Correlation between transition percentage of minute volume (TMV%) and outcome of patients with acute respiratory failure.

Journal Article (Journal Article)

PURPOSE: We have previously shown in patients receiving adaptive support ventilation (ASV) that there existed a Transition %MinVol (TMV%) where the patient's work of breathing began to reduce. In this study, we tested the hypothesis that higher TMV% would be associated with poorer outcome in patients with acute respiratory failure. MATERIALS AND METHODS: In this prospective observational study, we recruited patients with acute respiratory failure on ASV between December 2012 and September 2013 in a mixed ICU. The TMV% was determined by adjusting % MinVol until mandatory respiratory frequency was between 0 and 1breath/min. TMV% was measured on the first two days of mechanical ventilation. RESULTS: A total of 337 patients (age: 70±16years) were recruited. In patients whose TMV% increased between Day 1 and Day 2, aOR for mortality was 7.0 (95%CI=2.7-18.3, p<0.001) compared to patients whose TMV% decreased. In patients whose TMV% was unchanged between Day 1 and Day2, aOR for mortality was 3.91 (95%CI=1.80-8.22, p<0.01). CONCLUSIONS: An increase, or lack of decrease, of TMV% from Day 1 to Day 2 was associated with higher risk of in-hospital death.

Full Text

Duke Authors

Cited Authors

  • Peng, C-K; Wu, S-F; Yang, S-H; Hsieh, C-F; Huang, C-C; Huang, Y-CT; Wu, C-P

Published Date

  • June 2017

Published In

Volume / Issue

  • 39 /

Start / End Page

  • 178 - 181

PubMed ID

  • 28278435

Electronic International Standard Serial Number (EISSN)

  • 1557-8615

Digital Object Identifier (DOI)

  • 10.1016/j.jcrc.2017.02.033


  • eng

Conference Location

  • United States