Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Pulmonary And Critical Care Medicine, Duke University School of Medicine 1988 - 1991
  • M.D., National Taiwan University 1983
• 

  Duke Appointment History

  • Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2007 - 2013
  • Instructor, Temporary in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2006 - 2007
  • Adjunct Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2001 - 2006
  • Adjunct Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1999 - 2001
  • Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1993 - 1999
  • Associate in the Department of Medicine, Medicine, Clinical Science Departments 1991 - 1993
• Expertise
• 

  Subject Headings

  • Air Pollutants
  • Air Pollution
  • Arteriovenous Malformations
  • Asthma
  • Environmental Exposure
  • Lung Compliance
  • Lung Injury
  • Lungs--Diseases, Obstructive
  • MRI Lung Imaging
  • Magnetic Resonance Imaging
  • Ozone
  • Pulmonary Diffusing Capacity
  • Pulmonary Gas Exchange
  • Pulmonary Ventilation
• Research
• 

  Selected Grants

  • Mechanisms that Direct Airway Remodeling in Obese Asthma awarded by National Institutes of Health 2017 - 2021
  • Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2020
  • Effects of glycopryrrolate/formoterol (Bevespi) on ventilation and gas exchange abnormalities in COPD assessed by 129Xe MRI awarded by AstraZeneca Pharmaceuticals, LP 2018 - 2019
  • LOTT Option 1 awarded by National Institutes of Health 2006 - 2016
  • Long-term Oxygen Treatment Trial (LOTT) - Regional Clinical Centers (RCCs) awarded by National Institutes of Health 2006 - 2012
  • Review of Asthma Clinic Database Records awarded by Environmental Protection Agency 2007 - 2009
  • Acute Lung Injury Mechanisms And Therapy awarded by National Institutes of Health 1984 - 1999
  • Acute Lung Injury - Mechanisms And Therapy awarded by National Institutes of Health 1984 - 1997
  • Acute Lung Injury And Repair awarded by National Institutes of Health 1993 - 1995
• Publications & Artistic Works
• 

  Selected Publications

  • Books

    • A Clinical Guide to Environmental and Occupational Medicine. Edited by YT Huang, LA Maier, and AJ Ghio. (Edited Book)

  • Academic Articles

    • Mahmood, K, Ebner, L, He, M, Robertson, SH, Wang, Z, McAdams, HP, Wahidi, MM, Shofer, SL, Huang, YT, and Driehuys, B. "Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 7 (July 2017): 1895-1904.  Full Text
    • Peng, C-K, Wu, S-F, Yang, S-H, Hsieh, C-F, Huang, C-C, Huang, Y-CT, and Wu, C-P. "Correlation between transition percentage of minute volume (TMV%) and outcome of patients with acute respiratory failure." Journal of critical care 39 (June 2017): 178-181.  Full Text
    • Wang, Z, Robertson, SH, Wang, J, He, M, Virgincar, RS, Schrank, GM, Bier, EA, Rajagopal, S, Huang, YC, O'Riordan, TG, Rackley, CR, McAdams, HP, and Driehuys, B. "Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI." Medical Physics 44, no. 6 (June 2017): 2415-2428.  Full Text
    • Nett, RJ, Cox-Ganser, JM, Hubbs, AF, Ruder, AM, Cummings, KJ, Huang, Y-CT, and Kreiss, K. "Non-malignant respiratory disease among workers in industries using styrene-A review of the evidence." American journal of industrial medicine 60, no. 2 (February 2017): 163-180. (Review)  Full Text
    • He, M, Driehuys, B, Que, LG, and Huang, Y-CT. "Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution." Academic Radiology 23, no. 12 (December 2016): 1521-1531.  Full Text
    • Evans, RB, Prezant, D, Huang, YCT, and Occupational and Environmental Health Network of CHEST, . "Hydraulic Fracturing (Fracking) and the Clean Air Act." Chest 148, no. 2 (August 2015): 298-300.  Full Text
    • Moitra, S, Puri, R, Paul, D, and Huang, Y-CT. "Global perspectives of emerging occupational and environmental lung diseases." Current opinion in pulmonary medicine 21, no. 2 (March 2015): 114-120. (Review)  Full Text
    • Chao, T-T, Wang, C-Y, Chen, Y-L, Lai, C-C, Chang, F-Y, Tsai, Y-T, Chao, C-HH, Shiau, C-W, Huang, Y-CT, Yu, C-J, and Chen, K-F. "Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A." Oncotarget 6, no. 4 (February 2015): 2164-2179.  Full Text
    • Chao, T-T, Wang, C-Y, Lai, C-C, Chen, Y-L, Tsai, Y-T, Chen, P-T, Lin, H-I, Huang, Y-CT, Shiau, C-W, Yu, C-J, and Chen, K-F. "TD-19, an erlotinib derivative, induces epidermal growth factor receptor wild-type nonsmall-cell lung cancer apoptosis through CIP2A-mediated pathway." The Journal of Pharmacology and Experimental Therapeutics 351, no. 2 (November 2014): 352-358.  Full Text
    • Yang, Z, Huang, Y-CT, Koziel, H, de Crom, R, Ruetten, H, Wohlfart, P, Thomsen, RW, Kahlert, JA, Sørensen, HT, Jozefowski, S, Colby, A, and Kobzik, L. "Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target." eLife 3 (October 15, 2014).  Full Text
    • Huang, Y-CT, and Tsuang, W. "Health effects associated with faulty application of spray polyurethane foam in residential homes." Environmental research 134 (October 2014): 295-300.  Full Text
    • Huang, Y-CT. "Outdoor air pollution: a global perspective." Journal of occupational and environmental medicine 56 Suppl 10 (October 2014): S3-S7.  Full Text
    • Wang, C-Y, Chao, T-T, Chang, F-Y, Chen, Y-L, Tsai, Y-T, Lin, H-I, Huang, Y-CT, Shiau, C-W, Yu, C-J, and Chen, K-F. "CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation." Lung Cancer (Amsterdam, Netherlands) 85, no. 2 (August 2014): 152-160.  Full Text
    • Alexis, NE, Huang, YCT, Rappold, AG, Kehrl, H, Devlin, R, and Peden, DB. "Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter." American Journal of Respiratory and Critical Care Medicine 190, no. 2 (July 2014): 235-237. (Letter)  Full Text
    • Yen, H, Huang, Y-CT, Hurwitz, LM, Miller, MJ, and Tsuang, WM. "A pulmonary arteriovenous malformation growing for 35 years comes to an end." American journal of respiratory and critical care medicine 189, no. 3 (February 2014): 356-357.  Full Text
    • Huang, JJ, Soukup, JM, Ghio, AJ, and Huang, Y-CT. "Host and environmental factors affect pulmonary responses measured in bronchoalveolar lavage." Inhalation toxicology 26, no. 1 (January 2014): 30-35.  Full Text
    • Wang, C-Y, Chao, T-T, Chang, F-Y, Chen, Y-L, Tsai, Y-T, Lin, H-I, Huang, Y-CT, Shiau, C-W, Yu, C-J, and Chen, K-F. "CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation." Lung Cancer (2014).
    • Chien, J-Y, Ruan, S-Y, Huang, Y-CT, Yu, C-J, and Yang, P-C. "Asynchronous thoraco-abdominal motion contributes to decreased 6-minute walk test in patients with COPD." Respiratory Care 58, no. 2 (2013): 320-326.  Full Text
    • Huang, Y-CT. "The role of in vitro gene expression profiling in particulate matter health research." Journal of Toxicology and Environmental Health - Part B: Critical Reviews 16, no. 6 (2013): 381-394.  Full Text
    • Huang, Y-CT, Rappold, AG, Graff, DW, Ghio, AJ, and Devlin, RB. "Synergistic effects of exposure to concentrated ambient fine pollution particles and nitrogen dioxide in humans." Inhal Toxicol 24, no. 12 (October 2012): 790-797.  Full Text  Link to Item
    • Huang, Y-CT, and Al-Hegelan, M. "Adverse effects of outdoor air pollution." Clinical Pulmonary Medicine 19, no. 1 (2012): 14-20.  Full Text
    • Hyseni, X, Soukup, JM, and Huang, Y-CT. "Pollutant particles induce arginase II in human bronchial epithelial cells." Journal of Toxicology and Environmental Health. Part A 75, no. 11 (January 2012): 624-636.  Full Text
    • Johnson, DB, Powers, MA, Wu, S, and Huang, Y-CT. "Follow-up recommendations for chest CT scan reports of incidental pulmonary nodules." Chest 141, no. 1 (2012): 280-281.  Full Text
    • Su, C-L, Chiang, L-L, Yang, S-H, Lin, H-I, Cheng, K-C, Huang, Y-CT, and Wu, C-P. "Preventive use of noninvasive ventilation after extubation: A prospective, multicenter randomized controlled trial." Respiratory Care 57, no. 2 (2012): 204-210.  Full Text
    • Tsuang, W, and Huang, Y-CT. "Asthma induced by exposure to spray polyurethane foam insulation in a residential home." Journal of Occupational and Environmental Medicine 54, no. 3 (2012): 272-273.  Full Text
    • Chen, C-W, Wu, C-P, Dai, Y-L, Perng, W-C, Chian, C-F, Su, W-L, and Huang, Y-CT. "Effects of implementing adaptive support ventilation in a medical intensive care unit." Respiratory Care 56, no. 7 (2011): 976-983.  Full Text
    • Huang, Y-CT, Karoly, ED, Dailey, LA, Schmitt, MT, Silbajoris, R, Graff, DW, and Devlin, RB. "Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter." J Toxicol Environ Health A 74, no. 5 (2011): 296-312.  Full Text  Link to Item
    • Huang, Y-CT, and Brook, RD. "The clean air act: Science, policy, and politics." Chest 140, no. 1 (2011): 1-2.  Full Text
    • Huang, Y-CT, Schmitt, M, Yang, Z, Que, LG, Stewart, JC, Frampton, MW, and Devlin, RB. "Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles." Inhal Toxicol 22, no. 10 (August 2010): 835-846.  Full Text  Link to Item
    • Wu, C-P, Lin, H-I, Perng, W-C, Yang, S-H, Chen, C-W, Huang, Y-CT, and Huang, K-L. "Correlation between the %MinVol setting and work of breathing during adaptive support ventilation in patients with respiratory failure." Respir Care 55, no. 3 (March 2010): 334-341.  Link to Item
    • Auten, RL, Potts, EN, Mason, SN, Fischer, B, Huang, Y, and Foster, WM. "Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice." American Journal of Respiratory and Critical Care Medicine 180, no. 12 (December 2009): 1218-1226.  Full Text
    • Huang, Y-CT, Li, Z, Carter, JD, Soukup, JM, Schwartz, DA, and Yang, IV. "Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages." American Journal of Respiratory Cell and Molecular Biology 41, no. 5 (November 2009): 544-552.  Full Text
    • Graff, DW, Cascio, WE, Rappold, A, Zhou, H, Huang, Y-CT, and Devlin, RB. "Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults." Environmental Health Perspectives 117, no. 7 (July 2009): 1089-1094.  Full Text
    • Samet, JM, Rappold, A, Graff, D, Cascio, WE, Berntsen, JH, Huang, Y-CT, Herbst, M, Bassett, M, Montilla, T, Hazucha, MJ, Bromberg, PA, and Devlin, RB. "Concentrated ambient ultrafine particle exposure induces cardiac changes in young healthy volunteers." Am J Respir Crit Care Med 179, no. 11 (June 1, 2009): 1034-1042.  Full Text  Link to Item
    • Huang, Y-CT, and Ghio, AJ. "Controlled human exposures to ambient pollutant particles in susceptible populations." Environmental Health : a Global Access Science Source 8 (January 2009): 33-null. (Review)  Full Text
    • Huang, Y-CT, Li, Z, Hyseni, X, Schmitt, M, Devlin, RB, Karoly, ED, and Soukup, JM. "Identification of gene biomarkers for respiratory syncytial virus infection in a bronchial epithelial cell line." Genomic Med 2, no. 3-4 (December 2008): 113-125.  Full Text  Link to Item
    • Chien, J-Y, Lin, M-S, Huang, Y-CT, Chien, Y-F, Yu, C-J, and Yang, P-C. "Changes in B-type natriuretic peptide improve weaning outcome predicted by spontaneous breathing trial." Crit Care Med 36, no. 5 (May 2008): 1421-1426.  Full Text  Link to Item
    • MacIntyre, N, and Huang, YC. "Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease." Proceedings of the American Thoracic Society 5, no. 4 (May 2008): 530-535. (Review)  Full Text
    • Huang, Y-CT. "Lung compliance measurement in mice." American Journal of Physiology. Lung Cellular and Molecular Physiology 294, no. 4 (April 2008): L815-null. (Letter)  Full Text
    • Huang, Y-CT, and Singh, J. "Basic Modes of Mechanical Ventilation." Mechanical Ventilation: Clinical Applications and Pathophysiology (2008): 247-255.  Full Text
    • Yang, L-Y, Huang, Y-CT, and Macintyre, NR. "Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation." J Crit Care 22, no. 3 (September 2007): 252-257.  Full Text  Link to Item
    • Karoly, ED, Li, Z, Dailey, LA, Hyseni, X, and Huang, Y-CT. "Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure." Environ Health Perspect 115, no. 4 (April 2007): 535-540.  Full Text  Link to Item
    • Samet, JM, Graff, D, Berntsen, J, Ghio, AJ, Huang, Y-CT, and Devlin, RB. "A comparison of studies on the effects of controlled exposure to fine, coarse and ultrafine ambient particulate matter from a single location." Inhal Toxicol 19 Suppl 1 (2007): 29-32.  Full Text  Link to Item
    • Kodavanti, UP, Schladweiler, MC, Ledbetter, AD, Ortuno, RV, Suffia, M, Evansky, P, Richards, JH, Jaskot, RH, Thomas, R, Karoly, E, Huang, Y-CT, Costa, DL, Gilmour, PS, and Pinkerton, KE. "The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease." Toxicological Sciences 94, no. 1 (November 2006): 193-205.  Full Text
    • Li, Z, Hyseni, X, Carter, JD, Soukup, JM, Dailey, LA, and Huang, Y-CT. "Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells." American Journal of Physiology. Cell Physiology 291, no. 2 (August 2006): C357-C365.  Full Text
    • Huang, Y-CT, O'brien, SR, Vredenburgh, J, Folz, RJ, and Macintyre, NR. "Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury." Respir Med 100, no. 7 (July 2006): 1226-1233.  Full Text  Link to Item
    • Huang, Y-CT, and Ghio, AJ. "Vascular effects of ambient pollutant particles and metals." Curr Vasc Pharmacol 4, no. 3 (July 2006): 199-203. (Review)  Link to Item
    • Huang, Y-CT, Bassett, MA, Levin, D, Montilla, T, and Ghio, AJ. "Acute phase reaction in healthy volunteers after bronchoscopy with lavage." Chest 129, no. 6 (June 2006): 1565-1569.  Full Text  Link to Item
    • Chang, L, Horng, C-F, Huang, Y-CT, and Hsieh, Y-Y. "Prognostic accuracy of Acute Physiology and Chronic Health Evaluation II scores in critically ill cancer patients." Am J Crit Care 15, no. 1 (January 2006): 47-53.  Link to Item
    • Li, Z, Stonehuerner, J, Devlin, RB, and Huang, Y-CT. "Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells." Environ Health Perspect 113, no. 12 (December 2005): 1747-1754.  Link to Item
    • Arredouani, MS, Palecanda, A, Koziel, H, Huang, Y-C, Imrich, A, Sulahian, TH, Ning, YY, Yang, Z, Pikkarainen, T, Sankala, M, Vargas, SO, Takeya, M, Tryggvason, K, and Kobzik, L. "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages." Journal of Immunology (Baltimore, Md. : 1950) 175, no. 9 (November 2005): 6058-6064.  Full Text
    • Huang, Y-CT. "Monitoring oxygen delivery in the critically ill." Chest 128, no. 5 Suppl 2 (November 2005): 554S-560S. (Review)  Full Text  Link to Item
    • McMahon, TJ, Ahearn, GS, Moya, MP, Gow, AJ, Huang, Y-CT, Luchsinger, BP, Nudelman, R, Yan, Y, Krichman, AD, Bashore, TM, Califf, RM, Singel, DJ, Piantadosi, CA, Tapson, VF, and Stamler, JS. "A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension." Proceedings of the National Academy of Sciences of the United States of America 102, no. 41 (October 3, 2005): 14801-14806.  Full Text
    • Lee, DL, Hsu, C-W, Lee, H, Chang, H-W, and Huang, Y-CT. "Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation." Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine 12, no. 9 (September 2005): 820-827.  Full Text
    • Becker, S, Dailey, LA, Soukup, JM, Grambow, SC, Devlin, RB, and Huang, Y-CT. "Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress." Environmental Health Perspectives 113, no. 8 (August 2005): 1032-1038.  Full Text
    • Li, Z, Carter, JD, Dailey, LA, and Huang, Y-CT. "Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor." Environmental Health Perspectives 113, no. 8 (August 2005): 1009-1014.  Full Text
    • Huang, Y-CT, Li, Z, Brighton, LE, Carson, JL, Becker, S, and Soukup, JM. "3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line." American Journal of Physiology. Lung Cellular and Molecular Physiology 288, no. 5 (May 2005): L988-L996.  Full Text
    • Lee, DL, Lee, H, Chang, H-W, Chang, AYW, Lin, S-L, and Huang, Y-CT. "Heliox improves hemodynamics in mechanically ventilated patients with chronic obstructive pulmonary disease with systolic pressure variations." Crit Care Med 33, no. 5 (May 2005): 968-973.  Link to Item
    • House, L, Clyde, MA, and Huang, YC. "Bayesian Identification of Differential Gene Expression Induced by Metals in Human Bronchial Epithelial Cells." Bayesisan Analysis 1, no. 1 (2005): 105-120.  Full Text
    • Huang, Y-CT, Li, Z, Harder, SD, and Soukup, JM. "Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages." Inhal Toxicol 16, no. 14 (December 15, 2004): 863-878.  Full Text  Link to Item
    • Kotani, M, Kotani, T, Li, Z, Silbajoris, R, Piantadosi, CA, and Huang, Y-CT. "Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch." Eur Respir J 24, no. 2 (August 2004): 238-246.  Link to Item
    • Kotani, M, Kotani, T, Ishizaka, A, Fujishima, S, Koh, H, Tasaka, S, Sawafuji, M, Ikeda, E, Moriyama, K, Kotake, Y, Morisaki, H, Aikawa, N, Ohashi, A, Matsushima, K, Huang, Y-CT, and Takeda, J. "Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung." Crit Care Med 32, no. 2 (February 2004): 514-519.  Full Text  Link to Item
    • Li, Z, Carter, JD, Dailey, LA, and Huang, Y-CT. "Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS." Environ Health Perspect 112, no. 2 (February 2004): 201-206.  Link to Item
    • Ghio, AJ, and Huang, Y-CT. "Exposure to concentrated ambient particles (CAPs): a review." Inhal Toxicol 16, no. 1 (January 2004): 53-59. (Review)  Full Text  Link to Item
    • Nozik-Grayck, E, Huang, Y-CT, Carraway, MS, and Piantadosi, CA. "Bicarbonate-dependent superoxide release and pulmonary artery tone." American Journal of Physiology. Heart and Circulatory Physiology 285, no. 6 (December 2003): H2327-H2335.  Full Text
    • Huang, Y-CT, Ghio, AJ, Stonehuerner, J, McGee, J, Carter, JD, Grambow, SC, and Devlin, RB. "The role of soluble components in ambient fine particles-induced changes in human lungs and blood." Inhalation Toxicology 15, no. 4 (April 2003): 327-342.  Full Text
    • Huang, Y-CT, Soukup, J, Harder, S, and Becker, S. "Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage." American Journal of Physiology Cell Physiology 284, no. 1 (January 2003): C24-C32.  Full Text
    • Huang, Y-CT, Soukup, J, Harder, S, and Becker, S. "Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage." American Journal of Physiology - Cell Physiology 284, no. 1 53-1 (2003): C24-C32.
    • Nozik-Grayck, E, Huang, Y-CT, Carraway, MS, and Piantadosi, CA. "Bicarbonate-dependent superoxide release and pulmonary artery tone." American Journal of Physiology - Heart and Circulatory Physiology 285, no. 6 54-6 (2003): H2327-H2335.
    • Huang, Y-CT, and Piantadosi, CA. "Alveolar barrier function assessed by hydrophobic and hydrophilic fluorescent solutes in rabbit lung." Respir Physiol Neurobiol 133, no. 1-2 (October 23, 2002): 153-166.  Link to Item
    • Huang, Y-CT, O'Brien, SR, and MacIntyre, NR. "Intrabreath diffusing capacity of the lung in healthy individuals at rest and during exercise." Chest 122, no. 1 (July 2002): 177-185.  Link to Item
    • Lee, DL, Chiang, H-T, Lin, S-L, Ger, L-P, Kun, M-H, and Huang, Y-CT. "Prone-position ventilation induces sustained improvement in oxygenation in patients with acute respiratory distress syndrome who have a large shunt." Crit Care Med 30, no. 7 (July 2002): 1446-1452.  Link to Item
    • Nozik-Grayck, E, McMahon, TJ, Huang, Y-CT, Dieterle, CS, Stamler, JS, and Piantadosi, CA. "Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione." American Journal of Physiology. Lung Cellular and Molecular Physiology 282, no. 5 (May 2002): L1057-L1065.  Full Text
    • Que, LG, George, SE, Gotoh, T, Mori, M, and Huang, Y-CT. "Effects of arginase isoforms on NO Production by nNOS." Nitric Oxide : Biology and Chemistry 6, no. 1 (February 2002): 1-8.  Full Text
    • Huang, Y-CT, Wu, W, Ghio, AJ, Carter, JD, Silbajoris, R, Devlin, RB, and Samet, JM. "Activation of EGF receptors mediates pulmonary vasoconstriction induced by residual oil fly ash." Exp Lung Res 28, no. 1 (January 2002): 19-38.  Link to Item
    • Nozik-Grayck, E, McMahon, TJ, Huang, Y-CT, Dieterle, CS, Stamler, JS, and Piantadosi, CA. "Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione." American Journal of Physiology - Lung Cellular and Molecular Physiology 282, no. 5 26-5 (2002): L1057-L1065.
    • Carraway, MS, Piantadosi, CA, and Wright, JR. "Alveolar proteinosis: a disease of mice and men." American Journal of Physiology. Lung Cellular and Molecular Physiology 280, no. 3 (March 2001): L377-L378. (Review)  Full Text
    • Huang, YT, Ghio, AJ, Nozik-Grayck, E, and Piantadosi, CA. "Vascular release of nonheme iron in perfused rabbit lungs." American Journal of Physiology. Lung Cellular and Molecular Physiology 280, no. 3 (March 2001): L474-L481.  Full Text
    • Welty-Wolf, KE, Carraway, MS, Huang, YC, Simonson, SG, Kantrow, SP, Kishimoto, TK, and Piantadosi, CA. "Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis." Am J Respir Crit Care Med 163, no. 3 Pt 1 (March 2001): 665-673.  Full Text  Link to Item
    • Huang, Y-CT, Ghio, AJ, Nozik-Grayck, E, and Piantadosi, CA. "Vascular release of nonheme iron in perfused rabbit lungs." American Journal of Physiology - Lung Cellular and Molecular Physiology 280, no. 3 24-3 (2001): L474-L481.
    • Welty-Wolf, KE, Carraway, MS, Huang, YCT, Simonson, SG, Kantrow, SP, Kishimoto, TK, and Piantadosi, CA. "Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis." American Journal of Respiratory and Critical Care Medicine 163, no. 3 I (January 1, 2001): 665-673.  Full Text
    • Welty-Wolf, KE, Carraway, MS, Ghio, A, Kantrow, SP, Huang, YC, and Piantadosi, CA. "Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy." Shock 13, no. 5 (May 2000): 404-409.  Link to Item
    • Que, LG, and Tony Huang, YC. "Pharmacologic adjuncts during mechanical ventilation." Semin Respir Crit Care Med 21, no. 3 (2000): 223-232.  Full Text  Link to Item
    • Carraway, MS, Welty-Wolf, KE, Kantrow, SP, Huang, YCT, Simonson, SG, Que, LG, Kishimoto, TK, and Piantadosi, CA. "Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons." American Journal of Respiratory and Critical Care Medicine 157, no. 3 PART I (December 1, 1998): 938-949.
    • Hills, BA. "Role of surfactant and hyperoxia." Journal of Applied Physiology (Bethesda, Md. : 1985) 85, no. 2 (August 1998): 770-771. (Letter)  Full Text
    • Welty-Wolf, KE, Carraway, MS, Huang, YC, Simonson, SG, Kantrow, SP, and Piantadosi, CA. "Bacterial priming increases lung injury in gram-negative sepsis." Am J Respir Crit Care Med 158, no. 2 (August 1998): 610-619.  Full Text  Link to Item
    • Que, LG, Kantrow, SP, Jenkinson, CP, Piantadosi, CA, and Huang, YCT. "Induction of arginase isoforms in the lung during hyperoxia." American Journal of Physiology Lung Cellular and Molecular Physiology 275, no. 1 19-1 (July 1, 1998).
    • Carraway, MS, Piantadosi, CA, Jenkinson, CP, and Huang, YC. "Differential expression of arginase and iNOS in the lung in sepsis." Exp Lung Res 24, no. 3 (May 1998): 253-268.  Link to Item
    • Que, LG, Kang, BH, Huang, YC, Piantadosi, CA, and Chang, LY. "Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis." Shock 9, no. 4 (April 1998): 304-309.  Link to Item
    • Carraway, MS, Welty-Wolf, KE, Kantrow, SP, Huang, YC, Simonson, SG, Que, LG, Kishimoto, TK, and Piantadosi, CA. "Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons." Am J Respir Crit Care Med 157, no. 3 Pt 1 (March 1998): 938-949.  Full Text  Link to Item
    • Brown, CD, MacIntyre, NR, and Huang, YC. "Diffusing capacity and pulmonary capillary blood flow during maximal exercise." Chest 114, no. 4 SUPPL. (1998): 335S-.
    • Huang, YC, Fisher, PW, Nozik-Grayck, E, and Piantadosi, CA. "Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury." The American Journal of Physiology 273, no. 3 Pt 1 (September 1997): L504-L512.  Full Text
    • Nozik-Grayck, E, Piantadosi, CA, van Adelsberg, J, Alper, SL, and Huang, YC. "Protection of perfused lung from oxidant injury by inhibitors of anion exchange." The American Journal of Physiology 273, no. 2 Pt 1 (August 1997): L296-L304.  Full Text
    • Simonson, SG, Welty-Wolf, KE, Huang, YC, Taylor, DE, Kantrow, SP, Carraway, MS, Crapo, JD, and Piantadosi, CA. "Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry." Journal of Applied Physiology (Bethesda, Md. : 1985) 83, no. 2 (August 1997): 550-558.  Full Text
    • Welty-Wolf, KE, Simonson, SG, Huang, YC, Kantrow, SP, Carraway, MS, Chang, LY, Crapo, JD, and Piantadosi, CA. "Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis." Journal of Applied Physiology (Bethesda, Md. : 1985) 83, no. 2 (August 1997): 559-568.  Full Text
    • Fryer, A, Huang, YC, Rao, G, Jacoby, D, Mancilla, E, Whorton, R, Piantadosi, CA, Kennedy, T, and Hoidal, J. "Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung." The Journal of Pharmacology and Experimental Therapeutics 282, no. 1 (July 1997): 208-219.
    • Kantrow, SP, Huang, YCT, Whorton, AR, Grayck, EN, Knight, JM, Millington, DS, and Piantadosi, CA. "Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung." American Journal of Physiology Lung Cellular and Molecular Physiology 272, no. 6 16-6 (June 1, 1997).
    • Simonson, SG, Huang, YC, Fracica, PJ, Welty-Wolf, KE, Moon, RE, Young, SL, and Piantadosi, CA. "Changes in the lung after prolonged positive pressure ventilation in normal baboons." J Crit Care 12, no. 2 (June 1997): 72-82.  Link to Item
    • Huang, Y-CT, Fisher, PW, Nozik-Grayck, E, and Piantadosi, CA. "Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury." American Journal of Physiology - Lung Cellular and Molecular Physiology 273, no. 3 17-3 (1997): L504-L512.
    • Huang, Y-CT, Fisher, PW, Nozik-Grayck, E, and Piantadosi, CA. "Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury." American Journal of Physiology 273, no. 3 PART 1 (1997): G721-G726.
    • Nozik-Grayck, E, Piantadosi, CA, Adelsberg, JV, Alper, SL, and Huang, Y-CT. "Protection of perfused lung from oxidant injury by inhibitors of anion exchange." American Journal of Physiology - Lung Cellular and Molecular Physiology 273, no. 2 17-2 (1997): L296-L304.
    • Kang, BH, Manderschied, BD, Huang, YC, Crapo, JD, and Chang, LY. "Contrasting response of lung parenchymal cells to instilled TNF alpha and IFN gamma: the inducibility of specific cell ICAM-1 in vivo." Am J Respir Cell Mol Biol 15, no. 4 (October 1996): 540-550.  Full Text  Link to Item
    • Su, WY, Day, BJ, Kang, BH, Crapo, JD, Huang, YC, and Chang, LY. "Lung epithelial cell-released nitric oxide protects against PMN-mediated cell injury." The American Journal of Physiology 271, no. 4 Pt 1 (October 1996): L581-L586.  Full Text
    • Huang, YC, Fracica, PJ, Simonson, SG, Crapo, JD, Young, SL, Welty-Wolf, KE, Moon, RE, and Piantadosi, CA. "VA/Q abnormalities during gram negative sepsis." Respir Physiol 105, no. 1-2 (August 1996): 109-121.  Link to Item
    • Welty-Wolf, KE, Simonson, SG, Huang, YC, Fracica, PJ, Patterson, JW, and Piantadosi, CA. "Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis." Shock (Augusta, Ga.) 5, no. 5 (May 1996): 378-384.
    • Carraway, MS, Piantadosi, CA, Jenkinson, CP, and Huang, YC. "Differential expression of lung arginase and inos in sepsis." Journal of Investigative Medicine 44, no. 3 (1996): 270a-.
    • Huang, YC, Sane, AC, Simonson, SG, Fawcett, TA, Moon, RE, Fracica, PJ, Menache, MG, Piantadosi, CA, and Young, SL. "Artificial surfactant attenuates hyperoxic lung injury in primates. I. Physiology and biochemistry." Journal of Applied Physiology (Bethesda, Md. : 1985) 78, no. 5 (May 1995): 1816-1822.  Full Text
    • Piantadosi, CA, Fracica, PJ, Duhaylongsod, FG, Huang, YC, Welty-Wolf, KE, Crapo, JD, and Young, SL. "Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis." Journal of Applied Physiology (Bethesda, Md. : 1985) 78, no. 5 (May 1995): 1823-1831.  Full Text
    • Nozik, ES, Huang, YC, and Piantadosi, CA. "L-arginine enhances injury in the isolated rabbit lung during hyperoxia." Respir Physiol 100, no. 1 (April 1995): 63-74.  Link to Item
    • Huang, YC, Fracica, PJ, and Piantadosi, CA. "Tumor necrosis factor-alpha-induced lung injury and its modulation by synthetic polynucleotide: a physiologic-morphometric analysis." Exp Lung Res 20, no. 6 (November 1994): 539-558.  Link to Item
    • Simonson, SG, Welty-Wolf, K, Huang, YT, Griebel, JA, Caplan, MS, Fracica, PJ, and Piantadosi, CA. "Altered mitochondrial redox responses in gram negative septic shock in primates." Circ Shock 43, no. 1 (May 1994): 34-43.  Link to Item
    • Huang, YC, Caminiti, SP, Fawcett, TA, Moon, RE, Fracica, PJ, Miller, FJ, Young, SL, and Piantadosi, CA. "Natural surfactant and hyperoxic lung injury in primates. I. Physiology and biochemistry." Journal of Applied Physiology (Bethesda, Md. : 1985) 76, no. 3 (March 1994): 991-1001.  Full Text
    • Huang, YC, Helms, MJ, and MacIntyre, NR. "Normal values for single exhalation diffusing capacity and pulmonary capillary blood flow in sitting, supine positions, and during mild exercise." Chest 105, no. 2 (February 1994): 501-508.  Full Text
    • Stockwell, JA, Huang, YC, Su, YF, and Piantadosi, CA. "Bactericidal antibiotics increase tumor necrosis factor-alpha and cardiac output in rats after cecal ligation and puncture." Circ Shock 42, no. 2 (February 1994): 68-75.  Link to Item
    • Huang, Y-CT, Nozik, ES, and Piantadosi, CA. "Superoxide dismutase potentiates platelet-activating factor-induced injury in perfused lung." American Journal of Physiology - Lung Cellular and Molecular Physiology 266, no. 3 10-3 (1994): L246-L254.
    • Dodam, JR, Moon, RE, Olson, NC, Exposito, AJ, Fawcett, TA, Huang, YC, Theil, DR, Camporesi, E, and Swanson, CR. "Effects of clenbuterol hydrochloride on pulmonary gas exchange and hemodynamics in anesthetized horses." Am J Vet Res 54, no. 5 (May 1993): 776-782.  Link to Item
    • Fisher, PW, Huang, Y-CT, Kennedy, TP, and Piantadosi, CA. "PO₂-dependent hydroxyl radical production during ischemia-reperfusion lung injury." American Journal of Physiology - Lung Cellular and Molecular Physiology 265, no. 3 9-3 (1993): L279-L285.
    • Fisher, PW, Huang, YCT, Kennedy, TP, and Piantadosi, CA. "PO2-dependent hydroxyl radical production during ischemia-reperfusion lung injury." American Journal of Physiology Lung Cellular and Molecular Physiology 265, no. 3 9-3 (January 1, 1993).
    • Huang, YC, Kennedy, TP, Su, YF, Watkins, WD, Whorton, AR, and Piantadosi, CA. "Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung." Journal of Applied Physiology (Bethesda, Md. : 1985) 74, no. 1 (January 1993): 251-258.  Full Text
    • Huang, YC, and Macintyre, NR. "Real-time gas analysis improves the measurement of single-breath diffusing capacity." Am Rev Respir Dis 146, no. 4 (October 1992): 946-950.  Full Text  Link to Item
    • Chang, LY, Huang, Y, Stockstill, BL, Graham, JA, Grose, EC, Menache, MG, Miller, FJ, Costa, DL, and Crapo, JD. "Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone." Toxicol Appl Pharmacol 115, no. 2 (August 1992): 241-252.  Link to Item
    • Chang, L, Miller, FJ, Ultman, J, Huang, Y, Stockstill, BL, Grose, E, Graham, JA, Ospital, JJ, and Crapo, JD. "Alveolar epithelial cell injuries by subchronic exposure to low concentrations of ozone correlate with cumulative exposure." Toxicol Appl Pharmacol 109, no. 2 (June 15, 1991): 219-234.  Link to Item
    • Huang, YT. "Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target."

  • Book Sections

    • Huang, Y, Lease, E, and Beachey, W. "Arterial Blood Gas Analysis and Sampling." In Respiratory Care: Principles and Practice. Jones & Bartlett Publishers, April 6, 2015. (Chapter)
    • Huang, YC, Lease, E, and Beachey, W. "Assessment of Acid-Base Balance." In Respiratory Care: Principles and Practice. Jones & Bartlett Publishers, April 6, 2015. (Chapter)
    • Huang, YT, Lease, E, and Beachey, W. "Assessment of Gas Exchange." In Respiratory Care: Principles and Practice. Jones & Bartlett Publishers, April 6, 2015. (Chapter)

  • Conference Papers

    • Bocharnikov, A, and Huang, YT. "Barriers for Delivering Care to COPD Patients: A Physician Survey." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018.  Link to Item
    • Huang, YT, He, M, Wang, Z, Rankine, L, Womack, S, Mammarappallil, J, McAdams, P, and Driehuys, B. "Ventilation and Gas Transfer Measured by 129Xe MRI in Alpha-1 Antitrypsin Heterozygotes: A Pilot Study." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018.  Link to Item
    • Huang, YT, Wang, Z, He, M, Rankine, L, Womack, S, McAdams, P, Mammarappalil, J, and Driehuys, B. "Ventilation and Gas Transfer Distribution in Alpha-1 Antitrypsin Deficiency After Replacement Therapy." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018.  Link to Item

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