Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Pulmonary And Critical Care Medicine, Duke University School of Medicine 1988 - 1991
  • M.D., National Taiwan University 1983
• 

  Duke Appointment History

  • Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2007 - 2013
  • Instructor, Temporary in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2006 - 2007
  • Adjunct Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2001 - 2006
  • Adjunct Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1999 - 2001
  • Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1993 - 1999
  • Associate in the Department of Medicine, Medicine, Clinical Science Departments 1991 - 1993
• Expertise
• 

  Subject Headings

  • Air Pollutants
  • Air Pollution
  • Arteriovenous Malformations
  • Asthma
  • Environmental Exposure
  • Lung Compliance
  • Lung Injury
  • Lungs--Diseases, Obstructive
  • MRI Lung Imaging
  • Magnetic Resonance Imaging
  • Ozone
  • Pulmonary Diffusing Capacity
  • Pulmonary Gas Exchange
  • Pulmonary Ventilation
• Research
• 

  Selected Grants

  • Mechanisms that Direct Airway Remodeling in Obese Asthma awarded by National Institutes of Health 2017 - 2021
  • Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2020
  • Effects of glycopryrrolate/formoterol (Bevespi) on ventilation and gas exchange abnormalities in COPD assessed by 129Xe MRI awarded by AstraZeneca Pharmaceuticals, LP 2018 - 2019
  • LOTT Option 1 awarded by National Institutes of Health 2006 - 2016
  • Long-term Oxygen Treatment Trial (LOTT) - Regional Clinical Centers (RCCs) awarded by National Institutes of Health 2006 - 2012
  • Review of Asthma Clinic Database Records awarded by Environmental Protection Agency 2007 - 2009
  • Acute Lung Injury Mechanisms And Therapy awarded by National Institutes of Health 1984 - 1999
  • Acute Lung Injury - Mechanisms And Therapy awarded by National Institutes of Health 1984 - 1997
  • Acute Lung Injury And Repair awarded by National Institutes of Health 1993 - 1995
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Mahmood, K, Ebner, L, He, M, Robertson, SH, Wang, Z, McAdams, HP, Wahidi, MM, Shofer, SL, Huang, YT, and Driehuys, B. "Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 7 (July 2017): 1895-1904.  Full Text
    • Peng, C-K, Wu, S-F, Yang, S-H, Hsieh, C-F, Huang, C-C, Huang, Y-CT, and Wu, C-P. "Correlation between transition percentage of minute volume (TMV%) and outcome of patients with acute respiratory failure." Journal of critical care 39 (June 2017): 178-181.  Full Text
    • Wang, Z, Robertson, SH, Wang, J, He, M, Virgincar, RS, Schrank, GM, Bier, EA, Rajagopal, S, Huang, YC, O'Riordan, TG, Rackley, CR, McAdams, HP, and Driehuys, B. "Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI." Medical Physics 44, no. 6 (June 2017): 2415-2428.  Full Text
    • Nett, RJ, Cox-Ganser, JM, Hubbs, AF, Ruder, AM, Cummings, KJ, Huang, Y-CT, and Kreiss, K. "Non-malignant respiratory disease among workers in industries using styrene-A review of the evidence." American journal of industrial medicine 60, no. 2 (February 2017): 163-180. (Review)  Full Text
    • He, M, Driehuys, B, Que, LG, and Huang, Y-CT. "Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution." Academic Radiology 23, no. 12 (December 2016): 1521-1531.  Full Text
    • Evans, RB, Prezant, D, Huang, YCT, and Occupational and Environmental Health Network of CHEST, . "Hydraulic Fracturing (Fracking) and the Clean Air Act." Chest 148, no. 2 (August 2015): 298-300.  Full Text
    • Moitra, S, Puri, R, Paul, D, and Huang, Y-CT. "Global perspectives of emerging occupational and environmental lung diseases." Current opinion in pulmonary medicine 21, no. 2 (March 2015): 114-120. (Review)  Full Text
    • Chao, T-T, Wang, C-Y, Chen, Y-L, Lai, C-C, Chang, F-Y, Tsai, Y-T, Chao, C-HH, Shiau, C-W, Huang, Y-CT, Yu, C-J, and Chen, K-F. "Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A." Oncotarget 6, no. 4 (February 2015): 2164-2179.  Full Text
    • Chao, T-T, Wang, C-Y, Lai, C-C, Chen, Y-L, Tsai, Y-T, Chen, P-T, Lin, H-I, Huang, Y-CT, Shiau, C-W, Yu, C-J, and Chen, K-F. "TD-19, an erlotinib derivative, induces epidermal growth factor receptor wild-type nonsmall-cell lung cancer apoptosis through CIP2A-mediated pathway." The Journal of Pharmacology and Experimental Therapeutics 351, no. 2 (November 2014): 352-358.  Full Text
    • Huang, Y-CT, and Tsuang, W. "Health effects associated with faulty application of spray polyurethane foam in residential homes." Environmental research 134 (October 2014): 295-300.  Full Text
    • Huang, Y-CT. "Outdoor air pollution: a global perspective." Journal of occupational and environmental medicine 56 Suppl 10 (October 2014): S3-S7.  Full Text
    • Wang, C-Y, Chao, T-T, Chang, F-Y, Chen, Y-L, Tsai, Y-T, Lin, H-I, Huang, Y-CT, Shiau, C-W, Yu, C-J, and Chen, K-F. "CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation." Lung Cancer (Amsterdam, Netherlands) 85, no. 2 (August 2014): 152-160.  Full Text
    • Alexis, NE, Huang, YCT, Rappold, AG, Kehrl, H, Devlin, R, and Peden, DB. "Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter." American Journal of Respiratory and Critical Care Medicine 190, no. 2 (July 2014): 235-237. (Letter)  Full Text
    • Yen, H, Huang, Y-CT, Hurwitz, LM, Miller, MJ, and Tsuang, WM. "A pulmonary arteriovenous malformation growing for 35 years comes to an end." American journal of respiratory and critical care medicine 189, no. 3 (February 2014): 356-357.  Full Text
    • Huang, JJ, Soukup, JM, Ghio, AJ, and Huang, Y-CT. "Host and environmental factors affect pulmonary responses measured in bronchoalveolar lavage." Inhalation toxicology 26, no. 1 (January 2014): 30-35.  Full Text
    • Wang, C-Y, Chao, T-T, Chang, F-Y, Chen, Y-L, Tsai, Y-T, Lin, H-I, Huang, Y-CT, Shiau, C-W, Yu, C-J, and Chen, K-F. "CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation." Lung Cancer (2014).
    • Chien, J-Y, Ruan, S-Y, Huang, Y-CT, Yu, C-J, and Yang, P-C. "Asynchronous thoraco-abdominal motion contributes to decreased 6-minute walk test in patients with COPD." Respiratory Care 58, no. 2 (2013): 320-326.  Full Text
    • Huang, Y-CT. "The role of in vitro gene expression profiling in particulate matter health research." Journal of Toxicology and Environmental Health - Part B: Critical Reviews 16, no. 6 (2013): 381-394.  Full Text
    • Huang, Y-CT, Rappold, AG, Graff, DW, Ghio, AJ, and Devlin, RB. "Synergistic effects of exposure to concentrated ambient fine pollution particles and nitrogen dioxide in humans." Inhal Toxicol 24, no. 12 (October 2012): 790-797.  Full Text  Link to Item
    • Huang, YCT, and Al-Hegelan, M. "Adverse effects of outdoor air pollution." Clinical Pulmonary Medicine 19, no. 1 (January 1, 2012): 14-20.  Full Text
    • Hyseni, X, Soukup, JM, and Huang, Y-CT. "Pollutant particles induce arginase II in human bronchial epithelial cells." Journal of Toxicology and Environmental Health. Part A 75, no. 11 (January 2012): 624-636.  Full Text
    • Johnson, DB, Powers, MA, Wu, S, and Huang, Y-CT. "Follow-up recommendations for chest CT scan reports of incidental pulmonary nodules." Chest 141, no. 1 (2012): 280-281.  Full Text
    • Su, C-L, Chiang, L-L, Yang, S-H, Lin, H-I, Cheng, K-C, Huang, Y-CT, and Wu, C-P. "Preventive use of noninvasive ventilation after extubation: A prospective, multicenter randomized controlled trial." Respiratory Care 57, no. 2 (2012): 204-210.  Full Text
    • Tsuang, W, and Huang, Y-CT. "Asthma induced by exposure to spray polyurethane foam insulation in a residential home." Journal of Occupational and Environmental Medicine 54, no. 3 (2012): 272-273.  Full Text
    • Chen, C-W, Wu, C-P, Dai, Y-L, Perng, W-C, Chian, C-F, Su, W-L, and Huang, Y-CT. "Effects of implementing adaptive support ventilation in a medical intensive care unit." Respiratory Care 56, no. 7 (2011): 976-983.  Full Text
    • Huang, Y-CT, Karoly, ED, Dailey, LA, Schmitt, MT, Silbajoris, R, Graff, DW, and Devlin, RB. "Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter." J Toxicol Environ Health A 74, no. 5 (2011): 296-312.  Full Text  Link to Item
    • Huang, Y-CT, and Brook, RD. "The clean air act: Science, policy, and politics." Chest 140, no. 1 (2011): 1-2.  Full Text
    • Huang, Y-CT, Schmitt, M, Yang, Z, Que, LG, Stewart, JC, Frampton, MW, and Devlin, RB. "Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles." Inhal Toxicol 22, no. 10 (August 2010): 835-846.  Full Text  Link to Item
    • Wu, C-P, Lin, H-I, Perng, W-C, Yang, S-H, Chen, C-W, Huang, Y-CT, and Huang, K-L. "Correlation between the %MinVol setting and work of breathing during adaptive support ventilation in patients with respiratory failure." Respir Care 55, no. 3 (March 2010): 334-341.  Link to Item
    • Auten, RL, Potts, EN, Mason, SN, Fischer, B, Huang, Y, and Foster, WM. "Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice." American Journal of Respiratory and Critical Care Medicine 180, no. 12 (December 2009): 1218-1226.  Full Text
    • Huang, Y-CT, Li, Z, Carter, JD, Soukup, JM, Schwartz, DA, and Yang, IV. "Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages." American Journal of Respiratory Cell and Molecular Biology 41, no. 5 (November 2009): 544-552.  Full Text
    • Graff, DW, Cascio, WE, Rappold, A, Zhou, H, Huang, Y-CT, and Devlin, RB. "Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults." Environmental Health Perspectives 117, no. 7 (July 2009): 1089-1094.  Full Text
    • Samet, JM, Rappold, A, Graff, D, Cascio, WE, Berntsen, JH, Huang, Y-CT, Herbst, M, Bassett, M, Montilla, T, Hazucha, MJ, Bromberg, PA, and Devlin, RB. "Concentrated ambient ultrafine particle exposure induces cardiac changes in young healthy volunteers." Am J Respir Crit Care Med 179, no. 11 (June 1, 2009): 1034-1042.  Full Text  Link to Item
    • Huang, Y-CT, and Ghio, AJ. "Controlled human exposures to ambient pollutant particles in susceptible populations." Environmental Health : a Global Access Science Source 8 (January 2009): 33-null. (Review)  Full Text
    • Huang, Y-CT, Li, Z, Hyseni, X, Schmitt, M, Devlin, RB, Karoly, ED, and Soukup, JM. "Identification of gene biomarkers for respiratory syncytial virus infection in a bronchial epithelial cell line." Genomic Med 2, no. 3-4 (December 2008): 113-125.  Full Text  Link to Item
    • Huang, YCT, and Singh, J. "Basic Modes of Mechanical Ventilation." (December 1, 2008): 247-255. (Chapter)  Full Text
    • Chien, J-Y, Lin, M-S, Huang, Y-CT, Chien, Y-F, Yu, C-J, and Yang, P-C. "Changes in B-type natriuretic peptide improve weaning outcome predicted by spontaneous breathing trial." Crit Care Med 36, no. 5 (May 2008): 1421-1426.  Full Text  Link to Item
    • MacIntyre, N, and Huang, YC. "Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease." Proceedings of the American Thoracic Society 5, no. 4 (May 2008): 530-535. (Review)  Full Text
    • Huang, Y-CT. "Lung compliance measurement in mice." American Journal of Physiology. Lung Cellular and Molecular Physiology 294, no. 4 (April 2008): L815-null. (Letter)  Full Text
    • Yang, L-Y, Huang, Y-CT, and Macintyre, NR. "Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation." J Crit Care 22, no. 3 (September 2007): 252-257.  Full Text  Link to Item
    • Karoly, ED, Li, Z, Dailey, LA, Hyseni, X, and Huang, Y-CT. "Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure." Environ Health Perspect 115, no. 4 (April 2007): 535-540.  Full Text  Link to Item
    • Samet, JM, Graff, D, Berntsen, J, Ghio, AJ, Huang, Y-CT, and Devlin, RB. "A comparison of studies on the effects of controlled exposure to fine, coarse and ultrafine ambient particulate matter from a single location." Inhal Toxicol 19 Suppl 1 (2007): 29-32.  Full Text  Link to Item
    • Kodavanti, UP, Schladweiler, MC, Ledbetter, AD, Ortuno, RV, Suffia, M, Evansky, P, Richards, JH, Jaskot, RH, Thomas, R, Karoly, E, Huang, Y-CT, Costa, DL, Gilmour, PS, and Pinkerton, KE. "The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease." Toxicological Sciences 94, no. 1 (November 2006): 193-205.  Full Text
    • Li, Z, Hyseni, X, Carter, JD, Soukup, JM, Dailey, LA, and Huang, Y-CT. "Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells." American Journal of Physiology. Cell Physiology 291, no. 2 (August 2006): C357-C365.  Full Text
    • Huang, Y-CT, O'brien, SR, Vredenburgh, J, Folz, RJ, and Macintyre, NR. "Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury." Respir Med 100, no. 7 (July 2006): 1226-1233.  Full Text  Link to Item
    • Huang, Y-CT, and Ghio, AJ. "Vascular effects of ambient pollutant particles and metals." Curr Vasc Pharmacol 4, no. 3 (July 2006): 199-203. (Review)  Link to Item
    • Huang, Y-CT, Bassett, MA, Levin, D, Montilla, T, and Ghio, AJ. "Acute phase reaction in healthy volunteers after bronchoscopy with lavage." Chest 129, no. 6 (June 2006): 1565-1569.  Full Text  Link to Item
    • Chang, L, Horng, C-F, Huang, Y-CT, and Hsieh, Y-Y. "Prognostic accuracy of Acute Physiology and Chronic Health Evaluation II scores in critically ill cancer patients." Am J Crit Care 15, no. 1 (January 2006): 47-53.  Link to Item
    • Li, Z, Stonehuerner, J, Devlin, RB, and Huang, Y-CT. "Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells." Environ Health Perspect 113, no. 12 (December 2005): 1747-1754.  Link to Item
    • Arredouani, MS, Palecanda, A, Koziel, H, Huang, Y-C, Imrich, A, Sulahian, TH, Ning, YY, Yang, Z, Pikkarainen, T, Sankala, M, Vargas, SO, Takeya, M, Tryggvason, K, and Kobzik, L. "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages." Journal of Immunology (Baltimore, Md. : 1950) 175, no. 9 (November 2005): 6058-6064.  Full Text
    • Huang, Y-CT. "Monitoring oxygen delivery in the critically ill." Chest 128, no. 5 Suppl 2 (November 2005): 554S-560S. (Review)  Full Text  Link to Item
    • McMahon, TJ, Ahearn, GS, Moya, MP, Gow, AJ, Huang, Y-CT, Luchsinger, BP, Nudelman, R, Yan, Y, Krichman, AD, Bashore, TM, Califf, RM, Singel, DJ, Piantadosi, CA, Tapson, VF, and Stamler, JS. "A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension." Proceedings of the National Academy of Sciences of the United States of America 102, no. 41 (October 3, 2005): 14801-14806.  Full Text
    • Lee, DL, Hsu, C-W, Lee, H, Chang, H-W, and Huang, Y-CT. "Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation." Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine 12, no. 9 (September 2005): 820-827.  Full Text
    • Becker, S, Dailey, LA, Soukup, JM, Grambow, SC, Devlin, RB, and Huang, Y-CT. "Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress." Environmental Health Perspectives 113, no. 8 (August 2005): 1032-1038.  Full Text
    • Li, Z, Carter, JD, Dailey, LA, and Huang, Y-CT. "Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor." Environmental Health Perspectives 113, no. 8 (August 2005): 1009-1014.  Full Text
    • Huang, Y-CT, Li, Z, Brighton, LE, Carson, JL, Becker, S, and Soukup, JM. "3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line." American Journal of Physiology. Lung Cellular and Molecular Physiology 288, no. 5 (May 2005): L988-L996.  Full Text
    • Lee, DL, Lee, H, Chang, H-W, Chang, AYW, Lin, S-L, and Huang, Y-CT. "Heliox improves hemodynamics in mechanically ventilated patients with chronic obstructive pulmonary disease with systolic pressure variations." Crit Care Med 33, no. 5 (May 2005): 968-973.  Link to Item
    • House, L, Clyde, MA, and Huang, YC. "Bayesian Identification of Differential Gene Expression Induced by Metals in Human Bronchial Epithelial Cells." Bayesisan Analysis 1, no. 1 (2005): 105-120.  Full Text
    • Huang, Y-CT, Li, Z, Harder, SD, and Soukup, JM. "Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages." Inhal Toxicol 16, no. 14 (December 15, 2004): 863-878.  Full Text  Link to Item
    • Kotani, M, Kotani, T, Li, Z, Silbajoris, R, Piantadosi, CA, and Huang, Y-CT. "Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch." Eur Respir J 24, no. 2 (August 2004): 238-246.  Link to Item
    • Kotani, M, Kotani, T, Ishizaka, A, Fujishima, S, Koh, H, Tasaka, S, Sawafuji, M, Ikeda, E, Moriyama, K, Kotake, Y, Morisaki, H, Aikawa, N, Ohashi, A, Matsushima, K, Huang, Y-CT, and Takeda, J. "Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung." Crit Care Med 32, no. 2 (February 2004): 514-519.  Full Text  Link to Item
    • Li, Z, Carter, JD, Dailey, LA, and Huang, Y-CT. "Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS." Environ Health Perspect 112, no. 2 (February 2004): 201-206.  Link to Item
    • Ghio, AJ, and Huang, Y-CT. "Exposure to concentrated ambient particles (CAPs): a review." Inhal Toxicol 16, no. 1 (January 2004): 53-59. (Review)  Full Text  Link to Item
    • Nozik-Grayck, E, Huang, Y-CT, Carraway, MS, and Piantadosi, CA. "Bicarbonate-dependent superoxide release and pulmonary artery tone." American Journal of Physiology. Heart and Circulatory Physiology 285, no. 6 (December 2003): H2327-H2335.  Full Text
    • Nozik-Grayck, E, Huang, YCT, Carraway, MS, and Piantadosi, CA. "Bicarbonate-dependent superoxide release and pulmonary artery tone." American Journal of Physiology Heart and Circulatory Physiology 285, no. 6 54-6 (December 1, 2003).
    • Huang, Y-CT, Ghio, AJ, Stonehuerner, J, McGee, J, Carter, JD, Grambow, SC, and Devlin, RB. "The role of soluble components in ambient fine particles-induced changes in human lungs and blood." Inhalation Toxicology 15, no. 4 (April 2003): 327-342.  Full Text
    • Huang, Y-CT, Soukup, J, Harder, S, and Becker, S. "Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage." American Journal of Physiology Cell Physiology 284, no. 1 (January 2003): C24-C32.  Full Text
    • Huang, YCT, Soukup, J, Harder, S, and Becker, S. "Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage." American Journal of Physiology Cell Physiology 284, no. 1 53-1 (January 1, 2003).
    • Huang, Y-CT, and Piantadosi, CA. "Alveolar barrier function assessed by hydrophobic and hydrophilic fluorescent solutes in rabbit lung." Respir Physiol Neurobiol 133, no. 1-2 (October 23, 2002): 153-166.  Link to Item
    • Huang, Y-CT, O'Brien, SR, and MacIntyre, NR. "Intrabreath diffusing capacity of the lung in healthy individuals at rest and during exercise." Chest 122, no. 1 (July 2002): 177-185.  Link to Item
    • Lee, DL, Chiang, H-T, Lin, S-L, Ger, L-P, Kun, M-H, and Huang, Y-CT. "Prone-position ventilation induces sustained improvement in oxygenation in patients with acute respiratory distress syndrome who have a large shunt." Crit Care Med 30, no. 7 (July 2002): 1446-1452.  Link to Item
    • Nozik-Grayck, E, McMahon, TJ, Huang, Y-CT, Dieterle, CS, Stamler, JS, and Piantadosi, CA. "Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione." American Journal of Physiology. Lung Cellular and Molecular Physiology 282, no. 5 (May 2002): L1057-L1065.  Full Text
    • Que, LG, George, SE, Gotoh, T, Mori, M, and Huang, Y-CT. "Effects of arginase isoforms on NO Production by nNOS." Nitric Oxide : Biology and Chemistry 6, no. 1 (February 2002): 1-8.  Full Text
    • Huang, Y-CT, Wu, W, Ghio, AJ, Carter, JD, Silbajoris, R, Devlin, RB, and Samet, JM. "Activation of EGF receptors mediates pulmonary vasoconstriction induced by residual oil fly ash." Experimental Lung Research 28, no. 1 (January 2002): 19-38.  Full Text
    • Carraway, MS, Piantadosi, CA, and Wright, JR. "Alveolar proteinosis: a disease of mice and men." American Journal of Physiology. Lung Cellular and Molecular Physiology 280, no. 3 (March 2001): L377-L378. (Review)  Full Text
    • Huang, YCT, Ghio, AJ, Nozik-Grayck, E, and Piantadosi, CA. "Vascular release of nonheme iron in perfused rabbit lungs." American Journal of Physiology Lung Cellular and Molecular Physiology 280, no. 3 24-3 (March 1, 2001).
    • Huang, YT, Ghio, AJ, Nozik-Grayck, E, and Piantadosi, CA. "Vascular release of nonheme iron in perfused rabbit lungs." American Journal of Physiology. Lung Cellular and Molecular Physiology 280, no. 3 (March 2001): L474-L481.  Full Text
    • Welty-Wolf, KE, Carraway, MS, Huang, YC, Simonson, SG, Kantrow, SP, Kishimoto, TK, and Piantadosi, CA. "Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis." Am J Respir Crit Care Med 163, no. 3 Pt 1 (March 2001): 665-673.  Full Text  Link to Item
    • Welty-Wolf, KE, Carraway, MS, Huang, YCT, Simonson, SG, Kantrow, SP, Kishimoto, TK, and Piantadosi, CA. "Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis." American Journal of Respiratory and Critical Care Medicine 163, no. 3 I (January 1, 2001): 665-673.  Full Text
    • Welty-Wolf, KE, Carraway, MS, Ghio, A, Kantrow, SP, Huang, YC, and Piantadosi, CA. "Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy." Shock 13, no. 5 (May 2000): 404-409.  Link to Item
    • Que, LG, and Tony Huang, YC. "Pharmacologic adjuncts during mechanical ventilation." Semin Respir Crit Care Med 21, no. 3 (2000): 223-232.  Full Text  Link to Item
    • Carraway, MS, Welty-Wolf, KE, Kantrow, SP, Huang, YCT, Simonson, SG, Que, LG, Kishimoto, TK, and Piantadosi, CA. "Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons." American Journal of Respiratory and Critical Care Medicine 157, no. 3 PART I (December 1, 1998): 938-949.
    • Brown, CD, MacIntyre, NR, and Huang, YC. "Diffusing capacity and pulmonary capillary blood flow during maximal exercise." Chest 114, no. 4 SUPPL. (October 1, 1998).
    • Hills, BA. "Role of surfactant and hyperoxia." Journal of Applied Physiology (Bethesda, Md. : 1985) 85, no. 2 (August 1998): 770-771. (Letter)  Full Text
    • Welty-Wolf, KE, Carraway, MS, Huang, YC, Simonson, SG, Kantrow, SP, and Piantadosi, CA. "Bacterial priming increases lung injury in gram-negative sepsis." Am J Respir Crit Care Med 158, no. 2 (August 1998): 610-619.  Full Text  Link to Item
    • Que, LG, Kantrow, SP, Jenkinson, CP, Piantadosi, CA, and Huang, YCT. "Induction of arginase isoforms in the lung during hyperoxia." American Journal of Physiology Lung Cellular and Molecular Physiology 275, no. 1 19-1 (July 1, 1998).
    • Carraway, MS, Piantadosi, CA, Jenkinson, CP, and Huang, YC. "Differential expression of arginase and iNOS in the lung in sepsis." Exp Lung Res 24, no. 3 (May 1998): 253-268.  Link to Item
    • Que, LG, Kang, BH, Huang, YC, Piantadosi, CA, and Chang, LY. "Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis." Shock 9, no. 4 (April 1998): 304-309.  Link to Item
    • Carraway, MS, Welty-Wolf, KE, Kantrow, SP, Huang, YC, Simonson, SG, Que, LG, Kishimoto, TK, and Piantadosi, CA. "Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons." Am J Respir Crit Care Med 157, no. 3 Pt 1 (March 1998): 938-949.  Full Text  Link to Item
    • Huang, YCT, Fisher, PW, Nozik-Grayck, E, and Piantadosi, CA. "Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury." American Journal of Physiology 273, no. 3 PART 1 (December 1, 1997).
    • Huang, YC, Fisher, PW, Nozik-Grayck, E, and Piantadosi, CA. "Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury." The American Journal of Physiology 273, no. 3 Pt 1 (September 1997): L504-L512.  Full Text
    • Huang, YCT, Fisher, PW, Nozik-Grayck, E, and Piantadosi, CA. "Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury." American Journal of Physiology Lung Cellular and Molecular Physiology 273, no. 3 17-3 (September 1, 1997).
    • Nozik-Grayck, E, Piantadosi, CA, van Adelsberg, J, Alper, SL, and Huang, YC. "Protection of perfused lung from oxidant injury by inhibitors of anion exchange." The American Journal of Physiology 273, no. 2 Pt 1 (August 1997): L296-L304.  Full Text
    • Simonson, SG, Welty-Wolf, KE, Huang, YC, Taylor, DE, Kantrow, SP, Carraway, MS, Crapo, JD, and Piantadosi, CA. "Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry." Journal of Applied Physiology (Bethesda, Md. : 1985) 83, no. 2 (August 1997): 550-558.  Full Text
    • Welty-Wolf, KE, Simonson, SG, Huang, YC, Kantrow, SP, Carraway, MS, Chang, LY, Crapo, JD, and Piantadosi, CA. "Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis." Journal of Applied Physiology (Bethesda, Md. : 1985) 83, no. 2 (August 1997): 559-568.  Full Text
    • Fryer, A, Huang, YC, Rao, G, Jacoby, D, Mancilla, E, Whorton, R, Piantadosi, CA, Kennedy, T, and Hoidal, J. "Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung." The Journal of Pharmacology and Experimental Therapeutics 282, no. 1 (July 1997): 208-219.
    • Kantrow, SP, Huang, YCT, Whorton, AR, Grayck, EN, Knight, JM, Millington, DS, and Piantadosi, CA. "Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung." American Journal of Physiology Lung Cellular and Molecular Physiology 272, no. 6 16-6 (June 1, 1997).
    • Simonson, SG, Huang, YC, Fracica, PJ, Welty-Wolf, KE, Moon, RE, Young, SL, and Piantadosi, CA. "Changes in the lung after prolonged positive pressure ventilation in normal baboons." J Crit Care 12, no. 2 (June 1997): 72-82.  Link to Item
    • Kang, BH, Manderschied, BD, Huang, YC, Crapo, JD, and Chang, LY. "Contrasting response of lung parenchymal cells to instilled TNF alpha and IFN gamma: the inducibility of specific cell ICAM-1 in vivo." Am J Respir Cell Mol Biol 15, no. 4 (October 1996): 540-550.  Full Text  Link to Item
    • Su, WY, Day, BJ, Kang, BH, Crapo, JD, Huang, YC, and Chang, LY. "Lung epithelial cell-released nitric oxide protects against PMN-mediated cell injury." The American Journal of Physiology 271, no. 4 Pt 1 (October 1996): L581-L586.  Full Text
    • Huang, YC, Fracica, PJ, Simonson, SG, Crapo, JD, Young, SL, Welty-Wolf, KE, Moon, RE, and Piantadosi, CA. "VA/Q abnormalities during gram negative sepsis." Respir Physiol 105, no. 1-2 (August 1996): 109-121.  Link to Item
    • Welty-Wolf, KE, Simonson, SG, Huang, YC, Fracica, PJ, Patterson, JW, and Piantadosi, CA. "Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis." Shock (Augusta, Ga.) 5, no. 5 (May 1996): 378-384.
    • Carraway, MS, Piantadosi, CA, Jenkinson, CP, and Huang, YC. "Differential expression of lung arginase and inos in sepsis." Journal of Investigative Medicine 44, no. 3 (January 1, 1996).
    • Huang, YC, Sane, AC, Simonson, SG, Fawcett, TA, Moon, RE, Fracica, PJ, Menache, MG, Piantadosi, CA, and Young, SL. "Artificial surfactant attenuates hyperoxic lung injury in primates. I. Physiology and biochemistry." Journal of Applied Physiology (Bethesda, Md. : 1985) 78, no. 5 (May 1995): 1816-1822.  Full Text
    • Piantadosi, CA, Fracica, PJ, Duhaylongsod, FG, Huang, YC, Welty-Wolf, KE, Crapo, JD, and Young, SL. "Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis." Journal of Applied Physiology (Bethesda, Md. : 1985) 78, no. 5 (May 1995): 1823-1831.  Full Text
    • Nozik, ES, Huang, YC, and Piantadosi, CA. "L-arginine enhances injury in the isolated rabbit lung during hyperoxia." Respir Physiol 100, no. 1 (April 1995): 63-74.  Link to Item
    • Huang, YC, Fracica, PJ, and Piantadosi, CA. "Tumor necrosis factor-alpha-induced lung injury and its modulation by synthetic polynucleotide: a physiologic-morphometric analysis." Exp Lung Res 20, no. 6 (November 1994): 539-558.  Link to Item
    • Simonson, SG, Welty-Wolf, K, Huang, YT, Griebel, JA, Caplan, MS, Fracica, PJ, and Piantadosi, CA. "Altered mitochondrial redox responses in gram negative septic shock in primates." Circ Shock 43, no. 1 (May 1994): 34-43.  Link to Item
    • Huang, YCT, Nozik, ES, and Piantadosi, CA. "Superoxide dismutase potentiates platelet-activating factor-induced injury in perfused lung." American Journal of Physiology Lung Cellular and Molecular Physiology 266, no. 3 10-3 (April 25, 1994).
    • Huang, YC, Caminiti, SP, Fawcett, TA, Moon, RE, Fracica, PJ, Miller, FJ, Young, SL, and Piantadosi, CA. "Natural surfactant and hyperoxic lung injury in primates. I. Physiology and biochemistry." Journal of Applied Physiology (Bethesda, Md. : 1985) 76, no. 3 (March 1994): 991-1001.  Full Text
    • Huang, YC, Helms, MJ, and MacIntyre, NR. "Normal values for single exhalation diffusing capacity and pulmonary capillary blood flow in sitting, supine positions, and during mild exercise." Chest 105, no. 2 (February 1994): 501-508.  Full Text
    • Stockwell, JA, Huang, YC, Su, YF, and Piantadosi, CA. "Bactericidal antibiotics increase tumor necrosis factor-alpha and cardiac output in rats after cecal ligation and puncture." Circ Shock 42, no. 2 (February 1994): 68-75.  Link to Item
    • Dodam, JR, Moon, RE, Olson, NC, Exposito, AJ, Fawcett, TA, Huang, YC, Theil, DR, Camporesi, E, and Swanson, CR. "Effects of clenbuterol hydrochloride on pulmonary gas exchange and hemodynamics in anesthetized horses." Am J Vet Res 54, no. 5 (May 1993): 776-782.  Link to Item
    • Fisher, PW, Huang, YCT, Kennedy, TP, and Piantadosi, CA. "PO₂-dependent hydroxyl radical production during ischemia-reperfusion lung injury." American Journal of Physiology Lung Cellular and Molecular Physiology 265, no. 3 9-3 (1993): L279-L285.
    • Fisher, PW, Huang, YCT, Kennedy, TP, and Piantadosi, CA. "PO2-dependent hydroxyl radical production during ischemia-reperfusion lung injury." American Journal of Physiology Lung Cellular and Molecular Physiology 265, no. 3 9-3 (January 1, 1993).
    • Huang, YC, Kennedy, TP, Su, YF, Watkins, WD, Whorton, AR, and Piantadosi, CA. "Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung." Journal of Applied Physiology (Bethesda, Md. : 1985) 74, no. 1 (January 1993): 251-258.  Full Text
    • Huang, YC, and Macintyre, NR. "Real-time gas analysis improves the measurement of single-breath diffusing capacity." Am Rev Respir Dis 146, no. 4 (October 1992): 946-950.  Full Text  Link to Item
    • Chang, LY, Huang, Y, Stockstill, BL, Graham, JA, Grose, EC, Menache, MG, Miller, FJ, Costa, DL, and Crapo, JD. "Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone." Toxicol Appl Pharmacol 115, no. 2 (August 1992): 241-252.  Link to Item
    • Chang, L, Miller, FJ, Ultman, J, Huang, Y, Stockstill, BL, Grose, E, Graham, JA, Ospital, JJ, and Crapo, JD. "Alveolar epithelial cell injuries by subchronic exposure to low concentrations of ozone correlate with cumulative exposure." Toxicol Appl Pharmacol 109, no. 2 (June 15, 1991): 219-234.  Link to Item
    • Huang, YT. "Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target."
    • Nozik-Grayck, E, McMahon, TJ, Huang, YCT, Dieterle, CS, Stamler, JS, and Piantadosi, CA. "Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione." American Journal of Physiology Lung Cellular and Molecular Physiology 282, no. 5 26-5 (June 29, 2002).
    • Nozik-Grayck, E, Piantadosi, CA, Van Adelsberg, J, Alper, SL, and Huang, YCT. "Protection of perfused lung from oxidant injury by inhibitors of anion exchange." American Journal of Physiology Lung Cellular and Molecular Physiology 273, no. 2 17-2 (October 18, 1997).
    • Yang, Z, Huang, Y-CT, Koziel, H, de Crom, R, Ruetten, H, Wohlfart, P, Thomsen, RW, Kahlert, JA, Sørensen, HT, Jozefowski, S, Colby, A, and Kobzik, L. "Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target(Published online)." Elife 3.  Full Text

  • Book Sections

    • Huang, Y, Lease, E, and Beachey, W. "Arterial Blood Gas Analysis and Sampling." In Respiratory Care: Principles and Practice. Jones & Bartlett Publishers, April 6, 2015. (Chapter)
    • Huang, YC, Lease, E, and Beachey, W. "Assessment of Acid-Base Balance." In Respiratory Care: Principles and Practice. Jones & Bartlett Publishers, April 6, 2015. (Chapter)
    • Huang, YT, Lease, E, and Beachey, W. "Assessment of Gas Exchange." In Respiratory Care: Principles and Practice. Jones & Bartlett Publishers, April 6, 2015. (Chapter)

  • Conference Papers

    • Bocharnikov, A, and Huang, YT. "Barriers for Delivering Care to COPD Patients: A Physician Survey." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018.  Link to Item
    • Huang, YT, He, M, Wang, Z, Rankine, L, Womack, S, Mammarappallil, J, McAdams, P, and Driehuys, B. "Ventilation and Gas Transfer Measured by 129Xe MRI in Alpha-1 Antitrypsin Heterozygotes: A Pilot Study." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018.  Link to Item
    • Huang, YT, Wang, Z, He, M, Rankine, L, Womack, S, McAdams, P, Mammarappalil, J, and Driehuys, B. "Ventilation and Gas Transfer Distribution in Alpha-1 Antitrypsin Deficiency After Replacement Therapy." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018.  Link to Item

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