
High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets.
Severe degenerative myocardial disease occurred in female C3H/OUJ mice fed purified diets for 36 weeks; the diet contained 5% or 20% fat as non-hydrogenated soybean oil. Deaths of lactating females of this group (17/35 high fat diet and 7/35 low fat diet animals) were due to sudden cardiovascular collapse. Cardiomegaly with marked atrial and ventricular myocardial mineralization was seen at necropsy. Histologically, the random, myopathic foci were characterized by severe myocardial degeneration, mineralization, and fibrosis. Mural thrombosis, pulmonary arteriosclerosis, and mild myocardial inflammatory cell infiltrates were also present. Pathological changes were similar to those of dystrophic cardiac calcinosis, an incidental necropsy finding in certain mouse strains.
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- Veterinary Sciences
- Sex Factors
- Rodent Diseases
- Pregnancy
- Myocardium
- Mice, Inbred C3H
- Mice
- Male
- Female
- Dietary Fats
Citation

Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Veterinary Sciences
- Sex Factors
- Rodent Diseases
- Pregnancy
- Myocardium
- Mice, Inbred C3H
- Mice
- Male
- Female
- Dietary Fats