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Kim Marie Huffman

Associate Professor of Medicine
Medicine, Rheumatology and Immunology
300 N Duke St, Durham, NC 27701
300 N Duke St, Carmichael, 51-202, Durham, NC 27701

Overview


Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis)

Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis

Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise

Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations

Current Appointments & Affiliations


Associate Professor of Medicine · 2018 - Present Medicine, Rheumatology and Immunology, Medicine
Member of Duke Molecular Physiology Institute · 2013 - Present Duke Molecular Physiology Institute, Institutes and Centers
Affiliate of the Duke Regeneration Center · 2021 - Present Duke Regeneration Center, Basic Science Departments

In the News


Published July 6, 2021
Metabolomics Lab’s Analysis Finds Near-Meat and Meat Not Nutritionally Equivalent

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Recent Publications


Differential response of tissue engineered skeletal muscle from rheumatoid arthritis patients and healthy controls.

Journal Article Commun Biol · April 9, 2025 Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting articular joints and skeletal muscle. To assess the role of cytokines upon muscle strength in RA, we developed an in vitro tissue-engineered human skeletal muscle model (myobundle). Myob ... Full text Link to item Cite

Effects of Blueberry Consumption on Fecal Microbiome Composition and Circulating Metabolites, Lipids, and Lipoproteins in a Randomized Controlled Trial of Older Adults with Overweight or Obesity: The BEACTIVE Trial.

Journal Article Nutrients · March 29, 2025 Background/Objectives: Generous consumption of phytonutrient-rich foods, including blueberries, provides benefits to multiple physiologic and metabolic systems. This study explored the potential that regular, generous blueberry intake could favorably modul ... Full text Link to item Cite

The CALERIE Genomic Data Resource.

Journal Article Nat Aging · February 2025 Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To ... Full text Link to item Cite
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Recent Grants


The Effect of Exercise on T Cell Aging in Rheumatoid Arthritis

ResearchMentor · Awarded by National Institutes of Health · 2024 - 2029

Duke/UNC ADAR Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Using Bioengineered Human Muscle to Develop Treatments for Juvenile Dermatomyositis

ResearchCollaborator · Awarded by Hartwell Foundation · 2025 - 2028

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Education, Training & Certifications


Medical University of South Carolina, College of Medicine · 2000 M.D.
Medical University of South Carolina, College of Medicine · 1998 Ph.D.