In the Wake of Systolic Blood Pressure Intervention Trial: New Targets for Improving Hypertension Management in Chronic Kidney Disease?


Journal Article

Systolic Blood Pressure Intervention Trial (SPRINT) was a multicenter randomized controlled trial showing the significant benefit of intensive reduction of blood pressure to a target of 120 mm Hg in individuals with hypertension and elevated cardiovascular risk. Because SPRINT includes the largest cohort of adults with chronic kidney disease (CKD) to be prospectively studied in a hypertension intervention trial, it has particular relevance to the field of nephrology. Here, we review the findings of SPRINT and assess their potential impact on guidelines for treatment of hypertension in patients with CKD. We believe that the data from SPRINT will support a recommendation for lowering blood pressure targets to 120 mm Hg in a substantial segment of adults with CKD.

Full Text

Duke Authors

Cited Authors

  • Tyson, CC; Coffman, TM

Published Date

  • 2017

Published In

Volume / Issue

  • 135 / 4

Start / End Page

  • 287 - 290

PubMed ID

  • 28161697

Pubmed Central ID

  • 28161697

Electronic International Standard Serial Number (EISSN)

  • 2235-3186

Digital Object Identifier (DOI)

  • 10.1159/000455130


  • eng

Conference Location

  • Switzerland