Journal ArticleContemp Clin Trials · January 18, 2025
BACKGROUND: Obesity and frailty are positively linked. Compared to other groups, older African American women have the highest rates of both obesity and frailty. Several academic weight loss interventions have shown that older adults can lose weight and im ...
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Journal ArticleESMO Open · July 2024
BACKGROUND: Low muscle mass (MM) predicts unfavorable outcomes in cancer. Protein intake supports muscle health, but oncologic recommendations are not well characterized. The objectives of this study were to evaluate the feasibility of dietary change to at ...
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Journal ArticleACR Open Rheumatol · March 2024
OBJECTIVE: To compare a remotely supervised weight loss and exercise intervention to lifestyle counseling for effects on cardiovascular disease risk, disease activity, and patient-reported outcomes in older patients with rheumatoid arthritis (RA) and overw ...
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Journal ArticleOsteoarthr Cartil Open · September 2023
OBJECTIVE: To examine the effects of a 6-month weight loss intervention on physical function, inflammatory biomarkers, and metabolic biomarkers in both those with and without osteoarthritis (OA). DESIGN: 59 individuals ≥60 years old with obesity and a func ...
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Journal ArticleACR Open Rheumatol · May 2023
Patients with rheumatoid arthritis (RA) remain at an increased risk for cardiovascular disease (CVD) and mortality. RA CVD results from a combination of traditional risk factors and RA-related systemic inflammation. One hypothetical means of improving over ...
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Journal ArticleFront Physiol · 2023
The purpose of this secondary analysis was to determine what portion of the effects of a Diabetes Prevention Program-like intervention on metabolic syndrome (MetS) could be achieved with exercise alone, as well as to determine the relative importance of ex ...
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Journal ArticleBr J Nutr · October 14, 2022
The Mediterranean diet (MedD) is a flexible dietary pattern which has such variability that has led to inconsistencies in definitions and assessment. The purpose of this narrative review is to evaluate scoring systems in a cultural and geographic context, ...
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Journal ArticleExp Gerontol · August 2022
OBJECTIVES: The aim was to determine the nutritional adequacy of calorie restricted (CR) diets during CR interventions up to 12 months. METHODS: The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) phase 1 trial consist ...
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Chapter · February 18, 2022
Essential vitamins and minerals are also known as micronutrients. They are uniquely required for essential biological and structural functions in the body, including as hormones, antioxidants, and enzyme cofactors and for one-carbon metabolism and DNA synt ...
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Journal ArticleBMJ Open Diabetes Res Care · January 2022
INTRODUCTION: To determine the relative contributions of various amounts and intensities of exercise alone to a combined lifestyle intervention on health-related quality of life (HrQoL) measures. RESEARCH DESIGN AND METHODS: Participants (n=162) were seden ...
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Chapter · January 1, 2022
Optimal nutrition is an essential element for the quality of life and health in older adults. Energy needs and thus food intake decrease with age, while requirements for other nutrients remain stable or increase. Thus, older adults are at greater risk for ...
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Journal ArticleTransl Behav Med · December 14, 2021
Older veterans with posttraumatic stress disorder (PTSD) are at increased risk of obesity and cardiometabolic disease. Physical activity and healthy eating are two behaviors that impact health, functional independence, and disease risk in later life, yet f ...
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Journal ArticleClin Nutr ESPEN · February 2021
BACKGROUND: Severe muscle mass (MM) loss is a defining feature of cancer observed across all types and stages of disease and is an independent predictor of poor clinical outcomes including higher incidences of chemotherapy toxicity and decreased survival. ...
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Journal ArticleFront Physiol · 2021
BACKGROUND: Lipoprotein Insulin Resistance Index (LP-IR) and Diabetes Risk Index are novel spectroscopic multimarkers of insulin resistance and type 2 diabetes risk. As the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE ...
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Journal ArticleJ Nutr Gerontol Geriatr · 2021
In contrast to recommendations for young and middle-aged adults, intentional weight loss among older adults remains controversial and is inconsistently advised. Recent research suggests that a higher protein diet can mitigate loss of lean mass during perio ...
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ConferenceCirculation · March 3, 2020
Introduction:
Lipoprotein Insulin Resistance Index (LP-IR) is a novel spectroscopic multimarker linked to future diabetes risk. We recently assessed changes in LP-IR across the three STRRIDE trials, w ...
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Journal ArticleJ Nutr Gerontol Geriatr · 2019
Both aging and obesity are associated with increased levels of pro-inflammatory metabolites, while weight reduction is associated with improvements in inflammatory status. However, few studies have explored the response of key inflammatory markers to the c ...
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Journal ArticleJ Clin Lipidol · 2019
BACKGROUND: The recognized benefits of a higher protein diet on muscle mass and strength in older adults are tempered by concerns of the potentially negative cardiometabolic impact of dietary sources of animal protein. OBJECTIVE: The aim of this study was ...
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Journal ArticleAdv Nutr · March 1, 2018
Throughout the world, a high prevalence of obesity in older populations has created a new phenotype of frailty: the obese, functionally frail older adult. The convergence of the obesity epidemic with global graying will undoubtedly increase the prevalence ...
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Journal ArticleJ Nutr Gerontol Geriatr · 2018
Increases in rates of obesity in the older population are hastening the development of chronic illnesses, including chronic kidney disease (CKD). However, obesity reduction in older adults is besought with concerns about the long-term benefit/risk, especia ...
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Journal ArticleJ Nutr Health Aging · 2018
OBJECTIVE: To examine the bi-directional associations of a weight loss intervention with quality of life and mental health in obese older adults with functional limitations. DESIGN: Combined-group analyses of secondary variables from the MEASUR-UP randomiz ...
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Journal ArticleCurr Dev Nutr · May 1, 2017
BACKGROUND: Women have higher rates of obesity than men and develop more pronounced functional deficits as a result. Yet, little is known about how obesity reduction affects their functional status, including whether their responses differ when protein int ...
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Journal ArticleJ Am Geriatr Soc · April 2017
BACKGROUND: Nursing home (NH) residents who require assistance during mealtimes are at risk for malnutrition. Supportive handfeeding is recommended, yet there is limited evidence supporting use of a specific handfeeding technique to increase meal intake. O ...
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Journal ArticleAm J Clin Nutr · April 2017
Background: Calorie restriction (CR) retards aging and increases longevity in many animal models. However, it is unclear whether CR can be implemented in humans without adverse effects on body composition.Objective: We evaluated the effect of a 2-y CR regi ...
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Journal ArticleOxid Med Cell Longev · 2017
GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to eval ...
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Journal ArticleJ Am Geriatr Soc · November 2016
The Veterans Affairs Geriatric Scholars Program (GSP) is a continuing professional development program to integrate geriatrics into the clinical practices of primary care providers and select associated health professions that support primary care teams. G ...
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Journal ArticleJ Gerontol A Biol Sci Med Sci · October 2016
BACKGROUND: Obesity is a significant cause of functional limitations in older adults; yet, concerns that weight reduction could diminish muscle along with fat mass have impeded progress toward an intervention. Meal-based enhancement of protein intake could ...
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Journal ArticleDiabetologia · October 2016
AIMS/HYPOTHESIS: Although the Diabetes Prevention Program (DPP) established lifestyle changes (diet, exercise and weight loss) as the 'gold standard' preventive therapy for diabetes, the relative contribution of exercise alone to the overall utility of the ...
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Journal ArticleNutrients · May 4, 2016
The global prevalence of obesity in the older adult population is growing, an increasing concern in both the developed and developing countries of the world. The study of geriatric obesity and its management is a relatively new area of research, especially ...
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Journal ArticleJ Bone Miner Res · January 2016
Although caloric restriction (CR) could delay biologic aging in humans, it is unclear if this would occur at the cost of significant bone loss. We evaluated the effect of prolonged CR on bone metabolism and bone mineral density (BMD) in healthy younger adu ...
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Chapter · January 1, 2016
The aim of this book chapter is to describe the beneficial properties of a Mediterranean diet in regard to healthy, overweight, and obese older adults, and to summarize the characteristics, prevalence, pathophysiology, impact, and controversial nature of l ...
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Journal ArticleDiabetologia · October 2015
AIMS/HYPOTHESES: Obesity is associated with decreased insulin sensitivity (IS) and elevated plasma branched-chain amino acids (BCAAs). The purpose of this study was to investigate the relationship between BCAA metabolism and IS in overweight (OW) individua ...
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Journal ArticleDiabet Med · August 2015
AIM: To investigate whether previous physical activity levels are associated with blood glucose levels in individuals with impaired glucose tolerance in the context of an international pharmaceutical trial. METHODS: Data were analysed from the NAVIGATOR tr ...
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Journal ArticleClin Geriatr Med · August 2015
The health challenges prompted by obesity in the older adult population are poorly recognized and understudied. A defined treatment of geriatric obesity is difficult to establish, as it must take into account biological heterogeneity, age-related comorbidi ...
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Journal ArticleJ Appl Physiol (1985) · June 15, 2015
Most health organizations recommend a combination of aerobic training (AT) and resistance training (RT), yet few studies have compared their acute (within 24 h of the last exercise bout) and sustained (after 14 days of no exercise training) effects alone a ...
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Journal ArticleCurr Nutr Rep · June 2015
A nutritionally vulnerable older adult has a reduced physical reserve that limits the ability to mount a vigorous recovery in the face of an acute health threat or stressor. Often this vulnerability contributes to more medical complications, longer hospita ...
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Chapter · January 1, 2015
This is the new and fully revised third edition of the well-received text that is the benchmark book in the field of nutrition and aging. The editors (specialists in geriatric nutrition, medical sociology, and clinical nutrition, respectively) and contribu ...
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Journal ArticleContemp Clin Trials · January 2015
Obese older adults with even modest functional limitations are at a disadvantage for maintaining their independence into late life. However, there is no established intervention for obesity in older individuals. The Measuring Eating, Activity, and Strength ...
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Chapter · January 1, 2015
By the year 2050, the number of persons with dementia aged 65 and older in the United States is expected to increase from 5.4 to 16 million persons [1]. While most persons with dementia (PWD) prefer to be cared for in their home environment, as the disease ...
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Journal ArticleAm J Clin Nutr · May 2014
Undergraduate medical education has undergone significant changes in development of new curricula, new pedagogies, and new forms of assessment since the Nutrition Academic Award was launched more than a decade ago. With an emphasis on a competency-based cu ...
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Journal ArticleAm J Clin Nutr · May 2014
Nutrition is a recognized determinant in 3 (ie, diseases of the heart, malignant neoplasms, cerebrovascular diseases) of the top 4 leading causes of death in the United States. However, many health care providers are not adequately trained to address lifes ...
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Journal ArticleJ Am Med Dir Assoc · April 2014
Many frail older adults are thin, weak, and undernourished; this component of frailty remains a critical concern in the geriatric field. However, there is also strong evidence that excessive adiposity contributes to frailty by reducing the ability of older ...
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Journal ArticleMetabolism · April 2014
OBJECTIVE: The cardiometabolic risk cluster metabolic syndrome (MS) includes ≥3 of elevated fasting glucose, hypertension, elevated triglycerides, reduced high-density lipoprotein cholesterol (HDL-c), and increased waist circumference. Each can be affected ...
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Journal ArticleLancet · March 22, 2014
BACKGROUND: The extent to which change in physical activity can modify the risk of cardiovascular disease in individuals at high cardiovascular risk is uncertain. We investigated whether baseline and change in objectively-assessed ambulatory activity is as ...
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Journal ArticleJ Acad Nutr Diet · December 2013
Older adults with multiple comorbidities are often undernourished or at high risk for becoming so, especially after a recent hospitalization. Randomized controlled trials of effective, innovative interventions are needed to support evidence-based approache ...
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Journal ArticleJ Cardiopulm Rehabil Prev · 2013
PURPOSE: While the impact of caloric restriction on human health is not fully understood, there is strong evidence to support further studies of its influence on cardiovascular health. The purpose of this review was to update the state of the science by ex ...
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Journal ArticleJ Appl Physiol (1985) · December 15, 2012
Recent guidelines on exercise for weight loss and weight maintenance include resistance training as part of the exercise prescription. Yet few studies have compared the effects of similar amounts of aerobic and resistance training on body mass and fat mass ...
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Journal ArticleMed Sci Sports Exerc · October 2012
PURPOSE: Our study characterizes food and energy intake responses to long-term aerobic training (AT) and resistance training (RT) during a controlled 8-month trial. METHODS: In the STRRIDE-AT/RT trial, overweight/obese sedentary dyslipidemic men and women ...
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Journal ArticleAm Heart J · July 2012
BACKGROUND: The standard clinical approach for reducing cardiovascular disease risk due to dyslipidemia is to prescribe changes in diet and physical activity. The purpose of the current study was to determine if, across a range of dietary patterns, there w ...
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Journal ArticleAm J Physiol Endocrinol Metab · November 2011
While the benefits of exercise are clear, many unresolved issues surround the optimal exercise prescription. Many organizations recommend aerobic training (AT) and resistance training (RT), yet few studies have compared their effects alone or in combinatio ...
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Journal ArticleContemp Clin Trials · November 2011
Animal studies have shown that life span is extended by caloric restriction (CR). This manuscript describes the design and methodology of an innovative CR intervention, which is the treatment arm of the CALERIE Study. This study is a multi-center, randomiz ...
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Journal ArticleAm J Cardiol · September 15, 2011
Aerobic training (AT) improves the metabolic syndrome (MS) and its component risk factors; however, to our knowledge, no randomized clinical studies have addressed whether resistance training (RT) improves the MS when performed alone or combined with AT. S ...
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Journal ArticleJ Nutr Gerontol Geriatr · 2011
We conducted a study designed to evaluate the efficacy and feasibility of a multilevel self-management intervention to improve nutritional intake in a group of older adults receiving Medicare home health services who were at especially high risk for experi ...
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Journal ArticleJ Gerontol A Biol Sci Med Sci · January 2011
BACKGROUND: In a robust and consistent manner, sustained caloric restriction (CR) has been shown to retard the aging process in a variety of animal species. Nonhuman primate studies suggest that CR may have similar effects in longer-lived species. The CALE ...
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Journal ArticleGerontol Geriatr Educ · 2011
Gerontology and geriatrics are interdisciplinary professions. The quality of the care and services provided by the members of these professions depends upon the strength and integrity of the partnerships between the professionals working together. This art ...
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Journal ArticleJ Nutr Elder · January 2010
The use of nutritional supplements (NS) with the intention of improving health and delaying age-related chronic disease is a common practice among older adults; however, randomized controlled trials have yielded mixed results regarding the likelihood that ...
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Chapter · January 1, 2009
In accompaniment with a rapidly increasing proportion of older adults (global graying), the worldwide trend is toward illness and death due to chronic diseases rather than infectious ones.China has one of the most rapidly “graying” populations of any count ...
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Chapter · January 1, 2009
Complex emergencies (CEs) can occur anywhere and are defined as crisis situations that greatly elevate the risk to nutrition and overall health (morbidity and mortality) of older individuals in the affected area.In urban areas with high population densitie ...
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Chapter · January 1, 2009
Nutritional frailty is an unintentional, precipitous loss of both lean and fat mass resulting almost entirely from a reduction in food intake.Unintentional weight loss is associated with functional decline and increased mortality.Efforts to minimize nutrit ...
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Journal ArticleObes Facts · 2009
The relationship between body mass (usually measured as BMI in kg/m(2)) and healthy longevity is a major focus of study in the nutrition and aging field. Over-nutrition now rivals frailty as the major nutritional concern; the number of older adults who are ...
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Journal ArticleJ Nutr Elder · 2009
The majority of older adults take nutritional supplements (NS) to prevent deficiencies and/or because they are interested in the potential health promoting effects of these nutrients. This review explores the evidence of benefit for supplements of multivit ...
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Journal ArticleClin Nutr · December 2008
On December 13th and 14th a group of scientists and clinicians met in Washington, DC, for the cachexia consensus conference. At the present time, there is no widely agreed upon operational definition of cachexia. The lack of a definition accepted by clinic ...
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Journal ArticleJ Am Med Dir Assoc · June 2008
OBJECTIVES: The purpose of this review was to describe the characteristics of late-life obesity, including prevalence, pathophysiology, and influences on morbidity and mortality. A second objective was to systematically review the empiric evidence on the e ...
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Journal ArticleMetabolism · April 2008
Adipose-derived cytokines play a prominent role in mediating the metabolic consequences of obesity and excess body fat. Given this, we hypothesized that alterations in adipose tissue stores incurred with exercise training would be reflected in changes in s ...
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Journal ArticleAm Heart J · November 2007
BACKGROUND: The quality and quantity of dietary carbohydrate intake, measured as dietary glycemic load (GL), are associated with a number of cardiovascular disease (CVD) risk factors and, in healthy young women, are related to increased high-sensitivity C- ...
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Chapter · January 1, 2007
Optimal nutritional status plays a critical role in successful aging, contributing to both health and quality of life.1 One key determinant of dietary intake and thus nutritional status in the later years of life is living situation, since living environme ...
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Journal ArticleAm Heart J · October 2006
BACKGROUND: High-sensitivity C-reactive protein (hsCRP) is promoted as an independent predictor of atherosclerotic risk. In addition, cardiorespiratory fitness is inversely related to hsCRP in single-sex cross-sectional analyses. Our objective was to deter ...
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Journal ArticleAm J Geriatr Psychiatry · September 2006
OBJECTIVE: The authors sought to examine the association of vascular nutritional factors and depression in an elderly cohort of depression (currently and recently depressed) and comparison (never depressed) subjects. METHOD: Nutrient intake over the past y ...
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Journal ArticleJ Appl Physiol (1985) · October 2005
Despite the importance of randomized, dose-response studies for proper evaluation of effective clinical interventions, there have been no dose-response studies on the effects of exercise amount on abdominal obesity, a major risk factor for metabolic syndro ...
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Chapter · January 1, 2005
The problem of obesity has reached epidemic proportions in the United States (see also other chapters by Boan and McMahon), and evidence of its negative impact on health is rapidly accumulating. Excessive body mass, defined as a body-mass index (BMI) over ...
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Journal ArticleArch Intern Med · January 12, 2004
BACKGROUND: Obesity is a major health problem due, in part, to physical inactivity. The amount of activity needed to prevent weight gain is unknown. OBJECTIVE: To determine the effects of different amounts and intensities of exercise training. DESIGN: Rand ...
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Journal ArticleJ Am Med Dir Assoc · 2004
OBJECTIVE: Weight loss is a common occurrence in Alzheimer's disease (AD). This study was undertaken to investigate the relationship between weight loss and behavioral symptoms in institutionalized AD subjects. DESIGN: Observational study. SETTING: Two fac ...
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Journal ArticleN Engl J Med · November 7, 2002
BACKGROUND: Increased physical activity is related to reduced risk of cardiovascular disease, possibly because it leads to improvement in the lipoprotein profile. However, the amount of exercise training required for optimal benefit is unknown. In a prospe ...
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Journal ArticleClin Geriatr Med · November 2002
Many elderly individuals accept or even seek alternative or complementary therapies, including dietary and nutritional treatments. Medical practitioners, nutritionists, and marketing strategists must recognize the special concerns regarding ADT use by the ...
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Journal ArticleAnnu Rev Nutr · 2002
The progression of the aging process leads to a decreased margin of homeostatic reserve and a reduced ability to accommodate metabolic challenges, including nutritional stress. Nutritional frailty refers to the disability that occurs in old age owing to ra ...
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Journal ArticleMed Sci Sports Exerc · October 2001
PURPOSE: The Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) trial is a randomized controlled clinical trial designed to study the effects of exercise training regimens differing in dose (kcal.wk-1) and/or intensity (re ...
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Journal ArticleAm J Clin Nutr · July 2001
BACKGROUND: Effects of diet on blood lipids are best known in white men, and effects of type of carbohydrate on triacylglycerol concentrations are not well defined. OBJECTIVE: Our goal was to determine the effects of diet on plasma lipids, focusing on subg ...
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Journal ArticlePharmacotherapy · 1996
We conducted a population survey to describe patterns and determine predictors of the use of nutritional supplements and single-ingredient vitamins and minerals among elderly living in five adjacent urban and rural counties in the Piedmont area of North Ca ...
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Journal ArticleJournal of the American Dietetic Association · September 1, 1995
The conventional recommendation that lipid-lowering diets contain reduced amounts of red meats limits an important dietary source of nutrients. In an effort to address this problem, we analyzed 10 cuts from the loin and shoulder of a newly developed leaner ...
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Journal ArticleJ Nutr Elder · 1995
There is a traditional belief that the elderly have difficulty coping with dietary change, and therefore have a diminished likelihood of successfully responding to nutritional interventions or restrictions. Using a controlled mild zinc-deficiency feeding s ...
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Journal ArticleJ Am Coll Nutr · October 1994
OBJECTIVE: Suspicions that mild zinc deficiency is common among the elderly cannot be confirmed or refuted because definitive indicators of zinc status are lacking. The goal of this study was to document the clinical responsiveness of parameters of zinc st ...
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Journal ArticleJ Am Geriatr Soc · April 1994
OBJECTIVE: To determine if there is a relationship between body mass index and the ability to perform the usual activities of living in a sample of community-dwelling elderly. DESIGN: Secondary data analysis of The National Health and Nutrition Examination ...
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Journal ArticleJournal of Women's Health · January 1, 1993
Objective: To determine whether older women and men with osteoporosis who participated in a medica. evaluation program showed improvement in psychosocial functioning when compared to a age-, gender-, and disease severity-matched group of osteoporotic patie ...
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Journal ArticleJ Am Geriatr Soc · July 1991
Osteoporosis, a metabolic bone disease most prevalent in older adults, is a major public health problem. Although management of osteoporosis through diet, exercise, and medication has improved, little is known about the psychosocial consequences of this di ...
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Journal ArticleEndocrinology · March 1991
We have previously observed elevated serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2D] levels in male rats treated with oral cyclosporin-A (CsA). This elevation was independent of changes in PTH, ionized calcium, or phosphate. This paper investigates the potent ...
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Journal ArticleJ Gerontol · September 1990
To determine the effect of calcium supplementation on parathyroid hormone levels (PTH) in a group of elderly subjects at risk for developing Type II (senile) osteoporosis, 40 healthy volunteers participated in a randomized double-blind crossover study. Cal ...
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Journal ArticleAm J Clin Nutr · March 1990
Normal concentrations of trace elements in parotid saliva, supernatant- and sediment-mixed saliva, plasma, and hair were determined in 278 healthy adults grouped as young (18-29 y), middle-aged (30-64 y), and elderly (65-93 y). Age-related increases (p les ...
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Journal ArticleJ Am Geriatr Soc · May 1989
Participants in a therapeutic program for osteoporosis were studied to determine if program participation improved psychological outcomes. The 4-day program included intensive education about the disease and its prognosis, physical therapy education, nutri ...
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Journal ArticleEndocrinology · May 1989
Although renal hypertrophy occurs rapidly after uninephrectomy, restoring the majority of renal excretory function, it remains unknown whether similar compensatory mechanisms maintain 1,25-dihydroxyvitamin D production (and calcium homeostasis). To address ...
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Journal ArticleJ Nutr · June 1988
Five healthy men, ages 19-20, were fed a diet for 105 d to measure manganese balance during consumption of conventional foods. The study was divided into five periods of 21, 21, 38, 11 and 14 d, in which the daily dietary intakes of manganese (Mn) were 2.8 ...
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Journal ArticleExp Gerontol · 1988
The effects of dietary restriction (calorie and/or protein) imposed at weaning on tissue concentrations of nucleic acids and protein were determined in young (one year) and old (two year) rats. In liver, calorie restriction increased protein concentration ...
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Journal ArticleJ Nutr · January 1987
A balance study was conducted to determine the minimum requirement for manganese (Mn) and to examine the effects of Mn depletion. Seven male subjects, age 19-22, were fed a Mn-adequate diet of conventional foods (2.59 mg Mn/d, 135 mg cholesterol, and P:S r ...
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Journal ArticleAm J Clin Nutr · November 1986
Plasma uptake of a 25 mg oral dose of zinc was measured at 0, 1, 2, 3, and 4 h postdose in 16 elderly (mean age = 7.25 yr) and 12 young (mean age = 24.0 yr) subjects selected from a group of 62 healthy nonsmokers. Elderly and young subjects were divided in ...
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Journal ArticleProstaglandins · May 1986
Zinc has been implicated in the regulation of prostaglandins and other arachidonic acid derivatives. Studies of zinc-deficient animals, however, are compromised by concomitant reduction in food intake that may also alter eicosanoid levels in body tissues a ...
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Journal ArticleJ Gerontol · January 1986
Male Wistar rats were maintained on four dietary regimens: fed ad libitum throughout life (A); fed intermittently either during the first year of life and ad libitum thereafter (RA) or vice versa (AR); and fed intermittently throughout life (R). Low body w ...
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Journal ArticleExp Gerontol · 1983
Numerous studies have shown caloric restriction retards the physiological decline and increases the life span of animals. However, in these studies protein consumption was also reduced; thus, whether the beneficial effects were due to caloric or to protein ...
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