Research Interests
Our research program focuses on modulating the pre-formed alloimmune response to donor antigen in sensitized recipients. Advances in organ transplantation, B cell immunology, and hematologic malignancy research led me to expand my goals to include identifying strategies for both desensitization and treating AMR by targeting components of the post-transplant humoral immune response. In addition, we applied the knowledge gained by studying the alloimmune response to xenotransplantation, with the goal of improving long-term outcomes of kidney xenotransplantation by decreasing xeno-reactive antibodies as well as alleviating post-xenotransplant AMR.
The six primary research interests of TIRTL are,
- Pre-clinical models for organ transplantation
- Desensitization strategies – Preclinical/Clinical
- Xenotransplantation
- Antibody-mediated rejection (AMR) treatment
- Optimal immunosuppression
- Tolerance