High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets.

Journal Article (Journal Article)

Severe degenerative myocardial disease occurred in female C3H/OUJ mice fed purified diets for 36 weeks; the diet contained 5% or 20% fat as non-hydrogenated soybean oil. Deaths of lactating females of this group (17/35 high fat diet and 7/35 low fat diet animals) were due to sudden cardiovascular collapse. Cardiomegaly with marked atrial and ventricular myocardial mineralization was seen at necropsy. Histologically, the random, myopathic foci were characterized by severe myocardial degeneration, mineralization, and fibrosis. Mural thrombosis, pulmonary arteriosclerosis, and mild myocardial inflammatory cell infiltrates were also present. Pathological changes were similar to those of dystrophic cardiac calcinosis, an incidental necropsy finding in certain mouse strains.

Full Text

Duke Authors

Cited Authors

  • Everitt, JI; Olson, LM; Mangum, JB; Visek, WJ

Published Date

  • March 1988

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 113 - 118

PubMed ID

  • 3363788

International Standard Serial Number (ISSN)

  • 0300-9858

Digital Object Identifier (DOI)

  • 10.1177/030098588802500202


  • eng

Conference Location

  • United States