Kim Marie Huffman

Journal Article Methods in molecular biology (Clifton, N.J.) · January 2025 Gene regulatory networks are foundational in the control of virtually all biological processes. These networks orchestrate a myriad of cell functions ranging from metabolic rate to the response to a drug or other intervention. The data required to accurate ... Full text Cite

Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase.

Journal Article Obesity (Silver Spring) · December 2024 OBJECTIVE: Caloric restriction (CR) is known to enhance insulin sensitivity and reduce the risk of metabolic disorders; however, its molecular mechanisms are not fully understood. This study aims to elucidate specific proteins and pathways responsible for ... Full text Link to item Cite

Predicting physical activity by the personality styles of the five-factor model.

Journal Article Health Psychol · October 2024 OBJECTIVE: Low neuroticism, high extraversion, and high conscientiousness are related to physical activity (PA). We tested whether the small size and heterogeneity of these relationships result because personality traits influence one another as well as be ... Full text Link to item Cite

Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol.

Journal Article J Appl Physiol (1985) · September 1, 2024 Physical activity, including structured exercise, is associated with favorable health-related chronic disease outcomes. Although there is evidence of various molecular pathways that affect these responses, a comprehensive molecular map of these molecular r ... Full text Link to item Cite

Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).

Journal Article Function (Oxf) · July 11, 2024 While regular physical activity is a cornerstone of health, wellness, and vitality, the impact of endurance exercise training on molecular signaling within and across tissues remains to be delineated. The Molecular Transducers of Physical Activity Consorti ... Full text Link to item Cite

The mitochondrial multi-omic response to exercise training across rat tissues.

Journal Article Cell Metab · June 4, 2024 Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consor ... Full text Link to item Cite

Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis.

Journal Article Aging Cell · June 2024 Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, no ... Full text Link to item Cite

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.

Journal Article Nat Metab · May 2024 Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrativ ... Full text Link to item Cite

The impact of exercise on gene regulation in association with complex trait genetics.

Journal Article Nat Commun · May 1, 2024 Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or easily biopsied tissues. Extensive transcript ... Full text Link to item Cite

Genome-Wide Genetic Analysis of Dropout in a Controlled Exercise Intervention in Sedentary Adults With Overweight or Obesity and Cardiometabolic Disease.

Journal Article Ann Behav Med · April 11, 2024 BACKGROUND: Despite the benefits of exercise, many individuals are unable or unwilling to adopt an exercise intervention. PURPOSE: The purpose of this analysis was to identify putative genetic variants associated with dropout from exercise training interve ... Full text Open Access Link to item Cite

Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT.

Journal Article Cell Rep · March 26, 2024 An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilized the MetRSL274 ... Full text Link to item Cite

Effect of Remotely Supervised Weight Loss and Exercise Training Versus Lifestyle Counseling on Cardiovascular Risk and Clinical Outcomes in Older Adults With Rheumatoid Arthritis: A Randomized Controlled Trial.

Journal Article ACR Open Rheumatol · March 2024 OBJECTIVE: To compare a remotely supervised weight loss and exercise intervention to lifestyle counseling for effects on cardiovascular disease risk, disease activity, and patient-reported outcomes in older patients with rheumatoid arthritis (RA) and overw ... Full text Link to item Cite

Calorie restriction reduces biomarkers of cellular senescence in humans.

Journal Article Aging Cell · February 2024 Calorie restriction (CR) with adequate nutrient intake is a potential geroprotective intervention. To advance this concept in humans, we tested the hypothesis that moderate CR in healthy young-to-middle-aged individuals would reduce circulating biomarkers ... Full text Link to item Cite

A population-based study of children suggests blunted morning cortisol rhythms are associated with alterations of the systemic inflammatory state.

Journal Article Psychoneuroendocrinology · January 2024 BACKGROUND: In children, digital media, lifestyle, and the COVID pandemic have impacted sunlight exposure, exercise, and diet patterns - cues that entrain the circadian clock. We hypothesized that low morning cortisol reflects a weak circadian clock, impac ... Full text Link to item Cite

Anti-CMV IgG Seropositivity is Associated with Plasma Biomarker Evidence of Amyloid-β Accumulation.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Some human studies have identified infection with cytomegalovirus (CMV), a member of the alpha herpesvirus family, as a risk factor for Alzheimer's disease and related dementias (ADRD). To our knowledge, no studies have evaluated associations o ... Full text Link to item Cite

Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study.

Journal Article Aging Cell · December 2023 The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by postponement of disease, preservation of function, and increased stress resistance. Whether CR elicits the same physiological and molecular responses in humans rema ... Full text Link to item Cite

Author Correction: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.

Journal Article Nat Aging · June 2023 Full text Link to item Cite

Remotely Supervised Weight Loss and Exercise Training to Improve Rheumatoid Arthritis Cardiovascular Risk: Rationale and Design of the Supervised Weight Loss Plus Exercise Training-Rheumatoid Arthritis Trial.

Journal Article ACR Open Rheumatol · May 2023 Patients with rheumatoid arthritis (RA) remain at an increased risk for cardiovascular disease (CVD) and mortality. RA CVD results from a combination of traditional risk factors and RA-related systemic inflammation. One hypothetical means of improving over ... Full text Open Access Link to item Cite

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.

Journal Article Nat Aging · March 2023 The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan1-3. Caloric restriction (CR), defined as lessening caloric intake without ... Full text Link to item Cite

Abstract P358: Racial Differences in Determinants and Timing of Dropout From an Exercise Intervention: The STRRIDE Trials

Conference Circulation · February 28, 2023 Introduction: Most adults recognize the positive health benefits of being physically active and maintaining a healthy weight, yet inactivity and obesity rates continue to rise. This disconnect is even ... Full text Cite

Effect of behavioral weight-loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial.

Journal Article Obesity (Silver Spring) · February 2023 OBJECTIVE: This study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12-month behavioral weight-loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers. M ... Full text Open Access Link to item Cite

Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: The kynurenine pathway (KP) comprises a family of tryptophan-derived metabolites that some studies have reported are associated with poorer cognitive performance and an increased risk of Alzheimer's disease and related dementias (ADRD). OBJECTI ... Full text Open Access Link to item Cite

Demographic, Clinical, and Psychosocial Predictors of Exercise Adherence: The STRRIDE Trials.

Journal Article Transl J Am Coll Sports Med · 2023 PURPOSE: To identify baseline demographic, clinical, and psychosocial predictors of exercise intervention adherence in the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) trials. METHODS: A total of 947 adults with dysl ... Full text Open Access Link to item Cite

Race and sex differences in dropout from the STRRIDE trials.

Journal Article Front Sports Act Living · 2023 PURPOSE: To determine if race and sex differences exist in determinants and timing of dropout among individuals enrolled in an exercise and/or caloric restriction intervention. METHODS: A total of 947 adults with dyslipidemia (STRRIDE I, STRRIDE AT/RT) or ... Full text Open Access Link to item Cite

Effects of exercise amount and intensity versus a combined exercise and lifestyle intervention on metabolic syndrome in adults with prediabetes: a STRRIDE-PD randomized trial.

Journal Article Front Physiol · 2023 The purpose of this secondary analysis was to determine what portion of the effects of a Diabetes Prevention Program-like intervention on metabolic syndrome (MetS) could be achieved with exercise alone, as well as to determine the relative importance of ex ... Full text Open Access Link to item Cite

Sex Differences In Determinants And Timing Of Dropout From An Exercise Intervention: The STRRIDE Trials

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · 2023 Cite

Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis.

Journal Article J Gerontol A Biol Sci Med Sci · December 29, 2022 Calorie restriction (CR) increases healthy life span and is accompanied by slowing or reversal of aging-associated DNA methylation (DNAm) changes in animal models. In the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIETM ... Full text Link to item Cite

Application of Heterogeneity of Treatment-Effects Methods: Exploratory Analyses of a Trial of Exercise-Based Interventions for Knee Osteoarthritis.

Journal Article Arthritis Care Res (Hoboken) · August 2022 OBJECTIVE: To evaluate heterogeneity of treatment effects in a trial of exercise-based interventions for knee osteoarthritis (OA). METHODS: Participants (n = 350) were randomized to standard physical therapy (PT; n = 140), internet-based exercise training ... Full text Link to item Cite

Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.

Journal Article Exp Gerontol · August 2022 Aging is a multifactorial process associated with progressive degradation of physiological integrity and function. One of the greatest factors contributing to the deleterious effects of aging is the decline of functional ability due to loss of muscle mass, ... Full text Link to item Cite

Differential Effects of Amount, Intensity, and Mode of Exercise Training on Insulin Sensitivity and Glucose Homeostasis: A Narrative Review.

Journal Article Sports Med Open · July 14, 2022 As type 2 diabetes remains a leading cause of morbidity and mortality, identifying the most appropriate preventive treatment early in the development of disease is an important public health matter. In general, lifestyle interventions incorporating exercis ... Full text Link to item Cite

Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness.

Journal Article Sci Rep · May 6, 2022 Rheumatoid arthritis (RA) T cells drive autoimmune features via metabolic reprogramming that reduces oxidative metabolism. Exercise training improves cardiorespiratory fitness (i.e., systemic oxidative metabolism) and thus may impact RA T cell oxidative me ... Full text Open Access Link to item Cite

Metabolomics analysis identifies a lipidomic profile in treatment-naïve juvenile dermatomyositis patients vs healthy control subjects.

Journal Article Rheumatology (Oxford) · April 11, 2022 OBJECTIVES: To perform an exploratory study to identify a JDM serum metabolic profile that differs from healthy controls (HCs) and responds to immunosuppressive treatment. METHODS: Blood was collected from 9 HCs and 10 patients diagnosed with probable (n = ... Full text Link to item Cite

Cost and Quality of Life Outcomes of the STepped Exercise Program for Patients With Knee OsteoArthritis Trial.

Journal Article Value Health · April 2022 OBJECTIVES: This study aimed to evaluate the cost-effectiveness of the randomized clinical trial STEP-KOA (STepped Exercise Program for patients with Knee OsteoArthritis). METHODS: The trial included 230 intervention and 115 control participants from 2 Vet ... Full text Link to item Cite

Abstract P080: Health-related Quality Of Life Predictors Of Exercise Intervention Dropout

Conference Circulation · March 2022 Introduction: Though many individuals know the health benefits of participating in exercise, few report sufficient activity to meet the US 2018 Physical Activity Guidelines. Current research assessing ... Full text Cite

Tissue engineered skeletal muscle model of rheumatoid arthritis using human primary skeletal muscle cells.

Journal Article J Tissue Eng Regen Med · February 2022 Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily targeting the joints. Autoreactive immune cells involved in RA affect other tissues, including skeletal muscle. Patients with RA experience diminished physical function, limited mobility ... Full text Link to item Cite

Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.

Journal Article EClinicalMedicine · January 2022 BACKGROUND: For many cardiovascular risk factors there is no lower limit to which further reduction will result in decreased disease risk; this includes values within ranges considered normal for healthy adults. This seems to be true for new emerging metab ... Full text Link to item Cite

Effects of a Weight and Pain Management Program in Patients With Rheumatoid Arthritis With Obesity: A Randomized Controlled Pilot Investigation.

Journal Article J Clin Rheumatol · January 1, 2022 BACKGROUND: Obesity is associated with poor outcomes for patients with rheumatoid arthritis (RA). Effective weight management is imperative. Although traditional lifestyle behavioral weight loss programs have demonstrated efficacy for reducing weight, thes ... Full text Link to item Cite

Amount and intensity effects of exercise training alone versus a combined diet and exercise lifestyle intervention on health-related quality of life in the STRRIDE-PD randomized trial.

Journal Article BMJ Open Diabetes Res Care · January 2022 INTRODUCTION: To determine the relative contributions of various amounts and intensities of exercise alone to a combined lifestyle intervention on health-related quality of life (HrQoL) measures. RESEARCH DESIGN AND METHODS: Participants (n=162) were seden ... Full text Link to item Cite

Determinants of Dropout from and Variation in Adherence to an Exercise Intervention: The STRRIDE Randomized Trials.

Journal Article Transl J Am Coll Sports Med · 2022 PURPOSE: This study aimed to characterize the timing and self-reported determinants of exercise dropout among sedentary adults with overweight or obesity. We also sought to explore variations in adherence among individuals who completed a 6- to 8-month str ... Full text Open Access Link to item Cite

Effects Of Exercise Training With And Without Weight Loss On Oral Disposition Index In STRRIDE-PD

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · 2022 Cite

Forearm Muscle Oxidative Capacity And Biomechanical Property Testing As Clinical Tools For Rheumatoid Arthritis

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · 2022 Cite

Evaluating Variation In Weight Change To An Exercise Intervention: The Strride Trials

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · 2022 Cite

Comparing the Chemical Profiles of Plant-Based and Traditional Meats Using GC–MS-Based Metabolomics

Journal Article LC-GC North America · January 1, 2022 As the consumer interest and market for plant-based meat alternatives grows, understanding the nutritional differences between alternative and traditional meats is essential. This article describes an untargeted gas chromatography–mass spectrometry (GC–MS) ... Full text Cite

Metabolic effects of high-intensity interval training and essential amino acids.

Journal Article Eur J Appl Physiol · December 2021 High-intensity interval training (HIIT) promotes positive cardiometabolic and body composition changes. Essential amino acids (EAA) may support changes associated with HIIT, but evaluation of potential synergistic effects is lacking. The purpose of this st ... Full text Link to item Cite

Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2.

Journal Article Exp Gerontol · November 2021 Caloric restriction (CR) improves markers of aging in humans; but it is not known if the fat mass and obesity-associated gene (FTO) rs9939609 single nucleotide polymorphism (SNP), which is associated with appetite and energy intake, influences adherence to ... Full text Link to item Cite

Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis.

Journal Article Arthritis Res Ther · July 10, 2021 BACKGROUND: Exercise training, including high-intensity interval training (HIIT), improves rheumatoid arthritis (RA) inflammatory disease activity via unclear mechanisms. Because exercise requires skeletal muscle, skeletal muscle molecular pathways may con ... Full text Link to item Cite

A metabolomics comparison of plant-based meat and grass-fed meat indicates large nutritional differences despite comparable Nutrition Facts panels.

Journal Article Scientific reports · July 2021 A new generation of plant-based meat alternatives-formulated to mimic the taste and nutritional composition of red meat-have attracted considerable consumer interest, research attention, and media coverage. This has raised questions of whether plant-based ... Full text Open Access Cite

Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial.

Journal Article Eur J Nutr · April 2021 PURPOSE: Calorie restriction (CR) is an effective treatment for obesity-related liver and metabolic disease. However, CR studies in individuals without obesity are needed to see if CR could delay disease onset. Liver biomarkers indicate hepatic health and ... Full text Link to item Cite

Stepped Exercise Program for Patients With Knee Osteoarthritis : A Randomized Controlled Trial.

Journal Article Ann Intern Med · March 2021 BACKGROUND: Evidence-based models are needed to deliver exercise-related services for knee osteoarthritis efficiently and according to patient needs. OBJECTIVE: To examine a stepped exercise program for patients with knee osteoarthritis (STEP-KOA). DESIGN: ... Full text Link to item Cite

Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis.

Journal Article J Appl Physiol (1985) · March 1, 2021 Rheumatoid arthritis (RA) is a systemic inflammatory arthritis impacting primarily joints and cardiac and skeletal muscle. RA's distinct impact on cardiac and skeletal muscle tissue is suggested by studies showing that new RA pharmacologic agents strongly ... Full text Link to item Cite

Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.

Journal Article Nutr Rev · January 1, 2021 Caloric restriction (CR) is a strategy that attenuates aging in multiple nonhuman species. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trials are part of a research program aiming to test the effects of CR on ag ... Full text Link to item Cite

High-intensity interval training and essential amino acid supplementation: Effects on muscle characteristics and whole-body protein turnover.

Journal Article Physiol Rep · January 2021 The purpose of this study was to compare the independent and combined effects of high-intensity interval training (HIIT) and essential amino acids (EAA) on lean mass, muscle characteristics of the quadriceps, and 24-hr whole-body protein turnover (WBPT) in ... Full text Link to item Cite

Effects of Amount, Intensity, and Mode of Exercise Training on Insulin Resistance and Type 2 Diabetes Risk in the STRRIDE Randomized Trials.

Journal Article Front Physiol · 2021 BACKGROUND: Lipoprotein Insulin Resistance Index (LP-IR) and Diabetes Risk Index are novel spectroscopic multimarkers of insulin resistance and type 2 diabetes risk. As the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE ... Full text Link to item Cite

Aerobic exercise training decreases multi-indicator, physiology-based measures of biological aging

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · 2021 Cite

A Pilot Study of Home-Based Exercise and Personalized Nutrition Counseling Intervention in Endometrial Cancer Survivors.

Journal Article Front Oncol · 2021 INTRODUCTION: To assess the feasibility of a home-based aerobic exercise and nutrition counseling intervention and effect on cardiorespiratory fitness, cardiovascular disease risk profile, and immune response in obese endometrial cancer survivors. METHODS: ... Full text Link to item Cite

Branched-Chain Amino Acid Catabolism and Cardiopulmonary Function Following Acute Maximal Exercise Testing in Adolescents.

Journal Article Front Cardiovasc Med · 2021 Background: To provide energy for cardiopulmonary function and maintenance of blood glucose, acute aerobic exercise induces lipolysis, fatty acid oxidation (FAO), glycolysis, and glycogenolysis/gluconeogenesis. These adaptations are mediated by increases i ... Full text Link to item Cite

The Relation of Accelerometer-Measured Physical Activity and Serum Uric Acid Using the National Health and Nutrition Survey (NHANES) 2003-2004.

Journal Article Front Sports Act Living · 2021 Objective: Gout is a crystal-induced inflammatory arthritis caused by elevated uric acid. Physical activity has the potential to reduce serum uric acid (SUA), thus improving the disease burden of gout. In this study, we examined the association of objectiv ... Full text Open Access Link to item Cite

GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases.

Journal Article Am J Prev Cardiol · December 2020 GlycA is a biomarker of systemic inflammation, quantifying both the protein concentrations and glycosylation states of several acute phase proteins. GlycA has been shown to be associated with both subclinical atherosclerosis and with cardiovascular disease ... Full text Link to item Cite

Metabolic and physiological effects of high intensity interval training in patients with knee osteoarthritis: A pilot and feasibility study.

Journal Article Osteoarthr Cartil Open · December 2020 OBJECTIVE: To examine the feasibility of a 6-week high intensity interval training (HIIT) program in patients with symptomatic knee osteoarthritis (OA). A secondary aim was to evaluate the change in whole-body metabolism. DESIGN: In a single-arm interventi ... Full text Link to item Cite

Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease.

Journal Article Vasc Med · October 2020 Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Exercise intolerance may result from reduced skeletal muscle capillary density and impaired muscle oxygen deliv ... Full text Link to item Cite

Biomarkers Associated with Physical Resilience After Hip Fracture.

Journal Article J Gerontol A Biol Sci Med Sci · September 25, 2020 BACKGROUND: Clinically similar older adults demonstrate variable responses to health stressors, heterogeneity attributable to differences in physical resilience. However, molecular mechanisms underlying physical resilience are unknown. We previously derive ... Full text Link to item Cite

Racial Differences in Performance-Based Function and Potential Explanatory Factors Among Individuals With Knee Osteoarthritis.

Journal Article Arthritis Care Res (Hoboken) · September 2020 OBJECTIVE: In individuals with knee osteoarthritis (OA), self-reported physical function is poorer in African Americans than in whites, but whether this difference holds true for objective assessments is unclear. The purpose of this study was to examine ra ... Full text Link to item Cite

Associations of self-reported eating disorder behaviors and personality in a college-educated sample.

Journal Article Appetite · August 1, 2020 OBJECTIVE: In order to better understand factors motivating eating disorder (ED) behaviors and better identify persons at-risk for these behaviors, we sought to identify which personality domains and facets were associated with behaviors for weight control ... Full text Link to item Cite

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.

Journal Article Cell · June 25, 2020 Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. ... Full text Link to item Cite

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm.

Journal Article Elife · May 5, 2020 Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints in trials of therapies designed to ... Full text Open Access Link to item Cite

Skeletal muscle disease in rheumatoid arthritis: the center of cardiometabolic comorbidities?

Journal Article Curr Opin Rheumatol · May 2020 PURPOSE OF REVIEW: Despite its critical roles in body movement, structure, and metabolism, skeletal muscle remains underappreciated in the context of rheumatoid arthritis. In rheumatoid arthritis, chronic inflammation, physical inactivity, and medication t ... Full text Link to item Cite

Benefits and promotion of physical activity in rheumatoid arthritis.

Journal Article Curr Opin Rheumatol · May 2020 PURPOSE OF REVIEW: The aim of this article is to describe the benefits of physical activity and exercise on rheumatoid arthritis disease activity, functioning, and symptoms; and offer recommendations for promotion of physical activity and exercise among pe ... Full text Link to item Cite

Two Approaches to Classifying and Quantifying Physical Resilience in Longitudinal Data.

Journal Article J Gerontol A Biol Sci Med Sci · March 9, 2020 BACKGROUND: Approaches for quantifying physical resilience in older adults have not been described. METHODS: We apply two conceptual approaches to defining physical resilience to existing longitudinal data sets in which outcomes are measured after an acute ... Full text Link to item Cite

Abstract P461: Genome-wide Analysis in Sedentary Adults of Non-completion of a Controlled Exercise Intervention

Conference Circulation · March 3, 2020 A wide range of health benefits of exercise have been documented in clinical lifestyle medicine. However, many individuals fail to complete or maintain an exercise program. We hypothesized that this behavior has biological underpinning ... Full text Cite

Implementation of a group physical therapy program for Veterans with knee osteoarthritis.

Journal Article BMC Musculoskelet Disord · February 3, 2020 BACKGROUND: A previous randomized clinical trial found that a Group Physical Therapy (PT) program for knee osteoarthritis yielded similar improvements in pain and function compared with traditional individual PT. Based on these findings the Group PT progra ... Full text Open Access Link to item Cite

Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes - A Pilot Study.

Journal Article Front Immunol · 2020 Neutrophil dysfunction is a common feature of aging, and is associated with the pathogenesis of many age-related diseases, including type 2 diabetes mellitus (T2DM). Although exercise training improves metabolic health, decreases risk of T2DM, and is assoc ... Full text Link to item Cite

FITBIT®-DERIVED EVIDENCE OF ENHANCED MOBILITY OF PATIENTS WITH KNEE OSTEOARTHRITIS TREATED WITH TRIAMCINOLONE ACETONIDE EXTENDED RELEASE: RESULTS FROM A PHASE 3B, SINGLE-ARM, OPEN-LABEL STUDY

Conference OSTEOARTHRITIS AND CARTILAGE · 2020 Cite