Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.

Journal Article (Journal Article)

A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.

Full Text

Duke Authors

Cited Authors

  • Walker, C; Goldsworthy, TL; Wolf, DC; Everitt, J

Published Date

  • March 27, 1992

Published In

Volume / Issue

  • 255 / 5052

Start / End Page

  • 1693 - 1695

PubMed ID

  • 1553556

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1553556


  • eng

Conference Location

  • United States