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The impact of exercise on gene regulation in association with complex trait genetics.

Publication ,  Journal Article
Vetr, NG; Gay, NR; MoTrPAC Study Group; Montgomery, SB
Published in: Nat Commun
May 1, 2024

Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or easily biopsied tissues. Extensive transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium has provided a unique opportunity to clarify how exercise can affect tissue-specific gene expression and further suggest how exercise adaptation may impact complex disease-associated genes. To build this map, we integrate this multi-tissue atlas of gene expression changes with gene-disease targets, genetic regulation of expression, and trait relationship data in humans. Consensus from multiple approaches prioritizes specific tissues and genes where endurance exercise impacts disease-relevant gene expression. Specifically, we identify a total of 5523 trait-tissue-gene triplets to serve as a valuable starting point for future investigations [Exercise; Transcription; Human Phenotypic Variation].

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

May 1, 2024

Volume

15

Issue

1

Start / End Page

3346

Location

England

Related Subject Headings

  • Transcriptome
  • Rats
  • Quantitative Trait Loci
  • Physical Conditioning, Animal
  • Phenotype
  • Multifactorial Inheritance
  • Male
  • Humans
  • Gene Expression Regulation
  • Gene Expression Profiling
 

Citation

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Vetr, N. G., Gay, N. R., MoTrPAC Study Group, & Montgomery, S. B. (2024). The impact of exercise on gene regulation in association with complex trait genetics. Nat Commun, 15(1), 3346. https://doi.org/10.1038/s41467-024-45966-w
Vetr, Nikolai G., Nicole R. Gay, MoTrPAC Study Group, and Stephen B. Montgomery. “The impact of exercise on gene regulation in association with complex trait genetics.Nat Commun 15, no. 1 (May 1, 2024): 3346. https://doi.org/10.1038/s41467-024-45966-w.
Vetr NG, Gay NR, MoTrPAC Study Group, Montgomery SB. The impact of exercise on gene regulation in association with complex trait genetics. Nat Commun. 2024 May 1;15(1):3346.
Vetr, Nikolai G., et al. “The impact of exercise on gene regulation in association with complex trait genetics.Nat Commun, vol. 15, no. 1, May 2024, p. 3346. Pubmed, doi:10.1038/s41467-024-45966-w.
Vetr NG, Gay NR, MoTrPAC Study Group, Montgomery SB. The impact of exercise on gene regulation in association with complex trait genetics. Nat Commun. 2024 May 1;15(1):3346.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

May 1, 2024

Volume

15

Issue

1

Start / End Page

3346

Location

England

Related Subject Headings

  • Transcriptome
  • Rats
  • Quantitative Trait Loci
  • Physical Conditioning, Animal
  • Phenotype
  • Multifactorial Inheritance
  • Male
  • Humans
  • Gene Expression Regulation
  • Gene Expression Profiling