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Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease.

Publication ,  Journal Article
Duscha, BD; Kraus, WE; Jones, WS; Robbins, JL; Piner, LW; Huffman, KM; Allen, JD; Annex, BH
Published in: Vasc Med
October 2020

Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Exercise intolerance may result from reduced skeletal muscle capillary density and impaired muscle oxygen delivery. This cross-sectional study tested the hypothesis that capillary density is related to claudication times and anaerobic threshold (AT) in patients with PAD. A total of 37 patients with PAD and 29 control subjects performed cardiopulmonary exercise testing on a treadmill for AT and gastrocnemius muscle biopsies. Skeletal muscle capillary density was measured using immunofluorescence staining. PAD had decreased capillary density (278 ± 87 vs 331 ± 86 endothelial cells/mm2, p = 0.05), peak VO2 (15.7 ± 3.9 vs 24.3 ± 5.2 mL/kg/min, p ⩽ 0.001), and VO2 at AT (11.5 ± 2.6 vs 16.1 ± 2.8 mL/kg/min, p ⩽ 0.001) compared to control subjects. In patients with PAD, but not control subjects, capillary density was related to VO2 at AT (r = 0.343; p = 0.038), time to AT (r = 0.381; p = 0.020), and time after AT to test termination (r = 0.610; p ⩽ 0.001). Capillary density was also related to time to claudication (r = 0.332; p = 0.038) and time after claudication to test termination (r = 0.584; p ⩽ 0.001). In conclusion, relationships between capillary density, AT, and claudication symptoms indicate that, in PAD, exercise limitations are likely partially dependent on limited skeletal muscle capillary density and oxidative metabolism.

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Published In

Vasc Med

DOI

EISSN

1477-0377

Publication Date

October 2020

Volume

25

Issue

5

Start / End Page

411 / 418

Location

England

Related Subject Headings

  • Regional Blood Flow
  • Peripheral Arterial Disease
  • Muscle, Skeletal
  • Middle Aged
  • Microvascular Density
  • Male
  • Intermittent Claudication
  • Humans
  • Female
  • Exercise Tolerance
 

Citation

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Duscha, B. D., Kraus, W. E., Jones, W. S., Robbins, J. L., Piner, L. W., Huffman, K. M., … Annex, B. H. (2020). Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease. Vasc Med, 25(5), 411–418. https://doi.org/10.1177/1358863X20945794
Duscha, Brian D., William E. Kraus, William S. Jones, Jennifer L. Robbins, Lucy W. Piner, Kim M. Huffman, Jason D. Allen, and Brian H. Annex. “Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease.Vasc Med 25, no. 5 (October 2020): 411–18. https://doi.org/10.1177/1358863X20945794.
Duscha BD, Kraus WE, Jones WS, Robbins JL, Piner LW, Huffman KM, et al. Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease. Vasc Med. 2020 Oct;25(5):411–8.
Duscha, Brian D., et al. “Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease.Vasc Med, vol. 25, no. 5, Oct. 2020, pp. 411–18. Pubmed, doi:10.1177/1358863X20945794.
Duscha BD, Kraus WE, Jones WS, Robbins JL, Piner LW, Huffman KM, Allen JD, Annex BH. Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease. Vasc Med. 2020 Oct;25(5):411–418.
Journal cover image

Published In

Vasc Med

DOI

EISSN

1477-0377

Publication Date

October 2020

Volume

25

Issue

5

Start / End Page

411 / 418

Location

England

Related Subject Headings

  • Regional Blood Flow
  • Peripheral Arterial Disease
  • Muscle, Skeletal
  • Middle Aged
  • Microvascular Density
  • Male
  • Intermittent Claudication
  • Humans
  • Female
  • Exercise Tolerance