Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.
Publication
, Journal Article
Walker, C; Goldsworthy, TL; Wolf, DC; Everitt, J
Published in: Science
March 27, 1992
A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
March 27, 1992
Volume
255
Issue
5052
Start / End Page
1693 / 1695
Location
United States
Related Subject Headings
- Rats, Mutant Strains
- Rats
- Kidney Neoplasms
- Kidney Cortex
- General Science & Technology
- Disease Models, Animal
- Dimethylnitrosamine
- Carcinoma, Renal Cell
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Walker, C., Goldsworthy, T. L., Wolf, D. C., & Everitt, J. (1992). Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene. Science, 255(5052), 1693–1695. https://doi.org/10.1126/science.1553556
Walker, C., T. L. Goldsworthy, D. C. Wolf, and J. Everitt. “Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.” Science 255, no. 5052 (March 27, 1992): 1693–95. https://doi.org/10.1126/science.1553556.
Walker C, Goldsworthy TL, Wolf DC, Everitt J. Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene. Science. 1992 Mar 27;255(5052):1693–5.
Walker, C., et al. “Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.” Science, vol. 255, no. 5052, Mar. 1992, pp. 1693–95. Pubmed, doi:10.1126/science.1553556.
Walker C, Goldsworthy TL, Wolf DC, Everitt J. Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene. Science. 1992 Mar 27;255(5052):1693–1695.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
March 27, 1992
Volume
255
Issue
5052
Start / End Page
1693 / 1695
Location
United States
Related Subject Headings
- Rats, Mutant Strains
- Rats
- Kidney Neoplasms
- Kidney Cortex
- General Science & Technology
- Disease Models, Animal
- Dimethylnitrosamine
- Carcinoma, Renal Cell
- Animals