Scholars@Duke
Connie Watkins Bales

Connie Watkins Bales

Professor Emeritus in Medicine
Medicine, Geriatrics and Palliative Care
bales001@mc.duke.edu
Duke Box 3003, Durham, NC 27710
2508 Busse Bldg, Durham, NC 27710

Overview

Research in our laboratory focuses on the role of nutrition (particularly vitamins and minerals) in the prevention and management of chronic diseases in older adults. Previous studies have concerned trace elements and cardiovascular disease, calcium and osteoporosis, and renal synthesis of vitamin D as it relates to bone health. Some of our newest work emphasizes the role of micronutrients as antioxidants and their interaction with the aging process. We are also working on various aspects of energy balance in older adults, ranging from failure to thrive in stroke patients with dysphagia to exercise and nutrition effects in overweight subjects who begin physical training. Thus we have a number of clinical and epidemiological projects on-going, many of which include a strong emphasis on nutrition assessment techniques in middle-aged and elderly subjects.

Current Appointments & Affiliations

Professor Emeritus in Medicine · 2024 - Present Medicine, Geriatrics and Palliative Care, Medicine
Senior Fellow in the Center for the Study of Aging and Human Development · 1988 - Present Center for the Study of Aging and Human Development, Institutes and Centers

Recent Publications

The impact of lifestyle modification on metabolic pathways in older adults with overweight/obesity and rheumatoid arthritis: a secondary exploratory analysis of the SWET-RA study.

Journal Article BMC Rheumatol · June 9, 2025 BACKGROUND: Rheumatoid arthritis (RA) is associated with increased cardiometabolic risk due to inflammation and traditional risk factors, both of which can be mitigated by lifestyle modifications. This study examines metabolic pathways influenced by lifest ... Full text Link to item Cite

Effects of Blueberry Consumption on Fecal Microbiome Composition and Circulating Metabolites, Lipids, and Lipoproteins in a Randomized Controlled Trial of Older Adults with Overweight or Obesity: The BEACTIVE Trial.

Journal Article Nutrients · March 29, 2025 Background/Objectives: Generous consumption of phytonutrient-rich foods, including blueberries, provides benefits to multiple physiologic and metabolic systems. This study explored the potential that regular, generous blueberry intake could favorably modul ... Full text Link to item Cite

Changes in weight and physical function for older African American women in Take Off Pounds Sensibly (TOPS): Study protocol for a randomized clinical trial.

Journal Article Contemp Clin Trials · March 2025 BACKGROUND: Obesity and frailty are positively linked. Compared to other groups, older African American women have the highest rates of both obesity and frailty. Several academic weight loss interventions have shown that older adults can lose weight and im ... Full text Link to item Cite
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Recent Grants

Weight loss, in vivo cartilage mechanics, and joint health

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2025

Behavior and Physiology in Aging

Inst. Training Prgm or CMEMentor · Awarded by National Institute on Aging · 2015 - 2025

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Education, Training & Certifications

University of Tennessee, Knoxville · 1981 Ph.D.