Overview
Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis)
Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis
Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise
Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations
Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis
Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise
Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations
Current Appointments & Affiliations
Professor of Medicine
·
2025 - Present
Medicine, Rheumatology and Immunology,
Medicine
Member of Duke Molecular Physiology Institute
·
2013 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Immunoglobulin G and plasma glycome in early rheumatoid arthritis differ from matched controls and link less fat-free mass to an accelerated aging phenotype: an exploratory study.
Journal Article Arthritis Res Ther · April 21, 2026 Full text Link to item CiteQuadriceps mitochondrial DNA quantity, quality, and gene expression after 2 years of calorie restriction: exploratory results from the CALERIE trial.
Journal Article Geroscience · March 26, 2026 The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)™ trial was a randomized, 2-year controlled trial of caloric restriction (CR) versus an ad libitum (AL) control condition in nonobese humans. We performed exploratory a ... Full text Link to item CiteIntegrative Multi-omics Analysis of the Human Skeletal Muscle Response to Endurance or Resistance Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).
Journal Article bioRxiv · March 6, 2026 The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to systematically characterize the molecular basis of the health benefits of exercise. Here, we present the integrative, multi-omics response of human skeletal muscle to ac ... Full text Link to item CiteRecent Grants
Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations (INSPIRE-COPD-E).
ResearchAdvisor · Awarded by National Institutes of Health · 2025 - 2030The Effect of Exercise on T Cell Aging in Rheumatoid Arthritis
ResearchMentor · Awarded by National Institute on Aging · 2024 - 2029Duke/UNC ADAR Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029View All Grants
Education
Medical University of South Carolina, College of Medicine ·
2000
M.D.
Medical University of South Carolina, College of Medicine ·
1998
Ph.D.