Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.
Journal Article (Journal Article)
A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.
Full Text
Duke Authors
Cited Authors
- Walker, C; Goldsworthy, TL; Wolf, DC; Everitt, J
Published Date
- March 27, 1992
Published In
Volume / Issue
- 255 / 5052
Start / End Page
- 1693 - 1695
PubMed ID
- 1553556
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.1553556
Language
- eng
Conference Location
- United States