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High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets.

Publication ,  Journal Article
Everitt, JI; Olson, LM; Mangum, JB; Visek, WJ
Published in: Vet Pathol
March 1988

Severe degenerative myocardial disease occurred in female C3H/OUJ mice fed purified diets for 36 weeks; the diet contained 5% or 20% fat as non-hydrogenated soybean oil. Deaths of lactating females of this group (17/35 high fat diet and 7/35 low fat diet animals) were due to sudden cardiovascular collapse. Cardiomegaly with marked atrial and ventricular myocardial mineralization was seen at necropsy. Histologically, the random, myopathic foci were characterized by severe myocardial degeneration, mineralization, and fibrosis. Mural thrombosis, pulmonary arteriosclerosis, and mild myocardial inflammatory cell infiltrates were also present. Pathological changes were similar to those of dystrophic cardiac calcinosis, an incidental necropsy finding in certain mouse strains.

Duke Scholars

Published In

Vet Pathol

DOI

ISSN

0300-9858

Publication Date

March 1988

Volume

25

Issue

2

Start / End Page

113 / 118

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Sex Factors
  • Rodent Diseases
  • Pregnancy
  • Myocardium
  • Mice, Inbred C3H
  • Mice
  • Male
  • Female
  • Dietary Fats
 

Citation

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Everitt, J. I., Olson, L. M., Mangum, J. B., & Visek, W. J. (1988). High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets. Vet Pathol, 25(2), 113–118. https://doi.org/10.1177/030098588802500202
Everitt, J. I., L. M. Olson, J. B. Mangum, and W. J. Visek. “High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets.Vet Pathol 25, no. 2 (March 1988): 113–18. https://doi.org/10.1177/030098588802500202.
Everitt JI, Olson LM, Mangum JB, Visek WJ. High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets. Vet Pathol. 1988 Mar;25(2):113–8.
Everitt, J. I., et al. “High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets.Vet Pathol, vol. 25, no. 2, Mar. 1988, pp. 113–18. Pubmed, doi:10.1177/030098588802500202.
Everitt JI, Olson LM, Mangum JB, Visek WJ. High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets. Vet Pathol. 1988 Mar;25(2):113–118.
Journal cover image

Published In

Vet Pathol

DOI

ISSN

0300-9858

Publication Date

March 1988

Volume

25

Issue

2

Start / End Page

113 / 118

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Sex Factors
  • Rodent Diseases
  • Pregnancy
  • Myocardium
  • Mice, Inbred C3H
  • Mice
  • Male
  • Female
  • Dietary Fats