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Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes.

Publication ,  Journal Article
Bartlett, DB; Slentz, CA; Connelly, MA; Piner, LW; Willis, LH; Bateman, LA; Granville, EO; Bales, CW; Huffman, KM; Kraus, WE
Published in: Oxid Med Cell Longev
2017

GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA in persons at risk for type 2 diabetes. GlycA, fitness, and body habitus were measured in 169 sedentary adults (45-75 years) with prediabetes randomly assigned to one of four six-month exercise-based lifestyle interventions. Interventions included exercise prescription based on the amount (energy expenditure (kcal/kg weight/week (KKW)) and intensity (%VO2peak). The groups were (1) low-amount/moderate-intensity (10KKW/50%) exercise; (2) high-amount/moderate-intensity (16KKW/50%) exercise; (3) high-amount/vigorous-intensity (16KKW/75%) exercise; and (4) a Clinical Lifestyle (combined diet plus low-amount/moderate-intensity exercise) intervention. Six months of exercise training and/or diet-reduced GlycA (mean Δ: -6.8 ± 29.2 μmol/L; p = 0.006) and increased VO2peak (mean Δ: 1.98 ± 2.6 mL/kg/min; p < 0.001). Further, visceral (mean Δ: -21.1 ± 36.6 cm2) and subcutaneous fat (mean Δ: -24.3 ± 41.0 cm2) were reduced, while liver density (mean Δ: +2.3 ± 6.5HU) increased, all p < 0.001. When including individuals in all four interventions, GlycA reductions were associated with reductions in visceral adiposity (p < 0.03). Exercise-based lifestyle interventions reduced GlycA concentrations through mechanisms related to exercise-induced modulations of visceral adiposity. This trial is registered with Clinical Trial Registration Number NCT00962962.

Duke Scholars

Published In

Oxid Med Cell Longev

DOI

EISSN

1942-0994

Publication Date

2017

Volume

2017

Start / End Page

5608287

Location

United States

Related Subject Headings

  • Prediabetic State
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Female
  • Exercise
  • Body Weight
  • Biomarkers
  • Aged
 

Citation

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ICMJE
MLA
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Bartlett, D. B., Slentz, C. A., Connelly, M. A., Piner, L. W., Willis, L. H., Bateman, L. A., … Kraus, W. E. (2017). Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes. Oxid Med Cell Longev, 2017, 5608287. https://doi.org/10.1155/2017/5608287
Bartlett, David B., Cris A. Slentz, Margery A. Connelly, Lucy W. Piner, Leslie H. Willis, Lori A. Bateman, Esther O. Granville, Connie W. Bales, Kim M. Huffman, and William E. Kraus. “Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes.Oxid Med Cell Longev 2017 (2017): 5608287. https://doi.org/10.1155/2017/5608287.
Bartlett DB, Slentz CA, Connelly MA, Piner LW, Willis LH, Bateman LA, et al. Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes. Oxid Med Cell Longev. 2017;2017:5608287.
Bartlett, David B., et al. “Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes.Oxid Med Cell Longev, vol. 2017, 2017, p. 5608287. Pubmed, doi:10.1155/2017/5608287.
Bartlett DB, Slentz CA, Connelly MA, Piner LW, Willis LH, Bateman LA, Granville EO, Bales CW, Huffman KM, Kraus WE. Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes. Oxid Med Cell Longev. 2017;2017:5608287.

Published In

Oxid Med Cell Longev

DOI

EISSN

1942-0994

Publication Date

2017

Volume

2017

Start / End Page

5608287

Location

United States

Related Subject Headings

  • Prediabetic State
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Female
  • Exercise
  • Body Weight
  • Biomarkers
  • Aged