 2019): 610–26. https://doi.org/10.1002/lt.25429.
    Full Text Link to Item
  - Burghuber, Christopher K., Miriam Manook, Brian Ezekian, Adriana C. Gibby, Frank V. Leopardi, Minqing Song, Jennifer Jenks, et al. “Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients.” Am J Transplant 19, no. 3 (March 2019): 724–36. https://doi.org/10.1111/ajt.15067.
    Full Text Link to Item
  - Gu, Yuyang, Chuyi Chen, Zeyu Wang, Po-Hsun Huang, Hai Fu, Lin Wang, Mengxi Wu, et al. “Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation.” Lab Chip 19, no. 3 (January 29, 2019): 394–402. https://doi.org/10.1039/c8lc00527c.
    Full Text Link to Item
  - Ezekian, Brian, Paul M. Schroder, Kyle Freischlag, Janghoon Yoon, Jean Kwun, and Stuart J. Knechtle. “Contemporary Strategies and Barriers to Transplantation Tolerance.” Transplantation 102, no. 8 (August 2018): 1213–22. https://doi.org/10.1097/TP.0000000000002242.
    Full Text Link to Item
  - Manook, Miriam, Jean Kwun, Steven Sacks, Anthony Dorling, Nizam Mamode, and Stuart Knechtle. “Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient.” Transplant Rev (Orlando) 32, no. 3 (July 2018): 119–26. https://doi.org/10.1016/j.trre.2018.01.001.
    Full Text Link to Item
  - “Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119.” Blood Adv 2, no. 2 (January 23, 2018): 89. https://doi.org/10.1182/bloodadvances.2017015446.
    Full Text Link to Item
  - Kwun, Jean, Jaeberm Park, John S. Yi, Alton B. Farris, Allan D. Kirk, and Stuart J. Knechtle. “IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.” Front Immunol 9 (2018): 2323. https://doi.org/10.3389/fimmu.2018.02323.
    Full Text Link to Item
  - Eppensteiner, John, Robert Patrick Davis, Andrew S. Barbas, Jean Kwun, and Jaewoo Lee. “Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults.” Front Immunol 9 (2018): 190. https://doi.org/10.3389/fimmu.2018.00190.
    Full Text Link to Item
  - Kwun, Jean, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, et al. “Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates.” Blood Adv 1, no. 24 (November 14, 2017): 2115–19. https://doi.org/10.1182/bloodadvances.2017010991.
    Full Text Link to Item
  - “Erratum.” Am J Transplant 17, no. 11 (November 2017): 2993. https://doi.org/10.1111/ajt.14501.
    Full Text Link to Item
  - Manook, M., J. Kwun, C. Burghuber, K. Samy, M. Mulvihill, J. Yoon, H. Xu, et al. “Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.” Am J Transplant 17, no. 8 (August 2017): 2055–64. https://doi.org/10.1111/ajt.14234.
    Full Text Link to Item
  - Kwun, Jean, Christopher Burghuber, Miriam Manook, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, and Stuart Knechtle. “Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients.” J Am Soc Nephrol 28, no. 7 (July 2017): 1991–96. https://doi.org/10.1681/ASN.2016070727.
    Full Text Link to Item
  - Kwun, Jean, Miriam Manook, Eugenia Page, Christopher Burghuber, Jungjoo Hong, and Stuart J. Knechtle. “Crosstalk Between T and B Cells in the Germinal Center After Transplantation.” Transplantation 101, no. 4 (April 2017): 704–12. https://doi.org/10.1097/TP.0000000000001588.
    Full Text Link to Item
  - Lee, Jaewoo, Jennifer G. Jackman, Jean Kwun, Miriam Manook, Angelo Moreno, Eric A. Elster, Allan D. Kirk, Kam W. Leong, and Bruce A. Sullenger. “Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis.” Biomaterials 120 (March 2017): 94–102. https://doi.org/10.1016/j.biomaterials.2016.12.024.
    Full Text Link to Item
  - Schroder, Paul M., Brian Ezekian, Mandy Ford, Stuart J. Knechtle, and Jean Kwun. “Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation.” Front Immunol 8 (2017): 1615. https://doi.org/10.3389/fimmu.2017.01615.
    Full Text Open Access Copy Link to Item
  - George, Roshan P., Aneesh K. Mehta, Sebastian D. Perez, Pamela Winterberg, Jennifer Cheeseman, Brandi Johnson, Jean Kwun, et al. “Premature T Cell Senescence in Pediatric CKD.” J Am Soc Nephrol 28, no. 1 (January 2017): 359–67. https://doi.org/10.1681/ASN.2016010053.
    Full Text Link to Item
  - Oh, B., J. Yoon, A. Farris, A. Kirk, S. Knechtle, and J. Kwun. “Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.” Am J Transplant 16, no. 9 (September 2016): 2612–23. https://doi.org/10.1111/ajt.13789.
    Full Text Open Access Copy Link to Item
  - Burghuber, C. K., J. Kwun, E. J. Page, M. Manook, A. C. Gibby, F. V. Leopardi, M. Song, et al. “Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.” Am J Transplant 16, no. 6 (June 2016): 1726–38. https://doi.org/10.1111/ajt.13688.
    Full Text Link to Item
  - Kwun, Jean, Alton B. Farris, Hyunjin Song, William T. Mahle, William J. Burlingham, and Stuart J. Knechtle. “Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.” Transplantation 99, no. 12 (December 2015): 2485–93. https://doi.org/10.1097/TP.0000000000000805.
    Full Text Open Access Copy Link to Item
  - Kwun, J., E. Page, J. J. Hong, A. Gibby, J. Yoon, A. B. Farris, F. Villinger, and S. Knechtle. “Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.” Am J Transplant 15, no. 3 (March 2015): 815–22. https://doi.org/10.1111/ajt.13045.
    Full Text Open Access Copy Link to Item
  - Kim, E. J., J. Kwun, A. C. Gibby, J. J. Hong, A. B. Farris, N. N. Iwakoshi, F. Villinger, A. D. Kirk, and S. J. Knechtle. “Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.” Am J Transplant 14, no. 1 (January 2014): 59–69. https://doi.org/10.1111/ajt.12526.
    Full Text Open Access Copy Link to Item
  - Page, Eugenia, Jean Kwun, Byoungchol Oh, and Stuart Knechtle. “Lymphodepletional strategies in transplantation.” Cold Spring Harb Perspect Med 3, no. 7 (July 1, 2013). https://doi.org/10.1101/cshperspect.a015511.
    Full Text Link to Item
  - Kwun, J., B. C. Oh, A. C. Gibby, R. Ruhil, V. T. Lu, D. W. Kim, E. K. Page, et al. “Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.” Am J Transplant 12, no. 10 (October 2012): 2641–51. https://doi.org/10.1111/j.1600-6143.2012.04181.x.
    Full Text Open Access Copy Link to Item
  - Page, E. K., A. J. Page, J. Kwun, A. C. Gibby, F. Leopardi, J. B. Jenkins, E. A. Strobert, et al. “Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.” Am J Transplant 12, no. 9 (September 2012): 2395–2405. https://doi.org/10.1111/j.1600-6143.2012.04074.x.
    Full Text Open Access Copy Link to Item
  - Kwun, Jean, Pinar Bulut, Eugenia Kim, Wasim Dar, Byoungchol Oh, Ravi Ruhil, Neal Iwakoshi, and Stuart J. Knechtle. “The role of B cells in solid organ transplantation.” Semin Immunol 24, no. 2 (April 2012): 96–108. https://doi.org/10.1016/j.smim.2011.08.022.
    Full Text Open Access Copy Link to Item
  - Kwun, Jean, Subramaniam Malarkannan, William J. Burlingham, and Stuart J. Knechtle. “Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.” J Immunol 187, no. 8 (October 15, 2011): 3997–4006. https://doi.org/10.4049/jimmunol.1003918.
    Full Text Open Access Copy Link to Item
  - Haustein, Silke, Jean Kwun, John Fechner, Ayhan Kayaoglu, Jean-Pierre Faure, Drew Roenneburg, Jose Torrealba, and Stuart J. Knechtle. “Interleukin-15 receptor blockade in non-human primate kidney transplantation.” Transplantation 89, no. 8 (April 27, 2010): 937–44. https://doi.org/10.1097/TP.0b013e3181d05a58.
    Full Text Open Access Copy Link to Item
  - Kwun, Jean, and Stuart J. Knechtle. “Overcoming Chronic Rejection-Can it B?” Transplantation 88, no. 8 (October 27, 2009): 955–61. https://doi.org/10.1097/TP.0b013e3181b96646.
    Full Text Link to Item
  - Bloom, D., Z. Chang, K. Pauly, J. Kwun, J. Fechner, C. Hayes, M. Samaniego, and S. Knechtle. “BAFF is increased in renal transplant patients following treatment with alemtuzumab.” Am J Transplant 9, no. 8 (August 2009): 1835–45. https://doi.org/10.1111/j.1600-6143.2009.02710.x.
    Full Text Link to Item
  - Hu, Huaizhong, Jean Kwun, Brian D. Aizenstein, and Stuart J. Knechtle. “Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine.” Transplantation 87, no. 12 (June 27, 2009): 1814–20. https://doi.org/10.1097/TP.0b013e3181a66b3e.
    Full Text Link to Item
  - Knechtle, S. J., J. Pascual, D. D. Bloom, J. R. Torrealba, E. Jankowska-Gan, W. J. Burlingham, J. Kwun, et al. “Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring.” Am J Transplant 9, no. 5 (May 2009): 1087–98. https://doi.org/10.1111/j.1600-6143.2009.02581.x.
    Full Text Link to Item
  - Knechtle, Stuart J., and Jean Kwun. “Unique aspects of rejection and tolerance in liver transplantation.” Semin Liver Dis 29, no. 1 (February 2009): 91–101. https://doi.org/10.1055/s-0029-1192058.
    Full Text Link to Item
  - Bloom, Debra D., Kyle Pauly, Zhen Chang, John H. Fechner, Jean Kwun, Millie Samaniego, and Stuart J. Knechtle. “BAFF Dysregulation in Renal Transplant Patients Treated with Campath-1H.” American Journal of Transplantation 9 (January 1, 2009): 226–226.
    Link to Item
  - Kwun, J., S. M. Hazinedaroglu, E. Schadde, H. A. Kayaoglu, J. Fechner, H. Z. Hu, D. Roenneburg, et al. “Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients.” Am J Transplant 8, no. 8 (August 2008): 1593–1603. https://doi.org/10.1111/j.1600-6143.2008.02250.x.
    Full Text Link to Item
  - Kwun, Jean, Huaizhong Hu, Erik Schadde, Drew Roenneburg, Kathleen A. Sullivan, Julie DeMartino, William J. Burlingham, and Stuart J. Knechtle. “Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients.” J Immunol 179, no. 12 (December 15, 2007): 8016–25. https://doi.org/10.4049/jimmunol.179.12.8016.
    Full Text Link to Item
  - Molitor-Dart, Melanie L., Joachim Andrassy, Jean Kwun, H Ayhan Kayaoglu, Drew A. Roenneburg, Lynn D. Haynes, Jose R. Torrealba, et al. “Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance.” J Immunol 179, no. 10 (November 15, 2007): 6749–61. https://doi.org/10.4049/jimmunol.179.10.6749.
    Full Text Link to Item
  - Kwun, Jean, Stuart J. Knechtle, and Huaizhong Hu. “Determination of the functional status of alloreactive T cells by interferon-gamma kinetics.” Transplantation 81, no. 4 (February 27, 2006): 590–98. https://doi.org/10.1097/01.tp.0000196353.04494.14.
    Full Text Link to Item
  - Jeon, Y., J. Kim, H. Yu, J. Kwun, S. Lee, J. Seo, and D. Hong. “Known postfix based cell search technique for OFDM cellular systems.” Ieice Transactions on Communications E89-B, no. 4 (January 1, 2006): 1405–11. https://doi.org/10.1093/ietcom/e89-b.4.1405.
    Full Text
  - Kanmaz, Turan, Ping Feng, Jose Torrealba, Jean Kwun, John H. Fechner, Jacqueline M. Schultz, Yinchen Dong, et al. “Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine.” Transplantation 78, no. 7 (October 15, 2004): 1002–7. https://doi.org/10.1097/01.tp.0000134397.55564.71.
    Full Text Link to Item
  - Kelsoe, Garnett, Shengli Song, Miriam Manook, Jean Kwun, Annette Jackson, and Stuart Knechtle. “A Novel Cell-Based Multiplex Immunoassay Platform,” n.d. https://doi.org/10.21203/rs.3.rs-464450/v1.
    Full Text
- Other Articles
  - Knechtle, Stuart J., Jean Kwun, and Neal Iwakoshi. “Prevention trumps treatment of antibody-mediated transplant rejection.” J Clin Invest, April 2010. https://doi.org/10.1172/JCI42532.
    Full Text Open Access Copy Link to Item
- Conference Papers
  - Kwun, J., E. David, Y. Gu, Z. Ma, M. Kuchibhatla, G. Arepally, T. J. Huang, and E. T. Chambers. “Acoustofluidic Device to Remove Donor Specific Antibody in a Sensitized Animal Model.” In American Journal of Transplantation, 21:401–401, 2021.
    Link to Item
  - Kwun, J., R. Schmitz, M. Manook, Z. Fitch, D. Olaso, A. Choi, J. Yoon, Y. Bae, J. Lambris, and S. Knechtle. “Belatacept and Carfilzomib-based Treatment of Active Antibody-mediated Rejection in a Sensitized Nonhuman Primate Model.” In American Journal of Transplantation, 21:476–476, 2021.
    Link to Item
  - Manook, M., J. Yoon, Z. Fitch, R. Schmitz, A. M. Jackson, J. Kwun, and S. Knechtle. “Natural Sensitization by Pregnancy, Testing Desensitization Strategies in Female NHPs Across Repeat Mismatches.” In American Journal of Transplantation, 21:475–475, 2021.
    Link to Item
  - Manook, M., W. Flores, R. Schmitz, Z. Fitch, J. Yoon, Y. Bae, B. I. Shaw, et al. “Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model.” In American Journal of Transplantation, 21:397–397, 2021.
    Link to Item
  - Olaso, D., M. Manook, J. Yoon, Y. Bae, A. Barbas, A. Adams, S. Knechtle, and J. Kwun. “Impact of Allosensitization on Xenotransplantation.” In American Journal of Transplantation, 21:477–78, 2021.
    Link to Item
  - Schmitz, R., Z. W. Fitch, M. Manook, J. Yoon, A. B. Farris, J. Kwun, and S. J. Knechtle. “Belatacept and Rapamycin Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model.” In American Journal of Transplantation, 21:521–521, 2021.
    Link to Item
  - Schmitz, Robin, Paul M. Schroder, Zachary W. Fitch, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Alton B. Farris, et al. “BLOCKING COMPLEMENT C3 IN A SENSITIZED NONHUMAN PRIMATE MODEL OF KIDNEY TRANSPLANTATION.” In Transplantation, 104:S121–S121, 2020.
    Link to Item
  - Schroder, Paul M., Robin Schmitz, Zachary W. Fitch, Brian Ezekian, Janghoon Yoon, Mingqing Song, Alton B. Farris, et al. “CARFILZOMIB AND LULIZUMAB-BASED DESENSITIZATION PROLONGS ALLOGRAFT SURVIVAL IN SENSITIZED NON-HUMAN PRIMATES KIDNEY TRANSPLANTATION MODEL.” In Transplantation, 104:S46–S46, 2020.
    Link to Item
  - Choi, A. Y., D. Olaso, Risoli T. Jr, M. Kuchibhatla, Z. Fitch, R. Schmitz, P. M. Schroder, et al. “Peak DSA Levels Pre-Transplant but Not at Transplant Predict Graft Survival.” In American Journal of Transplantation, 20:432–432, 2020.
    Link to Item
  - Fitch, Z. W., R. Schmitz, M. Manook, A. Y. Choi, J. Yoon, J. Kwun, and S. J. Knechtle. “Targeting the CD40/CD40L Axis in Sensitized Nonhuman Primate Allotransplantation.” In American Journal of Transplantation, 20:644–644, 2020.
    Link to Item
  - Fitch, Z. W., R. Schmitz, P. M. Schroder, M. Manook, A. Y. Choi, J. Yoon, J. Kwun, and S. J. Knechtle. “Desensitization for Deceased Donor Transplantation: Testing a New Paradigm in the Nonhuman Primate.” In American Journal of Transplantation, 20:307–307, 2020.
    Link to Item
  - Kwun, J., Y. Gu, M. Manook, M. Wu, J. Yoon, S. Knechtle, and T. J. Huang. “Isolation of Preformed Antibodies from Whole Blood by Integrating Acoustics and Microfluidics in Sensitized Animal Model.” In American Journal of Transplantation, 20:645–645, 2020.
    Link to Item
  - Moris, D. P., A. Atia, M. Rae, M. Song, L. Stempora, F. Leopardi, K. Williams, et al. “Th17 Cell Inhibition in a Costimulation Blockade Based Regimen for Vascularized Composite Allotransplantation Using A Non-Human Primate Model.” In American Journal of Transplantation, 20:537–537, 2020.
    Link to Item
  - Schmitz, R., P. M. Schroder, Z. W. Fitch, A. Y. Choi, M. Manook, J. Yoon, A. Farris, et al. “Blocking Complement Component C3 in a Sensitized Nonhuman Primate Model of Kidney Allotransplantation.” In American Journal of Transplantation, 20:711–711, 2020.
    Link to Item
  - Schmitz, R., Z. W. Fitch, A. Y. Choi, M. Manook, J. Yoon, J. D. Lambris, J. Kwun, and S. J. Knechtle. “Novel Treatment of Acute Antibody-Mediated Rejection in a Nonhuman Primate Model of Kidney Allotransplantation.” In American Journal of Transplantation, 20:402–3, 2020.
    Link to Item
  - Schmitz, R., Z. W. Fitch, P. M. Schroder, A. Y. Choi, M. Manook, J. Yoon, J. Kwun, and S. J. Knechtle. “Costimulation Blockade-Based Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model.” In American Journal of Transplantation, 20:341–42, 2020.
    Link to Item
  - Yoon, J., M. Manook, Z. Fitch, R. Schmitz, A. Choi, A. M. Jackson, S. Knechtle, and J. Kwun. “Sensitization via Pregnancy Generates Alloantibody and Cross-Reactive Xeno-Antibody in a Non-Human Primate Model.” In American Journal of Transplantation, 20:757–757, 2020.
    Link to Item
  - Jelly, Evan T., Wesley Kendall, Robin Schmitz, Stuart J. Knechtle, Debra L. Sudan, Abel Joseph, Jatin Roper, Jean Kwun, and Adam Wax. “Novel Implementations of Optical Coherence Tomography for Clinical Applications in the Lower Gastrointestinal Tract.” In Optical Coherence Tomography, OTu4E-4, 2020.
  - Schmitz, R., J. Yoon, M. Song, E. Jelly, A. P. Wax, S. J. Knechtle, D. L. Sudan, and J. Kwun. “A Nonhuman Primate Model of Intestinal Transplantation-Technical Aspects and Early Outcomes.” In American Journal of Transplantation, 20:400–400, 2020.
  - Kwun, Jean, Janghoon Yoon, Adella Clark, Dong-Feng Chen, Stuart J. Knechtle, and Annette M. Jackson. “P153 Utilizing single HLA antigen beads to sensitized nonhuman primate model.” In Human Immunology, 80:174–174. Elsevier BV, 2019. https://doi.org/10.1016/j.humimm.2019.07.206.
    Full Text
  - Kwun, J., B. Ezekian, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Yi, and S. Knechtle. “Costimulation Blockade Modulates Humoral Responses in Highly Sensitized Transplant Recipients.” In American Journal of Transplantation, 19:326–326. WILEY, 2019.
    Link to Item
  - Scheuermann, U., E. R. Seyferth, M. Zhu, M. Song, J. Yerxa, R. P. Davis, W. Parker, et al. “Damage-Associated Molecular Pattern Release and Toll-Like Receptor Activation during Cold Storage and Ex Vivo Reperfusion of Old Rat livers.” In American Journal of Transplantation, 19:742–43. WILEY, 2019.
    Link to Item
  - Schmitz, R., M. S. Mulvihill, P. M. Schroder, Z. Fitch, F. Leopardi, D. Magnani, J. Kwun, S. J. Knechtle, and A. D. Kirk. “Depletional Induction Therapy in Non-Human Primates - Preclinical Modeling of Polyclonal Depletion with Rhesus-Specific ATG.” In American Journal of Transplantation, 19:597–597. WILEY, 2019.
    Link to Item
  - Schroder, P. M., R. Schmitz, Z. Fitch, B. Ezekian, J. Yoon, A. Choi, A. Barbas, et al. “Dual Targeting Desensitization with Carfilzomib Plus Lulizumab Significantly Prolongs Kidney Transplant Survival in Allosensitized Nonhuman Primates.” In American Journal of Transplantation, 19:429–429. WILEY, 2019.
    Link to Item
  - Schroder, P., J. S. Yi, K. J. Weinhold, C. Chan, M. Joshi, C. Walters, J. Kwun, and S. J. Knechtle. “Pre-Transplant Multidimensional Flow Cytometric Analysis of Kidney Transplant Recipients Reveals Novel Immune Signature of Allograft Rejection.” In American Journal of Transplantation, 19:765–66. WILEY, 2019.
    Link to Item
  - Schroder, P., J. Yoon, R. Schmitz, Z. Fitch, J. Kwun, and S. J. Knechtle. “Novel In Vitro Germinal Center Culture System Demonstrates More Aggressive B Cell to Plasma Blast Differentiation in Allosensitized Nonhuman Primates.” In American Journal of Transplantation, 19:1090–1090. WILEY, 2019.
    Link to Item
  - Yoon, J., B. Ezekian, M. Manook, J. Kwun, and S. Knechtle. “alpha-1,3-galactosyltransferase Knockout Porcine Tissue And Organ May Reduce The Risks Of Antibody Mediated Rejection Via Less Rhesus Igm Cross-reactivity.” In American Journal of Transplantation, 19:1057–1057. WILEY, 2019.
    Link to Item
  - Scheuermann, Uwe, Minghua Zhu, Mingqing Song, John Yerxa, Qimeng Gao, Robert Davis, Min Zhang, et al. “DAMP Release and Inflammasome Activation during Machine Preservation of the Liver.” In American Journal of Transplantation, 19:34–35. WILEY, 2019.
    Link to Item
  - Ezekian, B., J. Kwun, M. Manook, P. Schroder, J. Yoon, M. Mulvihill, K. Freischlag, et al. “Combination Proteasome Inhibition and Anti-BAFF Therapy Permits Highly Sensitized Rhesus Kidney Transplantation.” In American Journal of Transplantation, 18:309–10. WILEY, 2018.
    Link to Item
  - Ezekian, B., J. Kwun, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, et al. “Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation.” In American Journal of Transplantation, 18:246–246. WILEY, 2018.
    Link to Item
  - Freischlag, K., B. Ezekian, P. Schroder, J. Everitt, J. Yoon, M. Swiderska-Syn, W. Parker, A. Diehl, J. Kwun, and S. Knechtle. “Long-Term HIF-1 alpha Stabilization is Associated with Fibrosis in Rat Lung Allografts.” In American Journal of Transplantation, 18:490–91. WILEY, 2018.
    Link to Item
  - Kwun, J., B. Ezekian, M. Manook, J. Park, J. Yoon, J. Sloan-Lancaster, C. Fortier, P. Rao, and S. Knechtle. “Targeting Calcium Release-Activated Calcium (CRAC) Channel in Non-Human Primate Kidney Transplantation.” In American Journal of Transplantation, 18:901–901. WILEY, 2018.
    Link to Item
  - Kwun, J., E. Brian, M. Manook, J. Park, K. Freischlag, J. Yoon, J. Yi, M. Stegall, and S. Knechtle. “Targeting Plasma Cells with Anti-CD38mAb (Daratumumab) and CXCR4 Antagonist (Plerixafor) for Desensitization.” In American Journal of Transplantation, 18:890–890. WILEY, 2018.
    Link to Item
  - Kwun, J., J. Li, C. Rouse, J. Park, A. Kirk, and L. Markert. “Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation.” In American Journal of Transplantation, 18:620–620. WILEY, 2018.
    Link to Item
  - Schroder, P., B. Ezekian, F. Saccoccio, J. Yoon, M. Dennis, K. Freischlag, J. Kwun, S. Permar, and S. Knechtle. “Humoral Immunity to CMV Remains Intact after Dual Targeting Desensitization in Allosensitized Nonhuman Primates.” In American Journal of Transplantation, 18:899–900. WILEY, 2018.
    Link to Item
  - Yoon, J., B. Ezekian, M. Manook, J. Kwun, and S. Knechtle. “Rhesus Monkey Have natural Antibody toward Swine That is Not Influenced by Allosensitization nor by Carfilzomib/tocilizumab.” In American Journal of Transplantation, 18:764–764. WILEY, 2018.
    Link to Item
  - Driscoll, J., S. Knechtle, J. Kwun, S. Tremblay, N. Salomonis, S. Potter, B. Aronow, et al. “Induction of Proliferative Responses in B Cell and Plasma Cell Populations Following Proteasome Inhibitor Desensitization Treatment in Rhesus Macacques and Humans.” In American Journal of Transplantation, 17:244–244. WILEY, 2017.
    Link to Item
  - Ezekian, B., J. Kwun, M. Manook, K. Freischlag, V. Curfman, E. Branum, J. Park, J. Yi, S. Jordan, and S. Knechtle. “Dual Targeting with Carfilzomib and Tocilizumab Abrogates Antibody-Mediated Rejection and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation.” In American Journal of Transplantation, 17:211–211. WILEY, 2017.
    Link to Item
  - Kwun, J., B. Ezekian, M. Manook, E. Branum, V. Curfman, J. Park, K. Freishlag, J. Yoon, and S. Knechtle. “Effective Targeting Plasma Cells with Daratumumab (Anti-CD38) and Mozobil (Anti-CXCR4) in a Sensitized Non-Human Primate Model.” In American Journal of Transplantation, 17:211–12. WILEY, 2017.
    Link to Item
  - Kwun, J., C. Burghuber, M. Manook, B. Ezekian, J. Park, K. Freishlag, J. Yoon, N. Iwakoshi, A. Farris, and S. Knechtle. “Dual Targeting of Costimulation and Proteasome to Desensitize and Prolong Graft Survival of Sensitized Nonhuman Primates.” In American Journal of Transplantation, 17:212–212. WILEY, 2017.
    Link to Item
  - Kwun, J., J. Lee, J. Jackman, M. Manook, E. Elster, A. Kirk, and B. Sullenger. “Nucleic Acid Scavenging Microfiber Mesh Inhibits Trauma Induced Inflammation and Thrombosis After Organ Transplantation.” In American Journal of Transplantation, 17:245–46. WILEY, 2017.
    Link to Item
  - Manook, M., J. Kwun, J. Yoon, K. Samy, A. MacDonald, H. Xu, R. Smith, et al. “Thrombalexin and Mirococept Synergistically Reduce IBMIR in a Porcine to Rhesus Xenoislet Model.” In American Journal of Transplantation, 17:616–616. WILEY, 2017.
    Link to Item
  - Manook, M., J. Kwun, J. Yoon, K. Samy, A. MacDonlad, H. Xu, R. Smith, et al. “Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.” In American Journal of Transplantation, 17:212–212. WILEY, 2017.
    Link to Item
  - Kwun, J., C. Burghuber, M. Manook, A. Clark, D. Chen, and S. Knechtle. “Utilizing HLA Single Antigen Flow Beads Assays to Evaluate Anti-MAMU Antibody in Sensitized Nonhuman Primate Model.” In American Journal of Transplantation, 16:410–410. WILEY-BLACKWELL, 2016.
    Link to Item
  - Kwun, J., C. Burghuber, N. Iwakoshi, A. Gibby, and S. Knechtle. “Limited Efficacy of Bortezomib on Desensitization via Rapid Humoral Compensation in a Sensitized Rhesus Model.” In American Journal of Transplantation, 16:406–406. WILEY-BLACKWELL, 2016.
    Link to Item
  - Manook, M., J. Kwun, J. Yoon, S. Sacks, A. Dorling, N. Mamode, R. Smith, and S. Knechtle. “Thrombalexin: Detection & Efficacy of a Membrane-Bound Anti-Thrombin Agent.” In American Journal of Transplantation, 16:719–20. WILEY-BLACKWELL, 2016.
    Link to Item
  - Burghuber, C. K., J. Kwun, E. J. Kim, F. V. Leopardi, A. C. Gibby, N. N. Iwakoshi, and S. J. Knechtle. “NEW DESENSITIZATION STRATEGY IN A KIDNEY TRANSPLANTATION MODEL WITH RHESUS MONKEYS.” In Transplant International, 28:12–12. WILEY-BLACKWELL, 2015.
    Link to Item
  - Burghuber, C., J. Kwun, A. Gibby, N. Iwakoshi, and S. Knechtle. “MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
    Link to Item
  - Burghuber, C., J. Kwun, E. Page, A. Gibby, F. Leopardi, A. Farris, N. Iwakoshi, and S. Knechtle. “Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
    Link to Item
  - Burghuber, C., J. Kwun, E. Page, F. Leopardi, A. Gibby, A. Farris, N. Iwakoshi, and S. Knechtle. “T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
    Link to Item
  - Burghuber, C., J. Kwun, F. Leopardi, A. Gibby, A. Farris, N. Iwakoshi, and S. Knechtle. “Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
    Link to Item
  - Kwun, J., B. Oh, H. Song, A. Farris, A. Kirk, W. Mahle, and S. Knechtle. “LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
    Link to Item
  - Kwun, J., C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, and S. Knechtle. “Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
    Link to Item
  - Mou, D., J. Espinosa, L. Stempora, J. Kwun, N. Iwakoshi, and A. Kirk. “Virus Induced CD28 Down-Regulation as a Potential Driver of Costimulation Blockade Resistant Rejection.” In American Journal of Transplantation, Vol. 15. WILEY-BLACKWELL, 2015.
    Link to Item
  - Kwun, J., E. Page, A. Gibby, J. Hong, A. Farris, F. Villinger, and S. Knechtle. “The Effect of Neutralizing BAFF With Atacicept in a T Cell Depletion-Induced Nonhuman Primate AMR Model.” In Transplantation, 98:380–81. Ovid Technologies (Wolters Kluwer Health), 2014. https://doi.org/10.1097/00007890-201407151-01244.
    Full Text
  - Burghuber, C., E. Kim, J. Kwun, F. Leopardi, A. Gibby, E. Strobert, N. Iwakoshi, and S. Knechtle. “Developing a Nonhuman Primate Model of Sensitization.” In Transplantation, 98:387–88. Ovid Technologies (Wolters Kluwer Health), 2014. https://doi.org/10.1097/00007890-201407151-01268.
    Full Text
  - Burghuber, C., J. Kwun, E. Kim, F. Leopardi, A. Gibby, E. Strobert, N. Iwakoshi, W. Wakwe, A. Adams, and S. Knechtle. “First Experiences With Kidney Transplantation in a Model of Sensitized Rhesus Macaques.” In Transplantation, 98:388–388. Ovid Technologies (Wolters Kluwer Health), 2014. https://doi.org/10.1097/00007890-201407151-01271.
    Full Text
  - Kwun, J., B. Oh, M. MaConmara, H. Song, and S. Knechtle. “The Role of Splenic CD4+CD25+ T reg Cells On Alloreactive B Cell Formation and DSA Production in a Murine CAMR Model.” In Transplantation, 98:385–385. Ovid Technologies (Wolters Kluwer Health), 2014. https://doi.org/10.1097/00007890-201407151-01257.
    Full Text
  - Kwun, J., C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, and S. Knechtle. “Successful Desensitization With Combination of Costimulation Blockade and Bortezomib Via Regulating Plasma Cells and Follicular Helper T Cells in Sensitized Rhesus Model.” In Transplantation, 98:378–378. Ovid Technologies (Wolters Kluwer Health), 2014. https://doi.org/10.1097/00007890-201407151-01235.
    Full Text
  - Kwun, J., E. Page, A. Gibby, and S. Knechtle. “The Effect of CCR5 Blockade On De Novo DSA and Long-Term Graft Survival in Non-Human Primate AMR Model.” In Transplantation, 98:26–26. Ovid Technologies (Wolters Kluwer Health), 2014. https://doi.org/10.1097/00007890-201407151-00078.
    Full Text
  - Burghuber, C., E. Kim, J. Kwun, F. Leopardi, A. Gibby, E. Strobert, N. Iwakoshi, and S. Knechtle. “Developing a Nonhuman Primate Model of Sensitization.” In American Journal of Transplantation, 14:387–88, 2014.
    Link to Item
  - Burghuber, C., J. Kwun, E. Kim, F. Leopardi, A. Gibby, E. Strobert, N. Iwakoshi, W. Wakwe, A. Adams, and S. Knechtle. “First Experiences With Kidney Transplantation in a Model of Sensitized Rhesus Macaques.” In American Journal of Transplantation, 14:388–388. WILEY-BLACKWELL, 2014.
    Link to Item
  - Kwun, J., B. Oh, M. MaConmara, H. Song, and S. Knechtle. “The Role of Splenic CD4(+)CD25(+) T reg Cells On Alloreactive B Cell Formation and DSA Production in a Murine CAMR Model.” In American Journal of Transplantation, 14:385–385. WILEY-BLACKWELL, 2014.
    Link to Item
  - Kwun, J., C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, and S. Knechtle. “Successful Desensitization With Combination of Costimulation Blockade and Bortezomib Via Regulating Plasma Cells and Follicular Helper T Cells in Sensitized Rhesus Model.” In American Journal of Transplantation, 14:378–378. WILEY-BLACKWELL, 2014.
    Link to Item
  - Kwun, J., E. Page, A. Gibby, J. Hong, A. Farris, F. Villinger, and S. Knechtle. “The Effect of Neutralizing BAFF With Atacicept in a T Cell Depletion-Induced Nonhuman Primate AMR Model.” In American Journal of Transplantation, 14:380–81. WILEY-BLACKWELL, 2014.
    Link to Item
  - Kwun, J., E. Page, A. Gibby, and S. Knechtle. “The Effect of CCR5 Blockade On De Novo DSA and Long-Term Graft Survival in Non-Human Primate AMR Model.” In American Journal of Transplantation, 14:26–26. WILEY-BLACKWELL, 2014.
    Link to Item
  - Kwun, J., B. Oh, A. Gibby, E. Page, N. Iwakoshi, and S. Knechtle. “The Role of CD4(+)CD25(+) T reg Cells on Allo-B Cell Formation and DSA Production in a Chronic Rejection Model after T Cell Depletion.” In American Journal of Transplantation, 13:459–459. WILEY-BLACKWELL, 2013.
    Link to Item
  - Kwun, J., E. Page, A. Gibby, J. Hong, A. Farris, A. Adams, N. Iwakoshi, C. Larsen, A. Kirk, and S. Knechtle. “Follicular Helper T Cell Modulation by Costimulation Blockade Prevents Antibody-Mediated Rejection in Nonhuman Primate Renal Transplantation.” In American Journal of Transplantation, 13:177–177. WILEY-BLACKWELL, 2013.
    Link to Item
  - Kwun, J., E. Page, A. Gibby, N. Iwakoshi, and S. Knechtle. “The Effect of Belatacept on Follicular Helper T Cell and Humoral Response in Sensitized Rhesus Macaques.” In American Journal of Transplantation, 13:465–465. WILEY-BLACKWELL, 2013.
    Link to Item
  - Oh, B., J. Kwun, R. Ruhil, A. Gibby, A. Kirk, S. Knechtle, and N. Iwakoshi. “CTLA-4 Ig Prevents Chronic Antibody-Mediated Rejection.” In American Journal of Transplantation, 13:463–463. WILEY-BLACKWELL, 2013.
    Link to Item
  - Oh, B., J. Kwun, R. Ruhil, A. Gibby, E. Page, A. Farris, A. Kirk, N. Iwakoshi, and S. Knechtle. “Rapamycin Enhances Early Alloantibody Production by Hampering the Homeostatic Proliferation of Regulatory T Cells.” In American Journal of Transplantation, 13:383–84. WILEY-BLACKWELL, 2013.
    Link to Item
  - Oh, B., R. Ruhil, O. Bulut, J. Kwun, A. Kirk, S. Knechtle, and N. Iwakoshi. “The Effects of Viral Infection on Chronic Anti-Mediated Rejection.” In American Journal of Transplantation, 13:132–132. WILEY-BLACKWELL, 2013.
    Link to Item
  - Page, E., J. Kwun, A. Gibby, B. Oh, N. Iwakoshi, and S. Knechtle. “The Development of a Nonhuman Primate Model of Sensitization after Transplantation.” In American Journal of Transplantation, 13:462–462. WILEY-BLACKWELL, 2013.
    Link to Item
  - Page, E., J. Kwun, A. Gibby, S. Knechtle, and N. Iwakoshi. “Immunophenotyping and Targeting of Plasma Cells in Sensitized Nonhuman Primates.” In American Journal of Transplantation, 13:461–461. WILEY-BLACKWELL, 2013.
    Link to Item
  - Kwun, J., B. Oh, A. Gibby, N. Iwakoshi, and S. J. Knechtle. “The Role of CD4(+)CD25(+) T reg Cells on Alloantibody Production in a Model of Chronic Rejection after T Cell Depletion.” In American Journal of Transplantation, 12:447–447. WILEY-BLACKWELL, 2012.
    Link to Item
  - Kwun, J., B. Oh, A. Gibby, R. Ruhil, V. Lu, O. P. Bulut, M. Song, et al. “Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection after Alemtuzumab Treatment.” In American Journal of Transplantation, 12:278–278. WILEY-BLACKWELL, 2012.
    Link to Item
  - Oh, B., J. Kwun, R. Ruhil, A. Gibby, E. Page, V. Lu, D. Kim, et al. “Rapamycin Enhances Donor-Specific Antibody and Chronic Rejection of Full MHC Mismatched Cardiac Allografts after Alemtuzumab Treatment.” In American Journal of Transplantation, 12:463–463. WILEY-BLACKWELL, 2012.
    Link to Item
  - Page, E. K., A. C. Gibby, J. Kwun, F. Leopardi, A. B. Adams, C. L. Courtney, J. B. Jenkins, E. Strobert, N. Iwakoshi, and S. J. Knechtle. “Belatacept Prevents De Novo Alloantibody Production in Rhesus Macaques.” In American Journal of Transplantation, 12:276–276. WILEY-BLACKWELL, 2012.
    Link to Item
  - Page, E. K., A. J. Page, J. Kwun, A. C. Gibby, F. Leopardi, E. Strobert, J. B. Jenkins, et al. “Enhanced De Novo Alloantibody and Antibody-Mediated Injury in Rhesus Macaques.” In American Journal of Transplantation, 12:51–51. WILEY-BLACKWELL, 2012.
    Link to Item
  - Ruhil, R., B. Oh, V. T. Lu, O. P. Bulut, J. Kwun, S. Talebagha, S. Knechtle, and N. Iwakoshi. “Tacrolimus Inhibits Alloantibody and Plasma Cell Development but Permits Germinal Center Reaction and Accumulation of Memory B Cells: Implications for Humoral Rejection.” In American Journal of Transplantation, 12:53–53. WILEY-BLACKWELL, 2012.
    Link to Item
  - Ruhil, R., D. Sairsingh, O. P. Bulut, S. Talebagha, B. Oh, J. Kwun, V. T. Lu, S. Knechtle, and N. N. Iwakoshi. “Chronic Viral Infection Leads to Distinct Alloreactive B Cell Development and Sustained Allosensitization.” In American Journal of Transplantation, 12:40–40. WILEY-BLACKWELL, 2012.
    Link to Item
  - Ruhil, R., S. Talebagha, O. P. Bulut, B. Oh, D. Sairsingh, J. Kwun, V. T. Lu, S. Knechtle, and N. Iwakoshi. “Acute Viral Infection Mediates Allosensitization and Abrogates Humoral Tolerance.” In American Journal of Transplantation, 12:39–39. WILEY-BLACKWELL, 2012.
    Link to Item
  - Bulut, O. P., V. T. Lu, R. Ruhil, J. Kwun, E. Dai, S. J. Knechtle, and N. N. Iwakoshi. “mTOR Inhibition Abrogates Costimulation-Blockade Induced Suppression of Alloantibody.” In American Journal of Transplantation, 11:139–139. WILEY-BLACKWELL, 2011.
    Link to Item
  - Gupta, N. A., V. Kolachala, J. Kwun, B. Chandrasekharan, R. Romero, F. Anania, A. Kirk, and S. Knechtle. “GLP-1R Agonists Improve Hepatic Cell Survival in ob/ob Mice Undergoing Ischemia Reperfusion Injury.” In American Journal of Transplantation, 11:505–505. WILEY-BLACKWELL, 2011.
    Link to Item
  - Kim, D., J. Beus, A. Gibby, L. Kean, A. D. Kirk, S. J. Knechtle, and J. Kwun. “Differential Effect of Costimulation Blockade on the Primary vs. Latent Infection in Minor Mismatched Skin Transplantation.” In American Journal of Transplantation, 11:523–523. WILEY-BLACKWELL, 2011.
    Link to Item
  - Kim, E. J., J. Kwun, A. J. Page, F. Leopardi, A. C. Gibby, A. D. Kirk, and S. J. Knechtle. “A Non-Human Primate Model for Alloantibody Production after T Cell Depletion.” In American Journal of Transplantation, 11:369–369. WILEY-BLACKWELL, 2011.
    Link to Item
  - Kim, E. J., J. Kwun, A. J. Page, F. Leopardi, A. C. Gibby, A. D. Kirk, and S. J. Knechtle. “Alefacept Overcomes Memory T Cell Barrier after T Cell Depletion with a Novel Recombinant CD3-Immunotoxin (A-DmDT390-ScfbDb) in a Non-Human Primate Renal Transplantation Model.” In American Journal of Transplantation, 11:453–453. WILEY-BLACKWELL, 2011.
    Link to Item
  - Lu, V. T., O. P. Bulut, R. Ruhil, J. Kwun, E. Dai, and N. N. Iwakoshi. “Identification of Novel IgM and IgG Donor-Specific Memory B-Cells in Murine Models.” In American Journal of Transplantation, 11:369–369. WILEY-BLACKWELL, 2011.
    Link to Item
  - Gupta, Nitika A., Jean Kwun, Allan D. Kirk, Frank A. Anania, Rene Romero, and Stuart J. Knechtle. “ROLE OF GLP-1R AGONISTS IN DECREASING HEPATIC STEATOSIS AND APOPTOSIS IN OB/OB MICE UNDERGOING ISCHEMIA REPERFUSION INJURY.” In Hepatology, 52:1041A-1042A. WILEY-BLACKWELL, 2010.
    Link to Item
  - Gupta, Nitin, Ashish Kumar, Barjesh Sharma, and Shiv K. Sarin. “ADDITION OF PROBIOTICS TO PROPRANOLOL IMPROVES RESPONSE FOR PRIMARY PROPHYLAXIS OF VARICEAL BLEEDING IN PATIENTS WITH CIRRHOSIS AND LARGE ESOPHAGEAL VARICES.” In Hepatology, 52:1064A-1064A. WILEY-BLACKWELL, 2010.
    Link to Item
  - Jackson, J. A., A. Mohammed, J. Kwun, B. Zhao, C. Walsh, B. Button, J. Rossio, L. Kean, and Allan Kirk. “Stable Grafts: What Lurks beneath the Guise of a Stable Creatinine?” In American Journal of Transplantation, 10:192–93. WILEY-BLACKWELL PUBLISHING, INC, 2010.
    Link to Item
  - Kwun, Jean, Andrew Page, Frank Leopardi, Adriana Cardona, Allan D. Kirk, and Stuart J. Knechtle. “Limited Effect of a Novel Recombinant CD3-Immunotoxin (A-DmDT390-ScfbDb) in a Non-Human Primate Model.” In American Journal of Transplantation, 10:214–214. WILEY-BLACKWELL PUBLISHING, INC, 2010.
    Link to Item
  - Kwun, Jean, Neal Iwakoshi, Adriana Cardona, Dongwoon Kim, Justin Mendel, Allan D. Kirk, and Stuart J. Knechtle. “Abrogation of Alloreactive B Cells and Alloantibody after TACI-Ig Treatment in Alemtuzumab Treated CD52Tg Cardiac Allograft Recipient Mice.” In American Journal of Transplantation, 10:116–17. WILEY-BLACKWELL PUBLISHING, INC, 2010.
    Link to Item
  - Mendel, Brett, Jean Kwun, Adriana Cardona, Kate M. Smith, Allan D. Kirk, Stuart Knechtle, and Neal N. Iwakoshi. “Unique Alloreactive B-Cell Development in an Alemtuzumab Treated CD52 Transgenic Cardiac Allograft Recipient Mice.” In American Journal of Transplantation, 10:400–400. WILEY-BLACKWELL PUBLISHING, INC, 2010.
    Link to Item
  - Rao, Vinaya, Jean Kwun, Kurinji Singaravelu, Alicia Deiner, Stuart J. Knechtle, and Babu Padanilam. “PARP-1 Mediates Inflammation in Mouse Renal Transplants.” In American Journal of Transplantation, 10:498–498. WILEY-BLACKWELL PUBLISHING, INC, 2010.
    Link to Item
  - Dart, Melanie L., Melissa Keller, Jean Kwun, Drew A. Roenneburg, Jose Torrealba, Daniel Greenspan, and William J. Burlingham. “Th17 Mediated Autoimmunity to Collagen V Causes Acute Rejection Pathology and Adventitial Fibrosis in B6 Heart Isografts.” In American Journal of Transplantation, 9:625–625. WILEY-BLACKWELL PUBLISHING, INC, 2009.
    Link to Item
  - Haustein, Silke V., Jeffrey J. Sundblad, Jean Kwun, Drew A. Roenneburg, Glen E. Leverson, Huaizhong Hu, Jose R. Torrealba, and Stuart J. Knechtle. “Cytokine and chemokine production differ in acute rejection and recurrent hepatitis C after liver transplantation.” In American Journal of Transplantation, 8:634–634. BLACKWELL PUBLISHING, 2008.
    Link to Item
  - Kwun, Jean, Huaizhong Hu, Jose Torrealba, William J. Burlingham, and Stuart J. Knechtle. “Immunodominant H60-specific CD8 T cells play a key role in acute rejection but not in chronic allograft vasculopathy.” In American Journal of Transplantation, 8:251–251. BLACKWELL PUBLISHING, 2008.
    Link to Item
  - Kwun, Jean, Subramaniam Malarkannan, William J. Burlingham, and Stuart J. Knechtle. “Mechanisms of differential T cell immunodominance in organ transplantation.” In American Journal of Transplantation, 8:417–417. BLACKWELL PUBLISHING, 2008.
    Link to Item
  - Molitor, M. L., J. Andrassy, J. Kwun, H. A. Kayaoglu, Lynn D. Haynes, and W. J. Burlingham. “Tolerance to a heart allograft expressing non-inherited maternal antigens is associated with a CD4+CD25+, latent TGF-beta expressing T regulatory cell and IL-10.” In American Journal of Transplantation, 7:171–171. BLACKWELL PUBLISHING, 2007.
    Link to Item
  - Hazinedaroglu, S. M., T. Kanmaz, J. H. Fechner, J. Torrealba, W. Dar, J. Kwun, D. Hines, et al. “Monoclonal antibody targeting of CD4(+) and CD8(+) cells for prolongation of baboon renal allograft survival.” In American Journal of Transplantation, 5:422–422. BLACKWELL PUBLISHING, 2005.
    Link to Item
  - Huaizhong, H., B. D. Aizenstein, J. Kwun, M. M. Hamawy, and S. J. Knechtle. “Detection of acute and chronic injury in human renal transplants by a urinary cytokine/chemokine multiplex assay.” In American Journal of Transplantation, 5:436–436. BLACKWELL PUBLISHING, 2005.
    Link to Item
  - Hancock, W. W., T. Kanmaz, Y. C. Dong, W. Dar, J. Kwun, J. R. Rottman, S. X. Qin, et al. “Beneficial effects of targeting the CXCR3 chemokine receptor in non-human primate renal allograft recipients.” In American Journal of Transplantation, 4:287–287. BLACKWELL MUNKSGAARD, 2004.
    Link to Item
  - Kanmaz, T., P. Feng, J. Torrealba, J. Kwun, J. H. Fechner, J. M. Schultz, Y. C. Dong, et al. “Association of urinary excretion of the IP-10, MIG, and I-TAC with acute allograft rejection in baboon kidney transplantation.” In American Journal of Transplantation, 4:248–248. BLACKWELL MUNKSGAARD, 2004.
    Link to Item
Scholarly, Clinical, & Service Activities
Service to the Profession

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Grants

Selected Publications

Academic Articles

Other Articles

Conference Papers

Service to the Profession