Vitamin A supply and biochemical development of the rat heart: studies on cellular DNA, RNA and protein.

Journal Article

The effect of restricted vitamin A supply to the mother on the biochemical development of the heart in rats has been studied. The vitamin A status of female rats was varied by supplying low, medium and adequate amounts (6, 40, 100 micrograms retinol/day/kg body weight respectively) of vitamin A during pregnancy and suckling. The vitamin A status of the mother caused an alteration in the developmental pattern of fetal heart in parameters of tissue weight, DNA, RNA and protein contents and the biosynthesis of DNA and protein from [3H]-thymidine and [3H]-leucine respectively. A dose-dependent effect of vitamin A on the metabolism of DNA, RNA and protein was observed in the developing rat hearts. Hence, emphasis should be given to the adequate availability of vitamin A to dams for the normal growth and development of fetal organs.

Full Text

Duke Authors

Cited Authors

  • Sharma, HS; Misra, UK

Published Date

  • June 1988

Published In

Volume / Issue

  • 27 / 2

Start / End Page

  • 119 - 125

PubMed ID

  • 2462768

International Standard Serial Number (ISSN)

  • 0044-264X

Digital Object Identifier (DOI)

  • 10.1007/bf02021651

Language

  • eng