Optimized temporal pattern of brain stimulation designed by computational evolution.

Journal Article (Journal Article)

Brain stimulation is a promising therapy for several neurological disorders, including Parkinson's disease. Stimulation parameters are selected empirically and are limited to the frequency and intensity of stimulation. We varied the temporal pattern of deep brain stimulation to ameliorate symptoms in a parkinsonian animal model and in humans with Parkinson's disease. We used model-based computational evolution to optimize the stimulation pattern. The optimized pattern produced symptom relief comparable to that from standard high-frequency stimulation (a constant rate of 130 or 185 Hz) and outperformed frequency-matched standard stimulation in a parkinsonian rat model and in patients. Both optimized and standard high-frequency stimulation suppressed abnormal oscillatory activity in the basal ganglia of rats and humans. The results illustrate the utility of model-based computational evolution of temporal patterns to increase the efficiency of brain stimulation in treating Parkinson's disease and thereby reduce the energy required for successful treatment below that of current brain stimulation paradigms.

Full Text

Duke Authors

Cited Authors

  • Brocker, DT; Swan, BD; So, RQ; Turner, DA; Gross, RE; Grill, WM

Published Date

  • January 4, 2017

Published In

Volume / Issue

  • 9 / 371

PubMed ID

  • 28053151

Pubmed Central ID

  • PMC5516784

Electronic International Standard Serial Number (EISSN)

  • 1946-6242

Digital Object Identifier (DOI)

  • 10.1126/scitranslmed.aah3532


  • eng

Conference Location

  • United States