Jean Kwun | Scholars@Duke

Jean Kwun
Assistant Professor of Surgery

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Current Appointments & Affiliations

Assistant Professor of Surgery, Surgery, Abdominal Transplant Surgery, Surgery 2015

Contact Information

362 Jones Building, 207 Research Dr, Durham, NC 27710
jean.kwun@duke.edu (919) 668-6792

Background
Education, Training, & Certifications
- Ph.D., University of Wisconsin at Madison 2007
Duke Appointment History
- Instructor, Temporary in the Department of Surgery, Surgery, Abdominal Transplant Surgery, Surgery 2015
Research
Selected Grants
- Prevention of Homograft Induced Cardiac Allograft Vasculopathy in Pediatric Heart Transplantation awarded by American Heart Association 2015 - 2018
- Thymus transplantation to induce tolerance to heart transplants awarded by Enzyvant Sciences Ltd. 2017 - 2018
- Transplant Tolerance in Non-Human Primates awarded by Emory University 2015 - 2017
- Preventing allograft rejection but not tolerance by blockade of the lymphocyte store-operated calcium channel awarded by Department of Defense 2016 - 2017
- Prevention of Homograft Induced Cardiac Allograft Vasculopathy in Pediatric Heart Transplantation awarded by Enduring Hearts 2015 - 2016
- Preventing allograft rejection but not tolerance by blockade of the lymphocyte store-operated calcium channel awarded by Synta Pharmaceuticals Corp. 2015 - 2016
- Inducible Regulatory B Cells in Transplantation Tolerance awarded by University of Wisconsin 2015 - 2016
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Ezekian, B, Kwun, J, Manook, M, Schroder, P, Yoon, J, Mulvihill, M, Freischlag, K, Park, J, Cochran, J, Kroning, K, Yi, J, and Knechtle, S. "Combination Proteasome Inhibition and Anti-BAFF Therapy Permits Highly Sensitized Rhesus Kidney Transplantation." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Ezekian, B, Kwun, J, Schroder, P, Manook, M, Yoon, J, Mulvihill, M, Freischlag, K, Cochran, J, Kroning, K, Yi, J, and Knechtle, S. "Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Freischlag, K, Ezekian, B, Schroder, P, Everitt, J, Yoon, J, Swiderska-Syn, M, Parker, W, Diehl, A, Kwun, J, and Knechtle, S. "Long-Term HIF-1 alpha Stabilization is Associated with Fibrosis in Rat Lung Allografts." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Kwun, J, Brian, E, Manook, M, Park, J, Freischlag, K, Yoon, J, Yi, J, Stegall, M, and Knechtle, S. "Targeting Plasma Cells with Anti-CD38mAb (Daratumumab) and CXCR4 Antagonist (Plerixafor) for Desensitization." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Kwun, J, Ezekian, B, Manook, M, Park, J, Yoon, J, Sloan-Lancaster, J, Fortier, C, Rao, P, and Knechtle, S. "Targeting Calcium Release-Activated Calcium (CRAC) Channel in Non-Human Primate Kidney Transplantation." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Kwun, J, Li, J, Rouse, C, Park, J, Kirk, A, and Markert, L. "Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Schroder, P, Ezekian, B, Saccoccio, F, Yoon, J, Dennis, M, Freischlag, K, Kwun, J, Permar, S, and Knechtle, S. "Humoral Immunity to CMV Remains Intact after Dual Targeting Desensitization in Allosensitized Nonhuman Primates." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Yoon, J, Ezekian, B, Manook, M, Kwun, J, and Knechtle, S. "Rhesus Monkey Have natural Antibody toward Swine That is Not Influenced by Allosensitization nor by Carfilzomib/tocilizumab." American Transplant Congress. Seattle, WA. June 2, 2018 - June 6, 2018.: WILEY, June 1, 2018. Link to Item
  - Driscoll, J, Knechtle, S, Kwun, J, Tremblay, S, Salomonis, N, Potter, S, Aronow, B, Manook, M, Alloway, R, Singh, H, and Woodle, E. "Induction of Proliferative Responses in B Cell and Plasma Cell Populations Following Proteasome Inhibitor Desensitization Treatment in Rhesus Macacques and Humans." April 2017. Link to Item
  - Ezekian, B, Kwun, J, Manook, M, Freischlag, K, Curfman, V, Branum, E, Park, J, Yi, J, Jordan, S, and Knechtle, S. "Dual Targeting with Carfilzomib and Tocilizumab Abrogates Antibody-Mediated Rejection and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation." April 2017. Link to Item
  - Kwun, J, Burghuber, C, Manook, M, Ezekian, B, Park, J, Freishlag, K, Yoon, J, Iwakoshi, N, Farris, A, and Knechtle, S. "Dual Targeting of Costimulation and Proteasome to Desensitize and Prolong Graft Survival of Sensitized Nonhuman Primates." April 2017. Link to Item
  - Kwun, J, Ezekian, B, Manook, M, Branum, E, Curfman, V, Park, J, Freishlag, K, Yoon, J, and Knechtle, S. "Effective Targeting Plasma Cells with Daratumumab (Anti-CD38) and Mozobil (Anti-CXCR4) in a Sensitized Non-Human Primate Model." April 2017. Link to Item
  - Kwun, J, Lee, J, Jackman, J, Manook, M, Elster, E, Kirk, A, and Sullenger, B. "Nucleic Acid Scavenging Microfiber Mesh Inhibits Trauma Induced Inflammation and Thrombosis After Organ Transplantation." April 2017. Link to Item
  - Manook, M, Kwun, J, Yoon, J, Samy, K, MacDonald, A, Xu, H, Smith, R, Dorling, A, Kirk, A, Mamode, N, and Knechtle, S. "Thrombalexin and Mirococept Synergistically Reduce IBMIR in a Porcine to Rhesus Xenoislet Model." April 2017. Link to Item
  - Manook, M, Kwun, J, Yoon, J, Samy, K, MacDonlad, A, Xu, H, Smith, R, Sacks, S, Dorling, A, Mamode, N, and Knechtle, S. "Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation." April 2017. Link to Item
  - Kwun, J, Burghuber, C, Iwakoshi, N, Gibby, A, and Knechtle, S. "Limited Efficacy of Bortezomib on Desensitization via Rapid Humoral Compensation in a Sensitized Rhesus Model." June 2016. Link to Item
  - Kwun, J, Burghuber, C, Manook, M, Clark, A, Chen, D, and Knechtle, S. "Utilizing HLA Single Antigen Flow Beads Assays to Evaluate Anti-MAMU Antibody in Sensitized Nonhuman Primate Model." June 2016. Link to Item
  - Manook, M, Kwun, J, Yoon, J, Sacks, S, Dorling, A, Mamode, N, Smith, R, and Knechtle, S. "Thrombalexin: Detection & Efficacy of a Membrane-Bound Anti-Thrombin Agent." June 2016. Link to Item
  - Burghuber, CK, Kwun, J, Kim, EJ, Leopardi, FV, Gibby, AC, Iwakoshi, NN, and Knechtle, SJ. "NEW DESENSITIZATION STRATEGY IN A KIDNEY TRANSPLANTATION MODEL WITH RHESUS MONKEYS." October 2015. Link to Item
  - Burghuber, C, Kwun, J, Gibby, A, Iwakoshi, N, and Knechtle, S. "MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation." May 2015. Link to Item
  - Burghuber, C, Kwun, J, Leopardi, F, Gibby, A, Farris, A, Iwakoshi, N, and Knechtle, S. "Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization." May 2015. Link to Item
  - Burghuber, C, Kwun, J, Page, E, Gibby, A, Leopardi, F, Farris, A, Iwakoshi, N, and Knechtle, S. "Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation." May 2015. Link to Item
  - Burghuber, C, Kwun, J, Page, E, Leopardi, F, Gibby, A, Farris, A, Iwakoshi, N, and Knechtle, S. "T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques." May 2015. Link to Item
  - Kwun, J, Burghuber, C, Page, E, Gibby, A, Iwakoshi, N, and Knechtle, S. "Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival." May 2015. Link to Item
  - Kwun, J, Oh, B, Song, H, Farris, A, Kirk, A, Mahle, W, and Knechtle, S. "LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection." May 2015. Link to Item
  - Mou, D, Espinosa, J, Stempora, L, Kwun, J, Iwakoshi, N, and Kirk, A. "Virus Induced CD28 Down-Regulation as a Potential Driver of Costimulation Blockade Resistant Rejection." May 2015. Link to Item
  - Burghuber, C, Kim, E, Kwun, J, Leopardi, F, Gibby, A, Strobert, E, Iwakoshi, N, and Knechtle, S. "Developing a Nonhuman Primate Model of Sensitization." July 15, 2014. Link to Item
  - Burghuber, C, Kwun, J, Kim, E, Leopardi, F, Gibby, A, Strobert, E, Iwakoshi, N, Wakwe, W, Adams, A, and Knechtle, S. "First Experiences With Kidney Transplantation in a Model of Sensitized Rhesus Macaques." July 15, 2014. Link to Item
  - Kwun, J, Burghuber, C, Page, E, Gibby, A, Iwakoshi, N, and Knechtle, S. "Successful Desensitization With Combination of Costimulation Blockade and Bortezomib Via Regulating Plasma Cells and Follicular Helper T Cells in Sensitized Rhesus Model." July 15, 2014. Link to Item
  - Kwun, J, Oh, B, MaConmara, M, Song, H, and Knechtle, S. "The Role of Splenic CD4(+)CD25(+) T reg Cells On Alloreactive B Cell Formation and DSA Production in a Murine CAMR Model." July 15, 2014. Link to Item
  - Kwun, J, Page, E, Gibby, A, and Knechtle, S. "The Effect of CCR5 Blockade On De Novo DSA and Long-Term Graft Survival in Non-Human Primate AMR Model." July 15, 2014. Link to Item
  - Kwun, J, Page, E, Gibby, A, Hong, J, Farris, A, Villinger, F, and Knechtle, S. "The Effect of Neutralizing BAFF With Atacicept in a T Cell Depletion-Induced Nonhuman Primate AMR Model." July 2014. Full Text
  - Burghuber, C, Kim, E, Kwun, J, Leopardi, F, Gibby, A, Strobert, E, Iwakoshi, N, and Knechtle, S. "Developing a Nonhuman Primate Model of Sensitization." June 2014. Link to Item
  - Burghuber, C, Kwun, J, Kim, E, Leopardi, F, Gibby, A, Strobert, E, Iwakoshi, N, Wakwe, W, Adams, A, and Knechtle, S. "First Experiences With Kidney Transplantation in a Model of Sensitized Rhesus Macaques." June 2014. Link to Item
  - Kwun, J, Burghuber, C, Page, E, Gibby, A, Iwakoshi, N, and Knechtle, S. "Successful Desensitization With Combination of Costimulation Blockade and Bortezomib Via Regulating Plasma Cells and Follicular Helper T Cells in Sensitized Rhesus Model." June 2014. Link to Item
  - Kwun, J, Oh, B, MaConmara, M, Song, H, and Knechtle, S. "The Role of Splenic CD4(+)CD25(+) T reg Cells On Alloreactive B Cell Formation and DSA Production in a Murine CAMR Model." June 2014. Link to Item
  - Kwun, J, Page, E, Gibby, A, Hong, J, Farris, A, Villinger, F, and Knechtle, S. "The Effect of Neutralizing BAFF With Atacicept in a T Cell Depletion-Induced Nonhuman Primate AMR Model." June 2014. Link to Item
  - Kwun, J, Page, E, Gibby, A, and Knechtle, S. "The Effect of CCR5 Blockade On De Novo DSA and Long-Term Graft Survival in Non-Human Primate AMR Model." June 2014. Link to Item
  - Kwun, J, Oh, B, Gibby, A, Page, E, Iwakoshi, N, and Knechtle, S. "The Role of CD4(+)CD25(+) T reg Cells on Allo-B Cell Formation and DSA Production in a Chronic Rejection Model after T Cell Depletion." April 2013. Link to Item
  - Kwun, J, Page, E, Gibby, A, Hong, J, Farris, A, Adams, A, Iwakoshi, N, Larsen, C, Kirk, A, and Knechtle, S. "Follicular Helper T Cell Modulation by Costimulation Blockade Prevents Antibody-Mediated Rejection in Nonhuman Primate Renal Transplantation." April 2013. Link to Item
  - Kwun, J, Page, E, Gibby, A, Iwakoshi, N, and Knechtle, S. "The Effect of Belatacept on Follicular Helper T Cell and Humoral Response in Sensitized Rhesus Macaques." April 2013. Link to Item
  - Oh, B, Kwun, J, Ruhil, R, Gibby, A, Kirk, A, Knechtle, S, and Iwakoshi, N. "CTLA-4 Ig Prevents Chronic Antibody-Mediated Rejection." April 2013. Link to Item
  - Oh, B, Kwun, J, Ruhil, R, Gibby, A, Page, E, III, FA, Kirk, A, Iwakoshi, N, and Knechtle, S. "Rapamycin Enhances Early Alloantibody Production by Hampering the Homeostatic Proliferation of Regulatory T Cells." April 2013. Link to Item
  - Oh, B, Ruhil, R, Bulut, O, Kwun, J, Kirk, A, Knechtle, S, and Iwakoshi, N. "The Effects of Viral Infection on Chronic Anti-Mediated Rejection." April 2013. Link to Item
  - Page, E, Kwun, J, Gibby, A, Knechtle, S, and Iwakoshi, N. "Immunophenotyping and Targeting of Plasma Cells in Sensitized Nonhuman Primates." April 2013. Link to Item
  - Page, E, Kwun, J, Gibby, A, Oh, B, Iwakoshi, N, and Knechtle, S. "The Development of a Nonhuman Primate Model of Sensitization after Transplantation." April 2013. Link to Item
  - Kwun, J, Oh, B, Gibby, A, Iwakoshi, N, and Knechtle, SJ. "The Role of CD4(+)CD25(+) T reg Cells on Alloantibody Production in a Model of Chronic Rejection after T Cell Depletion." May 2012. Link to Item
  - Kwun, J, Oh, B, Gibby, A, Ruhil, R, Lu, V, Bulut, OP, Song, M, Page, E, Kim, D, Farris, AB, Kirk, AD, Knechtle, SJ, and Iwakoshi, NN. "Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection after Alemtuzumab Treatment." May 2012. Link to Item
  - Oh, B, Kwun, J, Ruhil, R, Gibby, A, Page, E, Lu, V, Kim, D, Bulut, OP, III, FA, Kirk, AD, Knechtle, SJ, and Iwakoshi, NN. "Rapamycin Enhances Donor-Specific Antibody and Chronic Rejection of Full MHC Mismatched Cardiac Allografts after Alemtuzumab Treatment." May 2012. Link to Item
  - Page, EK, Gibby, AC, Kwun, J, Leopardi, F, Adams, AB, Courtney, CL, Jenkins, JB, Strobert, E, Iwakoshi, N, and Knechtle, SJ. "Belatacept Prevents De Novo Alloantibody Production in Rhesus Macaques." May 2012. Link to Item
  - Page, EK, Page, AJ, Kwun, J, Gibby, AC, Leopardi, F, Strobert, E, Jenkins, JB, Song, M, Hennigar, RA, Iwakoshi, N, and Knechtle, SJ. "Enhanced De Novo Alloantibody and Antibody-Mediated Injury in Rhesus Macaques." May 2012. Link to Item
  - Ruhil, R, Oh, B, Lu, VT, Bulut, OP, Kwun, J, Talebagha, S, Knechtle, S, and Iwakoshi, N. "Tacrolimus Inhibits Alloantibody and Plasma Cell Development but Permits Germinal Center Reaction and Accumulation of Memory B Cells: Implications for Humoral Rejection." May 2012. Link to Item
  - Ruhil, R, Sairsingh, D, Bulut, OP, Talebagha, S, Oh, B, Kwun, J, Lu, VT, Knechtle, S, and Iwakoshi, NN. "Chronic Viral Infection Leads to Distinct Alloreactive B Cell Development and Sustained Allosensitization." May 2012. Link to Item
  - Ruhil, R, Talebagha, S, Bulut, OP, Oh, B, Sairsingh, D, Kwun, J, Lu, VT, Knechtle, S, and Iwakoshi, N. "Acute Viral Infection Mediates Allosensitization and Abrogates Humoral Tolerance." May 2012. Link to Item
  - Bulut, OP, Lu, VT, Ruhil, R, Kwun, J, Dai, E, Knechtle, SJ, and Iwakoshi, NN. "mTOR Inhibition Abrogates Costimulation-Blockade Induced Suppression of Alloantibody." April 2011. Link to Item
  - Gupta, NA, Kolachala, V, Kwun, J, Chandrasekharan, B, Romero, R, Anania, F, Kirk, A, and Knechtle, S. "GLP-1R Agonists Improve Hepatic Cell Survival in ob/ob Mice Undergoing Ischemia Reperfusion Injury." April 2011. Link to Item
  - Kim, D, Beus, J, Gibby, A, Kean, L, Kirk, AD, Knechtle, SJ, and Kwun, J. "Differential Effect of Costimulation Blockade on the Primary vs. Latent Infection in Minor Mismatched Skin Transplantation." April 2011. Link to Item
  - Kim, EJ, Kwun, J, Page, AJ, Leopardi, F, Gibby, AC, Kirk, AD, and Knechtle, SJ. "A Non-Human Primate Model for Alloantibody Production after T Cell Depletion." April 2011. Link to Item
  - Kim, EJ, Kwun, J, Page, AJ, Leopardi, F, Gibby, AC, Kirk, AD, and Knechtle, SJ. "Alefacept Overcomes Memory T Cell Barrier after T Cell Depletion with a Novel Recombinant CD3-Immunotoxin (A-DmDT390-ScfbDb) in a Non-Human Primate Renal Transplantation Model." April 2011. Link to Item
  - Lu, VT, Bulut, OP, Ruhil, R, Kwun, J, Dai, E, and Iwakoshi, NN. "Identification of Novel IgM and IgG Donor-Specific Memory B-Cells in Murine Models." April 2011. Link to Item
  - Gupta, N, Kumar, A, Sharma, B, and Sarin, SK. "ADDITION OF PROBIOTICS TO PROPRANOLOL IMPROVES RESPONSE FOR PRIMARY PROPHYLAXIS OF VARICEAL BLEEDING IN PATIENTS WITH CIRRHOSIS AND LARGE ESOPHAGEAL VARICES." October 2010. Link to Item
  - Gupta, NA, Kwun, J, Kirk, AD, Anania, FA, Romero, R, and Knechtle, SJ. "ROLE OF GLP-1R AGONISTS IN DECREASING HEPATIC STEATOSIS AND APOPTOSIS IN OB/OB MICE UNDERGOING ISCHEMIA REPERFUSION INJURY." October 2010. Link to Item
  - Jackson, JA, Mohammed, A, Kwun, J, Zhao, B, Walsh, C, Button, B, Rossio, J, Kean, L, and Kirk, A. "Stable Grafts: What Lurks beneath the Guise of a Stable Creatinine?." April 2010. Link to Item
  - Kwun, J, Iwakoshi, N, Cardona, A, Kim, D, Mendel, J, Kirk, AD, and Knechtle, SJ. "Abrogation of Alloreactive B Cells and Alloantibody after TACI-Ig Treatment in Alemtuzumab Treated CD52Tg Cardiac Allograft Recipient Mice." April 2010. Link to Item
  - Kwun, J, Page, A, Leopardi, F, Cardona, A, Kirk, AD, and Knechtle, SJ. "Limited Effect of a Novel Recombinant CD3-Immunotoxin (A-DmDT390-ScfbDb) in a Non-Human Primate Model." April 2010. Link to Item
  - Mendel, B, Kwun, J, Cardona, A, Smith, KM, Kirk, AD, Knechtle, S, and Iwakoshi, NN. "Unique Alloreactive B-Cell Development in an Alemtuzumab Treated CD52 Transgenic Cardiac Allograft Recipient Mice." April 2010. Link to Item
  - Rao, V, Kwun, J, Singaravelu, K, Deiner, A, Knechtle, SJ, and Padanilam, B. "PARP-1 Mediates Inflammation in Mouse Renal Transplants." April 2010. Link to Item
  - Dart, ML, Keller, M, Kwun, J, Roenneburg, DA, Torrealba, J, Greenspan, D, and Burlingham, WJ. "Th17 Mediated Autoimmunity to Collagen V Causes Acute Rejection Pathology and Adventitial Fibrosis in B6 Heart Isografts." 2009. Link to Item
  - Haustein, SV, Sundblad, JJ, Kwun, J, Roenneburg, DA, Leverson, GE, Hu, H, Torrealba, JR, and Knechtle, SJ. "Cytokine and chemokine production differ in acute rejection and recurrent hepatitis C after liver transplantation." May 2008. Link to Item
  - Kwun, J, Hu, H, Torrealba, J, Burlingham, WJ, and Knechtle, SJ. "Immunodominant H60-specific CD8 T cells play a key role in acute rejection but not in chronic allograft vasculopathy." May 2008. Link to Item
  - Kwun, J, Malarkannan, S, Burlingham, WJ, and Knechtle, SJ. "Mechanisms of differential T cell immunodominance in organ transplantation." May 2008. Link to Item
  - Molitor, ML, Andrassy, J, Kwun, J, Kayaoglu, HA, Haynes, LD, and Burlingham, WJ. "Tolerance to a heart allograft expressing non-inherited maternal antigens is associated with a CD4+CD25+, latent TGF-beta expressing T regulatory cell and IL-10." May 2007. Link to Item
  - Hazinedaroglu, SM, Kanmaz, T, Fechner, JH, Torrealba, J, Dar, W, Kwun, J, Hines, D, Ching, SM, Ponath, P, Rao, PE, Ringler, DJ, Waldmann, H, Kim, HT, Dong, Y, Baba, F, Oberly, TD, Schultz, JM, Hu, HH, Hamawy, MM, and Knechtle, SJ. "Monoclonal antibody targeting of CD4(+) and CD8(+) cells for prolongation of baboon renal allograft survival." May 2005. Link to Item
  - Huaizhong, H, Aizenstein, BD, Kwun, J, Hamawy, MM, and Knechtle, SJ. "Detection of acute and chronic injury in human renal transplants by a urinary cytokine/chemokine multiplex assay." May 2005. Link to Item
  - Hancock, WW, Kanmaz, T, Dong, YC, Dar, W, Kwun, J, Rottman, JR, Qin, SX, Newman, W, Ye, QR, Torrealba, JR, Fechner, JH, and Knechtle, SJ. "Beneficial effects of targeting the CXCR3 chemokine receptor in non-human primate renal allograft recipients." 2004. Link to Item
  - Kanmaz, T, Feng, P, Torrealba, J, Kwun, J, Fechner, JH, Schultz, JM, Dong, YC, Kim, HT, Dar, W, Hamawy, MM, Knechtle, SJ, and Hu, HZ. "Association of urinary excretion of the IP-10, MIG, and I-TAC with acute allograft rejection in baboon kidney transplantation." 2004. Link to Item
- Journal Articles
  - Burghuber, CK, Manook, M, Ezekian, B, Gibby, AC, Leopardi, FV, Song, M, Jenks, J, Saccoccio, F, Permar, S, Farris, AB, Iwakoshi, NN, Kwun, J, and Knechtle, SJ. "Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons (August 13, 2018). Full Text
  - Ezekian, B, Schroder, PM, Freischlag, K, Yoon, J, Kwun, J, and Knechtle, SJ. "Contemporary Strategies and Barriers to Transplantation Tolerance." Transplantation 102, no. 8 (August 2018): 1213-1222. Full Text
  - Manook, M, Kwun, J, Sacks, S, Dorling, A, Mamode, N, and Knechtle, S. "Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient." Transplantation Reviews (Orlando, Fla.) 32, no. 3 (July 2018): 119-126. (Review) Full Text
  - "Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119." Blood advances 2, no. 2 (January 2018): 89-. Full Text
  - Eppensteiner, J, Davis, RP, Barbas, AS, Kwun, J, and Lee, J. "Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults." Frontiers in Immunology 9 (January 2018): 190-null. (Review) Full Text
  - Kwun, J, Park, J, Yi, JS, Farris, AB, Kirk, AD, and Knechtle, SJ. "IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade." Frontiers in Immunology 9 (January 2018): 2323-null. Full Text
  - "Erratum." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 11 (November 2017): 2993-. Full Text
  - Kwun, J, Burghuber, C, Manook, M, Ezekian, B, Park, J, Yoon, J, Yi, JS, Iwakoshi, N, Gibby, A, Hong, JJ, Farris, AB, Kirk, AD, and Knechtle, SJ. "Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates." Blood advances 1, no. 24 (November 2017): 2115-2119. Full Text
  - Manook, M, Kwun, J, Burghuber, C, Samy, K, Mulvihill, M, Yoon, J, Xu, H, MacDonald, AL, Freischlag, K, Curfman, V, Branum, E, Howell, D, Farris, AB, Smith, RA, Sacks, S, Dorling, A, Mamode, N, and Knechtle, SJ. "Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 8 (August 2017): 2055-2064. Full Text
  - Kwun, J, Burghuber, C, Manook, M, Iwakoshi, N, Gibby, A, Hong, JJ, and Knechtle, S. "Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients." Journal of the American Society of Nephrology : Jasn 28, no. 7 (July 2017): 1991-1996. Full Text
  - Kwun, J, Manook, M, Page, E, Burghuber, C, Hong, J, and Knechtle, SJ. "Crosstalk Between T and B Cells in the Germinal Center After Transplantation." Transplantation 101, no. 4 (April 2017): 704-712. (Review) Full Text
  - Lee, J, Jackman, JG, Kwun, J, Manook, M, Moreno, A, Elster, EA, Kirk, AD, Leong, KW, and Sullenger, BA. "Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis." Biomaterials 120 (March 2017): 94-102. Full Text
  - George, RP, Mehta, AK, Perez, SD, Winterberg, P, Cheeseman, J, Johnson, B, Kwun, J, Monday, S, Stempora, L, Warshaw, B, and Kirk, AD. "Premature T Cell Senescence in Pediatric CKD." Journal of the American Society of Nephrology : JASN 28, no. 1 (January 2017): 359-367. Full Text
  - Schroder, PM, Ezekian, B, Ford, M, Knechtle, SJ, and Kwun, J. "Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation." Frontiers in immunology 8 (January 2017): 1615-. Full Text Open Access Copy
  - Oh, B, Yoon, J, Farris, A, Kirk, A, Knechtle, S, and Kwun, J. "Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 9 (September 2016): 2612-2623. Full Text Open Access Copy
  - Burghuber, CK, Kwun, J, Page, EJ, Manook, M, Gibby, AC, Leopardi, FV, Song, M, Farris, AB, Hong, JJ, Villinger, F, Adams, AB, Iwakoshi, NN, and Knechtle, SJ. "Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 6 (June 2016): 1726-1738. Full Text
  - Kwun, J, Farris, AB, Song, H, Mahle, WT, Burlingham, WJ, and Knechtle, SJ. "Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft." Transplantation 99, no. 12 (December 2015): 2485-2493. Full Text Open Access Copy
  - Kwun, J, Page, E, Hong, JJ, Gibby, A, Yoon, J, Farris, AB, Villinger, F, and Knechtle, S. "Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 3 (March 2015): 815-822. Full Text Open Access Copy
  - Kim, EJ, Kwun, J, Gibby, AC, Hong, JJ, Farris, AB, Iwakoshi, NN, Villinger, F, Kirk, AD, and Knechtle, SJ. "Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 1 (January 2014): 59-69. Full Text Open Access Copy
  - Page, E, Kwun, J, Oh, B, and Knechtle, S. "Lymphodepletional strategies in transplantation." Cold Spring Harbor Perspectives in Medicine 3, no. 7 (July 2013). (Review) Full Text
  - Kwun, J, Oh, BC, Gibby, AC, Ruhil, R, Lu, VT, Kim, DW, Page, EK, Bulut, OP, Song, MQ, Farris, AB, Kirk, AD, Knechtle, SJ, and Iwakoshi, NN. "Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 12, no. 10 (October 2012): 2641-2651. Full Text Open Access Copy
  - Page, EK, Page, AJ, Kwun, J, Gibby, AC, Leopardi, F, Jenkins, JB, Strobert, EA, Song, M, Hennigar, RA, Iwakoshi, N, and Knechtle, SJ. "Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 12, no. 9 (September 2012): 2395-2405. Full Text Open Access Copy
  - Kwun, J, Bulut, P, Kim, E, Dar, W, Oh, B, Ruhil, R, Iwakoshi, N, and Knechtle, SJ. "The role of B cells in solid organ transplantation." Seminars in immunology 24, no. 2 (April 2012): 96-108. (Review) Full Text Open Access Copy
  - Kwun, J, Malarkannan, S, Burlingham, WJ, and Knechtle, SJ. "Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation." Journal of Immunology (Baltimore, Md. : 1950) 187, no. 8 (October 2011): 3997-4006. Full Text Open Access Copy
  - Haustein, S, Kwun, J, Fechner, J, Kayaoglu, A, Faure, J-P, Roenneburg, D, Torrealba, J, and Knechtle, SJ. "Interleukin-15 receptor blockade in non-human primate kidney transplantation." Transplantation 89, no. 8 (April 2010): 937-944. Full Text Open Access Copy
  - Kwun, J, and Knechtle, SJ. "Overcoming Chronic Rejection-Can it B?." Transplantation 88, no. 8 (October 2009): 955-961. (Review) Full Text
  - Bloom, D, Chang, Z, Pauly, K, Kwun, J, Fechner, J, Hayes, C, Samaniego, M, and Knechtle, S. "BAFF is increased in renal transplant patients following treatment with alemtuzumab." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 9, no. 8 (August 2009): 1835-1845. Full Text
  - Hu, H, Kwun, J, Aizenstein, BD, and Knechtle, SJ. "Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine." Transplantation 87, no. 12 (June 2009): 1814-1820. Full Text
  - Knechtle, SJ, Pascual, J, Bloom, DD, Torrealba, JR, Jankowska-Gan, E, Burlingham, WJ, Kwun, J, Colvin, RB, Seyfert-Margolis, V, Bourcier, K, and Sollinger, HW. "Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 9, no. 5 (May 2009): 1087-1098. Full Text
  - Knechtle, SJ, and Kwun, J. "Unique aspects of rejection and tolerance in liver transplantation." Seminars in Liver Disease 29, no. 1 (February 23, 2009): 91-101. (Review) Full Text
  - Bloom, DD, Pauly, K, Chang, Z, Fechner, JH, Kwun, J, Samaniego, M, and Knechtle, SJ. "BAFF Dysregulation in Renal Transplant Patients Treated with Campath-1H." AMERICAN JOURNAL OF TRANSPLANTATION 9 (2009): 226-226. Link to Item
  - Kwun, J, Hazinedaroglu, SM, Schadde, E, Kayaoglu, HA, Fechner, J, Hu, HZ, Roenneburg, D, Torrealba, J, Shiao, L, Hong, X, Peng, R, Szewczyk, JW, Sullivan, KA, DeMartino, J, and Knechtle, SJ. "Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 8, no. 8 (August 2008): 1593-1603. Full Text
  - Kwun, J, Hu, H, Schadde, E, Roenneburg, D, Sullivan, KA, DeMartino, J, Burlingham, WJ, and Knechtle, SJ. "Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients." Journal of immunology (Baltimore, Md. : 1950) 179, no. 12 (December 2007): 8016-8025. Full Text
  - Molitor-Dart, ML, Andrassy, J, Kwun, J, Kayaoglu, HA, Roenneburg, DA, Haynes, LD, Torrealba, JR, Bobadilla, JL, Sollinger, HW, Knechtle, SJ, and Burlingham, WJ. "Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance." Journal of Immunology (Baltimore, Md. : 1950) 179, no. 10 (November 2007): 6749-6761. Full Text
  - Kwun, J, Knechtle, SJ, and Hu, H. "Determination of the functional status of alloreactive T cells by interferon-gamma kinetics." Transplantation 81, no. 4 (February 2006): 590-598. Full Text
  - Kanmaz, T, Feng, P, Torrealba, J, Kwun, J, Fechner, JH, Schultz, JM, Dong, Y, Kim, HT, Dar, W, Hamawy, MM, Knechtle, SJ, and Hu, H. "Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine." Transplantation 78, no. 7 (October 2004): 1002-1007. Full Text
- Other Articles
  - Knechtle, SJ, Kwun, J, and Iwakoshi, N. "Prevention trumps treatment of antibody-mediated transplant rejection." The Journal of Clinical Investigation 120, no. 4 (April 2010): 1036-1039. Full Text Open Access Copy

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